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PRJNA207719: Tissue specific transcriptome profiling

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Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 2.71

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Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Gene Symbol Gene ID Gene Info
ENSDARG00000013615 pre-B-cell leukemia homeobox 3b
ENSDARG00000019717 pre-B-cell leukemia homeobox 2
ENSDARG00000089262 pre-B-cell leukemia homeobox 3a
ENSDARG00000100494 pre-B-cell leukemia homeobox 1a
ENSDARG00000101131 pre-B-cell leukemia homeobox 1b
ENSDARG00000110194 pre-B-cell leukemia homeobox 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pbx3bdr11_v1_chr8_-_34052019_340520190.894.6e-02Click!
pbx3adr11_v1_chr5_-_5394335_53944680.828.7e-02Click!
pbx1adr11_v1_chr2_-_18830722_188307830.801.1e-01Click!
pbx1bdr11_v1_chr6_+_2271559_22715590.761.4e-01Click!
pbx2dr11_v1_chr16_+_48626780_486267800.405.1e-01Click!

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_62380146 2.88 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr5_+_59278593 2.17 ENSDART00000097374
RAS p21 protein activator 4
chr2_-_44283554 2.15 ENSDART00000184684
myelin protein zero
chr22_-_13851297 1.99 ENSDART00000080306
S100 calcium binding protein, beta (neural)
chr4_+_9669717 1.78 ENSDART00000004604
si:dkey-153k10.9
chr18_+_13792490 1.73 ENSDART00000136754
cadherin 13, H-cadherin (heart)
chr11_-_101758 1.71 ENSDART00000173015
engulfment and cell motility 2
chr2_-_44946094 1.70 ENSDART00000036997
calcium/calmodulin-dependent protein kinase II inhibitor 1a
chr24_+_29382109 1.64 ENSDART00000184620
ENSDART00000188414
ENSDART00000186132
ENSDART00000191489
netrin g1a
chr24_+_37370064 1.62 ENSDART00000185870
si:ch211-183d21.3
chr5_+_59278193 1.62 ENSDART00000160025
RAS p21 protein activator 4
chr4_-_5291256 1.61 ENSDART00000150864
si:ch211-214j24.9
chr15_-_12545683 1.59 ENSDART00000162807
sodium channel, voltage-gated, type II, beta
chr24_+_29381946 1.55 ENSDART00000189551
netrin g1a
chr23_+_45579497 1.54 ENSDART00000110381
early growth response 4
chr2_-_24996441 1.54 ENSDART00000144795
solute carrier family 35, member G2a
chr21_+_30563115 1.51 ENSDART00000028566
si:ch211-200p22.4
chr19_-_9829965 1.46 ENSDART00000136842
ENSDART00000142766
calcium channel, voltage-dependent, gamma subunit 8a
chr6_+_14949950 1.41 ENSDART00000149202
ENSDART00000149949
POU class 3 homeobox 3b
chr14_-_52521460 1.40 ENSDART00000172110
G protein-coupled receptor 151
chr10_-_27046639 1.40 ENSDART00000041841
cornichon family AMPA receptor auxiliary protein 2
chr19_+_37857936 1.39 ENSDART00000189289
neurexophilin 1
chr8_+_7144066 1.38 ENSDART00000146306
solute carrier family 6 (neurotransmitter transporter), member 6a
chr19_-_97159 1.37 ENSDART00000179342
adhesion G protein-coupled receptor B1b
chr15_+_16521785 1.34 ENSDART00000062191
polypeptide N-acetylgalactosaminyltransferase 17
chr10_+_34426256 1.33 ENSDART00000102566
neurobeachin a
chr1_+_12763461 1.33 ENSDART00000159226
ENSDART00000180121
protocadherin 10a
chr11_+_25129013 1.31 ENSDART00000132879
ndrg family member 3a
chr21_+_11468934 1.31 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr14_+_33458294 1.30 ENSDART00000075278
ATPase Na+/K+ transporting subunit beta 4
chr20_+_29743904 1.28 ENSDART00000146366
ENSDART00000153154
kinase D-interacting substrate 220b
chr9_-_44295071 1.28 ENSDART00000011837
neuronal differentiation 1
chr2_-_54039293 1.27 ENSDART00000166013
abhydrolase domain containing 8a
chr24_+_41931585 1.25 ENSDART00000130310
erythrocyte membrane protein band 4.1-like 3a
chr5_+_33301005 1.25 ENSDART00000006021
ubiquitin specific peptidase 20
chr21_-_12119711 1.22 ENSDART00000131538
CUGBP, Elav-like family member 4
chr5_-_13766651 1.20 ENSDART00000134064
MAX dimerization protein 1
chr25_+_21324588 1.20 ENSDART00000151842
leucine rich repeat neuronal 3a
chr15_-_34213898 1.18 ENSDART00000191945
ENSDART00000186089
ets variant 1
chr3_+_35005062 1.17 ENSDART00000181163
protein kinase C, beta b
chr17_-_15528597 1.16 ENSDART00000150232
FYN proto-oncogene, Src family tyrosine kinase a
chr1_+_32528097 1.16 ENSDART00000128317
neuroligin 4a
chr16_+_50434668 1.15 ENSDART00000193500
zgc:110372
chr4_-_27398385 1.14 ENSDART00000142117
ENSDART00000150553
ENSDART00000182746
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr13_-_10261383 1.13 ENSDART00000080808
SIX homeobox 3a
chr5_+_19320554 1.12 ENSDART00000165119
RUN and SH3 domain containing 2
chr15_-_19677511 1.12 ENSDART00000043743
si:dkey-4p15.3
chr6_+_48618512 1.11 ENSDART00000111190
si:dkey-238f9.1
chr15_-_34214440 1.11 ENSDART00000167052
ets variant 1
chr1_-_57280585 1.11 ENSDART00000152220
si:dkey-27j5.5
chr11_-_42554290 1.11 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr3_-_50124413 1.11 ENSDART00000189920
claudin k
chr7_-_38633867 1.09 ENSDART00000137424
C1q and TNF related 4
chr15_+_47161917 1.09 ENSDART00000167860
growth associated protein 43
chr16_+_7626535 1.08 ENSDART00000182670
ENSDART00000065514
ENSDART00000150212
syntaxin 12, like
chr2_-_19109304 1.07 ENSDART00000168028
si:dkey-225f23.5
chr23_+_28582865 1.05 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr1_-_6494384 1.05 ENSDART00000109356
Kruppel-like factor 7a
chr2_-_7431590 1.05 ENSDART00000185699
agouti signaling protein, nonagouti homolog (mouse) 2b
chr15_+_5901970 1.04 ENSDART00000114134
tryptophan rich basic protein
chr15_+_36115955 1.03 ENSDART00000032702
somatostatin 1, tandem duplicate 2
chr15_-_30505607 1.02 ENSDART00000155212
musashi RNA-binding protein 2b
chr8_-_9570511 1.02 ENSDART00000044000
plexin A3
chr16_+_41873708 1.01 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
sodium channel, voltage-gated, type I, beta a
chr19_-_30562648 1.01 ENSDART00000171006
hippocalcin like 4
chr2_-_44038698 0.99 ENSDART00000079582
ENSDART00000146804
kirre like nephrin family adhesion molecule 1b
chr7_-_69636502 0.98 ENSDART00000126739
tetraspanin 5a
chr17_+_52822831 0.97 ENSDART00000193368
Meis homeobox 2a
chr1_-_50611031 0.97 ENSDART00000148285
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr22_-_23253481 0.97 ENSDART00000054807
LIM homeobox 9
chr4_-_27301356 0.95 ENSDART00000100444
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr10_+_37500234 0.95 ENSDART00000132096
ENSDART00000099473
musashi RNA-binding protein 2a
chr23_+_41799748 0.95 ENSDART00000144257
prodynorphin
chr23_+_23182037 0.95 ENSDART00000137353
kelch-like family member 17
chr16_+_14710436 0.95 ENSDART00000027982
collagen, type XIV, alpha 1a
chr8_+_13849999 0.94 ENSDART00000143784
double C2-like domains, delta
chr8_+_25247245 0.94 ENSDART00000045798
adenosine monophosphate deaminase 2b
chr22_+_34430310 0.94 ENSDART00000109860
adhesion molecule with Ig-like domain 3
chr2_+_12349870 0.94 ENSDART00000134083
Rho GTPase activating protein 21b
chr4_-_16124417 0.92 ENSDART00000128079
ENSDART00000077664
ATPase plasma membrane Ca2+ transporting 1a
chr23_-_30431333 0.91 ENSDART00000146633
calmodulin binding transcription activator 1a
chr2_-_10192459 0.90 ENSDART00000128535
ENSDART00000017173
diencephalon/mesencephalon homeobox 1a
chr21_-_38619305 0.89 ENSDART00000139178
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr16_+_50100420 0.89 ENSDART00000128167
nuclear receptor subfamily 1, group D, member 2a
chr11_+_3005536 0.88 ENSDART00000174539
copine Vb
chr21_-_23746916 0.86 ENSDART00000017229
neural cell adhesion molecule 1a
chr14_+_22591624 0.86 ENSDART00000108987
GDNF family receptor alpha 4b
chr13_+_11436130 0.85 ENSDART00000169895
zinc finger and BTB domain containing 18
chr17_+_52822422 0.85 ENSDART00000158273
ENSDART00000161414
Meis homeobox 2a
chr18_+_27738349 0.84 ENSDART00000187816
tetraspanin 18b
chr10_+_13283568 0.84 ENSDART00000186615
transmembrane protein 267
chr2_-_3678029 0.83 ENSDART00000146861
matrix metallopeptidase 16b (membrane-inserted)
chr18_-_51015718 0.83 ENSDART00000190698

chr20_+_26095530 0.83 ENSDART00000139350
spectrin repeat containing, nuclear envelope 1a
chr12_-_14922955 0.83 ENSDART00000002078
neurogenic differentiation 2
chr3_-_19200571 0.82 ENSDART00000131503
ENSDART00000012335
regulatory factor X, 1a (influences HLA class II expression)
chr20_-_34868814 0.82 ENSDART00000153049
stathmin-like 4
chr22_-_38607504 0.82 ENSDART00000164609
si:ch211-126j24.1
chr14_-_47314011 0.81 ENSDART00000178523
follistatin-like 5
chr11_-_33919014 0.80 ENSDART00000181203
phosphorylase kinase, alpha 2 (liver)
chr1_+_40034061 0.80 ENSDART00000011727
coiled-coil domain containing 149b
chr8_+_25761654 0.80 ENSDART00000137899
ENSDART00000062403
transmembrane protein 9
chr20_+_28434196 0.80 ENSDART00000034245
D4, zinc and double PHD fingers, family 3
chr18_+_16963881 0.79 ENSDART00000147583
si:ch211-242e8.1
chr21_-_34658266 0.79 ENSDART00000023038
dachshund a
chr5_+_68112194 0.79 ENSDART00000162468

chr16_-_13730152 0.79 ENSDART00000138772
tweety family member 1
chr13_-_33000649 0.78 ENSDART00000133677
RNA binding motif protein 25a
chr21_-_35832548 0.78 ENSDART00000180840
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr20_-_44575103 0.78 ENSDART00000192573
UBX domain protein 2A
chr5_+_65536095 0.78 ENSDART00000189898
si:dkey-21e5.1
chr16_+_11151699 0.78 ENSDART00000140674
capicua transcriptional repressor b
chr13_+_28702104 0.77 ENSDART00000135481
si:ch211-67n3.9
chr20_-_29420713 0.77 ENSDART00000147464
ryanodine receptor 3
chr11_+_25010491 0.77 ENSDART00000167285
zgc:92107
chr1_-_54947592 0.77 ENSDART00000129710
cartilage acidic protein 1a
chr2_-_30770736 0.77 ENSDART00000131230
regulator of G protein signaling 20
chr3_+_35005730 0.76 ENSDART00000029451
protein kinase C, beta b
chr1_-_44704261 0.76 ENSDART00000133210
si:dkey-28b4.8
chr10_+_34426571 0.76 ENSDART00000144529
neurobeachin a
chr16_+_23598908 0.76 ENSDART00000131627
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr11_+_28218141 0.75 ENSDART00000043756
eph receptor B2b
chr8_-_33114202 0.75 ENSDART00000098840
Ral GEF with PH domain and SH3 binding motif 1
chr2_+_59015878 0.74 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
chr1_+_14073891 0.74 ENSDART00000021693
ankyrin 2a, neuronal
chr9_+_6009077 0.74 ENSDART00000057484
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr20_+_18225329 0.73 ENSDART00000144172
potassium channel tetramerization domain containing 1
chr22_-_15385442 0.73 ENSDART00000090975
transmembrane protein 264
chr17_+_28340138 0.73 ENSDART00000033943
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr24_+_3963684 0.72 ENSDART00000182959
ENSDART00000185926
ENSDART00000167043
ENSDART00000033394
phosphofructokinase, platelet a
chr15_+_18863875 0.72 ENSDART00000062603
cell adhesion molecule 1b
chr15_-_19250543 0.72 ENSDART00000092705
ENSDART00000138895
immunoglobulin superfamily, member 9Ba
chr13_-_21739142 0.72 ENSDART00000078460
si:dkey-191g9.5
chr19_-_867071 0.71 ENSDART00000122257
eomesodermin homolog a
chr12_+_16233077 0.71 ENSDART00000152409
membrane protein, palmitoylated 3b (MAGUK p55 subfamily member 3)
chr18_-_26675699 0.70 ENSDART00000113280
si:ch211-69m14.1
chr22_-_21392748 0.70 ENSDART00000144648
ankyrin repeat domain 24
chr2_+_40294313 0.70 ENSDART00000037292
eph receptor A4b
chr17_-_43287290 0.70 ENSDART00000156885
si:dkey-1f12.3
chr1_+_49814461 0.70 ENSDART00000132405
lymphoid enhancer-binding factor 1
chr12_-_48992527 0.69 ENSDART00000169696
cadherin related family member 1
chr12_-_31103187 0.69 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
transcription factor 7 like 2
chr3_+_40407352 0.69 ENSDART00000155112
trinucleotide repeat containing 18
chr1_-_46401385 0.68 ENSDART00000150029
ATPase phospholipid transporting 11A
chr5_+_70155935 0.68 ENSDART00000165570
regulator of G protein signaling 3a
chr14_+_29609245 0.68 ENSDART00000043058
si:dkey-34l15.2
chr11_+_3006124 0.67 ENSDART00000126071
copine Vb
chr3_+_62353650 0.67 ENSDART00000112428
IQ motif containing K
chr12_+_25600685 0.67 ENSDART00000077157
SIX homeobox 3b
chr5_-_69482891 0.67 ENSDART00000109487

chr11_+_14622379 0.66 ENSDART00000112589
ephrin-A2b
chr10_+_43797130 0.66 ENSDART00000027242
nuclear receptor subfamily 2, group F, member 1b
chr2_-_31735142 0.65 ENSDART00000130903
RALY RNA binding protein like
chr13_-_37545487 0.65 ENSDART00000131269
synaptotagmin XVI
chr20_+_54280549 0.65 ENSDART00000151048
ARP10 actin related protein 10 homolog
chr18_+_50907675 0.64 ENSDART00000159950
si:ch1073-450f2.1
chr6_-_6423885 0.64 ENSDART00000092257
si:ch211-194e18.2
chr9_-_48937089 0.64 ENSDART00000193442
ceramide synthase 6
chr17_+_52823015 0.64 ENSDART00000160507
ENSDART00000186979
Meis homeobox 2a
chr20_-_20821783 0.64 ENSDART00000152577
ENSDART00000027603
ENSDART00000145601
creatine kinase, brain b
chr2_-_50298337 0.63 ENSDART00000155125
contactin associated protein like 2b
chr5_+_31779911 0.63 ENSDART00000098163
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25b
chr1_-_7659870 0.63 ENSDART00000085203
ephrin-B2b
chr15_-_2184638 0.63 ENSDART00000135460
short stature homeobox 2
chr13_-_36184701 0.63 ENSDART00000146522
mitogen-activated protein kinase kinase kinase 9
chr5_-_40210447 0.63 ENSDART00000131323
si:dkey-193c22.1
chr4_-_19883985 0.63 ENSDART00000014440
calcium channel, voltage-dependent, alpha 2/delta subunit 1a
chr24_-_28381404 0.62 ENSDART00000148406
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr6_+_2271559 0.62 ENSDART00000165223
pre-B-cell leukemia homeobox 1b
chr5_-_20678300 0.62 ENSDART00000088639
WSC domain containing 2
chr10_+_26515946 0.62 ENSDART00000134276
synaptojanin 1
chr17_-_20430177 0.61 ENSDART00000114236
sortilin related VPS10 domain containing receptor 3b
chr17_+_11507131 0.61 ENSDART00000013170
kinesin family member 26Ba
chr23_+_19590006 0.61 ENSDART00000021231
sarcolemma associated protein b
chr15_+_40665310 0.61 ENSDART00000154187
ENSDART00000042082
FAT atypical cadherin 3a
chr2_-_52550135 0.61 ENSDART00000044411
guanine nucleotide binding protein (G protein), alpha 11b (Gq class)
chr10_-_31220558 0.61 ENSDART00000134866
pbx/knotted 1 homeobox 2
chr20_-_24963038 0.61 ENSDART00000102788
ENSDART00000159122
eph receptor A7
chr6_+_4872883 0.60 ENSDART00000186730
ENSDART00000092290
ENSDART00000151674
protocadherin 9
chr1_+_51312752 0.60 ENSDART00000063938
microtubule associated serine/threonine kinase 1a
chr25_+_23358924 0.58 ENSDART00000156965
oxysterol binding protein-like 5
chr1_-_17650223 0.58 ENSDART00000043484
si:dkey-256e7.5
chr25_+_33849647 0.58 ENSDART00000121449
RAR-related orphan receptor A, paralog a
chr3_-_25646149 0.58 ENSDART00000122735
ubiquitin specific peptidase 43b
chr25_+_13791627 0.58 ENSDART00000159278
zgc:92873
chr10_-_23358357 0.57 ENSDART00000135475
cell adhesion molecule 2a
chr13_-_3155243 0.57 ENSDART00000139183
ENSDART00000050934
protein kinase domain containing, cytoplasmic a
chr6_+_37752781 0.56 ENSDART00000154364
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr12_-_25065916 0.56 ENSDART00000159167
suppressor of cytokine signaling 5a
chr12_+_28854410 0.56 ENSDART00000152991
nuclear factor, erythroid 2-like 1b
chr24_+_32472155 0.56 ENSDART00000098859
neuronal differentiation 6a
chr6_-_1863270 0.56 ENSDART00000156936
discs, large (Drosophila) homolog-associated protein 4b
chr21_+_1380099 0.56 ENSDART00000184516
transcription factor 4
chr12_+_34127573 0.55 ENSDART00000153413
cytohesin 1b
chr1_+_45217425 0.55 ENSDART00000179983
ENSDART00000074683
si:ch211-239f4.1
chr19_+_8144556 0.55 ENSDART00000027274
ENSDART00000147218
ephrin-A3a
chr19_-_19025998 0.55 ENSDART00000186156
ENSDART00000163359
ENSDART00000167951
dynein, cytoplasmic 1, light intermediate chain 1
chr2_-_48171441 0.55 ENSDART00000123040
phosphofructokinase, platelet b
chr5_-_3574199 0.54 ENSDART00000060162
heat shock protein, alpha-crystallin-related, 1
chr24_+_26345427 0.54 ENSDART00000089756
leucine rich repeat containing 34

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0032369 negative regulation of lipid transport(GO:0032369)
0.3 1.4 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.3 1.0 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.3 0.9 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.2 1.2 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.2 0.7 GO:0021611 facial nerve formation(GO:0021611)
0.2 0.7 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 1.7 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.2 0.8 GO:0060074 synapse maturation(GO:0060074)
0.2 1.0 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 1.9 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.2 1.3 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.2 0.9 GO:0034505 tooth mineralization(GO:0034505)
0.2 0.7 GO:0010226 response to lithium ion(GO:0010226)
0.2 1.0 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.2 4.5 GO:0070831 basement membrane assembly(GO:0070831)
0.2 1.7 GO:0061615 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.7 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.1 0.7 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.5 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.7 GO:1901907 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.6 GO:0099612 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.1 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.5 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 1.5 GO:0051963 regulation of synapse assembly(GO:0051963)
0.1 3.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 1.9 GO:0097324 melanocyte migration(GO:0097324)
0.1 0.3 GO:0048677 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.6 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.8 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.7 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 1.5 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.2 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 1.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.3 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 1.8 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 1.8 GO:0072176 pronephric duct development(GO:0039022) nephric duct development(GO:0072176)
0.1 1.1 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.8 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.2 GO:0019408 dolichol biosynthetic process(GO:0019408)
0.1 0.9 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 3.9 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.3 GO:0015074 DNA integration(GO:0015074)
0.1 0.9 GO:0032264 IMP salvage(GO:0032264)
0.1 0.8 GO:0035264 multicellular organism growth(GO:0035264)
0.1 0.5 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 1.0 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 0.3 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.1 0.6 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.4 GO:0035989 tendon development(GO:0035989)
0.1 0.4 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 0.4 GO:0036268 swimming(GO:0036268)
0.1 0.6 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.2 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 1.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.5 GO:0070142 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) synaptic vesicle budding(GO:0070142)
0.1 1.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.4 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.4 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 1.4 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 1.4 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.1 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.0 0.6 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.2 GO:1904590 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.0 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.7 GO:0035476 angioblast cell migration(GO:0035476)
0.0 0.5 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.1 GO:0030814 regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of adenylate cyclase activity(GO:0045761)
0.0 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934)
0.0 0.2 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.3 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.4 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.6 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.1 GO:0097037 heme export(GO:0097037)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 1.2 GO:0032400 melanosome localization(GO:0032400)
0.0 0.2 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.2 GO:0021654 rhombomere boundary formation(GO:0021654)
0.0 1.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.1 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.0 0.6 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 2.1 GO:0016358 dendrite development(GO:0016358)
0.0 0.1 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.8 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:2000622 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.3 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 1.2 GO:0006885 regulation of pH(GO:0006885) regulation of cellular pH(GO:0030641)
0.0 0.1 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.0 0.7 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.6 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 1.1 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.1 GO:0001709 cell fate determination(GO:0001709)
0.0 0.1 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.3 GO:0000272 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.8 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.2 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 1.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.1 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.0 0.4 GO:1902656 calcium ion transmembrane import into cytosol(GO:0097553) calcium ion import across plasma membrane(GO:0098703) calcium ion import into cytosol(GO:1902656) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0003272 endocardial cushion formation(GO:0003272)
0.0 0.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.4 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.3 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 1.6 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.7 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.0 GO:0044042 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 0.6 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 2.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.2 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.4 GO:0043049 otic placode formation(GO:0043049)
0.0 0.4 GO:0030901 midbrain development(GO:0030901)
0.0 0.2 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.3 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.4 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.1 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.1 GO:0009078 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.0 0.3 GO:0010675 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.5 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 1.1 GO:0048278 vesicle docking(GO:0048278)
0.0 0.3 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.4 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.9 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.4 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.5 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 1.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.9 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 2.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:1902017 regulation of cilium assembly(GO:1902017)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0070062 extracellular exosome(GO:0070062)
0.3 1.1 GO:0032584 growth cone membrane(GO:0032584)
0.2 1.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 1.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 1.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.2 0.7 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 1.7 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 2.7 GO:0043209 myelin sheath(GO:0043209)
0.1 3.2 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 1.5 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 1.3 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.5 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.1 0.8 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.1 0.6 GO:0033010 paranodal junction(GO:0033010)
0.1 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.2 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.1 1.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 2.0 GO:0005844 polysome(GO:0005844)
0.1 0.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.0 GO:0005869 dynactin complex(GO:0005869)
0.1 2.1 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.1 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.0 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.5 GO:0035101 FACT complex(GO:0035101)
0.0 0.2 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.0 1.5 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.4 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.8 GO:0071565 nBAF complex(GO:0071565)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 5.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 2.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.0 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.6 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0044545 NSL complex(GO:0044545)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0044548 S100 protein binding(GO:0044548)
0.3 1.7 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.3 2.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 1.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.2 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.2 0.9 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.2 0.8 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 1.7 GO:0003872 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.1 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.7 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 2.4 GO:0035258 steroid hormone receptor binding(GO:0035258)
0.1 0.7 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.1 0.4 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.1 1.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.3 GO:0031628 opioid receptor binding(GO:0031628)
0.1 3.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 0.4 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 2.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.9 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.3 GO:0004134 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.1 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.6 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 2.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.1 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.2 GO:0031716 calcitonin receptor binding(GO:0031716)
0.1 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.9 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 1.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.2 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 2.9 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.6 GO:0034596 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 3.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0000035 acyl binding(GO:0000035)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:1990931 RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0008126 acetylesterase activity(GO:0008126)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 3.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.0 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.0 0.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.8 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 4.3 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 4.3 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.3 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription