PRJNA207719: Tissue specific transcriptome profiling


Results for nr4a2a

Z-value: 1.72

Motif logo

Transcription factors associated with nr4a2a

Gene Symbol Gene ID Gene Info
ENSDARG00000017007 nuclear receptor subfamily 4, group A, member 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of nr4a2a motif

Sorted Z-values of nr4a2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_19220459 2.05 ENSDART00000163070
chr11_-_12198765 1.47 ENSDART00000104203
kertain 95
chr2_+_45191049 1.45 ENSDART00000165392
chemokine (C-C motif) ligand 20a, duplicate 3
chr7_-_7810348 1.37 ENSDART00000171984
chemokine (C-X-C motif) ligand 19
chr23_+_5631381 1.30 ENSDART00000149143
plakophilin 1a
chr8_+_22478090 1.23 ENSDART00000170263
chr19_-_30404096 1.22 ENSDART00000103475
anterior gradient 2
chr5_-_14509137 1.21 ENSDART00000180742
chr3_+_57820913 1.19 ENSDART00000168101

chr20_+_2589414 1.17 ENSDART00000043626
interleukin 20 receptor, alpha
chr5_-_41831646 1.04 ENSDART00000134326
chr19_-_47571456 1.03 ENSDART00000158071
ribonucleotide reductase M2 polypeptide
chr22_+_19486711 1.01 ENSDART00000144389
chr19_-_30403922 0.99 ENSDART00000181841
anterior gradient 2
chr18_+_38321039 0.95 ENSDART00000132534
ALX homeobox 4b
chr19_+_11214007 0.94 ENSDART00000127362
chr7_+_12950507 0.92 ENSDART00000067629
serum amyloid A
chr17_+_53424415 0.89 ENSDART00000157022
solute carrier family 9 member A1b
chr14_+_35428152 0.89 ENSDART00000172597
synaptotagmin-like 4
chr20_-_29499363 0.88 ENSDART00000152889
ribonucleotide reductase M2 polypeptide
chr20_+_36806398 0.83 ENSDART00000153317
ABRA C-terminal like
chr19_-_7144548 0.82 ENSDART00000147177
proteasome subunit beta 8A
proteasome subunit beta 13a
chr12_+_46634736 0.81 ENSDART00000008009
tripartite motif containing 16
chr7_+_20344222 0.81 ENSDART00000141186
plac8 onzin related protein 1
chr5_-_41841892 0.78 ENSDART00000167089
chr15_-_41762530 0.77 ENSDART00000187125
finTRIM family, member 91
chr21_-_22724980 0.76 ENSDART00000035469
complement component 1, q subcomponent, A chain
chr2_-_53592532 0.76 ENSDART00000184066
chemokine (C-C motif) ligand 25a
chr3_+_31680592 0.76 ENSDART00000172456
myosin, light chain kinase 5
chr5_+_4564233 0.73 ENSDART00000193435

chr6_-_8480815 0.73 ENSDART00000162300
RAS protein activator like 3
chr17_+_6217704 0.72 ENSDART00000129100

chr3_-_34115886 0.72 ENSDART00000151531
immunoglobulin heavy variable 4-1
chr5_-_41838354 0.72 ENSDART00000146793
chr20_-_39735952 0.71 ENSDART00000101049
tumor protein D52-like 1
chr17_-_53353653 0.71 ENSDART00000180744
un-named sa911
chr4_-_67799941 0.70 ENSDART00000185830
chr23_-_36313431 0.70 ENSDART00000125860
nuclear factor, erythroid 2
chr5_-_38197080 0.70 ENSDART00000140708
chr1_-_48933 0.69 ENSDART00000171162
immunoglobulin-like domain containing receptor 1a
chr22_+_19247255 0.68 ENSDART00000144053
chr11_-_11458208 0.68 ENSDART00000005485
keratin 93
chr1_-_39859626 0.67 ENSDART00000053763
dCMP deaminase
chr14_+_31788733 0.66 ENSDART00000109063
CD40 ligand
chr3_-_4591643 0.65 ENSDART00000138144
finTRIM family, member 50
chr5_-_10082244 0.63 ENSDART00000036421
checkpoint kinase 2
chr11_-_30634286 0.63 ENSDART00000191019
chr25_+_13191615 0.60 ENSDART00000168849
chr8_+_22477922 0.59 ENSDART00000189766
chr21_-_43428040 0.58 ENSDART00000148325
serine/threonine protein kinase 26
chr15_-_33834577 0.57 ENSDART00000163354
matrix metallopeptidase 13b
chr10_+_15064433 0.57 ENSDART00000179978
prostate androgen-regulated mucin-like protein 1
chr23_+_19701587 0.56 ENSDART00000104425
deoxyribonuclease I-like 1
chr6_-_607063 0.55 ENSDART00000189900
lectin, galactoside-binding, soluble, 2b
chr8_-_36399884 0.55 ENSDART00000108538
chr9_-_9419704 0.54 ENSDART00000138996
chr21_-_7940043 0.53 ENSDART00000099733
coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1
chr23_+_26142807 0.52 ENSDART00000158878
protein tyrosine phosphatase, non-receptor type 22
chr4_+_30785713 0.51 ENSDART00000165945
chr19_+_7043634 0.51 ENSDART00000133954
major histocompatibility complex class I UKA
chr22_-_23000815 0.51 ENSDART00000137111
protein tyrosine phosphatase, receptor type, C
chr17_+_5976683 0.50 ENSDART00000110276
chr8_-_17184482 0.50 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr17_-_17764801 0.50 ENSDART00000155261
SRA stem-loop interacting RNA binding protein
chr12_-_28983584 0.49 ENSDART00000112374
chr17_-_15189397 0.48 ENSDART00000133710
WD repeat and HMG-box DNA binding protein 1
chr1_+_58260886 0.48 ENSDART00000110453
chr1_+_19332837 0.48 ENSDART00000078594
tyrosinase-related protein 1b
chr4_+_77971104 0.48 ENSDART00000188609
chr17_-_51202339 0.47 ENSDART00000167117
chr21_-_5879897 0.47 ENSDART00000184034
ribosomal protein L35
chr24_-_30263301 0.47 ENSDART00000162328
sorting nexin 7
chr5_+_37729207 0.46 ENSDART00000184378
CDC42 effector protein (Rho GTPase binding) 2
chr23_+_26142613 0.46 ENSDART00000165046
protein tyrosine phosphatase, non-receptor type 22
chr7_-_33351485 0.44 ENSDART00000146420
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr16_-_33095161 0.43 ENSDART00000187648
dopey family member 1
chr14_-_14659023 0.43 ENSDART00000170355
NAD(P) dependent steroid dehydrogenase-like
chr21_-_1635268 0.43 ENSDART00000151258
chr7_+_11459235 0.43 ENSDART00000159611
interleukin 16
chr2_-_34138400 0.42 ENSDART00000056667
centromere protein L
chr1_+_58353661 0.42 ENSDART00000140074
chr20_+_49081967 0.42 ENSDART00000112689
crooked neck pre-mRNA splicing factor 1
chr1_-_52494122 0.41 ENSDART00000131407
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr23_+_5524247 0.40 ENSDART00000189679
TEA domain family member 3 a
chr12_-_23658888 0.40 ENSDART00000088319
mitogen-activated protein kinase kinase kinase 8
chr2_-_56649883 0.40 ENSDART00000191786
glutathione peroxidase 4b
chr6_-_43047774 0.40 ENSDART00000161722
glycerate kinase
chr19_-_7043355 0.40 ENSDART00000104845
TAP binding protein (tapasin), tandem duplicate 1
chr7_-_26601307 0.40 ENSDART00000188934
phospholipid scramblase 3b
chr20_+_6535438 0.39 ENSDART00000145763
chr16_+_41517188 0.39 ENSDART00000049976
chr4_+_9536860 0.39 ENSDART00000130083
LSM8 homolog, U6 small nuclear RNA associated
chr22_+_9764731 0.39 ENSDART00000161441

chr7_+_73801377 0.38 ENSDART00000184051
chr6_-_13206255 0.38 ENSDART00000065373
eukaryotic translation elongation factor 1 beta 2
chr5_+_36896933 0.38 ENSDART00000151984
serine/arginine-rich splicing factor 7a
chr24_-_21934571 0.37 ENSDART00000113092
transgelin 3b
chr20_+_25879826 0.37 ENSDART00000018519
chr2_+_7192966 0.36 ENSDART00000142735
chr6_+_47843760 0.36 ENSDART00000140943
peptidyl arginine deiminase, type II
chr1_+_44767657 0.36 ENSDART00000073717
chr11_-_44194132 0.36 ENSDART00000182954

chr23_+_44157682 0.36 ENSDART00000164474
chr1_+_58312187 0.35 ENSDART00000142285
chr22_+_19266995 0.35 ENSDART00000133995
chr18_+_38288877 0.34 ENSDART00000134247
LIM domain only 2 (rhombotin-like 1)
chr2_+_52065884 0.34 ENSDART00000146418
Src homology 2 domain containing transforming protein D, a
chr2_+_11028923 0.33 ENSDART00000076725
acyl-CoA thioesterase 11a
chr16_-_560574 0.32 ENSDART00000148452
iroquois homeobox 2a
chr5_-_28016805 0.32 ENSDART00000078642
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr7_+_22293894 0.32 ENSDART00000056790
transmembrane protein 256
chr21_-_25250594 0.32 ENSDART00000163862
nuclear factor related to kappaB binding protein
chr1_+_58303892 0.31 ENSDART00000147678

chr19_+_28187480 0.31 ENSDART00000183825
iroquois homeobox 4b
chr1_+_58094551 0.31 ENSDART00000146316
chr15_+_38007237 0.31 ENSDART00000182271

chr22_-_14247276 0.31 ENSDART00000033332
chr18_-_48492951 0.31 ENSDART00000146346
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr5_+_63288599 0.30 ENSDART00000140065
chr15_+_29727799 0.30 ENSDART00000182006
chr24_-_6024466 0.30 ENSDART00000040865
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr4_-_42242844 0.29 ENSDART00000163476
chr20_+_49119633 0.29 ENSDART00000151435
CD109 molecule
chr20_-_10288156 0.29 ENSDART00000064110
chr8_+_16758304 0.28 ENSDART00000133514
ELOVL fatty acid elongase 7a
chr16_-_31675669 0.28 ENSDART00000168848
complement component 1, r subcomponent
chr5_-_41841675 0.28 ENSDART00000141683
chr23_+_2185397 0.28 ENSDART00000109373
C1q and TNF related 7
chr12_-_29305533 0.27 ENSDART00000189410
SH2 domain containing 4Bb
chr7_+_46020508 0.27 ENSDART00000170294
cyclin E1
chr3_-_8510201 0.27 ENSDART00000009151

chr5_+_8246603 0.27 ENSDART00000167373
chr8_+_45338073 0.27 ENSDART00000185024
poly(A) binding protein, cytoplasmic 1-like
chr10_-_41285235 0.27 ENSDART00000141190
BRF2, RNA polymerase III transcription initiation factor
chr22_-_14262115 0.27 ENSDART00000168264
chr16_+_23975930 0.26 ENSDART00000147858
apolipoprotein C-IV
chr3_-_14695033 0.26 ENSDART00000133850
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr8_-_22542467 0.26 ENSDART00000182588
cold shock domain containing E1, RNA-binding
chr20_-_40729364 0.26 ENSDART00000101014
connexin 32.2
chr16_+_23976227 0.26 ENSDART00000193013
apolipoprotein C-IV
chr23_+_5736226 0.26 ENSDART00000134527
finTRIM family, member 57
chr17_+_17764979 0.26 ENSDART00000105013
alkB homolog 1, histone H2A dioxygenase
chr12_-_44122412 0.25 ENSDART00000169094
chr1_-_58868306 0.25 ENSDART00000166615
dynamin 2b
chr18_+_44769211 0.25 ENSDART00000177181
ilvB (bacterial acetolactate synthase)-like
chr11_+_5880562 0.25 ENSDART00000129663
DAZ associated protein 1
chr3_+_42923275 0.25 ENSDART00000168228
transmembrane protein 184a
chr2_-_22660232 0.25 ENSDART00000174742
THAP domain containing 4
chr3_+_3454610 0.25 ENSDART00000024900
chr17_-_25303486 0.25 ENSDART00000162235
peptidylprolyl isomerase E (cyclophilin E)
chr19_+_19756425 0.25 ENSDART00000167606
homeobox A3a
chr2_-_3045861 0.25 ENSDART00000105818
guanylate kinase 1a
chr3_+_46764022 0.24 ENSDART00000023814
protein kinase C substrate 80K-H
chr22_+_20141528 0.24 ENSDART00000187770
eukaryotic translation elongation factor 2a, tandem duplicate 1
chr1_+_24557414 0.24 ENSDART00000076519
dCTP pyrophosphatase 1
chr7_+_29012033 0.23 ENSDART00000173909
dynein, axonemal, assembly factor 1
chr22_-_24285432 0.23 ENSDART00000164083
chr2_+_10127762 0.23 ENSDART00000100726
insulin-like 5b
chr24_+_25471196 0.23 ENSDART00000066625
small muscle protein, X-linked
chr13_+_2523032 0.23 ENSDART00000172261
luteinizing hormone, beta polypeptide
chr1_-_33556428 0.23 ENSDART00000187346
cAMP responsive element binding protein 1a
chr4_-_16451375 0.23 ENSDART00000192700
chr1_+_58067815 0.22 ENSDART00000156678
chr14_+_30340251 0.22 ENSDART00000148448
microtubule associated tumor suppressor 1a
chr3_+_36646054 0.22 ENSDART00000170013
G1 to S phase transition 1, like
chr15_+_9053059 0.22 ENSDART00000012039
protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)
chr24_-_36723116 0.22 ENSDART00000088204
chr12_+_25223843 0.22 ENSDART00000077180
metastasis associated 1 family, member 3
chr17_+_53156530 0.22 ENSDART00000126277
diphthamine biosynthesis 6
chr15_+_11840311 0.22 ENSDART00000167671
protein kinase D2
chr20_-_18351510 0.21 ENSDART00000158098
G protein-coupled receptor 132b
chr6_-_49873020 0.21 ENSDART00000148511
GNAS complex locus
chr15_-_21165237 0.21 ENSDART00000157069
chr18_-_48550426 0.21 ENSDART00000145189
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr2_-_55298075 0.20 ENSDART00000186404
RAB8A, member RAS oncogene family
chr9_+_38645136 0.20 ENSDART00000135505
solute carrier family 12, member 8
chr16_+_8716800 0.20 ENSDART00000124693
chr2_-_24289641 0.20 ENSDART00000128784
myosin heavy chain 7-like
chr14_+_7898372 0.20 ENSDART00000159593
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr9_+_32872690 0.19 ENSDART00000020798
chr25_+_20272145 0.19 ENSDART00000109605
chr2_-_10564019 0.19 ENSDART00000132167
coiled-coil domain containing 18
chr18_-_2222128 0.19 ENSDART00000171402
phosphatidylinositol glycan anchor biosynthesis, class B
chr17_+_12730025 0.19 ENSDART00000064513
interleukin 17a/f2
chr13_+_25449681 0.19 ENSDART00000101328
atonal bHLH transcription factor 7
chr22_+_1123110 0.19 ENSDART00000171017
chr21_-_28640316 0.19 ENSDART00000128237
neuregulin 2a
chr6_-_1587291 0.19 ENSDART00000067592
chr22_-_37834312 0.18 ENSDART00000076128
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr22_+_21252790 0.18 ENSDART00000079046
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr3_-_33961589 0.18 ENSDART00000151533
immunoglobulin heavy constant delta
chr20_+_37825804 0.18 ENSDART00000152865
TatD DNase domain containing 3
chr10_+_10788811 0.18 ENSDART00000101077
prostaglandin D2 synthase a
chr8_+_10823069 0.18 ENSDART00000081341
mitogen-activated protein kinase 13
chr21_-_22189719 0.18 ENSDART00000126908
olfactory marker protein b
chr13_+_7241170 0.18 ENSDART00000109434
apoptosis-inducing factor, mitochondrion-associated, 2
chr23_+_22597624 0.18 ENSDART00000054337
G protein-coupled receptor 157
chr5_-_3839285 0.18 ENSDART00000122292
MLX interacting protein like
chr12_-_4598237 0.17 ENSDART00000152489
interferon regulatory factor 3
chr16_+_32736588 0.17 ENSDART00000075191

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0072679 thymocyte migration(GO:0072679)
0.2 0.2 GO:0009219 pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
0.2 2.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 2.2 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 0.6 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.2 1.3 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 0.7 GO:0002637 regulation of immunoglobulin production(GO:0002637) positive regulation of immunoglobulin production(GO:0002639)
0.2 0.9 GO:0051883 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.1 0.3 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.1 1.2 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.1 0.5 GO:1902369 negative regulation of RNA catabolic process(GO:1902369)
0.1 0.5 GO:0097066 response to thyroid hormone(GO:0097066)
0.1 0.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.9 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:0045124 regulation of bone resorption(GO:0045124)
0.1 1.4 GO:1902882 regulation of response to oxidative stress(GO:1902882)
0.1 0.8 GO:0061333 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.1 0.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.5 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 0.3 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 2.8 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 0.3 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.1 0.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.5 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.2 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.3 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.0 0.2 GO:0030728 ovulation(GO:0030728)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.4 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0089700 endocardial cushion formation(GO:0003272) protein kinase D signaling(GO:0089700)
0.0 0.7 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.6 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 0.2 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.0 0.2 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.1 GO:0048313 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.0 1.7 GO:0006958 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.0 0.5 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.2 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.0 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.4 GO:0050926 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.0 0.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.2 GO:0046865 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0 1.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.6 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.0 0.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:0009397 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0006837 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
0.0 0.3 GO:0072160 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) nephron tubule epithelial cell differentiation(GO:0072160)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.6 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.1 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:1901998 toxin transport(GO:1901998)
0.0 0.0 GO:1901862 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of muscle tissue development(GO:1901862) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.0 0.4 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.4 GO:0001878 response to yeast(GO:0001878)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.3 GO:0005948 acetolactate synthase complex(GO:0005948)
0.1 1.3 GO:0030057 desmosome(GO:0030057)
0.1 0.3 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.2 GO:0017177 glucosidase II complex(GO:0017177)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.1 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.5 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 1.0 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.3 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.1 0.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.4 GO:0008887 glycerate kinase activity(GO:0008887)
0.1 0.3 GO:0003984 acetolactate synthase activity(GO:0003984)
0.1 0.9 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.2 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.5 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.3 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.6 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.6 GO:0016936 galactoside binding(GO:0016936)
0.1 2.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.1 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0050780 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0001016 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 3 promoter sequence-specific DNA binding(GO:0001006) RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0051380 norepinephrine binding(GO:0051380)
0.0 0.1 GO:0015222 serotonin:sodium symporter activity(GO:0005335) serotonin transmembrane transporter activity(GO:0015222)
0.0 0.3 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.2 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.3 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.5 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.7 GO:0019239 deaminase activity(GO:0019239)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.7 PID ATM PATHWAY ATM pathway
0.0 1.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 0.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.2 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter