PRJNA207719: Tissue specific transcriptome profiling


Results for pdx1_pbx4

Z-value: 1.84

Motif logo

Transcription factors associated with pdx1_pbx4

Gene Symbol Gene ID Gene Info
ENSDARG00000002779 pancreatic and duodenal homeobox 1
ENSDARG00000109275 pancreatic and duodenal homeobox 1
ENSDARG00000052150 pre-B-cell leukemia transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of pdx1_pbx4 motif

Sorted Z-values of pdx1_pbx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_+_38301080 17.54 ENSDART00000105672
myosin binding protein C, fast type b
chr21_-_23308286 1.68 ENSDART00000184419
zinc finger and BTB domain containing 16a
chr2_+_47623202 1.64 ENSDART00000154465
chr24_-_6898302 1.35 ENSDART00000158646
dipeptidyl-peptidase 6a
chr21_-_23307653 1.25 ENSDART00000140284
zinc finger and BTB domain containing 16a
chr15_+_4632782 1.17 ENSDART00000156012
chr24_-_6897884 1.16 ENSDART00000080766
dipeptidyl-peptidase 6a
chr20_-_8443425 1.06 ENSDART00000083908
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr5_-_23280098 1.03 ENSDART00000126540
proteolipid protein 1b
chr4_+_21129752 1.00 ENSDART00000169764
synaptotagmin Ia
chr13_-_24447332 0.95 ENSDART00000043004
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr10_-_39011514 0.78 ENSDART00000075123
Purkinje cell protein 4a
chr12_+_39685485 0.77 ENSDART00000163403

chr3_-_32818607 0.76 ENSDART00000075465
myosin light chain, phosphorylatable, fast skeletal muscle a
chr24_-_4973765 0.72 ENSDART00000127597
zic family member 1 (odd-paired homolog, Drosophila)
chr10_-_17745345 0.70 ENSDART00000132690
chr19_-_26869103 0.69 ENSDART00000089699
proline-rich transmembrane protein 1
chr11_-_1509773 0.68 ENSDART00000050762
phosphatase and actin regulator 3b
chr7_+_29952719 0.68 ENSDART00000173737
chr15_-_10341048 0.66 ENSDART00000171013
teneurin transmembrane protein 4
chr19_+_37925616 0.64 ENSDART00000148348
neurexophilin 1
chr9_-_22834860 0.63 ENSDART00000146486
chr2_-_54039293 0.59 ENSDART00000166013
abhydrolase domain containing 8a
chr3_+_33300522 0.58 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr4_-_25485404 0.58 ENSDART00000041402
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_-_9277986 0.57 ENSDART00000146065
ubinuclein 1
chr21_-_43079161 0.56 ENSDART00000144151
janus kinase and microtubule interacting protein 2
chr9_-_23217196 0.55 ENSDART00000083567
kinesin family member 5C
chr1_+_17676745 0.55 ENSDART00000030665
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr9_+_42066030 0.52 ENSDART00000185311
poly(rC) binding protein 3
chr18_-_36135799 0.52 ENSDART00000059344
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a
chr3_-_16068236 0.48 ENSDART00000157315
chr24_-_40009446 0.47 ENSDART00000087422
amine oxidase, copper containing 1
chr18_+_783936 0.46 ENSDART00000193357
ribonuclease P and MRP subunit p25, b
chr3_-_62380146 0.45 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr4_-_5291256 0.45 ENSDART00000150864
chr22_+_3223489 0.45 ENSDART00000082011
lens intrinsic membrane protein 2.2
chr24_+_34113424 0.42 ENSDART00000105572
gastrulation brain homeobox 1
chr20_-_29420713 0.42 ENSDART00000147464
ryanodine receptor 3
chr17_+_27434626 0.41 ENSDART00000052446
vestigial-like family member 2b
chr23_-_11870962 0.41 ENSDART00000143481
chr4_-_4780667 0.41 ENSDART00000133973
chr23_+_6077503 0.41 ENSDART00000081714
myosin binding protein Ha
chr8_+_22931427 0.41 ENSDART00000063096
synaptophysin a
chr11_-_13341483 0.41 ENSDART00000164978
microtubule associated serine/threonine kinase 3b
chr14_+_35237613 0.40 ENSDART00000163465
early B cell factor 3a
chr19_-_10395683 0.40 ENSDART00000109488
chr13_+_38990939 0.39 ENSDART00000145979
collagen, type XIX, alpha 1
chr18_+_41495841 0.39 ENSDART00000098671
chr11_-_13341051 0.39 ENSDART00000121872
microtubule associated serine/threonine kinase 3b
chr14_+_36231126 0.39 ENSDART00000141766
ELOVL fatty acid elongase 6
chr15_-_33925851 0.38 ENSDART00000187807
myelin associated glycoprotein
chr4_-_4261673 0.38 ENSDART00000150694
CD9 molecule b
chr25_-_4482449 0.38 ENSDART00000056278
solute carrier family 25 member 22a
chr18_-_38088099 0.37 ENSDART00000146120
leucine zipper protein 2
chr15_-_27710513 0.37 ENSDART00000005641
LIM homeobox 1a
chr22_-_38508112 0.37 ENSDART00000192004
kinesin light chain 4
chr20_+_15015557 0.36 ENSDART00000039345
chr16_-_13004166 0.36 ENSDART00000133735
calcium channel, voltage-dependent, gamma subunit 7b
chr24_-_24881996 0.36 ENSDART00000145712
corticotropin releasing hormone b
chr17_-_200316 0.36 ENSDART00000190561

chr14_-_31893996 0.35 ENSDART00000173222
G protein-coupled receptor 101
chr19_-_10243148 0.35 ENSDART00000148073
shisa family member 7
chr8_+_49778756 0.35 ENSDART00000083790
neurotrophic tyrosine kinase, receptor, type 2a
chr7_-_52842007 0.35 ENSDART00000182710
microtubule-associated protein 1Aa
chr22_+_24715282 0.35 ENSDART00000088027
synovial sarcoma, X breakpoint 2 interacting protein b
chr17_-_12385308 0.35 ENSDART00000080927
synaptosomal-associated protein, 25b
chr1_-_8428736 0.34 ENSDART00000138435
synaptogyrin 3b
chr16_-_44649053 0.34 ENSDART00000184807

chr4_-_27301356 0.34 ENSDART00000100444
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr16_+_26777473 0.34 ENSDART00000188870
cadherin 17, LI cadherin (liver-intestine)
chr25_+_15354095 0.34 ENSDART00000090397
KIAA1549-like a
chr21_+_31151197 0.33 ENSDART00000137728
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr13_+_14006118 0.33 ENSDART00000131875
chr25_-_29363934 0.33 ENSDART00000166889
neuroplastin a
chr5_-_29643930 0.33 ENSDART00000161250
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr8_+_49778486 0.33 ENSDART00000131732
neurotrophic tyrosine kinase, receptor, type 2a
chr1_-_19215336 0.33 ENSDART00000162949
protein tyrosine phosphatase, receptor type, D, b
chr4_+_842010 0.32 ENSDART00000067461
chr25_-_13842618 0.32 ENSDART00000160258
mitogen-activated protein kinase 8 interacting protein 1a
chr12_+_38770654 0.32 ENSDART00000155367
kinesin family member 19
chr22_+_15438513 0.31 ENSDART00000010846
glypican 5b
chr13_+_38302665 0.31 ENSDART00000145777
adhesion G protein-coupled receptor B3
chr21_-_26918901 0.31 ENSDART00000100685
leucine rich repeat and fibronectin type III domain containing 4a
chr1_-_7917062 0.31 ENSDART00000177068
monocyte to macrophage differentiation-associated 2b
chr4_+_13810811 0.30 ENSDART00000067168
PDZ domain containing ring finger 4
chr18_-_42172101 0.30 ENSDART00000124211
contactin 5
chr8_-_34052019 0.29 ENSDART00000040126
pre-B-cell leukemia homeobox 3b
chr5_-_7834582 0.29 ENSDART00000162626
PDZ and LIM domain 5a
chr16_-_18960333 0.29 ENSDART00000143185
formin homology 2 domain containing 3b
chr17_+_23937262 0.29 ENSDART00000113276
chr20_-_42702832 0.29 ENSDART00000134689
chr2_+_24199276 0.29 ENSDART00000140575
microtubule associated protein 4 like
chr14_-_32403554 0.29 ENSDART00000172873
fibroblast growth factor 13a
chr24_+_39186940 0.28 ENSDART00000155817
splA/ryanodine receptor domain and SOCS box containing 3b
chr2_+_27010439 0.28 ENSDART00000030547
cadherin 7a
chr21_+_25181003 0.28 ENSDART00000169700
chr12_-_26406323 0.28 ENSDART00000131896
myozenin 1b
chr7_+_50109239 0.28 ENSDART00000021605
chr24_+_41915878 0.28 ENSDART00000171523
transmembrane protein 200C
chr25_+_21833287 0.28 ENSDART00000187606
creatine kinase, mitochondrial 1
chr14_-_2199573 0.28 ENSDART00000124485
protocadherin 2 alpha b 8
chr24_+_37370064 0.28 ENSDART00000185870
chr17_+_19626479 0.28 ENSDART00000044993
regulator of G protein signaling 7a
chr13_+_24842857 0.28 ENSDART00000123866
dual specificity phosphatase 13a
chr20_-_29418620 0.28 ENSDART00000172634
ryanodine receptor 3
chr7_+_4384863 0.27 ENSDART00000042955
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr23_+_40460333 0.27 ENSDART00000184658
SOGA family member 3b
chr1_-_40227166 0.27 ENSDART00000146680
chr13_+_30421472 0.27 ENSDART00000143569
zinc finger, MIZ-type containing 1a
chr13_+_23282549 0.26 ENSDART00000101134
KH domain containing, RNA binding, signal transduction associated 2
chr1_-_681116 0.26 ENSDART00000165894
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_25129013 0.26 ENSDART00000132879
ndrg family member 3a
chr5_-_50992690 0.26 ENSDART00000149553
3-hydroxy-3-methylglutaryl-CoA reductase a
chr17_+_50127648 0.26 ENSDART00000156460
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr18_+_13792490 0.25 ENSDART00000136754
cadherin 13, H-cadherin (heart)
chr15_-_25527580 0.25 ENSDART00000167005
hypoxia-inducible factor 1, alpha subunit, like
chr6_-_53143667 0.25 ENSDART00000079694
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr2_+_42724404 0.25 ENSDART00000075392
brain abundant, membrane attached signal protein 1
chr7_+_4386753 0.25 ENSDART00000172915
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr11_-_4220167 0.24 ENSDART00000185406
chr8_+_23165749 0.24 ENSDART00000063057
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr20_+_522457 0.24 ENSDART00000138585
5'-nucleotidase domain containing 1
chr19_-_25149034 0.24 ENSDART00000148432
protein tyrosine phosphatase type IVA, member 3
chr2_+_24199073 0.24 ENSDART00000144110
microtubule associated protein 4 like
chr20_+_34717403 0.24 ENSDART00000034252
prepronociceptin b
chr3_-_12890670 0.23 ENSDART00000159934
BTB (POZ) domain containing 17b
chr3_-_59981476 0.23 ENSDART00000035878
cerebellar degeneration-related protein 2-like
chr1_-_26023678 0.23 ENSDART00000054202
chr16_+_30301539 0.23 ENSDART00000186018

chr7_+_30875273 0.23 ENSDART00000173693
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr15_+_30917282 0.22 ENSDART00000129474
oligodendrocyte myelin glycoprotein b
chr5_+_23622177 0.22 ENSDART00000121504
connexin 27.5
chr24_+_32472155 0.22 ENSDART00000098859
neuronal differentiation 6a
chr7_+_26629084 0.22 ENSDART00000101044
heat shock factor binding protein 1a
chr2_-_10188598 0.22 ENSDART00000189122
diencephalon/mesencephalon homeobox 1a
chr5_-_34185115 0.22 ENSDART00000192771
fibrinogen C domain containing 1
chr10_-_26744131 0.22 ENSDART00000020096
fibroblast growth factor 13b
chr13_+_22249636 0.22 ENSDART00000108472
synaptopodin 2-like a
chr15_+_43093044 0.22 ENSDART00000141125
potassium voltage-gated channel, Isk-related family, member 4
chr18_+_28102620 0.22 ENSDART00000132342
KIAA1549-like b
chr6_-_53144336 0.22 ENSDART00000154429
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr7_+_46252993 0.21 ENSDART00000167149
zinc finger protein 536
chr21_-_20328375 0.21 ENSDART00000079593
solute carrier family 26 (anion exchanger), member 1
chr4_+_26496489 0.21 ENSDART00000160652
IQ motif and Sec7 domain 3a
chr3_+_56366395 0.21 ENSDART00000154367
calcium channel, voltage-dependent, gamma subunit 5b
chr10_-_27741793 0.21 ENSDART00000129369
autism susceptibility candidate 2a
chr10_-_20445549 0.21 ENSDART00000064613
lysyl oxidase-like 2a
chr5_+_44654535 0.21 ENSDART00000182190
death-associated protein kinase 1
chr17_-_6399920 0.21 ENSDART00000022010
human immunodeficiency virus type I enhancer binding protein 2b
chr7_-_19940473 0.20 ENSDART00000127669
prospero homeobox 1b
chr25_-_16818978 0.20 ENSDART00000104140
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr23_+_23182037 0.20 ENSDART00000137353
kelch-like family member 17
chr18_-_25051846 0.20 ENSDART00000013082
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr24_+_27548474 0.20 ENSDART00000105774
eph-like kinase 1
chr6_+_39232245 0.20 ENSDART00000187351
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr22_-_33679277 0.20 ENSDART00000169948

chr5_+_64842730 0.20 ENSDART00000144732
leucine rich repeat containing 8 VRAC subunit Ab
chr18_-_14836600 0.19 ENSDART00000045232
metastasis suppressor 1-like a
chr20_-_54381034 0.19 ENSDART00000136779
ectonucleoside triphosphate diphosphohydrolase 5b
chr25_-_7925269 0.19 ENSDART00000014274
glucuronic acid epimerase a
chr12_-_31009315 0.19 ENSDART00000133854
transcription factor 7 like 2
chr19_-_10425140 0.19 ENSDART00000145319
chr23_+_216012 0.19 ENSDART00000181115
chr7_-_41964877 0.19 ENSDART00000092351
neuropilin (NRP) and tolloid (TLL)-like 2b
chr5_-_11573490 0.19 ENSDART00000109577

chr25_+_20215964 0.19 ENSDART00000139235
troponin T2d, cardiac
chr3_-_16227490 0.19 ENSDART00000057159
calcium channel, voltage-dependent, beta 1 subunit
chr19_+_9790806 0.18 ENSDART00000155948
calcium channel, voltage-dependent, gamma subunit 6a
chr6_-_47246948 0.18 ENSDART00000162435
glutamate receptor, metabotropic 4
chr9_-_23156908 0.18 ENSDART00000135461
LY6/PLAUR domain containing 6B
chr23_+_27703749 0.18 ENSDART00000027224
limb development membrane protein 1-like
chr1_-_23557877 0.18 ENSDART00000145942
family with sequence similarity 184, member B
chr25_-_7925019 0.18 ENSDART00000183309
glucuronic acid epimerase a
chr1_+_39387876 0.18 ENSDART00000084891
teneurin transmembrane protein 3
chr13_-_36545258 0.18 ENSDART00000186171

chr24_+_18948665 0.18 ENSDART00000106186
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_34827808 0.18 ENSDART00000105533
TEPSIN, adaptor related protein complex 4 accessory protein
chr16_-_29458806 0.18 ENSDART00000047931
leucine rich repeat and Ig domain containing 4b
chr17_+_31914877 0.18 ENSDART00000177801
family with sequence similarity 196 member A
chr21_+_20715020 0.18 ENSDART00000015224
growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1
chr19_-_867071 0.18 ENSDART00000122257
eomesodermin homolog a
chr6_+_18367388 0.18 ENSDART00000163394
diacylglycerol kinase, epsilon
chr8_-_19051906 0.18 ENSDART00000089024
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr2_-_10192459 0.18 ENSDART00000128535
diencephalon/mesencephalon homeobox 1a
chr3_-_28857195 0.17 ENSDART00000114319
chr15_-_34213898 0.17 ENSDART00000191945
ets variant 1
chr2_+_35240764 0.17 ENSDART00000015827
tenascin R (restrictin, janusin)
chr16_+_14707960 0.17 ENSDART00000137912
collagen, type XIV, alpha 1a
chr16_+_23282655 0.17 ENSDART00000015956
chr22_-_3595439 0.17 ENSDART00000083308
protein tyrosine phosphatase, receptor type, s, a
chr6_+_4872883 0.17 ENSDART00000186730
protocadherin 9
chr8_-_31393429 0.17 ENSDART00000192369
NIM1 serine/threonine protein kinase
chr15_-_5467477 0.17 ENSDART00000123839
arrestin, beta 1
chr20_+_46897504 0.17 ENSDART00000158124
chr12_+_9703172 0.17 ENSDART00000091489
protein phosphatase 1, regulatory subunit 9Bb
chr2_+_2223837 0.16 ENSDART00000101038
transmembrane inner ear
chr21_+_43669943 0.16 ENSDART00000136025
trimethyllysine hydroxylase, epsilon
chr10_+_26571174 0.16 ENSDART00000148617
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6b
chr13_-_16191674 0.16 ENSDART00000147868
von Willebrand factor C domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of pdx1_pbx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 2.9 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.2 1.4 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.6 GO:0051503 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 0.7 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.4 GO:0035902 response to immobilization stress(GO:0035902)
0.1 0.7 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.1 0.6 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.1 0.3 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.5 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.6 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 0.6 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.1 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 2.2 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 0.3 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.2 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.1 0.2 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 17.1 GO:0060537 muscle tissue development(GO:0060537)
0.0 0.2 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.5 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 1.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:1903385 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.0 0.1 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.0 0.2 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.2 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.4 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.6 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.0 0.2 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.6 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.0 0.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:0003311 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.3 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0 0.4 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.9 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.1 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.1 GO:1901910 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:0015882 L-ascorbic acid transport(GO:0015882)
0.0 0.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.4 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.9 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 0.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.3 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.0 GO:0033292 T-tubule organization(GO:0033292)
0.0 0.1 GO:0048644 muscle organ morphogenesis(GO:0048644)
0.0 0.4 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.4 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.2 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.1 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.1 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.2 GO:0034394 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.0 0.3 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.3 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.2 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.1 GO:0016199 axon choice point recognition(GO:0016198) axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.0 0.0 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.0 GO:0099563 modification of synaptic structure(GO:0099563)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.4 GO:0070062 extracellular exosome(GO:0070062)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.0 GO:0043209 myelin sheath(GO:0043209)
0.1 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0043679 axon terminus(GO:0043679)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060175 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 2.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 0.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 0.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 0.4 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0015562 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.0 0.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.2 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.1 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.0 0.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 2.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.4 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.0 0.1 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.3 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0035255 GKAP/Homer scaffold activity(GO:0030160) ionotropic glutamate receptor binding(GO:0035255)
0.0 0.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.2 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 1.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.0 GO:0070699 adrenergic receptor binding(GO:0031690) beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.9 GO:0016247 channel regulator activity(GO:0016247)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808) spermidine binding(GO:0019809)
0.0 0.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus