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PRJNA207719: Tissue specific transcriptome profiling

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Results for nr3c2

Z-value: 0.62

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Transcription factors associated with nr3c2

Gene Symbol Gene ID Gene Info
nr3c2
ENSDARG00000102082 nuclear receptor subfamily 3, group C, member 2
nr3c2
ENSDARG00000115513 nuclear receptor subfamily 3, group C, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr3c2dr11_v1_chr1_-_37087966_370879660.138.3e-01Click!

Activity profile of nr3c2 motif

Sorted Z-values of nr3c2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_41096058 0.85 ENSDART00000028373
fkbp5
FK506 binding protein 5
chr8_+_7359294 0.58 ENSDART00000121708
pcsk1nl
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr6_+_41099787 0.58 ENSDART00000186884
fkbp5
FK506 binding protein 5
chr5_-_43935119 0.46 ENSDART00000142271
si:ch211-204c21.1
si:ch211-204c21.1
chr16_+_50089417 0.46 ENSDART00000153675
nr1d2a
nuclear receptor subfamily 1, group D, member 2a
chr5_-_43935460 0.45 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
si:ch211-204c21.1
chr24_-_38097305 0.36 ENSDART00000124321
crp2
C-reactive protein 2
chr14_-_46113321 0.35 ENSDART00000169040
ENSDART00000161475
ENSDART00000124925
si:ch211-235e9.8
si:ch211-235e9.8
chr11_+_34522554 0.35 ENSDART00000109833
zmat3
zinc finger, matrin-type 3
chr3_-_25275364 0.34 ENSDART00000163782
ENSDART00000145420
ENSDART00000133718
ENSDART00000055492
ddx5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr4_-_15420452 0.32 ENSDART00000016230
plxna4
plexin A4
chr11_+_34523132 0.31 ENSDART00000192257
zmat3
zinc finger, matrin-type 3
chr14_-_28001986 0.31 ENSDART00000054115
tsc22d3
TSC22 domain family, member 3
chr2_-_32512648 0.29 ENSDART00000170674
abcf2a
ATP-binding cassette, sub-family F (GCN20), member 2a
chr17_+_29345606 0.28 ENSDART00000086164
kctd3
potassium channel tetramerization domain containing 3
chr7_+_48288762 0.28 ENSDART00000083569
oaz2b
ornithine decarboxylase antizyme 2b
chr1_-_39909985 0.27 ENSDART00000181673
stox2a
storkhead box 2a
chr3_-_40051425 0.25 ENSDART00000146700
llgl1
lethal giant larvae homolog 1 (Drosophila)
chr5_-_54792239 0.24 ENSDART00000056213
pik3r1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr22_-_36519590 0.23 ENSDART00000129318
CABZ01045212.1

chr15_-_18429550 0.23 ENSDART00000136208
ncam1b
neural cell adhesion molecule 1b
chr6_-_6448519 0.20 ENSDART00000180157
ENSDART00000191112
si:ch211-194e18.2
si:ch211-194e18.2
chr15_+_40188076 0.19 ENSDART00000063779
efhd1
EF-hand domain family, member D1
chr7_+_58699718 0.18 ENSDART00000049264
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr8_-_50525360 0.18 ENSDART00000175648
CABZ01060030.1

chr23_+_44732863 0.16 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr11_-_34147205 0.16 ENSDART00000173216
atp13a3
ATPase 13A3
chr11_-_43473824 0.16 ENSDART00000179561
tmem63bb
transmembrane protein 63Bb
chr15_+_37559570 0.16 ENSDART00000085522
hspb6
heat shock protein, alpha-crystallin-related, b6
chr5_-_31901468 0.16 ENSDART00000147814
ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr3_-_37476475 0.15 ENSDART00000148107
si:ch211-278a6.1
si:ch211-278a6.1
chr24_-_20641000 0.11 ENSDART00000166135
zbtb47b
zinc finger and BTB domain containing 47b
chr16_+_11188810 0.10 ENSDART00000186011
cicb
capicua transcriptional repressor b
chr13_+_29510023 0.10 ENSDART00000187398
chst3a
carbohydrate (chondroitin 6) sulfotransferase 3a
chr20_+_54336137 0.09 ENSDART00000113792
cipcb
CLOCK-interacting pacemaker b
chr18_-_44611252 0.08 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr5_+_9417409 0.07 ENSDART00000125421
ENSDART00000130265
ugt2b5
UDP glucuronosyltransferase 2 family, polypeptide B5
chr10_-_13178853 0.05 ENSDART00000163740
ENSDART00000166327
ENSDART00000160265
ENSDART00000164299
musk
muscle, skeletal, receptor tyrosine kinase
chr16_+_46430627 0.05 ENSDART00000127681
rpz6
rapunzel 6
chr22_-_34979139 0.04 ENSDART00000116455
ENSDART00000133537
arhgap19
Rho GTPase activating protein 19
chr1_+_54199406 0.04 ENSDART00000176578
tsc2
TSC complex subunit 2
chr8_-_45835056 0.03 ENSDART00000022242
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr4_+_11723852 0.02 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr8_-_45834825 0.02 ENSDART00000132965
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr25_-_3470910 0.02 ENSDART00000029067
ENSDART00000186737
hbp1
HMG-box transcription factor 1
chr1_-_28473350 0.02 ENSDART00000190608
ENSDART00000148175
si:ch1073-440b2.1
si:ch1073-440b2.1
chr5_+_9382301 0.01 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr5_-_9540641 0.01 ENSDART00000124384
ENSDART00000160079
gak
cyclin G associated kinase
chr7_-_51749683 0.00 ENSDART00000083190
hdac8
histone deacetylase 8

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0007414 axonal defasciculation(GO:0007414)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.0 0.3 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.2 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.3 GO:0006595 polyamine metabolic process(GO:0006595)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling