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PRJNA207719: Tissue specific transcriptome profiling
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Results for nr1h4
Z-value: 1.51
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Transcription factors associated with nr1h4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr1h4 | dr11_v1_chr18_+_15644559_15644559 | 0.21 | 7.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_4346854 Show fit | 1.57 |
ENSDART00000004273
|
si:dkey-73p2.3 |
|
| chr3_-_34027178 Show fit | 1.37 |
ENSDART00000170201
ENSDART00000151408 |
immunoglobulin heavy variable 1-4 immunoglobulin heavy variable 14-1 |
|
| chr9_+_48007081 Show fit | 1.17 |
ENSDART00000060593
ENSDART00000099835 |
zgc:92380 |
|
| chr23_+_19790962 Show fit | 1.16 |
ENSDART00000142228
|
filamin A, alpha (actin binding protein 280) |
|
| chr18_+_46151505 Show fit | 1.07 |
ENSDART00000015034
ENSDART00000141287 |
biliverdin reductase B |
|
| chr1_-_58900851 Show fit | 1.02 |
ENSDART00000183085
ENSDART00000188855 ENSDART00000182567 |
Danio rerio microfibril-associated glycoprotein 4-like (LOC100334800), transcript variant 2, mRNA. |
|
| chr18_-_16791331 Show fit | 0.94 |
ENSDART00000148222
|
adenosine monophosphate deaminase 3b |
|
| chr3_-_4303262 Show fit | 0.92 |
ENSDART00000112819
|
si:dkey-73p2.2 |
|
| chr20_-_19864131 Show fit | 0.89 |
ENSDART00000057819
|
protein tyrosine kinase 2 beta, b |
|
| chr6_-_27139396 Show fit | 0.87 |
ENSDART00000055848
|
zgc:103559 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr1h4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 1.6 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.1 | 1.2 | GO:0019730 | antimicrobial humoral response(GO:0019730) |
| 0.0 | 1.1 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.1 | 0.9 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 0.9 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.2 | 0.7 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.1 | 0.7 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.0 | 0.7 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.0 | 0.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.6 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.4 | GO:0005673 | transcription factor TFIIE complex(GO:0005673) |
| 0.1 | 0.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.4 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 1.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 1.0 | GO:0042806 | fucose binding(GO:0042806) |
| 0.1 | 1.0 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.2 | 0.9 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.1 | 0.9 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.9 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.1 | 0.7 | GO:0008097 | 5S rRNA binding(GO:0008097) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 1.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.5 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.4 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.3 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.2 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |