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PRJNA207719: Tissue specific transcriptome profiling
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Results for pax2b
Z-value: 1.81
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Transcription factors associated with pax2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax2b | dr11_v1_chr12_-_45876387_45876387 | 0.83 | 8.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_25112269 Show fit | 1.40 |
ENSDART00000147546
|
ndrg family member 3a |
|
| chr24_-_7632187 Show fit | 1.26 |
ENSDART00000041714
|
ATPase H+ transporting V0 subunit a1b |
|
| chr16_-_45069882 Show fit | 1.21 |
ENSDART00000058384
|
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
|
| chr22_-_11136625 Show fit | 1.10 |
ENSDART00000016873
ENSDART00000125561 |
ATPase H+ transporting accessory protein 2 |
|
| chr23_-_4915118 Show fit | 1.03 |
ENSDART00000060714
|
ATPase H+ transporting accessory protein 1a |
|
| chr15_-_163586 Show fit | 1.02 |
ENSDART00000163597
|
septin-4 |
|
| chr15_+_28989573 Show fit | 1.02 |
ENSDART00000076648
|
CAP-GLY domain containing linker protein 3 |
|
| chr24_+_39158283 Show fit | 1.02 |
ENSDART00000053139
|
ATPase H+ transporting V0 subunit cb |
|
| chr16_+_10777116 Show fit | 0.96 |
ENSDART00000190902
|
ATPase Na+/K+ transporting subunit alpha 3b |
|
| chr24_-_6158933 Show fit | 0.78 |
ENSDART00000021609
|
glutamate decarboxylase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.1 | 2.2 | GO:0036376 | cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436) |
| 0.0 | 1.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 1.7 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.1 | 1.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 1.3 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.0 | 1.3 | GO:1902667 | regulation of axon guidance(GO:1902667) |
| 0.0 | 1.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 1.1 | GO:0035622 | intrahepatic bile duct development(GO:0035622) |
| 0.1 | 1.0 | GO:0061075 | positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.2 | 1.7 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.0 | 1.5 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.0 | 1.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.4 | 1.1 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.1 | 1.1 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 1.0 | GO:0033181 | plasma membrane proton-transporting V-type ATPase complex(GO:0033181) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 1.6 | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) |
| 0.0 | 1.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 1.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 1.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 1.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 1.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.3 | 1.2 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.0 | 1.2 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.0 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.5 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.4 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 1.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 1.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 0.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 0.7 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 0.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |