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PRJNA207719: Tissue specific transcriptome profiling
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Results for nr2f1a
Z-value: 1.48
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Transcription factors associated with nr2f1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr2f1a | dr11_v1_chr5_+_49744713_49744713 | -0.59 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_42454292 Show fit | 1.40 |
ENSDART00000171459
|
y cytochrome P450, family 2, subfamily AA, polypeptide 2 |
|
| chr19_-_3303995 Show fit | 1.34 |
ENSDART00000105150
|
si:ch211-133n4.9 |
|
| chr9_+_38292947 Show fit | 1.25 |
ENSDART00000146663
|
transcription factor CP2-like 1 |
|
| chr22_-_24818066 Show fit | 1.24 |
ENSDART00000143443
|
vitellogenin 6 |
|
| chr15_-_21239416 Show fit | 1.16 |
ENSDART00000155787
|
si:dkey-105h12.2 |
|
| chr3_+_12816362 Show fit | 1.14 |
ENSDART00000163743
ENSDART00000170788 |
cytochrome P450, family 2, subfamily K, polypeptide 6 |
|
| chr10_+_26747755 Show fit | 1.13 |
ENSDART00000100329
|
coagulation factor IXb |
|
| chr16_-_45917322 Show fit | 1.05 |
ENSDART00000060822
|
antifreeze protein type IV |
|
| chr16_+_23913943 Show fit | 1.01 |
ENSDART00000175404
ENSDART00000129525 |
apolipoprotein A-IV b, tandem duplicate 1 |
|
| chr5_-_69934558 Show fit | 0.98 |
ENSDART00000124954
|
UDP glucuronosyltransferase 2 family, polypeptide A4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr2f1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0042738 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.4 | 1.8 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.1 | 1.7 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 1.7 | GO:0060030 | dorsal convergence(GO:0060030) |
| 0.1 | 1.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.4 | 1.2 | GO:0019628 | urate catabolic process(GO:0019628) urate metabolic process(GO:0046415) |
| 0.4 | 1.1 | GO:1901376 | mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376) |
| 0.0 | 1.1 | GO:0003323 | type B pancreatic cell development(GO:0003323) |
| 0.0 | 1.1 | GO:0007596 | blood coagulation(GO:0007596) |
| 0.2 | 1.0 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.4 | 1.8 | GO:0034359 | mature chylomicron(GO:0034359) |
| 0.0 | 1.4 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.3 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 1.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.6 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.0 | 0.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.6 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.0 | 3.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 1.8 | GO:0070325 | low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325) |
| 0.2 | 1.7 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 1.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 1.2 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.1 | 1.2 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 0.0 | 1.0 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.9 | GO:0004144 | diacylglycerol O-acyltransferase activity(GO:0004144) |
| 0.1 | 0.9 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.1 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.1 | 0.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 0.8 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.2 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 0.7 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 0.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 0.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |