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PRJNA207719: Tissue specific transcriptome profiling
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Results for onecut3a+onecut3b
Z-value: 1.48
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Transcription factors associated with onecut3a+onecut3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| onecut3a | dr11_v1_chr22_+_20461488_20461488 | 0.90 | 3.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_5291256 Show fit | 2.02 |
ENSDART00000150864
|
si:ch211-214j24.9 |
|
| chr1_-_21409877 Show fit | 1.81 |
ENSDART00000102782
|
glutamate receptor, ionotropic, AMPA 2a |
|
| chr14_+_35748385 Show fit | 1.72 |
ENSDART00000064617
ENSDART00000074671 ENSDART00000172803 |
glutamate receptor, ionotropic, AMPA 2b |
|
| chr14_+_35748206 Show fit | 1.69 |
ENSDART00000177391
|
glutamate receptor, ionotropic, AMPA 2b |
|
| chr3_-_28665291 Show fit | 1.64 |
ENSDART00000151670
|
F-box and leucine-rich repeat protein 16 |
|
| chr6_+_3828560 Show fit | 1.61 |
ENSDART00000185273
ENSDART00000179091 |
glutamate decarboxylase 1b |
|
| chr8_-_14052349 Show fit | 1.58 |
ENSDART00000135811
|
ATPase plasma membrane Ca2+ transporting 3a |
|
| chr19_+_25649626 Show fit | 1.53 |
ENSDART00000146947
|
tachykinin 1 |
|
| chr2_+_47581997 Show fit | 1.41 |
ENSDART00000112579
|
secretogranin II (chromogranin C), b |
|
| chr2_+_47582488 Show fit | 1.33 |
ENSDART00000149967
|
secretogranin II (chromogranin C), b |
Network of associatons between targets according to the STRING database.
First level regulatory network of onecut3a+onecut3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | GO:1903670 | regulation of sprouting angiogenesis(GO:1903670) |
| 0.3 | 2.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 1.8 | GO:0048899 | anterior lateral line development(GO:0048899) |
| 0.5 | 1.6 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.3 | 1.5 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.1 | 1.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.1 | 1.2 | GO:0021988 | olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988) |
| 0.3 | 1.1 | GO:0046551 | retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220) |
| 0.1 | 1.1 | GO:0032228 | regulation of synaptic transmission, GABAergic(GO:0032228) |
| 0.1 | 1.1 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 3.3 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 2.7 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 1.6 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.5 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 1.1 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 1.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.9 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.8 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.5 | 1.6 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.1 | 1.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.5 | 1.5 | GO:0031835 | neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835) |
| 0.0 | 1.5 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 1.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.3 | 1.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 1.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 1.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.8 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.3 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 0.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 0.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.2 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |