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PRJNA207719: Tissue specific transcriptome profiling

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Results for nr1d2a

Z-value: 1.38

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Transcription factors associated with nr1d2a

Gene Symbol Gene ID Gene Info
ENSDARG00000003820 nuclear receptor subfamily 1, group D, member 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr1d2adr11_v1_chr16_+_50089417_500894170.711.8e-01Click!

Activity profile of nr1d2a motif

Sorted Z-values of nr1d2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_70155935 2.02 ENSDART00000165570
regulator of G protein signaling 3a
chr17_-_6738538 1.92 ENSDART00000157125
visinin-like 1b
chr7_+_40228422 1.53 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr18_-_39473055 1.52 ENSDART00000122930
secretogranin III
chr6_+_57541776 1.46 ENSDART00000157330
N-terminal EF-hand calcium binding protein 3
chr23_+_19564392 1.40 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr3_+_35298078 1.37 ENSDART00000110126
calcium channel, voltage-dependent, gamma subunit 3b
chr17_-_15528597 1.29 ENSDART00000150232
FYN proto-oncogene, Src family tyrosine kinase a
chr25_+_6306885 1.26 ENSDART00000142705
ENSDART00000067510
cellular retinoic acid binding protein 1a
chr3_-_2592350 1.24 ENSDART00000192325
si:dkey-217f16.5
chr6_-_39605734 1.23 ENSDART00000044276
ENSDART00000179059
disco-interacting protein 2 homolog Bb
chr3_-_2591942 1.19 ENSDART00000127971
si:dkey-217f16.5
chr14_-_42997145 1.18 ENSDART00000172801
protocadherin 10b
chr18_+_22302635 1.13 ENSDART00000141051
capping protein regulator and myosin 1 linker 2
chr2_-_16380283 1.10 ENSDART00000149992
si:dkey-231j24.3
chr12_+_28574863 1.09 ENSDART00000153284
TBK1 binding protein 1
chr20_+_16750177 1.06 ENSDART00000185357
calmodulin 1b
chr8_-_33114202 1.05 ENSDART00000098840
Ral GEF with PH domain and SH3 binding motif 1
chr5_-_11573490 1.05 ENSDART00000109577

chr5_-_67878064 1.03 ENSDART00000111203
transgelin 3a
chr2_+_20430366 0.99 ENSDART00000155108
si:ch211-153l6.6
chr22_-_38480186 0.99 ENSDART00000171704
heme-binding protein soul4
chr22_-_11124419 0.97 ENSDART00000149634
ATPase H+ transporting accessory protein 2
chr1_-_44704261 0.95 ENSDART00000133210
si:dkey-28b4.8
chr18_-_42313798 0.95 ENSDART00000098639
contactin 5
chr9_-_48937089 0.91 ENSDART00000193442
ceramide synthase 6
chr1_+_9708801 0.90 ENSDART00000189621
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr22_+_17828267 0.89 ENSDART00000136016
hyaluronan and proteoglycan link protein 4
chr25_-_1235457 0.88 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr6_-_49159207 0.87 ENSDART00000041942
tetraspanin 2a
chr10_+_2232023 0.87 ENSDART00000097695
contactin associated protein like 3
chr1_-_30039331 0.86 ENSDART00000086935
ENSDART00000143800
zgc:153256
chr25_+_14165447 0.85 ENSDART00000145387
SH3 and multiple ankyrin repeat domains 2
chr10_+_44692272 0.84 ENSDART00000157458
ubiquitin C
chr9_+_17982737 0.84 ENSDART00000192569
A kinase (PRKA) anchor protein 11
chr16_-_8927425 0.79 ENSDART00000000382
trio Rho guanine nucleotide exchange factor b
chr20_+_36233873 0.79 ENSDART00000131867
cornichon family AMPA receptor auxiliary protein 3
chr12_-_3756405 0.77 ENSDART00000150839
family with sequence similarity 57, member Bb
chr16_+_12632428 0.74 ENSDART00000184600
ENSDART00000180537
N-acetyltransferase 14 (GCN5-related, putative)
chr19_-_15335787 0.74 ENSDART00000187131
human immunodeficiency virus type I enhancer binding protein 3a
chr9_-_43207768 0.69 ENSDART00000192523
SEC14 and spectrin domains 1
chr11_+_30672282 0.68 ENSDART00000023981
ENSDART00000188846
tau tubulin kinase 1a
chr24_-_32408404 0.67 ENSDART00000144157
si:ch211-56a11.2
chr22_-_834106 0.67 ENSDART00000105873
cryptochrome circadian clock 4
chr8_+_21146262 0.67 ENSDART00000045684
porcupine O-acyltransferase
chr18_+_907266 0.66 ENSDART00000171729
pyruvate kinase M1/2a
chr18_+_27738349 0.65 ENSDART00000187816
tetraspanin 18b
chr12_-_979789 0.64 ENSDART00000128188
diacylglycerol lipase, beta
chr17_-_42213285 0.64 ENSDART00000140549
NK2 homeobox 2a
chr3_+_32698424 0.63 ENSDART00000055340
FUS RNA binding protein
chr15_+_2559875 0.63 ENSDART00000178505
SH2B adaptor protein 2
chr1_+_19930520 0.58 ENSDART00000158344
amyloid beta (A4) precursor protein-binding, family B, member 2b
chr10_-_25628555 0.56 ENSDART00000143978
T cell lymphoma invasion and metastasis 1a
chr12_+_12112384 0.55 ENSDART00000152431
glutamate receptor, ionotropic, delta 1b
chr1_-_49498116 0.54 ENSDART00000137357
zgc:175214
chr1_-_21297748 0.54 ENSDART00000142109
neuropeptide Y receptor Y1
chr8_+_43016714 0.53 ENSDART00000142671
Ras association (RalGDS/AF-6) domain family member 2a
chr12_+_19305390 0.52 ENSDART00000183987
ENSDART00000066391
casein kinase 1, epsilon
chr19_-_8732037 0.50 ENSDART00000138971
si:ch211-39a7.1
chr5_+_43470544 0.49 ENSDART00000111587
Rho-related BTB domain containing 2a
chr20_-_14680897 0.49 ENSDART00000063857
ENSDART00000161314
secernin 2
chr5_-_30079434 0.49 ENSDART00000133981
beta-carotene oxygenase 2a
chr18_-_35736591 0.48 ENSDART00000036015
ryanodine receptor 1b (skeletal)
chr1_-_31140096 0.48 ENSDART00000172243
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr17_-_7371564 0.47 ENSDART00000060336
RAB32b, member RAS oncogene family
chr16_-_24561354 0.46 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
chr3_-_26190804 0.45 ENSDART00000136001
yippee-like 3
chr2_-_42558549 0.44 ENSDART00000025997
disco-interacting protein 2 homolog Cb
chr7_+_15871408 0.44 ENSDART00000014572
paired box 6b
chr6_+_32415132 0.43 ENSDART00000155790
KN motif and ankyrin repeat domains 4
chr10_-_7988396 0.42 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr4_-_22519516 0.42 ENSDART00000130409
ENSDART00000186258
ENSDART00000002851
ENSDART00000123801
lysine (K)-specific demethylase 7Aa
chr7_+_66048102 0.39 ENSDART00000104523
aryl hydrocarbon receptor nuclear translocator-like 1b
chr15_+_17100412 0.38 ENSDART00000154418
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr5_-_23179319 0.38 ENSDART00000161883
ENSDART00000136260
si:dkey-114c15.5
chr6_-_45995401 0.37 ENSDART00000154392
carbonic anhydrase XVI b
chr11_-_21303946 0.34 ENSDART00000185786
si:dkey-85p17.3
chr21_-_2209012 0.34 ENSDART00000158345
zgc:162971
chr15_+_42599501 0.33 ENSDART00000177646
glutamate receptor, ionotropic, kainate 1b
chr20_+_46620374 0.33 ENSDART00000005548
basic leucine zipper transcription factor, ATF-like
chr17_+_5793248 0.33 ENSDART00000153743
retinitis pigmentosa 1-like 1a
chr21_-_40557281 0.30 ENSDART00000172327
TAO kinase 1b
chr9_-_43213229 0.30 ENSDART00000139775
SEC14 and spectrin domains 1
chr8_+_42917515 0.30 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr9_+_35860975 0.29 ENSDART00000134447
regulator of calcineurin 1a
chr5_-_13778726 0.29 ENSDART00000051655
small nuclear ribonucleoprotein 27 (U4/U6.U5)
chr20_+_34320635 0.28 ENSDART00000153207
influenza virus NS1A binding protein a
chr16_+_4838808 0.28 ENSDART00000179363
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr13_+_30172645 0.28 ENSDART00000137114
phosphatase domain containing, paladin 1b
chr22_-_29689485 0.28 ENSDART00000182173
programmed cell death 4b
chr6_+_37752781 0.27 ENSDART00000154364
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr12_-_7234915 0.26 ENSDART00000048866
inositol polyphosphate multikinase b
chr5_-_35888499 0.26 ENSDART00000193932
relaxin/insulin-like family peptide receptor 2, like
chr21_+_30549512 0.25 ENSDART00000132831
RAB38c, member of RAS oncogene family
chr23_-_44233408 0.23 ENSDART00000149318
ENSDART00000085528
zgc:158659
chr8_+_30452945 0.23 ENSDART00000062303
forkhead box D5
chr14_-_25111496 0.23 ENSDART00000158108
si:rp71-1d10.8
chr15_+_17100697 0.22 ENSDART00000183565
ENSDART00000123197
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr25_-_17918810 0.21 ENSDART00000023959
aryl hydrocarbon receptor nuclear translocator-like 1a
chr7_+_15871156 0.19 ENSDART00000145946
paired box 6b
chr6_-_40768654 0.16 ENSDART00000184668
ENSDART00000146470
actin related protein 2/3 complex, subunit 4
chr21_+_26606741 0.14 ENSDART00000002767
estrogen-related receptor alpha
chr12_-_32013125 0.14 ENSDART00000153355
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr23_+_21278948 0.14 ENSDART00000156701
ENSDART00000033970
ubiquitin protein ligase E3 component n-recognin 4
chr8_+_21225064 0.14 ENSDART00000129210
cryptochrome circadian clock 1ba
chr17_+_49500820 0.13 ENSDART00000170306
apoptosis resistant E3 ubiquitin protein ligase 1
chr17_-_23416897 0.13 ENSDART00000163391
si:ch211-149k12.3
chr23_+_44427188 0.12 ENSDART00000160207
eukaryotic translation initiation factor 4E family member 2 related sequence 1
chr6_-_8244474 0.12 ENSDART00000151358
ral guanine nucleotide dissociation stimulator-like 3a
chr14_-_29859067 0.12 ENSDART00000136380
sorbin and SH3 domain containing 2b
chr9_-_8661436 0.11 ENSDART00000130442
collagen, type IV, alpha 1
chr12_+_23912074 0.11 ENSDART00000152864
supervillin a
chr9_+_33267211 0.11 ENSDART00000025635
ubiquitin specific peptidase 9
chr10_-_1788376 0.11 ENSDART00000123842
erythrocyte membrane protein band 4.1 like 4A
chr2_+_35733335 0.11 ENSDART00000113489
RAS protein activator like 2
chr2_-_56655769 0.11 ENSDART00000113589
glutathione peroxidase 4b
chr22_+_786556 0.10 ENSDART00000125347
cryptochrome circadian clock 1bb
chr9_-_43213057 0.09 ENSDART00000059448
ENSDART00000133589
SEC14 and spectrin domains 1
chr17_-_29271359 0.08 ENSDART00000104219
REST corepressor 1
chr2_-_38337122 0.08 ENSDART00000076523
ENSDART00000187473
solute carrier family 7 (amino acid transporter light chain, L system), member 8b
chr21_-_32781612 0.08 ENSDART00000031028
CCR4-NOT transcription complex, subunit 6a
chr7_+_71586485 0.08 ENSDART00000165582
structural maintenance of chromosomes flexible hinge domain containing 1
chr19_+_24896409 0.08 ENSDART00000049840
EYA transcriptional coactivator and phosphatase 3
chr22_-_15704704 0.07 ENSDART00000017838
ENSDART00000130238
scaffold attachment factor B
chr16_+_26612401 0.07 ENSDART00000145571
erythrocyte membrane protein band 4.1 like 4B
chr3_+_52684556 0.06 ENSDART00000139037
6-phosphogluconolactonase
chr21_+_27189490 0.06 ENSDART00000125349
BCL2 associated agonist of cell death a
chr17_-_24364527 0.06 ENSDART00000155192
WD repeat containing planar cell polarity effector
chr8_+_2530065 0.06 ENSDART00000063943
mitochondrial ribosomal protein L40
chr9_-_10068004 0.06 ENSDART00000011922
ENSDART00000162818
speckle-type POZ protein-like a
chr11_+_5666325 0.06 ENSDART00000092270
R3H domain containing 4
chr3_-_16039619 0.05 ENSDART00000143324
splA/ryanodine receptor domain and SOCS box containing 3a
chr7_+_22313533 0.05 ENSDART00000123457
si:dkey-11f12.2
chr10_-_7555660 0.05 ENSDART00000163689
Werner syndrome
chr1_+_55752593 0.05 ENSDART00000108838
ENSDART00000134770
trans-2,3-enoyl-CoA reductase b
chr19_-_10295173 0.05 ENSDART00000136697
CCR4-NOT transcription complex, subunit 3b
chr8_-_2602572 0.04 ENSDART00000110482
zinc finger, DHHC-type containing 12a
chr12_+_9542124 0.03 ENSDART00000127952
prolyl 4-hydroxylase, alpha polypeptide I a
chr3_+_34985895 0.02 ENSDART00000121981
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr23_-_27442544 0.01 ENSDART00000019521
disco-interacting protein 2 homolog Ba
chr24_-_23716097 0.01 ENSDART00000084954
ENSDART00000129028
phosphatidylinositol glycan anchor biosynthesis, class N
chr10_+_15454745 0.00 ENSDART00000129441
ENSDART00000123935
ENSDART00000163446
ENSDART00000087680
ENSDART00000193752
erbb2 interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of nr1d2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:2000051 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 1.3 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.2 0.7 GO:0061355 Wnt protein secretion(GO:0061355)
0.2 1.5 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 0.6 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 1.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 0.6 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 1.2 GO:0021794 thalamus development(GO:0021794)
0.1 0.6 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.1 0.3 GO:0042832 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.1 0.3 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.1 0.5 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.1 1.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 1.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 1.1 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.0 1.0 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.7 GO:0032438 melanosome organization(GO:0032438)
0.0 1.0 GO:0009648 photoperiodism(GO:0009648)
0.0 1.4 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 0.3 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.7 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.1 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.3 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.5 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.1 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 1.1 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.9 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 1.5 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.5 GO:0030141 secretory granule(GO:0030141)
0.0 1.5 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.1 GO:0097541 axonemal basal plate(GO:0097541)
0.0 0.9 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.4 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.5 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.5 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.8 GO:0031386 protein tag(GO:0031386)
0.0 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.9 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.8 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.7 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock