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PRJNA207719: Tissue specific transcriptome profiling
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Results for nfia
Z-value: 2.87
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Transcription factors associated with nfia
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfia | dr11_v1_chr22_-_16997246_16997246 | 0.24 | 6.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_13256415 Show fit | 1.96 |
ENSDART00000144542
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like |
|
| chr5_-_32292965 Show fit | 1.94 |
ENSDART00000183522
ENSDART00000131983 |
myosin, heavy polypeptide 1.2, skeletal muscle |
|
| chr5_+_32228538 Show fit | 1.92 |
ENSDART00000077471
|
myosin heavy chain 4 |
|
| chr5_+_32222303 Show fit | 1.86 |
ENSDART00000051362
|
myosin heavy chain 4 |
|
| chr13_+_30804367 Show fit | 1.82 |
ENSDART00000053946
|
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) |
|
| chr5_+_32247310 Show fit | 1.74 |
ENSDART00000182649
|
myosin, heavy chain a |
|
| chr13_+_50375800 Show fit | 1.43 |
ENSDART00000099537
|
cytochrome c oxidase subunit Vb 2 |
|
| chr22_-_26945493 Show fit | 1.37 |
ENSDART00000077411
|
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) |
|
| chr21_+_10866421 Show fit | 1.37 |
ENSDART00000137858
|
alpha-kinase 2 |
|
| chr9_-_6927587 Show fit | 1.35 |
ENSDART00000059092
|
transmembrane protein 182a |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfia
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.2 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) |
| 0.1 | 3.1 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.2 | 2.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 2.9 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.4 | 2.3 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.1 | 2.3 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 2.0 | GO:0006821 | chloride transport(GO:0006821) |
| 0.1 | 1.8 | GO:0001757 | somite specification(GO:0001757) |
| 0.0 | 1.8 | GO:0001756 | somitogenesis(GO:0001756) |
| 0.1 | 1.7 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 3.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.6 | 2.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 2.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 2.3 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.1 | 1.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 1.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 1.2 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.4 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 3.8 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 3.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 2.3 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 1.9 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 1.8 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 1.5 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 1.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.4 | 1.3 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.2 | 1.2 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.4 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 1.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.0 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |