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PRJNA207719: Tissue specific transcriptome profiling

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Results for otpa+otpb

Z-value: 0.70

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Transcription factors associated with otpa+otpb

Gene Symbol Gene ID Gene Info
ENSDARG00000014201 orthopedia homeobox a
ENSDARG00000058379 orthopedia homeobox b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otpadr11_v1_chr21_+_7582036_7582059-0.612.8e-01Click!
otpbdr11_v1_chr5_-_51619262_51619321-0.424.8e-01Click!

Activity profile of otpa+otpb motif

Sorted Z-values of otpa+otpb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_31713239 0.52 ENSDART00000122379
hyaluronan binding protein 2
chr9_+_34127005 0.50 ENSDART00000167384
ENSDART00000078065
coagulation factor V
chr5_+_2815021 0.47 ENSDART00000020472
4-hydroxyphenylpyruvate dioxygenase a
chr10_+_26747755 0.46 ENSDART00000100329
coagulation factor IXb
chr24_-_10006158 0.36 ENSDART00000106244
zgc:171750
chr2_-_17392799 0.33 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr15_-_21014270 0.29 ENSDART00000154019
si:ch211-212c13.10
chr20_-_43663494 0.29 ENSDART00000144564

chr22_+_19552987 0.29 ENSDART00000105315
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr2_-_17393216 0.26 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr25_-_28674739 0.26 ENSDART00000067073
leucine rich repeat containing 10
chr7_+_21272833 0.26 ENSDART00000052942
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr18_+_14619544 0.25 ENSDART00000010821
UTP4, small subunit processome component
chr3_+_3681116 0.25 ENSDART00000109618
ADP-ribosyltransferase 4 (Dombrock blood group)
chr10_-_13343831 0.24 ENSDART00000135941
interleukin 11 receptor, alpha
chr3_-_59297532 0.24 ENSDART00000187991

chr11_+_40812590 0.24 ENSDART00000186690
ERBB receptor feedback inhibitor 1a
chr2_+_29842878 0.23 ENSDART00000131376
si:ch211-207d6.2
chr22_-_16154771 0.23 ENSDART00000009464
solute carrier family 30 (zinc transporter), member 7
chr6_+_612594 0.23 ENSDART00000150903
kynureninase
chr12_-_35830625 0.22 ENSDART00000180028

chr23_+_1029450 0.21 ENSDART00000189196
si:zfos-905g2.1
chr6_+_25257728 0.21 ENSDART00000162581
kynurenine aminotransferase 3
chr11_+_44617021 0.20 ENSDART00000158887
RNA binding motif protein 34
chr25_+_22320738 0.20 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr16_+_23796612 0.19 ENSDART00000131698
RAB13, member RAS oncogene family
chr17_+_16564921 0.19 ENSDART00000151904
forkhead box N3
chr17_+_50524573 0.19 ENSDART00000187974

chr4_+_57881965 0.17 ENSDART00000162234
si:dkeyp-44b5.4
chr10_-_34916208 0.17 ENSDART00000187371
cyclin A1
chr7_+_38811800 0.17 ENSDART00000052322
zgc:110699
chr12_+_20587179 0.17 ENSDART00000170127
arylsulfatase G
chr8_+_49065348 0.16 ENSDART00000032277
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr22_+_19366866 0.16 ENSDART00000137301
si:dkey-21e2.12
chr22_-_14247276 0.16 ENSDART00000033332
si:ch211-246m6.5
chr14_-_7207961 0.14 ENSDART00000167994
ENSDART00000166532
storkhead box 2b
chr17_+_24821627 0.14 ENSDART00000112389
WD repeat domain 43
chr5_+_71802014 0.14 ENSDART00000124939
ENSDART00000097164
LIM homeobox 3
chr20_+_25586099 0.14 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr6_+_25261297 0.14 ENSDART00000162824
ENSDART00000163490
ENSDART00000157790
ENSDART00000160978
ENSDART00000161545
ENSDART00000159978
kynurenine aminotransferase 3
chr11_-_10456387 0.13 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr11_-_10456553 0.13 ENSDART00000169509
ENSDART00000185574
ENSDART00000188276
epithelial cell transforming 2
chr14_-_451555 0.13 ENSDART00000190906
FAT atypical cadherin 4
chr13_-_52089003 0.13 ENSDART00000187600
transmembrane protein 254
chr22_-_10156581 0.13 ENSDART00000168304
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_6880694 0.13 ENSDART00000171846
protocadherin-related 15b
chr20_-_49889111 0.13 ENSDART00000058858
kinesin family member 13Bb
chr14_+_44794936 0.12 ENSDART00000128881
zgc:195212
chr1_-_9195629 0.12 ENSDART00000143587
ENSDART00000192174
endoplasmic reticulum to nucleus signaling 2
chr14_-_33481428 0.12 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lysosomal-associated membrane protein 2
chr4_-_9891874 0.12 ENSDART00000067193
adrenomedullin 2a
chr4_+_54618332 0.12 ENSDART00000171824
si:ch211-227e10.2
chr9_+_37152564 0.12 ENSDART00000189497
GLI family zinc finger 2a
chr11_+_7214353 0.12 ENSDART00000156764
NACHT and WD repeat domain containing 1
chr20_-_9095105 0.12 ENSDART00000140792
OMA1 zinc metallopeptidase
chr21_-_1644414 0.12 ENSDART00000105736
ENSDART00000124904
zgc:152948
chr22_+_508290 0.11 ENSDART00000135403
NUAK family, SNF1-like kinase, 2
chr17_+_20589553 0.11 ENSDART00000154447
si:ch73-288o11.4
chr22_+_5532003 0.10 ENSDART00000106174
si:ch73-256j6.2
chr19_+_31873308 0.10 ENSDART00000146560
ENSDART00000133045
si:dkeyp-34f6.4
chr22_-_9183944 0.10 ENSDART00000188599
si:ch211-213a13.5
chr14_-_48765262 0.10 ENSDART00000166463
CCR4-NOT transcription complex, subunit 6b
chr21_-_2814709 0.10 ENSDART00000097664
semaphorin 4D
chr22_-_36530902 0.10 ENSDART00000056188
info polymerase (RNA) II (DNA directed) polypeptide H
chr10_+_11261576 0.09 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr1_+_51721851 0.09 ENSDART00000040397
peroxiredoxin 2
chr1_+_52792439 0.09 ENSDART00000123972
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr17_-_4245902 0.09 ENSDART00000151851
growth differentiation factor 3
chr15_+_5360407 0.09 ENSDART00000110420
odorant receptor, family A, subfamily 112, member 1
chr23_+_11285662 0.09 ENSDART00000111028
cell adhesion molecule L1-like a
chr1_+_9086942 0.09 ENSDART00000055023
calcium channel, voltage-dependent, gamma subunit 3a
chr16_+_23303859 0.08 ENSDART00000006093
solute carrier family 50 (sugar efflux transporter), member 1
chr1_-_31534089 0.08 ENSDART00000007770
ladybird homeobox 1b
chr15_+_37965953 0.08 ENSDART00000154192
si:dkey-238d18.10
chr3_+_23029484 0.08 ENSDART00000187900
N-acetylglutamate synthase
chr24_-_35282568 0.08 ENSDART00000167406
ENSDART00000088609
syntrophin, gamma 1
chr14_+_46313396 0.08 ENSDART00000047525
crystallin, beta A1, like 1
chr24_+_7800486 0.07 ENSDART00000145504
protein tyrosine phosphatase, receptor type, h
chr23_-_1660708 0.07 ENSDART00000175138

chr7_-_52388734 0.07 ENSDART00000174186
WD repeat domain 93
chr3_+_6469754 0.07 ENSDART00000185809
nucleoporin 85
chr14_-_413273 0.07 ENSDART00000163976
ENSDART00000179907
FAT atypical cadherin 4
chr22_+_1568306 0.07 ENSDART00000163223
si:ch211-255f4.9
chr25_+_2263857 0.07 ENSDART00000076439
tyrosyl-tRNA synthetase 2, mitochondrial
chr18_+_41527877 0.07 ENSDART00000146972
selenoprotein T, 1b
chr7_+_24573721 0.07 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr9_+_48761455 0.07 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr18_+_7456597 0.07 ENSDART00000142270
telomere repeat binding bouquet formation protein 1
chr21_+_38634296 0.07 ENSDART00000114467

chr5_+_67390115 0.07 ENSDART00000193255
early B cell factor 2
chr20_+_98179 0.07 ENSDART00000022725
si:ch1073-155h21.1
chr6_+_39905021 0.07 ENSDART00000064904
endonuclease, polyU-specific
chr1_+_11882186 0.07 ENSDART00000193419
sorting nexin 8b
chr23_+_12406722 0.07 ENSDART00000145008
phosphatidylinositol glycan anchor biosynthesis, class T
chr15_-_40267485 0.06 ENSDART00000152253
potassium inwardly-rectifying channel, subfamily J, member 13
chr1_-_5455498 0.06 ENSDART00000040368
ENSDART00000114035
motor neuron and pancreas homeobox 2b
chr17_-_40956035 0.06 ENSDART00000124715
si:dkey-16j16.4
chr17_-_16422654 0.06 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr12_+_36428052 0.06 ENSDART00000131300
unkempt family zinc finger
chr1_-_45616470 0.06 ENSDART00000150165
activating transcription factor 7 interacting protein
chr22_+_34784075 0.06 ENSDART00000167538
ligand dependent nuclear receptor corepressor
chr9_-_12811936 0.06 ENSDART00000188490
myosin X-like 3
chr11_+_17984354 0.06 ENSDART00000179986
RNA pseudouridylate synthase domain containing 4
chr7_-_30174882 0.06 ENSDART00000110409
FERM domain containing 5
chr8_-_53044300 0.06 ENSDART00000191653
nuclear receptor subfamily 6, group A, member 1a
chr11_-_2838699 0.06 ENSDART00000066189
LHFPL tetraspan subfamily member 5a
chr18_+_7456888 0.06 ENSDART00000081468
telomere repeat binding bouquet formation protein 1
chr16_+_28932038 0.06 ENSDART00000149480
natriuretic peptide receptor 1b
chr8_-_13046089 0.06 ENSDART00000137784
si:dkey-208b23.5
chr5_-_11809710 0.05 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
neurofibromin 2a (merlin)
chr9_-_9415000 0.05 ENSDART00000146210
si:ch211-214p13.9
chr21_-_36571804 0.05 ENSDART00000138129
WW and C2 domain containing 1
chr25_-_21031007 0.05 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr23_-_16484383 0.05 ENSDART00000187839
si:dkeyp-100a5.4
chr23_-_16485190 0.05 ENSDART00000155038
si:dkeyp-100a5.4
chr22_+_1556948 0.04 ENSDART00000159050
si:ch211-255f4.8
chr11_+_17984167 0.04 ENSDART00000020283
ENSDART00000188329
RNA pseudouridylate synthase domain containing 4
chr3_+_13848226 0.04 ENSDART00000184342
interleukin enhancer binding factor 3b
chr18_+_35128685 0.04 ENSDART00000151579
si:ch211-195m9.3
chr11_+_34760628 0.04 ENSDART00000087216
si:dkey-202e22.2
chr1_-_8963484 0.04 ENSDART00000188035
suppressor of cytokine signaling 1b
chr18_-_5527050 0.04 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
chr4_+_13449775 0.04 ENSDART00000172552
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr24_+_19415124 0.03 ENSDART00000186931
sulfatase 1
chr17_+_49281597 0.03 ENSDART00000155599
zgc:113176
chr17_+_44697604 0.03 ENSDART00000156625
placental growth factor b
chr23_+_11347313 0.03 ENSDART00000135406
cell adhesion molecule L1-like a
chr9_-_25055722 0.03 ENSDART00000137131
dynein, axonemal, heavy chain 7
chr6_+_14980761 0.03 ENSDART00000087782
mitochondrial ribosomal protein S9
chr7_+_20512419 0.03 ENSDART00000173907
si:dkey-19b23.14
chr7_+_72441515 0.02 ENSDART00000167827

chr18_-_17485419 0.02 ENSDART00000018764
forkhead box L1
chr24_+_23202545 0.02 ENSDART00000143862
peroxisomal biogenesis factor 2
chr24_-_7995960 0.02 ENSDART00000186594
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr4_+_59845617 0.02 ENSDART00000167626
ENSDART00000123157
si:dkey-196n19.2
chr3_-_16039619 0.02 ENSDART00000143324
splA/ryanodine receptor domain and SOCS box containing 3a
chr9_+_24065855 0.01 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
leucine rich repeat (in FLII) interacting protein 1a
chr6_-_33878665 0.01 ENSDART00000129916
transmembrane protein 69
chr8_-_33381430 0.01 ENSDART00000190019
LIM homeobox transcription factor 1, beta b
chr10_-_11353469 0.01 ENSDART00000191847
lin-54 DREAM MuvB core complex component
chr5_+_41477526 0.01 ENSDART00000153567
protein inhibitor of activated STAT, 2
chr22_-_21897203 0.01 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr20_-_45812144 0.01 ENSDART00000147897
ENSDART00000147637
fermitin family member 1
chr11_-_40742424 0.01 ENSDART00000173399
ENSDART00000021369
taste receptor, type 1, member 3
chr17_+_22577472 0.01 ENSDART00000045099
Yip1 domain family, member 4
chr6_-_35046735 0.01 ENSDART00000143649
UDP-N-acetylglucosamine pyrophosphorylase 1
chr1_+_47499888 0.01 ENSDART00000027624
STN1, CST complex subunit
chr6_+_24420523 0.01 ENSDART00000185461
transforming growth factor, beta receptor III
chr17_-_25831569 0.00 ENSDART00000148743
hedgehog acyltransferase
chr22_-_14739491 0.00 ENSDART00000133385
low density lipoprotein receptor-related protein 1Ba
chr16_+_28994709 0.00 ENSDART00000088023
gon-4-like (C. elegans)
chr11_+_45436703 0.00 ENSDART00000168295
ENSDART00000173293
son of sevenless homolog 1 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of otpa+otpb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.2 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.0 0.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.1 GO:0034397 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.2 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.1 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.2 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.0 0.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.3 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.3 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 1.5 GO:0007599 hemostasis(GO:0007599)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.1 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.0 0.1 GO:0051876 pigment granule dispersal(GO:0051876)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.1 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.1 0.6 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.1 0.2 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.2 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.1 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0016229 steroid dehydrogenase activity(GO:0016229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition