ISMARA results: nfkb1

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PRJNA207719: Tissue specific transcriptome profiling

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Results for nfkb1_rela

Z-value: 2.14

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Transcription factors associated with nfkb1_rela

Gene Symbol	Gene ID	Gene Info
nfkb1 NCBI UniProt	ENSDARG00000105261	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
rela NCBI UniProt	ENSDARG00000098696	v-rel avian reticuloendotheliosis viral oncogene homolog A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nfkb1	dr11_v1_chr14_-_49859747_49859823	0.62	2.6e-01	Click!
rela	dr11_v1_chr7_-_804515_804515	-0.02	9.7e-01	Click!

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_51307815 Show fit	2.65	ENSDART00000098833	nfkbie NCBI UniProt Show fit	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr1_+_18716 Show fit	1.99	ENSDART00000172454 ENSDART00000161190	nfkbiz NCBI UniProt Show fit	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr18_-_5527050 Show fit	1.94	ENSDART00000145400 ENSDART00000132498 ENSDART00000146209	zgc:153317 NCBI UniProt Show fit	zgc:153317
chr1_-_52437056 Show fit	1.77	ENSDART00000138337	si:ch211-217k17.12 NCBI UniProt Show fit	si:ch211-217k17.12
chr1_-_52431220 Show fit	1.72	ENSDART00000111256	zgc:194101 NCBI UniProt Show fit	zgc:194101
chr6_-_436658 Show fit	1.72	ENSDART00000191515	grap2b NCBI UniProt Show fit	GRB2-related adaptor protein 2b
chr8_-_12432604 Show fit	1.57	ENSDART00000133350 ENSDART00000140699 ENSDART00000101174	traf1 NCBI UniProt Show fit	TNF receptor-associated factor 1
chr20_+_16881883 Show fit	1.55	ENSDART00000130107	nfkbiaa NCBI UniProt Show fit	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr13_+_30692669 Show fit	1.53	ENSDART00000187818	CR762483.1 NCBI UniProt Show fit
chr2_+_45191049 Show fit	1.39	ENSDART00000165392	ccl20a.3 NCBI UniProt Show fit	chemokine (C-C motif) ligand 20a, duplicate 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	GO:0048247	lymphocyte chemotaxis(GO:0048247)
0.1	2.4	GO:0055092	cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1	2.2	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1	1.9	GO:0038061	NIK/NF-kappaB signaling(GO:0038061)
0.0	1.9	GO:0007259	JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.5	1.5	GO:1901533	negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.5	1.5	GO:0002468	dendritic cell antigen processing and presentation(GO:0002468)
0.5	1.4	GO:0034138	toll-like receptor 3 signaling pathway(GO:0034138)
0.1	1.3	GO:0034122	regulation of toll-like receptor signaling pathway(GO:0034121) negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1	1.3	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)

Showing 1 to 10 of 91 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.1	1.9	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.2	1.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.2	1.2	GO:0042611	MHC protein complex(GO:0042611)
0.0	1.2	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	1.1	GO:0001726	ruffle(GO:0001726)
0.1	0.9	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.9	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.8	GO:0030496	midbody(GO:0030496)
0.0	0.7	GO:0048787	presynaptic active zone membrane(GO:0048787)

Showing 1 to 10 of 25 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.1	3.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	2.0	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.1	1.9	GO:0016675	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	1.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	1.2	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	1.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	1.0	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.1	1.0	GO:0008118	N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0	1.0	GO:0048306	calcium-dependent protein binding(GO:0048306)

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.0	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	3.1	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	2.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	1.5	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	1.3	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	1.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.8	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.6	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.2	3.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	1.9	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.3	1.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	0.8	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.8	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.1	0.7	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	0.7	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.5	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma

Showing 1 to 10 of 30 entries

Results for nfkb1_rela

Z-value: 2.14

Motif logo

Transcription factors associated with nfkb1_rela

Activity-expression correlation:

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: