PRJNA207719: Tissue specific transcriptome profiling


Results for pitx2

Z-value: 1.54

Motif logo

Transcription factors associated with pitx2

Gene Symbol Gene ID Gene Info
ENSDARG00000036194 paired-like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_45510977 3.16 ENSDART00000090596
fibroblast growth factor 12b
chr23_+_28731379 1.14 ENSDART00000047378
chr7_-_48173440 1.13 ENSDART00000124075
metastasis suppressor 1-like b
chr5_-_23277939 1.12 ENSDART00000003514
proteolipid protein 1b
chr11_-_4235811 1.01 ENSDART00000121716
chr4_+_6643421 0.96 ENSDART00000099462
G protein-coupled receptor 85
chr13_-_30028103 0.94 ENSDART00000183889
stearoyl-CoA desaturase b
chr11_+_25101220 0.90 ENSDART00000183700
ndrg family member 3a
chr8_+_41533268 0.87 ENSDART00000142377
chr2_-_2020044 0.86 ENSDART00000024135
tubulin, beta 2A class IIa
chr12_+_47917971 0.79 ENSDART00000185933
thymus, brain and testes associated
chr19_-_9829965 0.77 ENSDART00000136842
calcium channel, voltage-dependent, gamma subunit 8a
chr25_-_13839743 0.76 ENSDART00000158780
mitogen-activated protein kinase 8 interacting protein 1a
chr21_+_22630297 0.75 ENSDART00000147175
chr19_-_25271155 0.74 ENSDART00000104027
regulating synaptic membrane exocytosis 3
chr19_+_12762887 0.74 ENSDART00000139909
melanocortin 5a receptor
chr25_+_21833287 0.71 ENSDART00000187606
creatine kinase, mitochondrial 1
chr5_+_26075230 0.70 ENSDART00000098473
Kruppel-like factor 9
chr23_-_24856025 0.68 ENSDART00000142171
synaptotagmin VIa
chr21_+_22630627 0.67 ENSDART00000193092
chr4_+_8168514 0.67 ENSDART00000150830
ninjurin 2
chr7_-_57933736 0.65 ENSDART00000142580
ankyrin 2b, neuronal
chr21_+_13366353 0.64 ENSDART00000151630
chr23_+_22267374 0.64 ENSDART00000079035
RAP1 GTPase activating protein
chr11_-_44409856 0.63 ENSDART00000162886
interleukin 1 receptor accessory protein-like 1b
chr18_+_26337869 0.60 ENSDART00000109257
chr15_-_12319065 0.59 ENSDART00000162973
FXYD domain containing ion transport regulator 6
chr25_+_21832938 0.57 ENSDART00000148299
creatine kinase, mitochondrial 1
chr25_+_6306885 0.57 ENSDART00000142705
cellular retinoic acid binding protein 1a
chr9_-_29321625 0.56 ENSDART00000158689
parathyroid hormone 2 receptor
chr14_-_2270973 0.56 ENSDART00000180729
protocadherin 2 alpha b 9
chr10_-_43392267 0.55 ENSDART00000142872
EGF-like repeats and discoidin I-like domains 3b
chr7_-_22132265 0.54 ENSDART00000125284
neuroligin 2a
chr9_+_22631672 0.54 ENSDART00000101770
ets variant 5a
chr2_-_42871286 0.53 ENSDART00000087823
adenylate cyclase 8 (brain)
chr22_+_696931 0.52 ENSDART00000149712
G protein-coupled receptor 37 like 1a
chr9_-_12034444 0.51 ENSDART00000038651
zinc finger protein 804A
chr16_-_13004166 0.51 ENSDART00000133735
calcium channel, voltage-dependent, gamma subunit 7b
chr19_+_37701450 0.51 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr24_+_24461341 0.50 ENSDART00000147658
basic helix-loop-helix family, member e22
chr5_-_29488245 0.49 ENSDART00000047719
calcium channel, voltage-dependent, N type, alpha 1B subunit, a
chr5_-_65158203 0.49 ENSDART00000171656
SH2 domain containing 3Cb
chr13_-_30027730 0.49 ENSDART00000044009
stearoyl-CoA desaturase b
chr5_+_52067723 0.48 ENSDART00000166902
SET binding protein 1
chr21_+_41743493 0.48 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr6_-_46162585 0.46 ENSDART00000017309
carbonic anhydrase XVI b
chr11_-_18468570 0.46 ENSDART00000155474
FYVE, RhoGEF and PH domain containing 5a
chr4_-_9579299 0.45 ENSDART00000183079
SH3 and multiple ankyrin repeat domains 3b
chr10_+_29963518 0.45 ENSDART00000011317
chr6_-_9581949 0.45 ENSDART00000144335
cytochrome P450, family 27, subfamily C, polypeptide 1
chr21_+_3854414 0.44 ENSDART00000122699
mitoguardin 2
chr2_-_2096055 0.44 ENSDART00000126566
solute carrier family 22, member 23
chr23_+_8989168 0.43 ENSDART00000034380
XK, Kell blood group complex subunit-related family, member 7
chr12_+_48390715 0.43 ENSDART00000149351
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_1894722 0.43 ENSDART00000165669
chr18_-_40508528 0.41 ENSDART00000185249
cholinergic receptor, nicotinic, alpha 5
chr13_-_24448278 0.41 ENSDART00000057584
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr14_+_44545092 0.41 ENSDART00000175454
leucine rich repeat and Ig domain containing 2a
chr13_+_16522608 0.40 ENSDART00000182838
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr5_-_38094130 0.40 ENSDART00000131831
chr20_+_41640687 0.40 ENSDART00000138686
family with sequence similarity 184, member A
chr23_+_40604951 0.40 ENSDART00000114959
cadherin 24, type 2a
chr22_+_17509422 0.40 ENSDART00000088419
membrane-associated ring finger (C3HC4) 2
chr8_+_14886452 0.39 ENSDART00000146589
sterol O-acyltransferase 1
chr22_-_23625351 0.39 ENSDART00000192588
complement factor H like 4
chr9_+_22632126 0.38 ENSDART00000139434
ets variant 5a
chr2_+_6253246 0.38 ENSDART00000058256
zona pellucida glycoprotein 3b
chr8_+_7737062 0.38 ENSDART00000166712
FYVE, RhoGEF and PH domain containing 1
chr1_+_33383644 0.38 ENSDART00000187194
dehydrogenase/reductase (SDR family) X-linked
chr6_-_12135741 0.38 ENSDART00000155090
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr14_+_8504410 0.38 ENSDART00000123364
vascular endothelial growth factor Ba
chr16_-_43971258 0.37 ENSDART00000141941
zinc finger protein, FOG family member 2a
chr23_+_40109353 0.37 ENSDART00000149249
growth hormone releasing hormone receptor, like
chr18_-_39702327 0.37 ENSDART00000149158
Dmx-like 2
chr25_-_7999756 0.36 ENSDART00000159908
calcium/calmodulin-dependent protein kinase 1Db
chr14_-_2206476 0.36 ENSDART00000081870
protocadherin 2 alpha b 6
chr23_-_15330168 0.36 ENSDART00000035865
sulfatase 2b
chr21_-_32467099 0.36 ENSDART00000186354
chr5_+_31049742 0.36 ENSDART00000173097
zinc finger, ZZ-type with EF hand domain 1
chr21_+_20715020 0.36 ENSDART00000015224
growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1
chr20_+_18225329 0.36 ENSDART00000144172
potassium channel tetramerization domain containing 1
chr10_+_15777258 0.36 ENSDART00000140511
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr5_+_62052538 0.35 ENSDART00000141574
chr6_+_21740672 0.35 ENSDART00000193734
lipoma HMGIC fusion partner-like 4a
chr10_+_15777064 0.34 ENSDART00000114483
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr1_+_38758261 0.34 ENSDART00000182756
WD repeat domain 17
chr2_-_17947389 0.34 ENSDART00000190089
protein tyrosine phosphatase, receptor type, f, b
chr23_-_24825863 0.34 ENSDART00000112493
synaptotagmin VIa
chr10_-_7857494 0.33 ENSDART00000143215
inositol polyphosphate-5-phosphatase Ja
chr9_-_32753535 0.33 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr2_-_6292510 0.33 ENSDART00000092182
protein phosphatase, Mg2+/Mn2+ dependent, 1La
chr12_+_27068525 0.33 ENSDART00000188634
Snf2-related CREBBP activator protein
chr3_+_26019426 0.33 ENSDART00000135389
FAD-dependent oxidoreductase domain containing 2
chr2_-_32738535 0.33 ENSDART00000135293
nuclear receptor binding protein 2a
chr8_+_50983551 0.33 ENSDART00000142061
chr17_+_33495194 0.32 ENSDART00000033691
parathyroid hormone 2
chr17_+_5915875 0.32 ENSDART00000184179
fibronectin type III domain containing 4b
chr17_+_25289431 0.32 ENSDART00000161002
kelch repeat and BTB (POZ) domain containing 11
chr14_+_30730749 0.32 ENSDART00000087884
coiled-coil domain containing 85B
chr10_+_37173029 0.31 ENSDART00000136510
kinase suppressor of ras 1a
chr5_-_71765780 0.31 ENSDART00000011955
G protein signaling modulator 1b
chr13_+_15816573 0.31 ENSDART00000137061
kinesin light chain 1a
chr8_+_694218 0.31 ENSDART00000147753
ring finger protein 165b
chr1_+_38758445 0.31 ENSDART00000136300
WD repeat domain 17
chr7_+_38255418 0.30 ENSDART00000052354
chr20_-_18731268 0.30 ENSDART00000183893
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr18_-_40509006 0.30 ENSDART00000021372
cholinergic receptor, nicotinic, alpha 5
chr11_-_43002262 0.30 ENSDART00000172477

chr21_+_10756154 0.30 ENSDART00000074833
retinal homeobox gene 3
chr25_+_26844028 0.29 ENSDART00000127274
semaphorin 7A
chr10_-_7821686 0.29 ENSDART00000121531
methionine adenosyltransferase II, alpha a
chr9_+_34127005 0.29 ENSDART00000167384
coagulation factor V
chr6_-_36182115 0.29 ENSDART00000154639
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
chr11_-_27057572 0.28 ENSDART00000043091
IQ motif and Sec7 domain 1b
chr7_+_30970045 0.28 ENSDART00000155974
tight junction protein 1a
chr7_+_28901786 0.28 ENSDART00000113998
docking protein 4
chr7_-_19369002 0.28 ENSDART00000165680
netrin 4
chr10_+_37182626 0.28 ENSDART00000137636
kinase suppressor of ras 1a
chr25_-_19090479 0.27 ENSDART00000027465
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr25_+_10458990 0.27 ENSDART00000130354
RIC8 guanine nucleotide exchange factor A
chr10_+_21511495 0.27 ENSDART00000178395

chr13_-_49666615 0.27 ENSDART00000148083
translocase of outer mitochondrial membrane 20
chr15_-_20024205 0.27 ENSDART00000161379
autism susceptibility candidate 2b
chr8_-_54304381 0.27 ENSDART00000184177
chr11_+_6456146 0.26 ENSDART00000036939
growth arrest and DNA-damage-inducible, beta a
chr5_-_20205075 0.26 ENSDART00000051611
D-amino-acid oxidase, tandem duplicate 3
chr17_-_16342388 0.26 ENSDART00000017930
potassium channel, subfamily K, member 13a
chr11_-_29563437 0.25 ENSDART00000163958
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr19_-_40776267 0.25 ENSDART00000189038
calcitonin receptor
chr5_+_33301005 0.25 ENSDART00000006021
ubiquitin specific peptidase 20
chr15_-_21014270 0.24 ENSDART00000154019
chr23_-_45682136 0.24 ENSDART00000164646
family with sequence similarity 160, member A1b
chr1_+_7546259 0.24 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr18_+_36806545 0.24 ENSDART00000098958
tetratricopeptide repeat domain 9B
chr15_-_21014015 0.24 ENSDART00000144991
chr18_-_21806613 0.24 ENSDART00000145721
neuritin 1-like a
chr19_+_42898239 0.24 ENSDART00000051724
cAMP-regulated phosphoprotein, 21
chr2_+_31475772 0.24 ENSDART00000130722
calcium channel, voltage-dependent, beta 2b
chr23_-_28239750 0.23 ENSDART00000003548
zinc finger protein 385A
chr25_-_13703826 0.23 ENSDART00000163398
phospholipase A2, group XV
chr18_+_48608366 0.23 ENSDART00000151229
potassium inwardly-rectifying channel, subfamily J, member 5
chr9_-_53537989 0.23 ENSDART00000114022
SLIT and NTRK-like family, member 5b
chr2_+_49522178 0.23 ENSDART00000056254
signal transducing adaptor family member 2a
chr17_-_24714837 0.22 ENSDART00000154871
chr5_+_483965 0.22 ENSDART00000150007
TEK tyrosine kinase, endothelial
chr2_+_2967255 0.22 ENSDART00000167649
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr13_+_9896845 0.21 ENSDART00000169076
chr12_+_17436904 0.21 ENSDART00000079130
ATPase family, AAA domain containing 1b
chr5_-_72125551 0.21 ENSDART00000149412
SET and MYND domain containing 1a
chr12_+_30653047 0.21 ENSDART00000148562
thrombospondin 2b
chr4_-_20232974 0.21 ENSDART00000193353
serine/threonine kinase 38 like
chr23_+_39413163 0.21 ENSDART00000184254
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr2_-_11258547 0.20 ENSDART00000165803
solute carrier family 44, member 5a
chr24_+_7336807 0.20 ENSDART00000137010
lysine (K)-specific methyltransferase 2Ca
chr21_+_10866421 0.20 ENSDART00000137858
alpha-kinase 2
chr7_+_29167744 0.20 ENSDART00000076345
solute carrier family 38, member 8b
chr23_+_21638258 0.20 ENSDART00000104188
immunoglobin superfamily, member 21b
chr3_-_37351225 0.20 ENSDART00000174685
chr19_+_4142529 0.20 ENSDART00000162913
chr18_+_507835 0.20 ENSDART00000189701
neural precursor cell expressed, developmentally down-regulated 4a
chr12_+_30706158 0.19 ENSDART00000133869
potassium channel, subfamily K, member 1a
chr17_+_21760032 0.19 ENSDART00000190425
IKAROS family zinc finger 5
chr10_+_26926654 0.19 ENSDART00000078980
RAB1B, member RAS oncogene family b
chr21_-_39177564 0.19 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr15_+_11693624 0.19 ENSDART00000193630
striatin, calmodulin binding protein 4
chr5_+_64840656 0.19 ENSDART00000073953
leucine rich repeat containing 8 VRAC subunit Ab
chr13_-_30149973 0.19 ENSDART00000041515
secretion associated, Ras related GTPase 1Ab
chr8_+_16990120 0.18 ENSDART00000018934
phosphodiesterase 4D, cAMP-specific
chr23_-_31400792 0.18 ENSDART00000132736
Leber congenital amaurosis 5
chr20_+_36233873 0.18 ENSDART00000131867
cornichon family AMPA receptor auxiliary protein 3
chr9_+_14028157 0.18 ENSDART00000134603
chr18_+_507618 0.18 ENSDART00000159464
neural precursor cell expressed, developmentally down-regulated 4a
chr3_+_52806347 0.18 ENSDART00000168151
LIM homeobox transcription factor 1, alpha-like
chr10_+_8534750 0.17 ENSDART00000183960
TBC1 domain family, member 10Ab
chr6_-_6248893 0.17 ENSDART00000124662
reticulon 4a
chr14_-_2004291 0.17 ENSDART00000114039
protocadherin 2 gamma 5
chr9_+_307863 0.17 ENSDART00000163474
SH3 and cysteine rich domain 3
chr23_+_45282858 0.17 ENSDART00000162353

chr18_-_17001056 0.17 ENSDART00000112627
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
chr1_+_33322555 0.17 ENSDART00000113486
matrix-remodelling associated 5a
chr19_+_10661520 0.17 ENSDART00000091813
argonaute RISC catalytic component 3b
chr18_-_17000842 0.17 ENSDART00000079832
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
chr20_-_25436389 0.17 ENSDART00000153266
intersectin 2a
chr5_-_68456987 0.17 ENSDART00000157810
eph receptor B4a
chr9_+_23748133 0.17 ENSDART00000180758
Fas apoptotic inhibitory molecule a
chr8_+_17184602 0.16 ENSDART00000050228
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr5_+_37978501 0.16 ENSDART00000012050
apolipoprotein A-Ia
chr19_-_3193912 0.16 ENSDART00000133159
chr14_-_2264494 0.16 ENSDART00000191149
protocadherin 2 alpha b 9
chr19_-_31802296 0.16 ENSDART00000103640
hes-related family bHLH transcription factor with YRPW motif 1
chr11_-_26832685 0.16 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr18_+_6054816 0.16 ENSDART00000113668
chr17_+_28624321 0.16 ENSDART00000122260
HEAT repeat containing 5a
chr16_-_45910050 0.15 ENSDART00000133213
antifreeze protein type IV
chr4_+_49664256 0.15 ENSDART00000155251
zinc finger protein 974
chr12_+_28995942 0.15 ENSDART00000076334
vertebrate ancient long opsin b
chr17_-_43552894 0.15 ENSDART00000181226
5'-nucleotidase, cytosolic IAb
chr13_+_50151407 0.15 ENSDART00000031858
G protein-coupled receptor 137Ba
chr7_+_47316944 0.15 ENSDART00000173534
dpy-19 like C-mannosyltransferase 3
chr6_-_39903393 0.15 ENSDART00000085945
Ts translation elongation factor, mitochondrial

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2 3.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.7 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.6 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.4 GO:0097401 regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546)
0.1 0.6 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.1 1.3 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.3 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.3 GO:0010934 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.4 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.1 0.6 GO:0098815 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 0.9 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 0.3 GO:0021742 abducens nucleus development(GO:0021742)
0.1 1.3 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 0.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 0.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.3 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 0.7 GO:0035094 response to nicotine(GO:0035094)
0.1 0.3 GO:0009080 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 0.6 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1 0.3 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 1.1 GO:0097178 ruffle assembly(GO:0097178)
0.1 1.1 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 0.4 GO:0021553 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.0 0.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.1 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.5 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.0 0.5 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.2 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 1.4 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.3 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.3 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.4 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.5 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.2 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.0 0.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.4 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.0 0.4 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.3 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.2 GO:1900186 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 0.5 GO:0033135 regulation of peptidyl-serine phosphorylation(GO:0033135)
0.0 1.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.3 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.2 GO:0072091 regulation of stem cell proliferation(GO:0072091)
0.0 0.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.0 0.6 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.0 0.1 GO:0019563 glycerol catabolic process(GO:0019563)
0.0 0.4 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 1.0 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.8 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0030431 sleep(GO:0030431)
0.0 0.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.2 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 0.1 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.1 GO:0042438 melanin biosynthetic process(GO:0042438) secondary metabolite biosynthetic process(GO:0044550)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:0043291 RAVE complex(GO:0043291)
0.1 0.3 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.8 GO:0043209 myelin sheath(GO:0043209)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.7 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.2 GO:0042627 chylomicron(GO:0042627)
0.0 0.3 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:1990923 PET complex(GO:1990923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0032896 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 0.6 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.1 3.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.0 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.4 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.7 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.2 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.3 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.3 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.3 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.1 0.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0010852 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.0 2.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling