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PRJNA207719: Tissue specific transcriptome profiling

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Results for phf21ab+rfx5

Z-value: 1.10

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Transcription factors associated with phf21ab+rfx5

Gene Symbol Gene ID Gene Info
phf21ab
ENSDARG00000021378 PHD finger protein 21Ab
rfx5
ENSDARG00000063258 regulatory factor X, 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phf21abdr11_v1_chr25_-_7759453_7759525-0.847.8e-02Click!
rfx5dr11_v1_chr19_-_7495006_7495006-0.701.9e-01Click!

Activity profile of phf21ab+rfx5 motif

Sorted Z-values of phf21ab+rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_7110617 1.72 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr3_-_19561058 1.27 ENSDART00000079323
zgc:163079
zgc:163079
chr10_-_22797959 1.22 ENSDART00000183269
pcolcea
procollagen C-endopeptidase enhancer a
chr21_+_33459524 0.99 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr19_+_43297546 0.92 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr12_+_14084291 0.81 ENSDART00000189734
si:ch211-217a12.1
si:ch211-217a12.1
chr21_-_17290941 0.78 ENSDART00000147993
gfi1b
growth factor independent 1B transcription repressor
chr1_-_7570181 0.72 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr4_-_76370630 0.69 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
si:ch73-158p21.3
chr4_-_75678082 0.68 ENSDART00000180201
si:dkey-165o8.1
si:dkey-165o8.1
chr7_-_3011514 0.68 ENSDART00000169589
zgc:171695
zgc:171695
chr16_-_13516745 0.67 ENSDART00000145410
si:dkeyp-69b9.3
si:dkeyp-69b9.3
chr4_+_7822773 0.63 ENSDART00000171391
si:ch1073-67j19.2
si:ch1073-67j19.2
chr9_-_31090593 0.63 ENSDART00000089136
gpr18
G protein-coupled receptor 18
chr2_-_37862380 0.61 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr3_-_29941357 0.60 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr8_+_36142734 0.60 ENSDART00000159361
ENSDART00000161194
mhc2b
major histocompatibility complex class II integral membrane beta chain gene
chr7_+_66822229 0.55 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr7_-_56606752 0.54 ENSDART00000138714
sult5a1
sulfotransferase family 5A, member 1
chr13_+_233482 0.50 ENSDART00000102511
cfap36
cilia and flagella associated protein 36
chr1_-_23274393 0.46 ENSDART00000147800
ENSDART00000130277
ENSDART00000054340
ENSDART00000054338
rpl9
ribosomal protein L9
chr8_-_36370552 0.45 ENSDART00000097932
ENSDART00000148323
si:busm1-104n07.3
si:busm1-104n07.3
chr11_-_24458786 0.45 ENSDART00000089713
mxra8a
matrix-remodelling associated 8a
chr19_-_27588842 0.44 ENSDART00000121643
si:dkeyp-46h3.2
si:dkeyp-46h3.2
chr9_+_20780813 0.42 ENSDART00000142787
fam46c
family with sequence similarity 46, member C
chr3_-_34102075 0.42 ENSDART00000151708
ighv5-2
immunoglobulin heavy variable 5-2
chr21_-_32097908 0.42 ENSDART00000147387
si:ch211-160j14.3
si:ch211-160j14.3
chr8_-_36412936 0.41 ENSDART00000159276
si:zfos-2070c2.3
si:zfos-2070c2.3
chr7_-_55051692 0.41 ENSDART00000170637
tpcn2
two pore segment channel 2
chr2_+_16173999 0.40 ENSDART00000177639
ENSDART00000157601
ENSDART00000190186
ENSDART00000045933
sh3glb1b
SH3-domain GRB2-like endophilin B1b
chr7_-_26924903 0.40 ENSDART00000124363
alx4a
ALX homeobox 4a
chr6_-_25165693 0.39 ENSDART00000167259
znf326
zinc finger protein 326
chr23_+_45025909 0.39 ENSDART00000188105
hmgb2b
high mobility group box 2b
chr21_-_45920 0.38 ENSDART00000040422
bhmt
betaine-homocysteine methyltransferase
chr15_-_38129845 0.36 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr18_+_8339596 0.32 ENSDART00000183323
ENSDART00000185397
BX276107.1

chr4_+_33095657 0.31 ENSDART00000150647
znf1112
zinc finger protein 1112
chr3_-_7912661 0.31 ENSDART00000161400
trim35-21
tripartite motif containing 35-21
chr18_+_8340886 0.30 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr7_-_26049282 0.29 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr13_-_16066997 0.29 ENSDART00000184790
SPATA48
spermatogenesis associated 48
chr7_+_26049818 0.29 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr6_-_54348568 0.28 ENSDART00000156501
zgc:101577
zgc:101577
chr6_+_26309968 0.27 ENSDART00000153805
dzip1l
DAZ interacting zinc finger protein 1-like
chr4_-_49982134 0.26 ENSDART00000186050
si:dkey-156k2.4
si:dkey-156k2.4
chr5_+_38662125 0.25 ENSDART00000136949
si:dkey-58f10.13
si:dkey-58f10.13
chr10_-_43294933 0.24 ENSDART00000062631
hapln1b
hyaluronan and proteoglycan link protein 1b
chr18_-_21640389 0.22 ENSDART00000100857
slc38a8a
solute carrier family 38, member 8a
chr4_-_43613424 0.22 ENSDART00000171524
si:dkey-16p6.4
si:dkey-16p6.4
chr13_+_22821647 0.21 ENSDART00000109798
ENSDART00000144094
dna2
DNA replication helicase/nuclease 2
chr8_-_32878228 0.21 ENSDART00000110897
si:dkey-56i24.1
si:dkey-56i24.1
chr4_+_30788743 0.20 ENSDART00000184557
si:dkey-178j11.5
si:dkey-178j11.5
chr4_-_36033377 0.19 ENSDART00000164348
ENSDART00000187058
zgc:174180
zgc:174180
chr15_-_17619306 0.19 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr4_+_68939595 0.18 ENSDART00000168331
ENSDART00000193212
si:dkey-264f17.2
si:dkey-264f17.2
chr4_-_330748 0.18 ENSDART00000067488
mrps10
mitochondrial ribosomal protein S10
chr8_-_11077230 0.16 ENSDART00000143844
dennd2c
DENN/MADD domain containing 2C
chr20_+_43396318 0.15 ENSDART00000060910
pimr138
Pim proto-oncogene, serine/threonine kinase, related 138
chr10_-_16028082 0.15 ENSDART00000122540
aldh7a1
aldehyde dehydrogenase 7 family, member A1
chr25_+_27873836 0.14 ENSDART00000163801
iqub
IQ motif and ubiquitin domain containing
chr9_-_41077934 0.14 ENSDART00000100342
ankar
ankyrin and armadillo repeat containing
chr23_+_41831224 0.13 ENSDART00000171885
scp2b
sterol carrier protein 2b
chr4_-_36032177 0.12 ENSDART00000170143
zgc:174180
zgc:174180
chr3_-_8873716 0.12 ENSDART00000171798
znf1150
zinc finger protein 1150
chr8_+_45294767 0.11 ENSDART00000191527
ubap2b
ubiquitin associated protein 2b
chr15_+_32411660 0.10 ENSDART00000113443
si:dkey-285b23.4
si:dkey-285b23.4
chr8_+_20415824 0.09 ENSDART00000009081
ENSDART00000145444
mob3a
MOB kinase activator 3A
chr22_+_34710473 0.09 ENSDART00000155906
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr19_-_45534392 0.08 ENSDART00000163920
trps1
trichorhinophalangeal syndrome I
chr13_-_17860307 0.07 ENSDART00000135920
ENSDART00000054579
march8
membrane-associated ring finger (C3HC4) 8
chr2_-_42958619 0.06 ENSDART00000144317
oc90
otoconin 90
chr20_+_39394308 0.06 ENSDART00000142554
pimr136
Pim proto-oncogene, serine/threonine kinase, related 136
chr18_-_3552414 0.05 ENSDART00000163762
ENSDART00000165434
ENSDART00000161197
ENSDART00000166841
ENSDART00000170260
dcun1d5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr22_+_34710036 0.05 ENSDART00000025820
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr21_+_40239192 0.05 ENSDART00000135857
or115-9
odorant receptor, family F, subfamily 115, member 9
chr16_-_47301376 0.05 ENSDART00000169697
mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr18_+_49225552 0.04 ENSDART00000135026
si:ch211-136a13.1
si:ch211-136a13.1
chr20_+_39373480 0.04 ENSDART00000136714
pimr131
Pim proto-oncogene, serine/threonine kinase, related 131
chr3_+_13929860 0.04 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr20_+_39416729 0.03 ENSDART00000099993
ENSDART00000144133
pimr128
Pim proto-oncogene, serine/threonine kinase, related 128
chr1_-_26045007 0.03 ENSDART00000129259
gpank1
G patch domain and ankyrin repeats 1
chr16_+_40301056 0.03 ENSDART00000058578
rspo3
R-spondin 3
chr10_-_36618674 0.02 ENSDART00000135302
rsf1b.1
remodeling and spacing factor 1b, tandem duplicate 1
chr10_+_36092564 0.02 ENSDART00000086490
smyd4
SET and MYND domain containing 4
chr2_+_37837249 0.02 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr17_-_45040813 0.01 ENSDART00000075514
entpd5a
ectonucleoside triphosphate diphosphohydrolase 5a
chr14_-_16476863 0.01 ENSDART00000089021
canx
calnexin
chr13_+_9368621 0.00 ENSDART00000109126
alms1
Alstrom syndrome protein 1
chr1_+_23274710 0.00 ENSDART00000036448
lias
lipoic acid synthetase
chr4_+_76440462 0.00 ENSDART00000174138
si:dkey-16p6.1
si:dkey-16p6.1

Network of associatons between targets according to the STRING database.

First level regulatory network of phf21ab+rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0010935 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1 0.7 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.1 0.7 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.6 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.3 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.1 1.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.4 GO:2000290 regulation of myotome development(GO:2000290)
0.0 0.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.7 GO:0006577 amino-acid betaine metabolic process(GO:0006577)
0.0 0.1 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.0 0.7 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.5 GO:0051923 sulfation(GO:0051923)
0.0 0.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.4 GO:0044609 DBIRD complex(GO:0044609)
0.1 1.7 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 1.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.8 GO:0030170 pyridoxal phosphate binding(GO:0030170)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism