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PRJNA207719: Tissue specific transcriptome profiling
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Results for nr4a1
Z-value: 1.46
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Transcription factors associated with nr4a1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr4a1 | dr11_v1_chr23_-_32156278_32156278 | 0.23 | 7.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_1278092 Show fit | 1.64 |
ENSDART00000147972
ENSDART00000159783 |
dynamin 1a |
|
| chr10_-_17745345 Show fit | 1.60 |
ENSDART00000132690
ENSDART00000135376 |
si:dkey-200l5.4 |
|
| chr6_-_31348999 Show fit | 1.50 |
ENSDART00000153734
|
DnaJ (Hsp40) homolog, subfamily C, member 6 |
|
| chr8_-_14052349 Show fit | 1.27 |
ENSDART00000135811
|
ATPase plasma membrane Ca2+ transporting 3a |
|
| chr4_-_7212875 Show fit | 1.06 |
ENSDART00000161297
|
leucine rich repeat neuronal 3b |
|
| chr4_+_12615836 Show fit | 1.04 |
ENSDART00000003583
|
LIM domain only 3 |
|
| chr2_+_34767171 Show fit | 1.01 |
ENSDART00000145451
|
astrotactin 1 |
|
| chr14_+_14225048 Show fit | 0.87 |
ENSDART00000168749
|
neuroligin 3a |
|
| chr25_+_3525494 Show fit | 0.86 |
ENSDART00000169775
|
RAB19, member RAS oncogene family |
|
| chr21_+_10076203 Show fit | 0.85 |
ENSDART00000190383
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of nr4a1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.3 | 1.5 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.1 | 1.4 | GO:0098884 | postsynaptic neurotransmitter receptor internalization(GO:0098884) |
| 0.0 | 1.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.3 | 0.8 | GO:1990575 | mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575) |
| 0.1 | 0.8 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 0.8 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.8 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.0 | 0.8 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.2 | 0.7 | GO:0006867 | asparagine transport(GO:0006867) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.1 | 1.4 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
| 0.0 | 0.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 0.7 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 0.5 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.5 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.0 | 0.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.4 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.0 | 1.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 1.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 1.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 0.8 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 0.8 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 0.8 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.8 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 0.7 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 0.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 0.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.3 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.1 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.1 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |