ISMARA results: pou4f2

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PRJNA207719: Tissue specific transcriptome profiling

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Results for pou4f2

Z-value: 1.69

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Transcription factors associated with pou4f2

Gene Symbol	Gene ID	Gene Info
pou4f2 NCBI UniProt	ENSDARG00000069737	POU class 4 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pou4f2	dr11_v1_chr1_+_36437585_36437585	0.89	4.3e-02	Click!

Activity profile of pou4f2 motif

Sorted Z-values of pou4f2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_15433518 Show fit	2.14	ENSDART00000026180	fabp7a NCBI UniProt Show fit	fatty acid binding protein 7, brain, a
chr17_+_15433671 Show fit	2.06	ENSDART00000149568	fabp7a NCBI UniProt Show fit	fatty acid binding protein 7, brain, a
chr7_+_73630751 Show fit	1.95	ENSDART00000159745	PCP4L1 NCBI UniProt Show fit	si:dkey-46i9.1
chr16_+_29303971 Show fit	1.75	ENSDART00000087149	hapln2 NCBI UniProt Show fit	hyaluronan and proteoglycan link protein 2
chr8_+_16025554 Show fit	1.69	ENSDART00000110171	elavl4 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr6_+_27146671 Show fit	1.67	ENSDART00000156792	kif1aa NCBI UniProt Show fit	kinesin family member 1Aa
chr2_-_21082695 Show fit	1.61	ENSDART00000032502	nebl NCBI UniProt Show fit	nebulette
chr19_-_31402429 Show fit	1.57	ENSDART00000137292	tmem106bb NCBI UniProt Show fit	transmembrane protein 106Bb
chr5_+_37966505 Show fit	1.55	ENSDART00000127648	pafah1b2 NCBI UniProt Show fit	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
chr19_-_32641725 Show fit	1.52	ENSDART00000165006 ENSDART00000188185	hpca NCBI UniProt Show fit	hippocalcin

Showing 1 to 10 of 142 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pou4f2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.1	2.2	GO:0070593	dendrite self-avoidance(GO:0070593)
0.3	1.7	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.1	1.6	GO:0032418	lysosome localization(GO:0032418)
0.2	1.5	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3	1.4	GO:0019242	methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2	1.4	GO:0003404	optic vesicle morphogenesis(GO:0003404)
0.0	1.3	GO:0046328	regulation of JNK cascade(GO:0046328)
0.2	1.2	GO:1901908	diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1	1.2	GO:0031952	regulation of protein autophosphorylation(GO:0031952)

Showing 1 to 10 of 42 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	2.4	GO:0005871	kinesin complex(GO:0005871)
0.1	2.3	GO:0043204	perikaryon(GO:0043204)
0.0	1.7	GO:0031902	late endosome membrane(GO:0031902)
0.0	1.6	GO:0005925	focal adhesion(GO:0005925)
0.0	1.4	GO:0005769	early endosome(GO:0005769)
0.0	1.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	1.2	GO:0016342	catenin complex(GO:0016342)
0.0	1.1	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	1.1	GO:0048786	presynaptic active zone(GO:0048786)

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.2	GO:0005504	fatty acid binding(GO:0005504)
0.1	2.2	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	1.8	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	1.7	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	1.6	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.3	1.4	GO:0008929	triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1	1.4	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.2	1.2	GO:0034432	endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1	1.2	GO:0072542	phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0	1.2	GO:0045296	cadherin binding(GO:0045296)

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	1.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	1.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	0.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.5	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.6	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	1.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	1.1	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.6	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.5	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling

Showing 1 to 10 of 11 entries

Results for pou4f2

Z-value: 1.69

Motif logo

Transcription factors associated with pou4f2

Activity-expression correlation:

Activity profile of pou4f2 motif

Sorted Z-values of pou4f2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pou4f2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: