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PRJNA207719: Tissue specific transcriptome profiling
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Results for prdm1a
Z-value: 1.71
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Transcription factors associated with prdm1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| prdm1a | dr11_v1_chr16_-_7443388_7443388 | 0.92 | 2.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_13373593 Show fit | 1.34 |
ENSDART00000051668
ENSDART00000183883 |
chemokine (C-C motif) ligand 19a, tandem duplicate 2 |
|
| chr25_+_10416583 Show fit | 0.89 |
ENSDART00000073907
|
ets homologous factor |
|
| chr10_+_17776981 Show fit | 0.84 |
ENSDART00000141693
|
chemokine (C-C motif) ligand 19b |
|
| chr15_-_47929455 Show fit | 0.79 |
ENSDART00000064462
|
proteasome subunit alpha 6, like |
|
| chr8_-_50259448 Show fit | 0.78 |
ENSDART00000146056
|
NK3 homeobox 1 |
|
| chr15_+_17752928 Show fit | 0.76 |
ENSDART00000155314
|
si:ch211-213d14.2 |
|
| chr6_+_46697710 Show fit | 0.71 |
ENSDART00000154969
|
thymocyte expressed, positive selection associated 1 |
|
| chr4_-_77216726 Show fit | 0.66 |
ENSDART00000099943
|
proteasome subunit beta 10 |
|
| chr6_-_40657653 Show fit | 0.65 |
ENSDART00000154359
|
peptidylprolyl isomerase (cyclophilin)-like 1 |
|
| chr11_-_18705303 Show fit | 0.64 |
ENSDART00000059732
|
inhibitor of DNA binding 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of prdm1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 2.7 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.1 | 1.3 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.0 | 1.1 | GO:0050673 | epithelial cell proliferation(GO:0050673) |
| 0.2 | 1.0 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.1 | 0.9 | GO:1900407 | regulation of cellular response to oxidative stress(GO:1900407) |
| 0.0 | 0.9 | GO:0009225 | nucleotide-sugar metabolic process(GO:0009225) |
| 0.1 | 0.6 | GO:0036368 | cone photoresponse recovery(GO:0036368) |
| 0.0 | 0.6 | GO:0098884 | postsynaptic neurotransmitter receptor internalization(GO:0098884) |
| 0.0 | 0.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.2 | 1.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.9 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.7 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 0.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 0.5 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 0.5 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 0.4 | GO:0000938 | GARP complex(GO:0000938) |
| 0.0 | 0.4 | GO:0005682 | U5 snRNP(GO:0005682) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 2.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 0.9 | GO:0004649 | poly(ADP-ribose) glycohydrolase activity(GO:0004649) |
| 0.0 | 0.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.5 | GO:0000254 | C-4 methylsterol oxidase activity(GO:0000254) |
| 0.0 | 0.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.5 | GO:0004675 | transmembrane receptor protein serine/threonine kinase activity(GO:0004675) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.6 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.4 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.1 | 0.4 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 0.4 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.4 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.2 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.1 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |