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PRJNA207719: Tissue specific transcriptome profiling
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Results for onecut1+onecutl
Z-value: 2.85
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Transcription factors associated with onecut1+onecutl
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| onecutl | dr11_v1_chr16_-_29528198_29528198 | 0.89 | 4.2e-02 | Click! |
| onecut1 | dr11_v1_chr18_+_38755023_38755024 | 0.77 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_7885707 Show fit | 3.03 |
ENSDART00000029981
|
protein phosphatase 3, catalytic subunit, beta isozyme |
|
| chr8_-_31919624 Show fit | 2.48 |
ENSDART00000085573
|
regulator of G protein signaling 7 binding protein a |
|
| chr8_-_19051906 Show fit | 2.47 |
ENSDART00000089024
|
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb |
|
| chr25_+_4837915 Show fit | 2.16 |
ENSDART00000168016
|
guanine nucleotide binding protein (G protein), beta 5a |
|
| chr19_-_9829965 Show fit | 2.16 |
ENSDART00000136842
ENSDART00000142766 |
calcium channel, voltage-dependent, gamma subunit 8a |
|
| chr13_+_16521898 Show fit | 2.10 |
ENSDART00000122557
|
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a |
|
| chr21_-_27881752 Show fit | 2.09 |
ENSDART00000132583
|
neurexin 2a |
|
| chr2_+_35240485 Show fit | 2.02 |
ENSDART00000179804
|
tenascin R (restrictin, janusin) |
|
| chr15_-_19677511 Show fit | 2.02 |
ENSDART00000043743
|
si:dkey-4p15.3 |
|
| chr10_+_1638876 Show fit | 2.00 |
ENSDART00000184484
ENSDART00000060946 ENSDART00000181251 |
small G protein signaling modulator 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of onecut1+onecutl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0007411 | axon guidance(GO:0007411) |
| 0.1 | 4.7 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 4.3 | GO:0007254 | JNK cascade(GO:0007254) |
| 0.0 | 4.1 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.3 | 3.7 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.2 | 3.5 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 0.0 | 3.1 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.2 | 3.0 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.0 | 2.9 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.2 | 2.4 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.3 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 6.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 3.4 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.5 | 3.0 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 2.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.7 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 1.7 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 3.7 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.5 | 3.0 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.3 | 3.0 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.2 | 2.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 2.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 2.2 | GO:0031682 | G-protein gamma-subunit binding(GO:0031682) |
| 0.1 | 2.2 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.9 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.1 | 1.8 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 2.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.4 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.0 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 3.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 2.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.3 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.0 | 1.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |