Project
PRJNA207719: Tissue specific transcriptome profiling
Navigation
Downloads
Results for pitx2
Z-value: 1.54
Motif logo
Transcription factors associated with pitx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pitx2 | dr11_v1_chr14_+_36223097_36223097 | 0.49 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_45510977 Show fit | 3.16 |
ENSDART00000090596
|
fibroblast growth factor 12b |
|
| chr23_+_28731379 Show fit | 1.14 |
ENSDART00000047378
|
cortistatin |
|
| chr7_-_48173440 Show fit | 1.13 |
ENSDART00000124075
|
metastasis suppressor 1-like b |
|
| chr5_-_23277939 Show fit | 1.12 |
ENSDART00000003514
|
proteolipid protein 1b |
|
| chr11_-_4235811 Show fit | 1.01 |
ENSDART00000121716
|
si:ch211-236d3.4 |
|
| chr4_+_6643421 Show fit | 0.96 |
ENSDART00000099462
|
G protein-coupled receptor 85 |
|
| chr13_-_30028103 Show fit | 0.94 |
ENSDART00000183889
|
stearoyl-CoA desaturase b |
|
| chr11_+_25101220 Show fit | 0.90 |
ENSDART00000183700
|
ndrg family member 3a |
|
| chr8_+_41533268 Show fit | 0.87 |
ENSDART00000142377
|
si:ch211-158d24.2 |
|
| chr2_-_2020044 Show fit | 0.86 |
ENSDART00000024135
|
tubulin, beta 2A class IIa |
Network of associatons between targets according to the STRING database.
First level regulatory network of pitx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.5 | 1.9 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.0 | 1.4 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.1 | 1.3 | GO:0042396 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.1 | 1.3 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.0 | 1.3 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.1 | 1.1 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.1 | 1.1 | GO:0022010 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 1.0 | GO:0051017 | actin filament bundle assembly(GO:0051017) |
| 0.1 | 0.9 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.3 | 0.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 0.8 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.7 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.0 | 0.6 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.6 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.5 | 1.9 | GO:0032896 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.1 | 1.3 | GO:0016775 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.1 | 1.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 0.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.8 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.7 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 0.4 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.2 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 0.7 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 0.6 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 0.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.5 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 0.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.2 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |