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PRJNA207719: Tissue specific transcriptome profiling
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Results for pdx1_pbx4
Z-value: 1.84
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Transcription factors associated with pdx1_pbx4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pbx4 | dr11_v1_chr3_+_53052769_53052769 | -0.07 | 9.1e-01 | Click! |
| pdx1 | dr11_v1_chr24_+_21684189_21684189 | -0.07 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_+_38301080 Show fit | 17.54 |
ENSDART00000105672
|
myosin binding protein C, fast type b |
|
| chr21_-_23308286 Show fit | 1.68 |
ENSDART00000184419
|
zinc finger and BTB domain containing 16a |
|
| chr2_+_47623202 Show fit | 1.64 |
ENSDART00000154465
|
si:ch211-165b10.3 |
|
| chr24_-_6898302 Show fit | 1.35 |
ENSDART00000158646
|
dipeptidyl-peptidase 6a |
|
| chr21_-_23307653 Show fit | 1.25 |
ENSDART00000140284
ENSDART00000134103 |
zinc finger and BTB domain containing 16a |
|
| chr15_+_4632782 Show fit | 1.17 |
ENSDART00000156012
|
si:dkey-35i13.1 |
|
| chr24_-_6897884 Show fit | 1.16 |
ENSDART00000080766
|
dipeptidyl-peptidase 6a |
|
| chr20_-_8443425 Show fit | 1.06 |
ENSDART00000083908
|
Dab, reelin signal transducer, homolog 1a (Drosophila) |
|
| chr5_-_23280098 Show fit | 1.03 |
ENSDART00000126540
ENSDART00000051533 |
proteolipid protein 1b |
|
| chr4_+_21129752 Show fit | 1.00 |
ENSDART00000169764
|
synaptotagmin Ia |
Network of associatons between targets according to the STRING database.
First level regulatory network of pdx1_pbx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.1 | GO:0060537 | muscle tissue development(GO:0060537) |
| 0.2 | 2.9 | GO:0032481 | positive regulation of type I interferon production(GO:0032481) |
| 0.1 | 2.2 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.2 | 1.4 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 0.1 | 1.1 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 1.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.9 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
| 0.0 | 0.9 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.2 | 0.7 | GO:0099540 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.1 | 0.7 | GO:0032289 | central nervous system myelin formation(GO:0032289) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 1.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.2 | 1.0 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.1 | 1.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.9 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 0.7 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 0.5 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 2.5 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 1.9 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.1 | 1.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 1.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.9 | GO:0016247 | channel regulator activity(GO:0016247) |
| 0.0 | 0.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 0.7 | GO:0060175 | brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.1 | 0.7 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.5 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 0.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |