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PRJNA207719: Tissue specific transcriptome profiling

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Results for onecut2

Z-value: 1.81

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Transcription factors associated with onecut2

Gene Symbol Gene ID Gene Info
ENSDARG00000090387 one cut homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
onecut2dr11_v1_chr21_-_1742159_17421590.791.1e-01Click!

Activity profile of onecut2 motif

Sorted Z-values of onecut2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_3828560 1.96 ENSDART00000185273
ENSDART00000179091
glutamate decarboxylase 1b
chr1_-_21409877 1.93 ENSDART00000102782
glutamate receptor, ionotropic, AMPA 2a
chr25_-_9805269 1.48 ENSDART00000192048
leucine rich repeat containing 4C
chr25_+_7229046 1.38 ENSDART00000149965
ENSDART00000041820
leucine rich repeat and Ig domain containing 1a
chr5_+_27267186 1.37 ENSDART00000182238
ENSDART00000087857
unc-5 netrin receptor Db
chr18_+_50276653 1.35 ENSDART00000192120
si:dkey-105e17.1
chr4_+_26628822 1.32 ENSDART00000191030
ENSDART00000186113
ENSDART00000186764
ENSDART00000165158
IQ motif and Sec7 domain 3a
chr4_-_5291256 1.31 ENSDART00000150864
si:ch211-214j24.9
chr18_+_50276337 1.23 ENSDART00000140352
si:dkey-105e17.1
chr8_-_23081511 1.21 ENSDART00000142015
ENSDART00000135764
ENSDART00000147021
si:dkey-70p6.1
chr3_-_28665291 1.18 ENSDART00000151670
F-box and leucine-rich repeat protein 16
chr17_-_45247332 1.13 ENSDART00000016815
tau tubulin kinase 2a
chr18_-_37007061 1.11 ENSDART00000136432
mitogen-activated protein kinase kinase kinase 10
chr9_+_44430705 1.09 ENSDART00000190696
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr7_+_20535869 1.08 ENSDART00000078181
zgc:158423
chr18_-_37007294 1.06 ENSDART00000088309
mitogen-activated protein kinase kinase kinase 10
chr9_+_44430974 1.04 ENSDART00000056846
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr4_-_8903240 1.04 ENSDART00000129983
metallophosphoesterase domain containing 1
chr3_-_28120092 1.03 ENSDART00000151143
RNA binding fox-1 homolog 1
chr24_+_25692802 1.02 ENSDART00000190493
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr18_+_642889 1.01 ENSDART00000189007

chr4_+_13810811 0.99 ENSDART00000067168
PDZ domain containing ring finger 4
chr5_-_29643930 0.90 ENSDART00000161250
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr3_-_46811611 0.89 ENSDART00000134092
ELAV like neuron-specific RNA binding protein 3
chr4_-_8902406 0.87 ENSDART00000192962
metallophosphoesterase domain containing 1
chr21_-_27881752 0.86 ENSDART00000132583
neurexin 2a
chr1_-_23157583 0.85 ENSDART00000144208
adhesion G protein-coupled receptor L3.1
chr13_+_36144341 0.83 ENSDART00000182930
ENSDART00000187327
si:ch211-259k16.3
chr14_-_2348917 0.80 ENSDART00000159004
si:ch73-233f7.8
chr2_-_39759059 0.79 ENSDART00000007333
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr2_+_5563077 0.79 ENSDART00000111220
Mab-21 domain containing 2
chr18_+_50890749 0.77 ENSDART00000174109
si:ch1073-450f2.1
chr3_+_39853788 0.74 ENSDART00000154869
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr16_-_26255877 0.74 ENSDART00000146214
Ets2 repressor factor like 1
chr21_+_19070921 0.74 ENSDART00000029874
NK6 homeobox 1
chr11_-_426525 0.74 ENSDART00000157054
zinc finger protein 831
chr7_-_71434298 0.73 ENSDART00000180507
leucine-rich repeat LGI family, member 2a
chr5_+_19309877 0.73 ENSDART00000190338
RUN and SH3 domain containing 2
chr19_+_4916233 0.71 ENSDART00000159512
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr25_-_21085661 0.70 ENSDART00000099355
proline rich 5a (renal)
chr20_-_19422496 0.69 ENSDART00000143658
si:ch211-278j3.3
chr15_-_5467477 0.68 ENSDART00000123839
arrestin, beta 1
chr23_-_15216654 0.66 ENSDART00000131649
sulfatase 2b
chr2_+_42871831 0.66 ENSDART00000171393
EFR3 homolog A (S. cerevisiae)
chr21_-_7687544 0.64 ENSDART00000134519
phosphodiesterase 8B
chr2_-_31735142 0.62 ENSDART00000130903
RALY RNA binding protein like
chr22_-_7129631 0.62 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr15_-_26552652 0.60 ENSDART00000152336
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr1_+_16144615 0.59 ENSDART00000054707
tumor suppressor candidate 3
chr25_+_19955598 0.58 ENSDART00000091547
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr8_+_35664152 0.58 ENSDART00000144520
si:dkeyp-14d3.1
chr9_+_44431174 0.58 ENSDART00000149726
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr19_-_41991104 0.56 ENSDART00000087055
trio Rho guanine nucleotide exchange factor a
chr5_+_61301525 0.56 ENSDART00000128773
double C2-like domains, beta
chr8_+_9866351 0.55 ENSDART00000133985
potassium voltage-gated channel, Shal-related subfamily, member 1
chr19_-_17526735 0.54 ENSDART00000189391
thyroid hormone receptor beta
chr18_-_25051846 0.54 ENSDART00000013082
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr17_-_14700889 0.54 ENSDART00000179975
protein tyrosine phosphatase type IVA, member 2a
chr5_-_65158203 0.53 ENSDART00000171656
SH2 domain containing 3Cb
chr4_-_4261673 0.53 ENSDART00000150694
CD9 molecule b
chr15_+_19458982 0.52 ENSDART00000132665
zgc:77784
chr8_-_2616326 0.47 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr17_+_43623598 0.47 ENSDART00000154138
zinc finger protein 365
chr11_+_43114108 0.46 ENSDART00000013642
ENSDART00000190266
forkhead box G1b
chr17_-_8169774 0.46 ENSDART00000091828
spectrin repeat containing, nuclear envelope 1b
chr15_-_26552393 0.46 ENSDART00000150152
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr18_-_44847855 0.45 ENSDART00000086823
signal recognition particle receptor (docking protein)
chr16_+_5612547 0.45 ENSDART00000140226
ENSDART00000189352
si:dkey-283b15.4
chr15_-_31265375 0.45 ENSDART00000086592
vascular endothelial zinc finger 1b
chr12_-_25217217 0.44 ENSDART00000152931
potassium voltage-gated channel, subfamily G, member 3
chr15_+_17446796 0.44 ENSDART00000157189
sorting nexin 19b
chr19_-_32641725 0.43 ENSDART00000165006
ENSDART00000188185
hippocalcin
chr19_+_19512515 0.43 ENSDART00000180065
JAZF zinc finger 1a
chr2_-_32505091 0.42 ENSDART00000141884
ENSDART00000056639
Fas apoptotic inhibitory molecule 2a
chr17_-_14701529 0.42 ENSDART00000185142
protein tyrosine phosphatase type IVA, member 2a
chr23_+_25832689 0.41 ENSDART00000138907
hepatocyte nuclear factor 4, alpha
chr10_-_15405564 0.40 ENSDART00000020665
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr23_-_3721444 0.38 ENSDART00000141682
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr4_-_2868112 0.38 ENSDART00000133843
phosphodiesterase 3A, cGMP-inhibited
chr11_-_22605981 0.37 ENSDART00000186923
myogenin
chr18_+_36769758 0.37 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
FBJ murine osteosarcoma viral oncogene homolog B
chr21_+_22878834 0.37 ENSDART00000065562
PCF11 cleavage and polyadenylation factor subunit
chr18_-_21806613 0.37 ENSDART00000145721
neuritin 1-like a
chr21_+_22878991 0.35 ENSDART00000186399
PCF11 cleavage and polyadenylation factor subunit
chr2_-_17044959 0.35 ENSDART00000090260
chloride channel, voltage-sensitive 2a
chr5_+_4366431 0.34 ENSDART00000168560
ENSDART00000149185
spermidine/spermine N1-acetyltransferase 1a, duplicate 2
chr4_-_9173552 0.33 ENSDART00000042963
carbohydrate (chondroitin 4) sulfotransferase 11
chr16_-_13612650 0.32 ENSDART00000080372
D site albumin promoter binding protein b
chr6_-_16456093 0.31 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr7_-_49651378 0.31 ENSDART00000015040
-Ha-ras Harvey rat sarcoma viral oncogene homolog b
chr21_-_43482426 0.31 ENSDART00000192901
ankyrin repeat domain 46a
chr5_+_7393346 0.30 ENSDART00000164238
si:ch73-72b7.1
chr19_-_18855513 0.30 ENSDART00000162708
palmitoyl-protein thioesterase 2
chr19_-_41472228 0.30 ENSDART00000113388
distal-less homeobox 5a
chr5_-_14211487 0.30 ENSDART00000135731
neuropeptide FF receptor 1 like 2
chr19_-_18855717 0.30 ENSDART00000158192
palmitoyl-protein thioesterase 2
chr18_+_36770166 0.29 ENSDART00000078151
FBJ murine osteosarcoma viral oncogene homolog B
chr2_+_45300512 0.29 ENSDART00000144704
calmodulin regulated spectrin-associated protein family, member 2b
chr23_+_28770225 0.29 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr14_+_7932973 0.28 ENSDART00000109941
CXXC finger protein 5b
chr3_-_8399774 0.27 ENSDART00000190238
ENSDART00000113140
ENSDART00000132949
RNA binding fox-1 homolog 3b
chr21_+_3901775 0.27 ENSDART00000053609
dolichyldiphosphatase 1
chr14_-_41243180 0.27 ENSDART00000184548
dystrophin related protein 2
chr23_-_19434199 0.27 ENSDART00000132543
kelch domain containing 8B
chr17_+_21760032 0.25 ENSDART00000190425
IKAROS family zinc finger 5
chr18_+_14529005 0.25 ENSDART00000186379
potassium voltage-gated channel, subfamily G, member 4a
chr20_-_6196989 0.24 ENSDART00000013343
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr18_-_20560007 0.24 ENSDART00000141367
ENSDART00000090186
si:ch211-238n5.4
chr3_-_60142530 0.23 ENSDART00000153247
si:ch211-120g10.1
chr4_+_7827261 0.23 ENSDART00000129568
phytanoyl-CoA 2-hydroxylase
chr6_-_8498676 0.23 ENSDART00000148627
peptidoglycan recognition protein 2
chr22_-_38360205 0.22 ENSDART00000162055
MAP/microtubule affinity-regulating kinase 1
chr15_-_35252522 0.22 ENSDART00000144153
ENSDART00000059195
mitochondrial fission factor
chr6_-_10828880 0.22 ENSDART00000131458
ENSDART00000020261
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr7_+_25036188 0.22 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr6_-_8498908 0.22 ENSDART00000149222
peptidoglycan recognition protein 2
chr1_-_9249943 0.21 ENSDART00000055011
zgc:136472
chr15_+_21947117 0.21 ENSDART00000156234
tetratricopeptide repeat domain 12
chr17_-_25737452 0.21 ENSDART00000152021
si:ch211-214p16.3
chr25_+_18964782 0.20 ENSDART00000017299
thymine DNA glycosylase, tandem duplicate 1
chr23_+_12454542 0.20 ENSDART00000182259
ENSDART00000193043
si:ch211-153a8.4
chr5_+_34549365 0.19 ENSDART00000009500
allograft inflammatory factor 1-like
chr7_-_41693004 0.18 ENSDART00000121509
MAM and LDL receptor class A domain containing 1
chr2_-_6262441 0.17 ENSDART00000092190
ADP-ribosylation factor-like 14
chr2_+_22042745 0.17 ENSDART00000132039
thymocyte selection-associated high mobility group box
chr25_-_7753207 0.17 ENSDART00000126499
PHD finger protein 21Ab
chr13_-_24877577 0.17 ENSDART00000182705
K(lysine) acetyltransferase 6B
chr13_+_22316746 0.16 ENSDART00000188968
ubiquitin specific peptidase 54a
chr1_+_45958904 0.15 ENSDART00000108528
Rho guanine nucleotide exchange factor (GEF) 7b
chr2_-_32387441 0.14 ENSDART00000148202
upstream binding transcription factor, like
chr8_-_621142 0.14 ENSDART00000187576
ENSDART00000190316
si:ch211-87m7.2
chr17_+_8175998 0.13 ENSDART00000131200
myc target 1b
chr11_+_37201483 0.13 ENSDART00000160930
ENSDART00000173439
ENSDART00000171273
zgc:112265
chr6_+_46431848 0.13 ENSDART00000181056
ENSDART00000144569
ENSDART00000064865
ENSDART00000133992
staufen double-stranded RNA binding protein 1
chr19_+_41006975 0.12 ENSDART00000138555
ENSDART00000049842
CAS1 domain containing 1
chr20_+_54274431 0.12 ENSDART00000099338
ARP10 actin related protein 10 homolog
chr9_+_7732714 0.11 ENSDART00000145853
si:ch1073-349o24.2
chr21_+_20229926 0.10 ENSDART00000025860
si:dkey-247m21.3
chr3_-_30434016 0.10 ENSDART00000150958
leucine rich repeat containing 4Ba
chr7_+_30933867 0.10 ENSDART00000156325
tight junction protein 1a
chr10_+_10801719 0.10 ENSDART00000193648
alpha-1-microglobulin/bikunin precursor
chr5_-_23675222 0.09 ENSDART00000135153
si:dkey-110k5.6
chr4_-_13255700 0.09 ENSDART00000162277
ENSDART00000026593
glutamate receptor interacting protein 1
chr17_-_43623356 0.09 ENSDART00000075596
ENSDART00000136431
rhotekin 2a
chr7_+_33372680 0.09 ENSDART00000193436
ENSDART00000099988
glucuronic acid epimerase b
chr12_+_26467847 0.08 ENSDART00000022495
nudE neurodevelopment protein 1-like 1a
chr11_+_5817202 0.08 ENSDART00000126084
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3
chr5_-_28102698 0.08 ENSDART00000138140
si:ch211-48m9.1
chr15_-_30984557 0.08 ENSDART00000080328
neurofibromin 1a
chr17_+_6957042 0.07 ENSDART00000103839
zgc:172341
chr14_-_1313480 0.07 ENSDART00000097748
interleukin 21
chr7_+_42206847 0.06 ENSDART00000149250
phosphorylase kinase, beta
chr6_-_49861506 0.06 ENSDART00000121809
GNAS complex locus
chr17_-_14451405 0.06 ENSDART00000146786
jnk1/mapk8 associated membrane protein
chr8_+_40477264 0.06 ENSDART00000085559
glucokinase (hexokinase 4)
chr8_-_37263524 0.06 ENSDART00000061327
Rh50-like protein
chr20_-_6812688 0.05 ENSDART00000170934
insulin-like growth factor binding protein 1a
chr8_-_14484599 0.05 ENSDART00000057644
LIM homeobox 4
chr19_-_27391179 0.05 ENSDART00000181108
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase b
chr4_-_76488854 0.05 ENSDART00000132323
finTRIM family, member 51
chr21_+_4116437 0.04 ENSDART00000167791
ENSDART00000123759
Rap guanine nucleotide exchange factor (GEF) 1b
chr20_+_22130284 0.04 ENSDART00000025575
clock circadian regulator a
chr24_-_37955993 0.04 ENSDART00000041805
meteorin, glial cell differentiation regulator
chr8_-_45279411 0.04 ENSDART00000175207
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr23_+_24598910 0.04 ENSDART00000126510
ENSDART00000078796
KAT8 regulatory NSL complex subunit 2
chr10_-_24391716 0.04 ENSDART00000141332
ENSDART00000100772
solute carrier family 43 (amino acid system L transporter), member 2b
chr13_-_40141630 0.04 ENSDART00000181618
ENSDART00000171583
ENSDART00000192780
cartilage acidic protein 1b
chr5_+_34549845 0.03 ENSDART00000139317
allograft inflammatory factor 1-like
chr16_-_16701718 0.03 ENSDART00000143550
si:dkey-8k3.2
chr21_-_22812417 0.03 ENSDART00000079151
ENSDART00000112175
transient receptor potential cation channel, subfamily C, member 6a
chr23_-_20002459 0.03 ENSDART00000163396
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr2_-_42958619 0.03 ENSDART00000144317
otoconin 90
chr19_+_42886413 0.02 ENSDART00000151298
cAMP-regulated phosphoprotein, 21
chr20_-_40755614 0.01 ENSDART00000061247
connexin 32.3
chr7_-_68419830 0.01 ENSDART00000191606

chr5_+_37406358 0.00 ENSDART00000162811
kelch-like family member 13

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 0.8 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2 0.7 GO:1900136 microglial cell activation(GO:0001774) regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.2 1.7 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.4 GO:0009595 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.1 0.5 GO:0060220 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 0.4 GO:1903334 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.1 1.9 GO:0048899 anterior lateral line development(GO:0048899)
0.1 0.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 2.2 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.3 GO:0006598 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.1 1.8 GO:0050796 regulation of insulin secretion(GO:0050796)
0.1 0.4 GO:1901910 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.4 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.4 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.7 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.7 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.0 0.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.3 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 1.4 GO:0031103 axon regeneration(GO:0031103)
0.0 0.3 GO:0045117 azole transport(GO:0045117)
0.0 1.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0086009 membrane repolarization(GO:0086009)
0.0 1.2 GO:0050868 negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.5 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.1 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 1.0 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.5 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.9 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 1.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.8 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.7 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 1.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 1.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.1 GO:0006865 amino acid transport(GO:0006865)
0.0 0.2 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.3 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.9 GO:0008045 motor neuron axon guidance(GO:0008045)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0072380 TRC complex(GO:0072380)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.6 GO:0044224 paranode region of axon(GO:0033270) juxtaparanode region of axon(GO:0044224)
0.0 1.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.1 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.7 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 0.8 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 2.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 1.0 GO:0010858 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 1.7 GO:0005042 netrin receptor activity(GO:0005042)
0.2 0.5 GO:0030882 lipid antigen binding(GO:0030882)
0.1 0.4 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.5 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 1.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.7 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 3.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.2 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.1 0.4 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 0.2 GO:0042165 neurotransmitter binding(GO:0042165) acetylcholine binding(GO:0042166)
0.1 0.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 1.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0019809 polyamine binding(GO:0019808) spermidine binding(GO:0019809)
0.0 0.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.3 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.1 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis