ISMARA results: nr3c1

Project

PRJNA207719: Tissue specific transcriptome profiling

Navigation

Downloads

Results for nr3c1_ar

Z-value: 3.47

Motif logo

Transcription factors associated with nr3c1_ar

Gene Symbol	Gene ID	Gene Info
nr3c1 NCBI UniProt	ENSDARG00000025032	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nr3c1 NCBI UniProt	ENSDARG00000112480	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nr3c1 NCBI UniProt	ENSDARG00000116957	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ar NCBI UniProt	ENSDARG00000067976	androgen receptor
ar NCBI UniProt	ENSDARG00000114287	androgen receptor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ar	dr11_v1_chr5_+_35561607_35561607	-0.13	8.3e-01	Click!
nr3c1	dr11_v1_chr14_-_23799345_23799349	-0.05	9.3e-01	Click!

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_41096058 Show fit	5.75	ENSDART00000028373	fkbp5 NCBI UniProt Show fit	FK506 binding protein 5
chr6_+_41099787 Show fit	4.94	ENSDART00000186884	fkbp5 NCBI UniProt Show fit	FK506 binding protein 5
chr21_+_20901505 Show fit	2.74	ENSDART00000132741	c7b NCBI UniProt Show fit	complement component 7b
chr8_+_7359294 Show fit	2.58	ENSDART00000121708	pcsk1nl NCBI UniProt Show fit	proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr12_+_13256415 Show fit	2.53	ENSDART00000144542	atp2a1l NCBI UniProt Show fit	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr16_+_50089417 Show fit	2.52	ENSDART00000153675	nr1d2a NCBI UniProt Show fit	nuclear receptor subfamily 1, group D, member 2a
chr7_+_48288762 Show fit	2.40	ENSDART00000083569	oaz2b NCBI UniProt Show fit	ornithine decarboxylase antizyme 2b
chr1_-_26782573 Show fit	2.37	ENSDART00000090611	sh3gl2a NCBI UniProt Show fit	SH3 domain containing GRB2 like 2a, endophilin A1
chr16_+_10777116 Show fit	2.20	ENSDART00000190902	atp1a3b NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit alpha 3b
chr17_-_6730247 Show fit	2.19	ENSDART00000031091	vsnl1b NCBI UniProt Show fit	visinin-like 1b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.7	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.3	4.8	GO:0030007	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0	3.5	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.1	3.4	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	2.8	GO:0006470	protein dephosphorylation(GO:0006470)
0.1	2.7	GO:0019835	cytolysis(GO:0019835)
0.0	2.7	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.4	2.4	GO:0035313	wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1	2.4	GO:0006595	polyamine metabolic process(GO:0006595)
0.2	2.2	GO:0010955	negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)

Showing 1 to 10 of 128 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.0	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	2.8	GO:0005925	focal adhesion(GO:0005925)
0.2	2.7	GO:0005579	membrane attack complex(GO:0005579)
0.1	2.5	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	2.4	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1	1.8	GO:0031594	neuromuscular junction(GO:0031594)
0.1	1.6	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	1.6	GO:0005802	trans-Golgi network(GO:0005802)
0.0	1.6	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2	1.4	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	10.7	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4	4.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	2.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.6	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1	2.5	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.6	2.4	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	2.0	GO:0005516	calmodulin binding(GO:0005516)
0.5	1.9	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.1	1.8	GO:0004016	adenylate cyclase activity(GO:0004016)
0.4	1.7	GO:0101006	inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.8	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	1.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.1	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	1.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	0.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	0.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.5	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.4	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.4	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	0.9	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	0.7	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.7	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1	0.6	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	0.6	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.1	0.6	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 21 entries

Results for nr3c1_ar

Z-value: 3.47

Motif logo

Transcription factors associated with nr3c1_ar

Activity-expression correlation:

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: