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PRJNA207719: Tissue specific transcriptome profiling
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Results for pou4f3_pou4f1+pou4f4
Z-value: 3.28
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Transcription factors associated with pou4f3_pou4f1+pou4f4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pou4f1 | dr11_v1_chr6_+_4539953_4539953 | 0.97 | 5.0e-03 | Click! |
| zgc:158291 | dr11_v1_chr21_+_38312549_38312549 | 0.90 | 3.7e-02 | Click! |
| pou4f3 | dr11_v1_chr9_+_54290896_54290896 | 0.75 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_21688176 Show fit | 4.74 |
ENSDART00000063825
|
shadow of prion protein |
|
| chr23_-_27345425 Show fit | 4.58 |
ENSDART00000022042
ENSDART00000191870 |
sodium channel, voltage gated, type VIII, alpha subunit a |
|
| chr20_+_9355912 Show fit | 4.13 |
ENSDART00000142337
|
si:dkey-174m14.3 |
|
| chr5_+_58372164 Show fit | 3.91 |
ENSDART00000057910
|
neurogranin (protein kinase C substrate, RC3) a |
|
| chr24_-_3419998 Show fit | 3.79 |
ENSDART00000066839
|
solute carrier family 35, member G2b |
|
| chr2_+_50608099 Show fit | 3.57 |
ENSDART00000185805
ENSDART00000111135 |
neuronal differentiation 6b |
|
| chr24_+_14713776 Show fit | 3.48 |
ENSDART00000134475
|
ganglioside induced differentiation associated protein 1 |
|
| chr23_-_24195723 Show fit | 3.42 |
ENSDART00000145489
|
anoctamin 11 |
|
| chr21_-_13123176 Show fit | 3.32 |
ENSDART00000144866
ENSDART00000024616 |
family with sequence similarity 219, member Aa |
|
| chr23_-_24195519 Show fit | 3.30 |
ENSDART00000112370
ENSDART00000180377 |
anoctamin 11 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pou4f3_pou4f1+pou4f4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.7 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) |
| 0.0 | 5.2 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 1.1 | 4.6 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.2 | 4.1 | GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity(GO:0098962) |
| 0.1 | 3.6 | GO:0060319 | primitive erythrocyte differentiation(GO:0060319) |
| 0.2 | 3.5 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 3.2 | GO:0030334 | regulation of cell migration(GO:0030334) |
| 1.0 | 3.0 | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630) |
| 0.7 | 2.9 | GO:0097112 | gamma-aminobutyric acid receptor clustering(GO:0097112) |
| 0.0 | 2.9 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.1 | 6.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 4.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 4.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 3.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.3 | 3.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 2.8 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.2 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 1.9 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.7 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.4 | 8.4 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 5.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 3.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.1 | 3.4 | GO:0080132 | fatty acid alpha-hydroxylase activity(GO:0080132) |
| 0.1 | 3.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 3.2 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 2.6 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 2.3 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 2.1 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.5 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 1.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.2 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 0.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 0.7 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 0.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.6 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |