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PRJNA207719: Tissue specific transcriptome profiling
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Results for nr4a2b
Z-value: 1.54
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Transcription factors associated with nr4a2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr4a2b | dr11_v1_chr6_+_12462079_12462079 | 0.65 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr4a2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0061620 | glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.1 | 1.5 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.1 | 1.3 | GO:0005979 | regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962) |
| 0.1 | 1.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 1.1 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.0 | 1.1 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
| 0.2 | 1.0 | GO:0071422 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423) |
| 0.0 | 0.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.8 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.8 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 1.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 1.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 1.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 1.3 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.8 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 0.6 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.6 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0070095 | 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 1.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.3 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 1.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 1.1 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.2 | 1.0 | GO:0015131 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) |
| 0.0 | 0.9 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 0.7 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.0 | 0.7 | GO:0008301 | DNA binding, bending(GO:0008301) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |