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PRJNA207719: Tissue specific transcriptome profiling
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Results for pax2a+pax5
Z-value: 3.03
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Transcription factors associated with pax2a+pax5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax2a | dr11_v1_chr13_+_29778610_29778610 | 0.93 | 2.1e-02 | Click! |
| pax5 | dr11_v1_chr1_+_21731382_21731382 | 0.40 | 5.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_12034444 Show fit | 2.74 |
ENSDART00000038651
|
zinc finger protein 804A |
|
| chr19_-_103289 Show fit | 2.43 |
ENSDART00000143118
|
adhesion G protein-coupled receptor B1b |
|
| chr5_+_36974931 Show fit | 2.18 |
ENSDART00000193063
|
gap junction protein delta 1a |
|
| chr14_+_50770537 Show fit | 1.98 |
ENSDART00000158723
|
synuclein, beta |
|
| chr5_+_38276582 Show fit | 1.77 |
ENSDART00000158532
|
guanine nucleotide binding protein (G protein), beta polypeptide 2 |
|
| chr11_-_44543082 Show fit | 1.74 |
ENSDART00000099568
|
G protein-coupled receptor 137Bb |
|
| chr3_-_46818001 Show fit | 1.70 |
ENSDART00000166505
|
ELAV like neuron-specific RNA binding protein 3 |
|
| chr14_-_36378494 Show fit | 1.63 |
ENSDART00000058503
|
glycoprotein M6Aa |
|
| chr8_-_23416362 Show fit | 1.60 |
ENSDART00000063005
|
G protein-coupled receptor 173 |
|
| chr16_-_27628994 Show fit | 1.57 |
ENSDART00000157407
|
NAC alpha domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax2a+pax5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.0 | 3.4 | GO:0050767 | regulation of neurogenesis(GO:0050767) |
| 0.3 | 3.1 | GO:1904071 | presynaptic active zone assembly(GO:1904071) |
| 0.0 | 3.0 | GO:0006612 | protein targeting to membrane(GO:0006612) |
| 0.0 | 3.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 2.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 2.6 | GO:0061515 | myeloid cell development(GO:0061515) |
| 0.1 | 2.5 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.6 | 2.4 | GO:0090387 | phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.5 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 7.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 4.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 3.5 | GO:0044309 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.3 | 3.1 | GO:0098982 | GABA-ergic synapse(GO:0098982) |
| 0.1 | 2.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 2.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 2.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 5.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 5.4 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 3.1 | GO:0098882 | structural constituent of presynaptic active zone(GO:0098882) |
| 0.1 | 2.9 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.5 | 2.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 2.5 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 2.4 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 2.3 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.2 | 2.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 1.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.8 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 0.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.7 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 2.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 1.9 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.2 | 1.7 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.1 | 1.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 1.5 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |