PRJNA207719: Tissue specific transcriptome profiling


Results for nfkb1_rela

Z-value: 2.14

Motif logo

Transcription factors associated with nfkb1_rela

Gene Symbol Gene ID Gene Info
ENSDARG00000105261 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
ENSDARG00000098696 v-rel avian reticuloendotheliosis viral oncogene homolog A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_51307815 2.65 ENSDART00000098833
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr1_+_18716 1.99 ENSDART00000172454
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr18_-_5527050 1.94 ENSDART00000145400
chr1_-_52437056 1.77 ENSDART00000138337
chr1_-_52431220 1.72 ENSDART00000111256
chr6_-_436658 1.72 ENSDART00000191515
GRB2-related adaptor protein 2b
chr8_-_12432604 1.57 ENSDART00000133350
TNF receptor-associated factor 1
chr20_+_16881883 1.55 ENSDART00000130107
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr13_+_30692669 1.53 ENSDART00000187818

chr2_+_45191049 1.39 ENSDART00000165392
chemokine (C-C motif) ligand 20a, duplicate 3
chr1_-_37377509 1.36 ENSDART00000113542
TNFAIP3 interacting protein 2
chr23_+_36115541 1.35 ENSDART00000130090
homeobox C6a
chr4_-_12795436 1.35 ENSDART00000131026
chr12_+_22576404 1.31 ENSDART00000172053
capping protein (actin filament), gelsolin-like b
chr14_+_3038473 1.25 ENSDART00000026021
CD74 molecule, major histocompatibility complex, class II invariant chain a
chr1_-_52447364 1.24 ENSDART00000140740
chr7_-_34262080 1.21 ENSDART00000183246
chr21_-_22693730 1.18 ENSDART00000158342
grass carp reovirus (GCRV)-induced gene 2d
chr13_-_25819825 1.17 ENSDART00000077612
v-rel avian reticuloendotheliosis viral oncogene homolog
chr13_+_32148338 1.12 ENSDART00000188591
odd-skipped related transciption factor 1
chr8_+_25302172 1.11 ENSDART00000046182
glutathione S-transferase mu tandem duplicate 3
chr5_+_22579975 1.09 ENSDART00000080877
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr13_+_22717366 1.09 ENSDART00000134122
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_+_54576520 1.08 ENSDART00000093199
TEA domain family member 3 b
chr2_-_45191319 1.07 ENSDART00000192272

chr12_+_20641102 1.03 ENSDART00000152964
calcium binding and coiled-coil domain 2
chr15_+_32727848 1.02 ENSDART00000161361
periostin, osteoblast specific factor b
chr24_+_26006730 1.02 ENSDART00000140384
chemokine (C-C motif) ligand 20b
chr23_+_31815423 1.00 ENSDART00000075730
v-myb avian myeloblastosis viral oncogene homolog
chr13_+_22717939 0.99 ENSDART00000188288
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr9_+_41156818 0.97 ENSDART00000105764
signal transducer and activator of transcription 4
chr16_+_23403602 0.97 ENSDART00000159848
S100 calcium binding protein W
chr5_+_13385837 0.96 ENSDART00000191190
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr5_+_13373593 0.93 ENSDART00000051668
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr11_+_8129536 0.93 ENSDART00000158112
protein kinase, cAMP-dependent, catalytic, beta a
chr9_+_41156287 0.92 ENSDART00000189195
signal transducer and activator of transcription 4
chr12_+_20641471 0.92 ENSDART00000133654
calcium binding and coiled-coil domain 2
chr19_-_7144548 0.91 ENSDART00000147177
proteasome subunit beta 8A
proteasome subunit beta 13a
chr4_-_149334 0.90 ENSDART00000163280
TANK-binding kinase 1
chr1_-_52443379 0.90 ENSDART00000144676
chr2_-_879800 0.90 ENSDART00000019733
interferon regulatory factor 4a
chr13_-_2010191 0.90 ENSDART00000161021
GDNF family receptor alpha like
chr8_+_24281512 0.89 ENSDART00000062845
matrix metallopeptidase 9
chr7_+_12950507 0.88 ENSDART00000067629
serum amyloid A
chr9_-_51563575 0.86 ENSDART00000167034
TRAF family member-associated NFKB activator
chr23_+_19701587 0.84 ENSDART00000104425
deoxyribonuclease I-like 1
chr8_-_18667693 0.84 ENSDART00000100516
signal transducing adaptor family member 2b
chr14_-_4120636 0.84 ENSDART00000059230
interferon regulatory factor 2
chr6_-_442163 0.83 ENSDART00000163564
GRB2-related adaptor protein 2b
chr5_+_24086227 0.82 ENSDART00000051549
tumor protein p53
chr16_-_29714540 0.78 ENSDART00000067854
tumor necrosis factor, alpha-induced protein 8-like 2b
chr3_+_59899452 0.77 ENSDART00000064311
Rho GDP dissociation inhibitor (GDI) alpha
chr14_-_4121052 0.77 ENSDART00000167074
interferon regulatory factor 2
chr8_-_13362757 0.75 ENSDART00000188608
coiled-coil domain containing 124
chr11_+_35050253 0.73 ENSDART00000124800
family with sequence similarity 212, member Aa
chr21_+_30937690 0.73 ENSDART00000022562
ras homolog family member Gb
chr25_+_5288665 0.72 ENSDART00000169540

chr6_+_3334710 0.70 ENSDART00000132848
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr19_+_7124337 0.69 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr5_+_9246018 0.69 ENSDART00000081769
sushi domain containing 1
chr24_+_22731228 0.68 ENSDART00000146733
chr11_+_14333441 0.68 ENSDART00000171969
polypyrimidine tract binding protein 1b
chr5_-_42077575 0.67 ENSDART00000181939
chemokine (C-X-C motif) ligand 11, duplicate 7
chemokine (C-X-C motif) ligand 11, duplicate 6
chr2_+_42191592 0.65 ENSDART00000144716
caveolae associated protein 4a
chr7_+_29293452 0.65 ENSDART00000127358
chr4_+_70151160 0.65 ENSDART00000111816
chr5_-_42883761 0.63 ENSDART00000167374

chr2_+_42344304 0.62 ENSDART00000136105
finTRIM family, member 10
chr1_-_49225890 0.61 ENSDART00000111598
chemokine (C-X-C motif) ligand 18b
chr4_-_22311610 0.61 ENSDART00000137814
hematopoietic cell-specific Lyn substrate 1
chr3_+_57820913 0.61 ENSDART00000168101

chr21_+_25226558 0.57 ENSDART00000168480
syncollin, tandem duplicate 2
chr23_-_38054 0.57 ENSDART00000170393

chr24_+_25919809 0.57 ENSDART00000006615
mitogen-activated protein kinase kinase kinase 15
chr14_-_1646360 0.56 ENSDART00000186528

chr11_-_25853212 0.56 ENSDART00000145655
transmembrane protein 51b
chr21_+_45626136 0.56 ENSDART00000158742
interferon regulatory factor 1b
chr5_-_42071505 0.55 ENSDART00000137224
chemokine (C-X-C motif) ligand 11, duplicate 7
centromere protein V
chr12_+_49100365 0.55 ENSDART00000171905

chr15_+_17100412 0.55 ENSDART00000154418
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr11_-_396724 0.55 ENSDART00000184375

chr22_+_661711 0.54 ENSDART00000113795
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr7_+_19835569 0.54 ENSDART00000149812
ovo-like zinc finger 1a
chr10_+_20608676 0.54 ENSDART00000140141
chr19_+_7717449 0.54 ENSDART00000104719
tuftelin 1b
chr8_+_53269657 0.53 ENSDART00000184212
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr4_+_76789395 0.53 ENSDART00000147574
chr24_-_12689571 0.53 ENSDART00000015517
programmed cell death 6
chr19_+_46113828 0.51 ENSDART00000159331
RNA binding motif protein 24a
chr24_-_33703504 0.51 ENSDART00000079292
caveolae associated protein 4b
chr14_+_30773764 0.51 ENSDART00000186961
atlastin 3
chr6_+_19933763 0.50 ENSDART00000166192
phosphoinositide-3-kinase, regulatory subunit 5
chr2_-_53592532 0.50 ENSDART00000184066
chemokine (C-C motif) ligand 25a
chr22_-_651719 0.50 ENSDART00000148692
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
chr7_-_73843720 0.50 ENSDART00000111622
caspase activity and apoptosis inhibitor 1
chr7_-_20241346 0.49 ENSDART00000173619
chr18_-_11729 0.49 ENSDART00000159781
WAS protein homolog associated with actin, golgi membranes and microtubules
chr7_+_34786591 0.48 ENSDART00000173700
chr21_+_19547806 0.47 ENSDART00000159707
retinoic acid induced 14
chr20_-_39367895 0.46 ENSDART00000136476
PDZ binding kinase
chr2_+_2737422 0.46 ENSDART00000032459
aquaporin 1a (Colton blood group), tandem duplicate 1
chr7_-_20338048 0.46 ENSDART00000125594
chr11_-_35763323 0.46 ENSDART00000026017
basic helix-loop-helix family, member e40
chr6_+_12316438 0.46 ENSDART00000156854
chr16_-_35975254 0.46 ENSDART00000167537
eva-1 homolog Ba (C. elegans)
chr12_-_30760971 0.45 ENSDART00000066257
ectonucleoside triphosphate diphosphohydrolase 1
chr14_+_36889893 0.45 ENSDART00000124159
chr9_-_98982 0.44 ENSDART00000147882
LIM and senescent cell antigen-like domains 2
chr2_+_36004381 0.44 ENSDART00000098706
laminin, gamma 2
chr18_+_2563756 0.44 ENSDART00000164147
purinergic receptor P2Y2, tandem duplicate 1
chr1_-_59232267 0.44 ENSDART00000169658
A kinase (PRKA) anchor protein 8-like
chr16_-_25739331 0.44 ENSDART00000189455
B cell CLL/lymphoma 3
chr11_-_11458208 0.43 ENSDART00000005485
keratin 93
chr17_-_7733037 0.42 ENSDART00000064657
syntaxin 11a
chr10_+_44437080 0.41 ENSDART00000181517
density-regulated protein
chr12_-_19151708 0.41 ENSDART00000057124
thyrotrophic embryonic factor a
chr23_-_32162810 0.41 ENSDART00000155905
nuclear receptor subfamily 4, group A, member 1
chr8_+_22355909 0.40 ENSDART00000146457
chr2_+_1988036 0.40 ENSDART00000155956
synovial sarcoma, X breakpoint 2 interacting protein a
chr17_-_51195651 0.40 ENSDART00000191205
papilin a, proteoglycan-like sulfated glycoprotein
chr17_-_29249258 0.40 ENSDART00000031458
TNF receptor-associated factor 3
chr1_+_12135129 0.39 ENSDART00000126020
serine peptidase inhibitor, Kazal type 4
chr23_-_12423778 0.39 ENSDART00000124091
WAP four-disulfide core domain 2
chr4_-_12914163 0.39 ENSDART00000140002
methionine sulfoxide reductase B3
chr13_+_22719789 0.37 ENSDART00000057672
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_+_49771626 0.37 ENSDART00000134207
cathepsin Z
chr7_-_22632938 0.37 ENSDART00000159867
chr22_+_16497670 0.37 ENSDART00000014330
immediate early response 5
chr7_-_22632518 0.37 ENSDART00000161046
chr16_+_35535375 0.36 ENSDART00000171675
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b
chr5_-_42878178 0.36 ENSDART00000162981
C-X-C motif chemokine ligand 11
chr21_-_435466 0.35 ENSDART00000110297
Kruppel-like factor 4
chr7_-_8309505 0.35 ENSDART00000182530
coagulation factor XIII, A1 polypeptide b
chr6_+_18298444 0.34 ENSDART00000166018
caspase recruitment domain family, member 14
chr6_+_49771372 0.34 ENSDART00000063251
cathepsin Z
chr15_+_17100697 0.33 ENSDART00000183565
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr18_-_50766660 0.33 ENSDART00000170663
chr16_+_24681177 0.32 ENSDART00000058956
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr13_-_51846224 0.32 ENSDART00000184663

chr6_-_55254786 0.32 ENSDART00000113805
nuclear factor of activated T cells 2b
chr8_+_25629722 0.32 ENSDART00000026807
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr8_-_20230559 0.32 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr9_-_23894392 0.31 ENSDART00000133417
ankyrin repeat and SOCS box containing 18
chr23_-_437467 0.31 ENSDART00000192106
tetraspanin 2b
chr2_-_30200206 0.31 ENSDART00000130142
ubiquitin-conjugating enzyme E2W (putative)
chr4_-_42391176 0.31 ENSDART00000189739
chr12_+_46740584 0.31 ENSDART00000171563
plasminogen activator, urokinase b
chr18_-_18543358 0.31 ENSDART00000126460
interleukin 34
chr25_-_13188214 0.31 ENSDART00000187298
chr9_-_6380653 0.31 ENSDART00000078523
esophageal cancer related gene 4a
chr17_-_24884966 0.31 ENSDART00000136142
chr16_+_35535171 0.30 ENSDART00000167001
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b
chr7_-_22632690 0.30 ENSDART00000165245
chr23_-_33738570 0.30 ENSDART00000131680
chr15_-_4152582 0.29 ENSDART00000171942
chr6_-_33916756 0.29 ENSDART00000137447
nuclear autoantigenic sperm protein (histone-binding)
chr16_+_34111919 0.29 ENSDART00000134037
transcription elongation factor A (SII), 3
chr6_+_3334392 0.29 ENSDART00000133707
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr4_-_71708855 0.28 ENSDART00000158819
chr8_+_10823069 0.28 ENSDART00000081341
mitogen-activated protein kinase 13
chr14_+_49382180 0.27 ENSDART00000158329
TNFAIP3 interacting protein 1
chr12_+_46745239 0.27 ENSDART00000057179
plasminogen activator, urokinase b
chr22_-_31672566 0.27 ENSDART00000128247
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr3_+_61391636 0.27 ENSDART00000126417
brain protein I3
chr19_-_7043355 0.27 ENSDART00000104845
TAP binding protein (tapasin), tandem duplicate 1
chr14_-_40850481 0.26 ENSDART00000173236
E74-like ETS transcription factor 1
chr18_+_7073130 0.26 ENSDART00000101216
chr4_+_8016457 0.26 ENSDART00000014036
chr5_+_9246458 0.26 ENSDART00000081772
sushi domain containing 1
chr14_-_30967284 0.26 ENSDART00000149435
interleukin 2 receptor, gamma b
chr6_-_19333947 0.26 ENSDART00000160887
ggolgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr6_+_15145123 0.25 ENSDART00000063648
NCK adaptor protein 2b
chr15_+_6459847 0.25 ENSDART00000157250
beta-site APP-cleaving enzyme 2
chr3_-_21242460 0.24 ENSDART00000007293
titin-cap (telethonin)
chr9_-_52999318 0.24 ENSDART00000176601

chr23_-_4704938 0.24 ENSDART00000067293
CCHC-type zinc finger, nucleic acid binding protein a
chr12_+_20627505 0.24 ENSDART00000074384
syntaxin 4
chr7_-_59123066 0.24 ENSDART00000175438
DENN/MADD domain containing 4C
chr8_-_49725430 0.24 ENSDART00000135675
G kinase anchoring protein 1
chr23_+_42819221 0.24 ENSDART00000180495
myosin, light chain 9a, regulatory
chr16_-_24819860 0.24 ENSDART00000183874
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_27690 0.23 ENSDART00000162928
embryonic ectoderm development
chr16_+_50006872 0.23 ENSDART00000157100
ubiquitin-conjugating enzyme E2E 2
chr20_+_23501535 0.23 ENSDART00000177922
palladin, cytoskeletal associated protein
chr12_-_11349899 0.23 ENSDART00000079645
chr20_+_46371458 0.23 ENSDART00000152912
adhesion G protein-coupled receptor G11
chr5_-_38107741 0.23 ENSDART00000156853
chr7_-_22941472 0.22 ENSDART00000190334
TNF superfamily member 10, like
chr8_-_20230802 0.22 ENSDART00000063400
MLLT1, super elongation complex subunit a
chr20_-_29498178 0.22 ENSDART00000152986
ribonucleotide reductase M2 polypeptide
chr5_-_44496553 0.22 ENSDART00000178081
growth arrest-specific 1a
chr5_-_44496805 0.22 ENSDART00000110076
growth arrest-specific 1a
chr4_-_62528215 0.22 ENSDART00000162499
chr3_+_55114097 0.22 ENSDART00000121686
hemoglobin beta embryonic-1.1
chr4_-_2059233 0.21 ENSDART00000188177
cleavage and polyadenylation specific factor 6
chr4_-_77561679 0.21 ENSDART00000180809

chr21_-_44009169 0.21 ENSDART00000028960
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
chr16_+_38394371 0.21 ENSDART00000137954
CD83 molecule
chr14_+_36885524 0.21 ENSDART00000032547
leukocyte cell-derived chemotaxin 2 like
chr1_+_57004178 0.21 ENSDART00000152690

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.5 1.5 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
0.5 1.4 GO:0034138 toll-like receptor 3 signaling pathway(GO:0034138)
0.4 1.1 GO:0048389 intermediate mesoderm development(GO:0048389)
0.3 0.9 GO:0002544 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.3 0.8 GO:1901216 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.2 0.9 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.2 1.1 GO:0051883 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.2 0.5 GO:0098528 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 1.0 GO:0045658 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.2 0.5 GO:0072679 thymocyte migration(GO:0072679)
0.2 0.5 GO:0043388 cytidine to uridine editing(GO:0016554) positive regulation of DNA binding(GO:0043388)
0.2 0.2 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.2 0.3 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.2 0.5 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.1 0.4 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.4 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.1 4.3 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 0.2 GO:1990120 messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 2.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 0.3 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 0.4 GO:0030091 protein repair(GO:0030091)
0.1 1.3 GO:0034122 regulation of toll-like receptor signaling pathway(GO:0034121) negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1 0.8 GO:0033292 T-tubule organization(GO:0033292)
0.1 1.9 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.1 1.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 0.5 GO:0070285 pigment cell development(GO:0070285)
0.1 0.5 GO:0007608 sensory perception of smell(GO:0007608)
0.1 2.4 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 0.5 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 0.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.3 GO:0048940 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.1 1.1 GO:0016203 muscle attachment(GO:0016203)
0.1 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 0.3 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.6 GO:0031639 plasminogen activation(GO:0031639)
0.1 0.3 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:0050688 regulation of defense response to virus(GO:0050688)
0.0 0.8 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.4 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 1.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:2000403 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 1.9 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.0 0.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.1 GO:2000058 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.0 0.4 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 1.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 1.1 GO:1902622 regulation of neutrophil migration(GO:1902622)
0.0 0.6 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.1 GO:0060546 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544) negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.0 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 1.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.3 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.2 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.1 GO:0060879 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.0 0.0 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 0.0 GO:0036445 neuronal stem cell division(GO:0036445) somatic stem cell division(GO:0048103)
0.0 0.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.3 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.7 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.5 GO:0072089 stem cell proliferation(GO:0072089)
0.0 0.1 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 1.2 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.0 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.0 0.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.2 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.0 0.0 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.0 0.0 GO:0072314 glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.0 0.1 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.0 0.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0003139 secondary heart field specification(GO:0003139)
0.0 0.9 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.4 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 1.2 GO:0042611 MHC protein complex(GO:0042611)
0.1 1.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.2 GO:0042382 paraspeckles(GO:0042382)
0.1 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0043514 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 0.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.1 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.9 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.2 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.6 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 1.1 GO:0001726 ruffle(GO:0001726)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.2 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 1.0 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 0.5 GO:0005549 odorant binding(GO:0005549)
0.1 1.0 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.1 2.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 4.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.3 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.1 3.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.8 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.3 GO:0038132 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.1 0.5 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 1.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 0.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.5 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.2 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.2 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.0 GO:0030623 U5 snRNA binding(GO:0030623)
0.0 0.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.0 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 2.2 PID CD40 PATHWAY CD40/CD40L signaling
0.1 1.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.2 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 1.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 3.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.7 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 3.8 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.0 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.1 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.0 0.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates