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PRJNA207719: Tissue specific transcriptome profiling

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Results for nrf1

Z-value: 3.51

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Transcription factors associated with nrf1

Gene Symbol Gene ID Gene Info
ENSDARG00000000018 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nrf1dr11_v1_chr4_-_15103646_151036960.884.7e-02Click!

Activity profile of nrf1 motif

Sorted Z-values of nrf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_1082100 1.91 ENSDART00000149276
leucine zipper, putative tumor suppressor family member 3b
chr15_-_45538773 1.91 ENSDART00000113494
Mab-21 domain containing 2
chr3_-_34801041 1.83 ENSDART00000103043
N-ethylmaleimide-sensitive factor a
chr7_+_73593814 1.79 ENSDART00000110544
zinc finger protein 219
chr14_-_33454595 1.72 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
transmembrane protein 255A
chr23_+_44732863 1.71 ENSDART00000160044
ENSDART00000172268
ATPase Na+/K+ transporting subunit beta 2a
chr18_+_17428258 1.59 ENSDART00000010452
zgc:91860
chr6_-_48311 1.58 ENSDART00000131010
zgc:114175
chr16_-_25285469 1.57 ENSDART00000183943
ENSDART00000191103
ENSDART00000154543
PRELI domain containing 3A
chr7_+_23495986 1.57 ENSDART00000190739
ENSDART00000115299
ENSDART00000101423
ENSDART00000142401
zgc:109889
chr25_+_21832938 1.48 ENSDART00000148299
creatine kinase, mitochondrial 1
chr14_+_22172047 1.48 ENSDART00000114750
ENSDART00000148259
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr1_+_53954230 1.47 ENSDART00000037729
ENSDART00000159900
centriole, cilia and spindle-associated protein a
chr17_-_36896560 1.45 ENSDART00000045287
microtubule-associated protein, RP/EB family, member 3a
chr6_+_27667359 1.38 ENSDART00000159624
ENSDART00000049177
RAB6B, member RAS oncogene family a
chr10_+_18952271 1.35 ENSDART00000146517
dihydropyrimidinase-like 2b
chr7_-_38340674 1.33 ENSDART00000075782
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10a
chr21_+_45733871 1.29 ENSDART00000187285
ENSDART00000193018
zgc:77058
chr17_+_33719415 1.28 ENSDART00000132294
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr1_-_26131088 1.28 ENSDART00000193973
ENSDART00000054209
cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
chr4_+_6643421 1.27 ENSDART00000099462
G protein-coupled receptor 85
chr24_+_7153628 1.27 ENSDART00000147715
si:dkeyp-101e12.1
chr8_-_52413032 1.27 ENSDART00000183039

chr18_-_19491162 1.23 ENSDART00000090413
small nuclear RNA activating complex, polypeptide 5
chr1_-_40227166 1.23 ENSDART00000146680
si:ch211-113e8.3
chr15_-_252813 1.23 ENSDART00000163441
LIM domain kinase 1a
chr2_+_22795494 1.23 ENSDART00000042255
RAB6B, member RAS oncogene family b
chr8_-_14050758 1.22 ENSDART00000133922
ATPase plasma membrane Ca2+ transporting 3a
chr20_-_31905968 1.20 ENSDART00000142806
syntaxin binding protein 5a (tomosyn)
chr21_-_14878220 1.20 ENSDART00000131237
unc-51 like autophagy activating kinase 1
chr7_-_65093209 1.18 ENSDART00000060545
ENSDART00000192447
DENN/MADD domain containing 5A
chr16_+_5156420 1.18 ENSDART00000012053
ELOVL fatty acid elongase 4a
chr18_+_17428506 1.18 ENSDART00000100223
zgc:91860
chr24_+_5840748 1.17 ENSDART00000139191
transient receptor potential cation channel, subfamily C, member 1
chr4_-_4780667 1.17 ENSDART00000133973
si:ch211-258f14.2
chr15_+_16886196 1.17 ENSDART00000139296
ENSDART00000049196
glycerophosphodiester phosphodiesterase domain containing 1
chr19_-_28367413 1.16 ENSDART00000079092
si:dkey-261i16.5
chr9_-_32177117 1.16 ENSDART00000078568
splicing factor 3b, subunit 1
chr13_-_23756700 1.16 ENSDART00000057612
regulator of G protein signaling 17
chr15_-_4415917 1.15 ENSDART00000062874
ATPase Na+/K+ transporting subunit beta 3b
chr8_+_68864 1.15 ENSDART00000164574
proline rich 16
chr14_+_23970818 1.14 ENSDART00000123338
ENSDART00000124944
kinesin family member 3A
chr5_+_24882633 1.14 ENSDART00000111302
rhomboid domain containing 3
chr10_-_31782616 1.14 ENSDART00000128839
fasciculation and elongation protein zeta 1 (zygin I)
chr3_-_26341959 1.13 ENSDART00000169344
ENSDART00000142878
ENSDART00000087196
zgc:153240
chr7_+_48288762 1.13 ENSDART00000083569
ornithine decarboxylase antizyme 2b
chr20_+_88168 1.13 ENSDART00000149283
zgc:112001
chr17_-_11329959 1.12 ENSDART00000015418
interferon regulatory factor 2 binding protein-like
chr16_+_52748263 1.11 ENSDART00000032275
ATPase H+ transporting V1 subunit C1a
chr9_+_53276356 1.09 ENSDART00000003310
SRY (sex determining region Y)-box 21b
chr6_+_41255485 1.09 ENSDART00000042683
ENSDART00000186013
Ca2+-dependent activator protein for secretion b
chr12_-_25916530 1.08 ENSDART00000186386
synuclein, gamma b (breast cancer-specific protein 1)
chr24_+_5840258 1.07 ENSDART00000087034
transient receptor potential cation channel, subfamily C, member 1
chr8_+_18624658 1.06 ENSDART00000089141
fibronectin type III and SPRY domain containing 1
chr6_-_38418862 1.06 ENSDART00000104135
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr2_-_16565690 1.06 ENSDART00000022549
ATPase Na+/K+ transporting subunit beta 3a
chr1_-_45633955 1.05 ENSDART00000044057
septin 3
chr8_-_17822259 1.05 ENSDART00000063587
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5b
chr19_-_19339285 1.04 ENSDART00000158413
ENSDART00000170479
chondroitin sulfate proteoglycan 5b
chr6_-_38419318 1.04 ENSDART00000138026
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr18_-_92046 1.04 ENSDART00000157709
GA binding protein transcription factor, beta subunit 1
chr7_+_73332486 1.04 ENSDART00000174119
ENSDART00000092051
ENSDART00000192388

chr16_-_23379464 1.04 ENSDART00000045891
tripartite motif containing 46a
chr20_+_37661229 1.04 ENSDART00000138539
androgen-induced 1 (H. sapiens)
chr21_-_45613564 1.03 ENSDART00000160324

chr25_+_21833287 1.03 ENSDART00000187606
creatine kinase, mitochondrial 1
chr4_-_1497384 1.02 ENSDART00000093236
zmp:0000000711
chr22_+_20208185 1.02 ENSDART00000142748
si:dkey-110c1.7
chr4_-_4780510 1.02 ENSDART00000109609
si:ch211-258f14.2
chr1_+_36436936 1.01 ENSDART00000124112
POU class 4 homeobox 2
chr6_+_12853655 1.01 ENSDART00000156341
family with sequence similarity 117, member Ba
chr10_-_15405564 1.00 ENSDART00000020665
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr24_+_39129316 1.00 ENSDART00000155346
TBC1 domain family, member 24
chr25_+_13791627 0.99 ENSDART00000159278
zgc:92873
chr15_-_22147860 0.99 ENSDART00000149784
sodium channel, voltage-gated, type III, beta
chr18_-_898870 0.99 ENSDART00000151777
ENSDART00000062654
poly (ADP-ribose) polymerase family, member 6a
chr2_-_32352946 0.97 ENSDART00000144870
ENSDART00000077151
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a
chr14_-_1949277 0.97 ENSDART00000159435
protocadherin 2 gamma 5
chr11_+_29856032 0.97 ENSDART00000079150
gastrin-releasing peptide receptor
chr16_+_46430627 0.97 ENSDART00000127681
rapunzel 6
chr13_+_45485185 0.96 ENSDART00000134730
ENSDART00000019774
ENSDART00000142381
transmembrane protein 50A
chr21_+_18313152 0.95 ENSDART00000170510
si:ch73-287m6.1
chr24_-_22702017 0.95 ENSDART00000179403
catenin (cadherin-associated protein), delta 2a
chr2_-_24996441 0.93 ENSDART00000144795
solute carrier family 35, member G2a
chr11_-_44037692 0.93 ENSDART00000186333

chr10_+_44584614 0.92 ENSDART00000163523
seizure related 6 homolog (mouse)-like
chr25_+_14165447 0.91 ENSDART00000145387
SH3 and multiple ankyrin repeat domains 2
chr22_-_38480186 0.91 ENSDART00000171704
heme-binding protein soul4
chr5_-_19932621 0.91 ENSDART00000088881
G protein-coupled receptor kinase interacting ArfGAP 2a
chr5_+_21144269 0.88 ENSDART00000028087
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr19_-_5254699 0.87 ENSDART00000081951
syntaxin 1B
chr22_-_38516922 0.86 ENSDART00000151257
ENSDART00000151785
kinesin light chain 4
chr24_+_35911300 0.85 ENSDART00000129679
ATP-binding cassette, sub-family D (ALD), member 4
chr2_-_3678029 0.84 ENSDART00000146861
matrix metallopeptidase 16b (membrane-inserted)
chr2_+_45300512 0.84 ENSDART00000144704
calmodulin regulated spectrin-associated protein family, member 2b
chr25_-_36282539 0.84 ENSDART00000073398
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10b
chr7_-_41489822 0.84 ENSDART00000006724
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr13_+_27314795 0.83 ENSDART00000128726
eukaryotic translation elongation factor 1 alpha 1a
chr12_+_29763546 0.83 ENSDART00000161533
gdnf family receptor alpha 1b
chr19_-_15397946 0.83 ENSDART00000143480
human immunodeficiency virus type I enhancer binding protein 3a
chr22_-_372723 0.83 ENSDART00000112895
si:zfos-1324h11.5
chr23_+_2752645 0.83 ENSDART00000146475
DNA topoisomerase I
chr4_-_11024767 0.82 ENSDART00000067261
ENSDART00000167631
transmembrane and tetratricopeptide repeat containing 2a
chr6_+_27146671 0.82 ENSDART00000156792
kinesin family member 1Aa
chr13_+_18366299 0.81 ENSDART00000133057
cell division cycle and apoptosis regulator 1
chr24_-_21172122 0.81 ENSDART00000154259
ATPase H+ transporting V1 subunit Ab
chr6_-_27057702 0.80 ENSDART00000149363
serine/threonine kinase 25a
chr9_+_30108641 0.80 ENSDART00000060174
jagunal homolog 1a
chr20_-_909953 0.80 ENSDART00000011283
cannabinoid receptor 1
chr7_-_39203799 0.79 ENSDART00000173727
cholinergic receptor, muscarinic 4a
chr11_+_2763168 0.79 ENSDART00000042972
SRSF protein kinase 1b
chr10_+_37268854 0.79 ENSDART00000131897
neurofibromin 1b
chr7_-_41489997 0.78 ENSDART00000174300
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr14_-_2221877 0.78 ENSDART00000106704
protocadherin 2 alpha b 1
chr18_+_28988373 0.78 ENSDART00000018685
synaptotagmin IXa
chr22_+_25049563 0.78 ENSDART00000078173
double zinc ribbon and ankyrin repeat domains 1
chr1_+_42225060 0.77 ENSDART00000138740
ENSDART00000101306
catenin (cadherin-associated protein), alpha 2
chr5_+_69716458 0.77 ENSDART00000159594
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr9_+_34380299 0.77 ENSDART00000131705
lysosomal-associated membrane protein 1
chr22_-_22416337 0.76 ENSDART00000142947
ENSDART00000089569
calmodulin regulated spectrin-associated protein family, member 2a
chr5_-_41142467 0.75 ENSDART00000129415
zinc finger RNA binding protein
chr25_+_388258 0.75 ENSDART00000166834
regulatory factor X7b
chr21_-_43606502 0.75 ENSDART00000151030
si:ch73-362m14.4
chr23_-_12345764 0.74 ENSDART00000133956
phosphatase and actin regulator 3a
chr15_+_19915345 0.74 ENSDART00000114267
microtubule-associated protein 6b
chr8_+_34720244 0.74 ENSDART00000181958
ENSDART00000189806
ENSDART00000190167
ENSDART00000183165
zgc:174461
chr12_-_9468618 0.73 ENSDART00000152737
ENSDART00000091519
post-GPI attachment to proteins 3
chr21_-_4764120 0.73 ENSDART00000129355
ENSDART00000102643
calmodulin regulated spectrin-associated protein 1a
chr25_-_20666328 0.73 ENSDART00000098076
C-terminal Src kinase
chr5_-_41142768 0.72 ENSDART00000074789
zinc finger RNA binding protein
chr16_+_12632428 0.72 ENSDART00000184600
ENSDART00000180537
N-acetyltransferase 14 (GCN5-related, putative)
chr1_-_16507812 0.72 ENSDART00000169081
myotubularin related protein 7b
chr7_-_51546386 0.71 ENSDART00000174306
NHS-like 2
chr1_+_6171585 0.71 ENSDART00000024358
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr7_+_29044888 0.70 ENSDART00000086871
glucose-fructose oxidoreductase domain containing 2
chr9_-_48036 0.70 ENSDART00000165230
ENSDART00000171335
mitogen-activated protein kinase kinase kinase kinase 4
chr4_+_9394426 0.70 ENSDART00000092013
transmembrane and tetratricopeptide repeat containing 1
chr1_-_25438934 0.69 ENSDART00000111686
FH2 domain containing 1
chr11_+_34824099 0.69 ENSDART00000037017
ENSDART00000146944
solute carrier family 38, member 3a
chr18_+_41495841 0.68 ENSDART00000098671
si:ch211-203b8.6
chr23_-_44494401 0.68 ENSDART00000114640
ENSDART00000148532
actin-like 6B
chr14_+_14225048 0.68 ENSDART00000168749
neuroligin 3a
chr5_+_41793001 0.68 ENSDART00000136439
ENSDART00000190477
ENSDART00000192289
BCL tumor suppressor 7A
chr1_-_51615437 0.67 ENSDART00000152185
ENSDART00000152237
ENSDART00000129052
ENSDART00000152595
si:dkey-202b17.4
chr18_-_46208581 0.67 ENSDART00000141278
si:ch211-14c7.2
chr24_+_35911020 0.67 ENSDART00000088480
ATP-binding cassette, sub-family D (ALD), member 4
chr19_-_10243148 0.66 ENSDART00000148073
shisa family member 7
chr1_-_46401385 0.66 ENSDART00000150029
ATPase phospholipid transporting 11A
chr6_-_57722816 0.66 ENSDART00000186163
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr5_-_31035198 0.66 ENSDART00000086534
cytochrome b5 domain containing 2
chr5_+_36611128 0.66 ENSDART00000097684
neuro-oncological ventral antigen 1
chr15_+_21252532 0.66 ENSDART00000162619
ENSDART00000019636
ENSDART00000144901
ENSDART00000138676
ENSDART00000133821
ENSDART00000146967
ENSDART00000143990
ENSDART00000142070
ENSDART00000132373
upstream transcription factor 1
chr25_+_3677650 0.66 ENSDART00000154348
prion protein, related sequence 3
chr24_-_24849091 0.65 ENSDART00000133649
ENSDART00000038290
corticotropin releasing hormone b
chr20_+_1121458 0.65 ENSDART00000064472
proline-rich nuclear receptor coactivator 1
chr19_-_307246 0.65 ENSDART00000145916
leucine rich repeat and Ig domain containing 4a
chr12_-_30032188 0.65 ENSDART00000042514
attractin-like 1b
chr7_+_61906903 0.65 ENSDART00000108540
tudor domain containing 7 b
chr10_+_3299829 0.65 ENSDART00000183684
zgc:56235
chr20_+_591505 0.65 ENSDART00000046438
potassium channel, subfamily K, member 2b
chr2_+_26682913 0.65 ENSDART00000010683
ENSDART00000131411
ENSDART00000137933
inositol monophosphatase 1
chr21_+_42226113 0.64 ENSDART00000170362
gamma-aminobutyric acid type A receptor beta2 subunit
chr14_+_14224730 0.64 ENSDART00000180112
ENSDART00000184891
ENSDART00000174760
neuroligin 3a
chr14_+_597532 0.64 ENSDART00000159805

chr16_-_6205790 0.64 ENSDART00000038495
catenin (cadherin-associated protein), beta 1
chr15_+_19915772 0.63 ENSDART00000188911
microtubule-associated protein 6b
chr24_-_30091937 0.63 ENSDART00000148249
phospholipid phosphatase related 4b
chr8_+_7875110 0.63 ENSDART00000167423
ENSDART00000160267
ENSDART00000180490
methyl-CpG binding domain protein 1a
chr17_+_24632440 0.63 ENSDART00000157092
mitogen-activated protein kinase kinase kinase kinase 3b
chr5_-_33460959 0.63 ENSDART00000085636
si:ch211-182d3.1
chr3_+_51563695 0.62 ENSDART00000008607
tweety homolog 2, like
chr2_-_32558795 0.62 ENSDART00000140026
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr24_+_4977862 0.61 ENSDART00000114537
zic family member 4
chr10_-_7988396 0.61 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr5_+_1278092 0.61 ENSDART00000147972
ENSDART00000159783
dynamin 1a
chr8_+_53269657 0.61 ENSDART00000184212
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr19_+_20787179 0.61 ENSDART00000193204
ADNP homeobox 2b
chr21_-_34032650 0.61 ENSDART00000138575
ENSDART00000047515
ring finger protein 145b
chr7_+_17096281 0.60 ENSDART00000035558
HIV-1 Tat interactive protein 2
chr21_+_45712247 0.60 ENSDART00000163982
calcium modulating ligand
chr10_+_9195190 0.60 ENSDART00000136364
anthrax toxin receptor 2b
chr16_-_44512882 0.60 ENSDART00000191241

chr18_-_5692292 0.59 ENSDART00000121503
complexin 3b
chr14_+_24277556 0.59 ENSDART00000122660
heterogeneous nuclear ribonucleoprotein A0a
chr18_+_9615147 0.59 ENSDART00000160284
piccolo presynaptic cytomatrix protein b
chr18_+_36601556 0.59 ENSDART00000127825
CLK4-associating serine/arginine rich protein
chr21_-_3613702 0.58 ENSDART00000139194
dymeclin
chr20_-_14925281 0.58 ENSDART00000152641
dynamin 3a
chr9_-_24209083 0.58 ENSDART00000134599
zgc:153521
chr9_+_25096500 0.58 ENSDART00000135074
ENSDART00000180436
ENSDART00000108629
leucine-rich repeats and calponin homology (CH) domain containing 1
chr14_+_10656975 0.58 ENSDART00000127594
ENSDART00000125865
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr5_+_11944054 0.58 ENSDART00000159448
zgc:110063
chr8_-_25120231 0.58 ENSDART00000147308
adhesion molecule with Ig-like domain 1
chr13_-_28674422 0.58 ENSDART00000122754
ENSDART00000057574
5'-nucleotidase, cytosolic IIa
chr17_-_22067451 0.57 ENSDART00000156872
tau tubulin kinase 1b
chr22_-_25078650 0.57 ENSDART00000131811
ENSDART00000141546
lysine acetyltransferase 14
chr6_-_8392104 0.57 ENSDART00000081561
ENSDART00000181178
interleukin enhancer binding factor 3a
chr22_-_15704704 0.57 ENSDART00000017838
ENSDART00000130238
scaffold attachment factor B
chr12_-_13966184 0.57 ENSDART00000066368
kelch-like family member 11
chr21_+_44684577 0.57 ENSDART00000099528
sprouty homolog 4 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of nrf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0042941 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
0.5 1.8 GO:0048211 Golgi vesicle docking(GO:0048211)
0.3 1.0 GO:1903644 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.3 1.2 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.3 1.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.3 1.1 GO:0006867 asparagine transport(GO:0006867)
0.3 0.8 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.3 1.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 2.2 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 1.0 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
0.2 1.0 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.2 0.7 GO:0035902 response to immobilization stress(GO:0035902)
0.2 0.6 GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000055)
0.2 1.5 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 1.0 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.2 3.9 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2 2.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.2 0.6 GO:1990868 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.2 1.7 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.2 2.3 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 1.0 GO:0016081 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.2 0.5 GO:0051958 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.2 1.1 GO:1990504 dense core granule exocytosis(GO:1990504)
0.2 2.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 0.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.4 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.1 1.0 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.1 2.5 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 1.9 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.7 GO:0021731 trigeminal motor nucleus development(GO:0021731)
0.1 1.3 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 1.3 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.3 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.1 1.0 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.1 2.4 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.8 GO:2000253 cannabinoid signaling pathway(GO:0038171) positive regulation of feeding behavior(GO:2000253)
0.1 0.3 GO:0001207 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.1 0.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.5 GO:0010939 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544)
0.1 0.3 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 2.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.6 GO:0031643 positive regulation of myelination(GO:0031643)
0.1 0.3 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 2.3 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.2 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.3 GO:0036065 fucosylation(GO:0036065)
0.1 0.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.5 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1 1.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 0.6 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.1 1.3 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.4 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.9 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.5 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.7 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.5 GO:0098926 postsynaptic signal transduction(GO:0098926)
0.1 0.3 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.7 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 1.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 0.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.6 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.3 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.3 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 0.5 GO:1901998 toxin transport(GO:1901998)
0.1 0.3 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.1 0.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 1.2 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.5 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.5 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.1 GO:0006595 polyamine metabolic process(GO:0006595)
0.0 0.3 GO:0021592 fourth ventricle development(GO:0021592)
0.0 0.6 GO:0090398 cellular senescence(GO:0090398)
0.0 1.0 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.4 GO:1901985 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.2 GO:0060760 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.3 GO:0098773 skin epidermis development(GO:0098773)
0.0 0.2 GO:0051204 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.8 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.2 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.4 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 2.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.3 GO:0070977 ossification involved in bone maturation(GO:0043931) bone maturation(GO:0070977)
0.0 0.6 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 2.2 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.2 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.6 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 1.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.3 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.2 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.6 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.5 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) nephron tubule epithelial cell differentiation(GO:0072160)
0.0 0.4 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.8 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.5 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.6 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.4 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 1.8 GO:0030903 notochord development(GO:0030903)
0.0 1.5 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 1.0 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 1.1 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.2 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.0 GO:0030859 polarized epithelial cell differentiation(GO:0030859)
0.0 0.2 GO:0007589 body fluid secretion(GO:0007589)
0.0 0.3 GO:0015781 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.4 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.8 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.2 GO:0030431 sleep(GO:0030431)
0.0 0.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.9 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.4 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.4 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0070813 hydrogen sulfide metabolic process(GO:0070813)
0.0 2.5 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.4 GO:0009649 entrainment of circadian clock(GO:0009649) entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.2 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.2 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.4 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.4 GO:0060030 dorsal convergence(GO:0060030)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.8 GO:0003401 axis elongation(GO:0003401)
0.0 0.6 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.4 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.2 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.3 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.4 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.9 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 0.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.2 GO:0021879 forebrain neuron differentiation(GO:0021879)
0.0 0.0 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531)
0.0 0.1 GO:2000047 cell-cell adhesion mediated by cadherin(GO:0044331) regulation of cell-cell adhesion mediated by cadherin(GO:2000047)
0.0 3.8 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 2.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 0.1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.7 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.3 1.0 GO:0072380 TRC complex(GO:0072380)
0.2 2.3 GO:0036449 microtubule minus-end(GO:0036449)
0.2 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 1.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 2.3 GO:0031209 SCAR complex(GO:0031209)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 0.4 GO:0008352 katanin complex(GO:0008352)
0.1 0.6 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.2 GO:0043679 axon terminus(GO:0043679)
0.1 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 2.6 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.6 GO:0072487 MSL complex(GO:0072487)
0.1 0.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.3 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 0.4 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.8 GO:0031045 dense core granule(GO:0031045)
0.1 0.5 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.4 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.2 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 0.5 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 0.5 GO:0034464 BBSome(GO:0034464)
0.1 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.4 GO:0071818 BAT3 complex(GO:0071818)
0.1 0.4 GO:0070847 core mediator complex(GO:0070847)
0.1 1.9 GO:0035869 ciliary transition zone(GO:0035869)
0.1 0.8 GO:0044545 NSL complex(GO:0044545)
0.1 1.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.1 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.0 0.5 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.7 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 1.1 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.8 GO:0046930 pore complex(GO:0046930)
0.0 3.1 GO:0005795 Golgi stack(GO:0005795)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.4 GO:0048179 activin receptor complex(GO:0048179)
0.0 3.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 3.3 GO:0030424 axon(GO:0030424)
0.0 0.1 GO:0071914 prominosome(GO:0071914)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.9 GO:0034703 cation channel complex(GO:0034703)
0.0 0.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0000781 chromosome, telomeric region(GO:0000781)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1903136 cuprous ion binding(GO:1903136)
0.3 1.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.3 2.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 1.6 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.2 0.9 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.2 0.6 GO:0052833 inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.2 0.8 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.2 3.9 GO:0001671 ATPase activator activity(GO:0001671)
0.2 1.1 GO:0015182 L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182)
0.2 2.3 GO:0030507 spectrin binding(GO:0030507)
0.2 2.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 0.5 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.2 0.8 GO:0015288 porin activity(GO:0015288)
0.2 2.1 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.5 GO:0102345 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 1.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.4 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.3 GO:1901612 phosphatidic acid binding(GO:0070300) phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 1.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 2.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.4 GO:0050699 WW domain binding(GO:0050699)
0.1 0.8 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.2 GO:0045159 myosin II binding(GO:0045159)
0.1 2.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.3 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.6 GO:0035198 miRNA binding(GO:0035198)
0.1 0.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.5 GO:0008494 translation activator activity(GO:0008494)
0.1 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 2.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:1990931 RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 1.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.6 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.4 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.7 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 4.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.0 0.7 GO:0016208 AMP binding(GO:0016208)
0.0 0.4 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:2001069 glycogen binding(GO:2001069)
0.0 1.9 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.1 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 1.4 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 2.7 GO:0060090 binding, bridging(GO:0060090)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 2.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 5.9 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.0 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 1.4 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.5 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 1.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.0 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.7 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.0 0.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.9 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor