ISMARA results: nr4a2a

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PRJNA207719: Tissue specific transcriptome profiling

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Results for nr4a2a

Z-value: 1.72

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Transcription factors associated with nr4a2a

Gene Symbol	Gene ID	Gene Info
nr4a2a NCBI UniProt	ENSDARG00000017007	nuclear receptor subfamily 4, group A, member 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr4a2a	dr11_v1_chr9_-_5045378_5045378	-0.58	3.0e-01	Click!

Activity profile of nr4a2a motif

Sorted Z-values of nr4a2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_19220459 Show fit	2.05	ENSDART00000163070	si:dkey-21e2.7 NCBI UniProt Show fit	si:dkey-21e2.7
chr11_-_12198765 Show fit	1.47	ENSDART00000104203 ENSDART00000128364 ENSDART00000166887 ENSDART00000041533	krt95 NCBI UniProt Show fit	kertain 95
chr2_+_45191049 Show fit	1.45	ENSDART00000165392	ccl20a.3 NCBI UniProt Show fit	chemokine (C-C motif) ligand 20a, duplicate 3
chr7_-_7810348 Show fit	1.37	ENSDART00000171984	cxcl19 NCBI UniProt Show fit	chemokine (C-X-C motif) ligand 19
chr23_+_5631381 Show fit	1.30	ENSDART00000149143	pkp1a NCBI UniProt Show fit	plakophilin 1a
chr8_+_22478090 Show fit	1.23	ENSDART00000170263	si:ch211-261n11.7 NCBI UniProt Show fit	si:ch211-261n11.7
chr19_-_30404096 Show fit	1.22	ENSDART00000103475	agr2 NCBI UniProt Show fit	anterior gradient 2
chr5_-_14509137 Show fit	1.21	ENSDART00000180742	si:ch211-244o22.2 NCBI UniProt Show fit	si:ch211-244o22.2
chr3_+_57820913 Show fit	1.19	ENSDART00000168101	CU571328.1 NCBI UniProt Show fit
chr20_+_2589414 Show fit	1.17	ENSDART00000043626	il20ra NCBI UniProt Show fit	interleukin 20 receptor, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.2	2.6	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.2	2.2	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.0	1.7	GO:0006958	humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.1	1.4	GO:1902882	regulation of response to oxidative stress(GO:1902882)
0.2	1.3	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.1	1.2	GO:0035306	positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0	1.0	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2	0.9	GO:0051883	killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.1	0.9	GO:0097369	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)

Showing 1 to 10 of 77 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0005882	intermediate filament(GO:0005882)
0.1	1.3	GO:0030057	desmosome(GO:0030057)
0.1	0.9	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.8	GO:0005839	proteasome core complex(GO:0005839)
0.1	0.5	GO:0019815	B cell receptor complex(GO:0019815)
0.1	0.5	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.5	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.5	GO:0043596	nuclear replication fork(GO:0043596)
0.1	0.4	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	2.3	GO:0042803	protein homodimerization activity(GO:0042803)
0.1	2.2	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.3	1.9	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	1.6	GO:0045296	cadherin binding(GO:0045296)
0.1	1.4	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.2	1.0	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	0.9	GO:0015385	monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.9	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)

Showing 1 to 10 of 59 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	PID E2F PATHWAY	E2F transcription factor network
0.0	1.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	0.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.7	PID ATM PATHWAY	ATM pathway
0.0	0.6	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	0.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	0.8	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.7	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.7	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	0.6	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	0.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.5	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.5	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis

Showing 1 to 10 of 20 entries

Results for nr4a2a

Z-value: 1.72

Motif logo

Transcription factors associated with nr4a2a

Activity-expression correlation:

Activity profile of nr4a2a motif

Sorted Z-values of nr4a2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: