ISMARA results: pou3f2a+pou3f2b+pou3f3a+pou3f3b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for pou3f2a+pou3f2b+pou3f3a+pou3f3b

Z-value: 1.56

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Transcription factors associated with pou3f2a+pou3f2b+pou3f3a+pou3f3b

Gene Symbol	Gene ID	Gene Info
pou3f3a NCBI UniProt	ENSDARG00000042032	POU class 3 homeobox 3a
pou3f2a NCBI UniProt	ENSDARG00000070220	POU class 3 homeobox 2a
pou3f2b NCBI UniProt	ENSDARG00000076262	POU class 3 homeobox 2b
pou3f3b NCBI UniProt	ENSDARG00000095896	POU class 3 homeobox 3b
pou3f2b NCBI UniProt	ENSDARG00000112713	POU class 3 homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pou3f2a	dr11_v1_chr4_+_5741733_5741733	-0.35	5.6e-01	Click!
pou3f3a	dr11_v1_chr9_-_6661657_6661666	-0.33	5.9e-01	Click!
pou3f3b	dr11_v1_chr6_+_14949950_14949950	-0.33	5.9e-01	Click!
pou3f2b	dr11_v1_chr16_+_32559821_32559821	-0.26	6.7e-01	Click!

Activity profile of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Sorted Z-values of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_25418856 Show fit	0.83	ENSDART00000013714	gata1a NCBI UniProt Show fit	GATA binding protein 1a
chr7_-_16562200 Show fit	0.75	ENSDART00000169093 ENSDART00000173491	csrp3 NCBI UniProt Show fit	cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr19_-_5380770 Show fit	0.64	ENSDART00000000221	krt91 NCBI UniProt Show fit	keratin 91
chr20_-_29482492 Show fit	0.63	ENSDART00000178308	actc1a NCBI UniProt Show fit	actin, alpha, cardiac muscle 1a
chr23_-_24263474 Show fit	0.55	ENSDART00000160312	hspb7 NCBI UniProt Show fit	heat shock protein family, member 7 (cardiovascular)
chr3_-_43770876 Show fit	0.51	ENSDART00000160162	zgc:92162 NCBI UniProt Show fit	zgc:92162
chr4_-_67799941 Show fit	0.46	ENSDART00000185830	si:ch211-66c13.1 NCBI UniProt Show fit	si:ch211-66c13.1
chr1_+_53945934 Show fit	0.45	ENSDART00000052838	acta1a NCBI UniProt Show fit	actin, alpha 1a, skeletal muscle
chr25_-_27819838 Show fit	0.44	ENSDART00000067106	lmod2a NCBI UniProt Show fit	leiomodin 2 (cardiac) a
chr10_-_42237304 Show fit	0.43	ENSDART00000140341	tcf7l1a NCBI UniProt Show fit	transcription factor 7 like 1a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f2a+pou3f2b+pou3f3a+pou3f3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0050482	icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2	0.8	GO:0030224	monocyte differentiation(GO:0030224)
0.2	0.7	GO:0035994	response to muscle stretch(GO:0035994)
0.0	0.7	GO:0006783	heme biosynthetic process(GO:0006783)
0.1	0.6	GO:0003272	endocardial cushion formation(GO:0003272)
0.1	0.5	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.0	0.5	GO:0030183	B cell differentiation(GO:0030183)
0.0	0.5	GO:0018149	peptide cross-linking(GO:0018149)
0.1	0.4	GO:0090131	mesenchyme migration(GO:0090131)
0.1	0.4	GO:0060829	negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)

Showing 1 to 10 of 112 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.6	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.5	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.1	0.4	GO:0061702	inflammasome complex(GO:0061702)
0.0	0.4	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.1	0.3	GO:0019815	B cell receptor complex(GO:0019815)
0.1	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.3	GO:0032021	NELF complex(GO:0032021)
0.0	0.3	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.3	GO:0030057	desmosome(GO:0030057)

Showing 1 to 10 of 45 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0042805	actinin binding(GO:0042805)
0.0	0.5	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.5	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	0.5	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.5	GO:0008013	beta-catenin binding(GO:0008013)
0.1	0.4	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.4	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.4	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0	0.4	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)

Showing 1 to 10 of 76 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.5	PID P53 REGULATION PATHWAY	p53 pathway
0.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.4	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.4	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Showing 1 to 10 of 22 entries

Results for pou3f2a+pou3f2b+pou3f3a+pou3f3b

Z-value: 1.56

Motif logo

Transcription factors associated with pou3f2a+pou3f2b+pou3f3a+pou3f3b

Activity-expression correlation:

Activity profile of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Sorted Z-values of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f2a+pou3f2b+pou3f3a+pou3f3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: