ISMARA results: nkx2.3+nkx2.7

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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx2.3+nkx2.7

Z-value: 1.40

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol	Gene ID	Gene Info
nkx2.7 NCBI UniProt	ENSDARG00000021232	NK2 transcription factor related 7
nkx2.3 NCBI UniProt	ENSDARG00000039095	NK2 homeobox 3
nkx2.3 NCBI UniProt	ENSDARG00000113490	NK2 homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nkx2.7	dr11_v1_chr8_-_50287949_50287949	-0.53	3.6e-01	Click!
nkx2.3	dr11_v1_chr13_-_40411908_40411917	-0.20	7.4e-01	Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_3828560 Show fit	1.63	ENSDART00000185273 ENSDART00000179091	gad1b NCBI UniProt Show fit	glutamate decarboxylase 1b
chr13_+_38430466 Show fit	1.53	ENSDART00000132691	adgrb3 NCBI UniProt Show fit	adhesion G protein-coupled receptor B3
chr9_-_51323545 Show fit	1.14	ENSDART00000139316	slc4a10b NCBI UniProt Show fit	solute carrier family 4, sodium bicarbonate transporter, member 10b
chr17_-_29119362 Show fit	1.10	ENSDART00000104204	foxg1a NCBI UniProt Show fit	forkhead box G1a
chr12_+_24342303 Show fit	1.08	ENSDART00000111239	nrxn1a NCBI UniProt Show fit	neurexin 1a
chr15_-_15357178 Show fit	1.02	ENSDART00000106120	ywhag2 NCBI UniProt Show fit	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr24_-_6158933 Show fit	1.02	ENSDART00000021609	gad2 NCBI UniProt Show fit	glutamate decarboxylase 2
chr4_+_21129752 Show fit	1.00	ENSDART00000169764	syt1a NCBI UniProt Show fit	synaptotagmin Ia
chr15_-_34213898 Show fit	0.98	ENSDART00000191945 ENSDART00000186089	etv1 NCBI UniProt Show fit	ets variant 1
chr5_-_10946232 Show fit	0.98	ENSDART00000163139 ENSDART00000031265	rtn4r NCBI UniProt Show fit	reticulon 4 receptor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.6	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	2.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	2.0	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.3	1.5	GO:0016322	neuron remodeling(GO:0016322)
0.1	1.5	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.1	1.3	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1	1.1	GO:0043584	nose development(GO:0043584)
0.1	1.1	GO:0007035	vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1	1.1	GO:0015701	bicarbonate transport(GO:0015701)
0.0	1.1	GO:0050919	negative chemotaxis(GO:0050919)

Showing 1 to 10 of 137 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0043679	axon terminus(GO:0043679)
0.0	1.9	GO:0031225	anchored component of membrane(GO:0031225)
0.0	1.6	GO:0099634	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.3	1.5	GO:0043083	synaptic cleft(GO:0043083)
0.0	1.3	GO:0005871	kinesin complex(GO:0005871)
0.0	1.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	1.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2	1.0	GO:0042584	chromaffin granule membrane(GO:0042584)
0.1	1.0	GO:0048788	cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.0	1.0	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Showing 1 to 10 of 48 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.6	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.1	2.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	1.6	GO:0016247	channel regulator activity(GO:0016247)
0.0	1.6	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	1.5	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	1.3	GO:0048495	Roundabout binding(GO:0048495)
0.0	1.3	GO:0044325	ion channel binding(GO:0044325)
0.0	1.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	1.2	GO:0015459	potassium channel regulator activity(GO:0015459)
0.1	1.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)

Showing 1 to 10 of 95 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	PID RHOA PATHWAY	RhoA signaling pathway
0.1	1.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	1.0	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.9	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.5	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	1.0	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	1.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	0.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	0.8	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.1	0.6	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)

Showing 1 to 10 of 24 entries

Results for nkx2.3+nkx2.7

Z-value: 1.40

Motif logo

Transcription factors associated with nkx2.3+nkx2.7

Activity-expression correlation:

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: