PRJNA207719: Tissue specific transcriptome profiling


Results for nfe2l2a

Z-value: 1.35

Motif logo

Transcription factors associated with nfe2l2a

Gene Symbol Gene ID Gene Info
ENSDARG00000042824 nuclear factor, erythroid 2-like 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of nfe2l2a motif

Sorted Z-values of nfe2l2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_7450796 1.86 ENSDART00000104750
MLLT11, transcription factor 7 cofactor
chr10_-_7974155 1.25 ENSDART00000147368
oxysterol binding protein 2
chr23_-_15878879 1.16 ENSDART00000010119
eukaryotic translation elongation factor 1 alpha 2
chr13_+_35746440 1.11 ENSDART00000187859
G protein-coupled receptor 75
chr22_-_13857729 0.91 ENSDART00000177971
S100 calcium binding protein, beta (neural)
chr19_-_6385594 0.90 ENSDART00000104950
ATPase Na+/K+ transporting subunit alpha 3a
chr18_+_1703984 0.88 ENSDART00000114010
SLIT and NTRK-like family, member 3a
chr15_+_37559570 0.80 ENSDART00000085522
heat shock protein, alpha-crystallin-related, b6
chr2_+_9822319 0.78 ENSDART00000144078
annexin A13, like
chr1_-_40227166 0.78 ENSDART00000146680
chr16_-_27640995 0.76 ENSDART00000019658
NAC alpha domain containing
chr13_-_21688176 0.75 ENSDART00000063825
shadow of prion protein
chr18_-_46763170 0.75 ENSDART00000171880
delta/notch-like EGF repeat containing
chr11_-_9948487 0.72 ENSDART00000189677
neuroligin 1
chr15_-_16679517 0.72 ENSDART00000177384
calneuron 1
chr24_+_24923166 0.71 ENSDART00000065288
phosphate cytidylyltransferase 1, choline, beta a
chr1_-_53750522 0.70 ENSDART00000190755
v-akt murine thymoma viral oncogene homolog 3b
chr8_+_24861264 0.70 ENSDART00000099607
solute carrier family 6 (neutral amino acid transporter), member 17
chr2_+_9821757 0.70 ENSDART00000018408
annexin A13, like
chr8_-_22660678 0.70 ENSDART00000181258
IQ motif and Sec7 domain 2a
chr5_-_31928913 0.63 ENSDART00000142919
slingshot protein phosphatase 1b
chr1_+_41690402 0.62 ENSDART00000177298
F-box protein 41
chr24_-_24146875 0.61 ENSDART00000173052
MAP7 domain containing 2b
chr4_+_13696537 0.61 ENSDART00000109195
neuronal cell adhesion molecule a
chr23_+_23183449 0.60 ENSDART00000132296
kelch-like family member 17
chr15_-_16070731 0.58 ENSDART00000122099
dynein, light chain, LC8-type 2a
chr8_-_34051548 0.57 ENSDART00000105204
pre-B-cell leukemia homeobox 3b
chr14_-_17588345 0.57 ENSDART00000143486
selenoprotein T, 2
chr3_-_21280373 0.57 ENSDART00000003939
synaptogyrin 1a
chr10_+_29963518 0.56 ENSDART00000011317
chr5_-_71460556 0.56 ENSDART00000108804
bone morphogenetic protein/retinoic acid inducible neural-specific 1
chr20_+_38724575 0.56 ENSDART00000015095
urotensin 1
chr24_+_41940299 0.56 ENSDART00000022349
erythrocyte membrane protein band 4.1-like 3a
chr6_-_35446110 0.55 ENSDART00000058773
regulator of G protein signaling 16
chr4_+_6572364 0.54 ENSDART00000122574
protein phosphatase 1, regulatory subunit 3Aa
chr3_+_17846890 0.54 ENSDART00000193384
zinc finger protein 385C
chr18_-_19405616 0.54 ENSDART00000191290
multiple EGF-like-domains 11
chr6_+_21395051 0.53 ENSDART00000017774
calcium channel, voltage-dependent, gamma subunit 5a
chr16_-_17162485 0.53 ENSDART00000123011
intermediate filament family orphan 1b
chr24_+_26039464 0.53 ENSDART00000131017
tyrosine kinase, non-receptor, 2a
chr16_+_25259313 0.52 ENSDART00000058938
F-box protein 32
chr23_+_19558574 0.50 ENSDART00000137811
ATPase H+ transporting accessory protein 1 like b
chr23_-_29376859 0.49 ENSDART00000146411
somatostatin 6
chr8_-_34052019 0.49 ENSDART00000040126
pre-B-cell leukemia homeobox 3b
chr14_-_48588422 0.48 ENSDART00000161147
chr13_-_226109 0.48 ENSDART00000161705
reticulon 4b
chr17_+_27176243 0.48 ENSDART00000162527
chr19_-_17658160 0.47 ENSDART00000151766
thyroid hormone receptor beta
chr7_-_52842605 0.46 ENSDART00000083002
microtubule-associated protein 1Aa
chr13_-_226393 0.45 ENSDART00000172677
reticulon 4b
chr21_+_9576176 0.45 ENSDART00000161289
mitogen-activated protein kinase 10
chr2_-_31800521 0.43 ENSDART00000112763
reticulophagy regulator 1
chr15_-_25518084 0.42 ENSDART00000158594
hypoxia-inducible factor 1, alpha subunit, like
chr9_+_11202552 0.41 ENSDART00000151931
acid-sensing (proton-gated) ion channel family member 4a
chr7_-_32833153 0.40 ENSDART00000099871
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr14_-_30490763 0.40 ENSDART00000193166
mitochondrial calcium uptake family, member 3b
chr20_-_39271844 0.39 ENSDART00000192708
chr5_-_40297003 0.39 ENSDART00000097526
heat shock protein, alpha-crystallin-related, b3
chr11_+_45300669 0.39 ENSDART00000172238
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr2_-_9544161 0.38 ENSDART00000124425
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, like
chr20_-_8443425 0.37 ENSDART00000083908
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr1_+_51312752 0.36 ENSDART00000063938
microtubule associated serine/threonine kinase 1a
chr21_+_25092300 0.36 ENSDART00000168505
DIX domain containing 1b
chr13_+_24519175 0.36 ENSDART00000190790
SERTA domain containing 2b
chr6_-_12135741 0.36 ENSDART00000155090
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr20_+_48100261 0.36 ENSDART00000158604
XK related 5a
chr23_-_18286822 0.36 ENSDART00000136672
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1a
chr14_-_30490465 0.35 ENSDART00000173107
mitochondrial calcium uptake family, member 3b
chr10_+_42462577 0.35 ENSDART00000133463
neuropeptide Y receptor Y8a
chr18_-_42333428 0.34 ENSDART00000034225
contactin 5
chr5_-_50640171 0.34 ENSDART00000183353
multiple C2 domains, transmembrane 1a
chr10_-_74408 0.33 ENSDART00000100073
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
chr21_-_31143903 0.33 ENSDART00000111571
RAP1 GTPase activating protein 2b
chr19_+_31404686 0.32 ENSDART00000078459
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr25_-_16818978 0.32 ENSDART00000104140
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr7_+_63325819 0.32 ENSDART00000085612
protocadherin 7b
chr17_-_22001303 0.31 ENSDART00000122190
solute carrier family 22 (organic anion transporter), member 7b, tandem duplicate 2
chr18_-_5692292 0.31 ENSDART00000121503
complexin 3b
chr21_-_24865217 0.31 ENSDART00000101136
immunoglobulin superfamily, member 9Bb
chr22_-_18116635 0.30 ENSDART00000005724
neurocan b
chr14_+_34068075 0.29 ENSDART00000135556
LON peptidase N-terminal domain and ring finger 1
chr15_+_40792667 0.29 ENSDART00000193186
FAT atypical cadherin 3a
chr24_-_29868151 0.28 ENSDART00000184802
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr22_-_26323893 0.27 ENSDART00000105099
calpain 1, (mu/I) large subunit b
chr12_+_5209822 0.27 ENSDART00000152610
chr15_-_39820491 0.27 ENSDART00000097134
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_+_36160979 0.27 ENSDART00000038525
chr16_+_10557504 0.27 ENSDART00000091241
chr10_+_29265463 0.26 ENSDART00000155390
CREB/ATF bZIP transcription factor
chr17_-_17948587 0.26 ENSDART00000090447
HHIP-like 1
chr3_+_41731527 0.26 ENSDART00000049007
carbohydrate (chondroitin 4) sulfotransferase 12a
chr21_-_929448 0.25 ENSDART00000133976
thioredoxin-like 1
chr14_+_24840669 0.25 ENSDART00000106039
Rho guanine nucleotide exchange factor (GEF) 37
chr3_-_26017831 0.25 ENSDART00000179982
heme oxygenase 1a
chr18_+_34478959 0.24 ENSDART00000059394
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr22_-_11829436 0.23 ENSDART00000126784
protein tyrosine phosphatase, non-receptor type 4b
chr7_+_13582256 0.23 ENSDART00000158477
ankyrin repeat and death domain containing 1A
chr17_+_28533102 0.23 ENSDART00000156218
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr25_-_11378623 0.23 ENSDART00000166586
ectodermal-neural cortex 2
chr17_-_22001935 0.22 ENSDART00000185429
solute carrier family 22 (organic anion transporter), member 7b, tandem duplicate 2
chr21_-_40782393 0.22 ENSDART00000075808
amyloid beta (A4) precursor protein-binding, family B, member 3
chr11_+_26609110 0.22 ENSDART00000042322
microtubule-associated protein 1 light chain 3 alpha
chr10_+_38775959 0.22 ENSDART00000192990
Down syndrome cell adhesion molecule a
chr10_+_38775408 0.21 ENSDART00000125045
Down syndrome cell adhesion molecule a
chr4_+_25630555 0.20 ENSDART00000133425
acyl-CoA thioesterase 15
chr2_+_37134281 0.20 ENSDART00000020135
peroxisomal biogenesis factor 19
chr21_+_38073210 0.20 ENSDART00000186309
Kruppel-like factor 8
chr7_+_756942 0.20 ENSDART00000152224
chr1_+_6640437 0.19 ENSDART00000147638
chr15_+_29393519 0.19 ENSDART00000193488
glycerophosphodiester phosphodiesterase domain containing 5b
chr10_+_17235370 0.19 ENSDART00000038780
signal peptide peptidase 3
chr13_-_22907260 0.19 ENSDART00000143097
RUN and FYVE domain containing 2
chr18_-_7456378 0.19 ENSDART00000081459
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr5_+_51909740 0.18 ENSDART00000162541
thrombospondin 4a
chr18_+_24922125 0.18 ENSDART00000180385
repulsive guidance molecule family member a
chr25_+_19710619 0.18 ENSDART00000156435
myxovirus (influenza virus) resistance G
chr14_-_30960470 0.18 ENSDART00000129989
chr2_-_24962002 0.17 ENSDART00000132050
helicase-like transcription factor
chr9_-_30145080 0.17 ENSDART00000133746
ABI family, member 3 (NESH) binding protein a
chr9_+_28688574 0.17 ENSDART00000101319
chr14_+_34780886 0.17 ENSDART00000130469
SH3 domain and tetratricopeptide repeats 2
chr6_-_12644563 0.17 ENSDART00000153797
dedicator of cytokinesis 9b
chr14_-_32486757 0.17 ENSDART00000148830
MCF.2 cell line derived transforming sequence a
chr7_-_40630698 0.17 ENSDART00000134547
ubiquitin protein ligase E3C
chr14_-_25985698 0.17 ENSDART00000172909
antioxidant 1 copper chaperone
chr14_+_5835134 0.17 ENSDART00000054867
ancient ubiquitous protein 1
chr24_+_35911020 0.17 ENSDART00000088480
ATP-binding cassette, sub-family D (ALD), member 4
chr2_-_6115688 0.17 ENSDART00000081663
peroxiredoxin 1
chr1_-_5745420 0.16 ENSDART00000166779
neuropilin 2a
chr8_+_20438884 0.16 ENSDART00000016422
MAP kinase interacting serine/threonine kinase 2b
chr8_+_10835456 0.16 ENSDART00000151388
mitogen-activated protein kinase 13
chr6_+_43903209 0.16 ENSDART00000006435
G protein-coupled receptor 27
chr21_-_929293 0.15 ENSDART00000006419
thioredoxin-like 1
chr5_-_64823750 0.15 ENSDART00000140305
limb and CNS expressed 1
chr11_-_3334248 0.15 ENSDART00000154314
chr15_+_45591669 0.15 ENSDART00000157459
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr13_-_35459928 0.15 ENSDART00000144109
SLX4 interacting protein
chr3_-_26017592 0.15 ENSDART00000030890
heme oxygenase 1a
chr9_+_22466218 0.15 ENSDART00000131214
diacylglycerol kinase, gamma
chr25_+_33046060 0.14 ENSDART00000165345
talin 2b
chr10_+_26747755 0.14 ENSDART00000100329
coagulation factor IXb
chr14_+_30279391 0.13 ENSDART00000172794
fibrinogen-like 1
chr18_+_37015185 0.13 ENSDART00000191305
signal-induced proliferation-associated 1 like 3
chr18_-_16315822 0.13 ENSDART00000136479
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr2_-_2813259 0.13 ENSDART00000032540
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr22_-_31059670 0.13 ENSDART00000022445
cullin-associated and neddylation-dissociated 2 (putative)
chr7_+_17992640 0.13 ENSDART00000173679
EH domain binding protein 1-like 1a
chr13_+_1430094 0.12 ENSDART00000169888
chr3_+_62140077 0.12 ENSDART00000108945
GID complex subunit 4 homolog
chr20_-_39103119 0.12 ENSDART00000143379
regulator of calcineurin 2
chr16_+_45930962 0.11 ENSDART00000124689
OTU deubiquitinase 7B
chr16_-_13613475 0.11 ENSDART00000139102
D site albumin promoter binding protein b
chr6_+_515181 0.11 ENSDART00000171374
chr8_-_18516385 0.11 ENSDART00000149446
chr12_-_1034383 0.10 ENSDART00000152455
polymerase (RNA) III (DNA directed) polypeptide E
chr2_-_3038904 0.10 ENSDART00000186795
guanylate kinase 1a
chr2_+_31437547 0.09 ENSDART00000141170
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr24_-_28229618 0.08 ENSDART00000145290
BCL2, apoptosis regulator a
chr7_-_62003831 0.08 ENSDART00000113585
phospholipase A2-activating protein
chr4_+_20085114 0.08 ENSDART00000186698
protein phosphatase 6, regulatory subunit 2a
chr12_-_19151708 0.08 ENSDART00000057124
thyrotrophic embryonic factor a
chr14_+_21755469 0.08 ENSDART00000186326
lysine (K)-specific demethylase 2Ab
chr2_-_6115389 0.08 ENSDART00000134921
peroxiredoxin 1
chr2_+_25278107 0.07 ENSDART00000131977
protein phosphatase 2, regulatory subunit B'', alpha
chr11_+_13528437 0.07 ENSDART00000011362
arrestin domain containing 2
chr14_-_2004291 0.07 ENSDART00000114039
protocadherin 2 gamma 5
chr13_+_42309688 0.07 ENSDART00000158367
insulin-degrading enzyme
chr14_-_34771371 0.07 ENSDART00000160598
actin binding LIM protein family, member 3
chr23_+_21278948 0.07 ENSDART00000156701
ubiquitin protein ligase E3 component n-recognin 4
chr7_-_23971497 0.07 ENSDART00000173603
chr7_-_44704910 0.07 ENSDART00000037850
dynein, cytoplasmic 1, light intermediate chain 2
chr23_+_3731375 0.06 ENSDART00000141782
small integral membrane protein 29
chr6_-_52723901 0.06 ENSDART00000033949
oxidative stress responsive serine-rich 1
chr1_+_41609676 0.06 ENSDART00000183675
mannosyl-oligosaccharide glucosidase
chr3_+_23669267 0.06 ENSDART00000111227
homeobox B10a
chr10_-_300000 0.06 ENSDART00000183273
EMSY BRCA2-interacting transcriptional repressor
chr6_+_20651398 0.06 ENSDART00000183663
solute carrier family 19 (folate transporter), member 1
chr22_-_16416882 0.05 ENSDART00000062749
cathepsin 12
chr14_-_48245816 0.05 ENSDART00000172452
relaxin/insulin-like family peptide receptor 1
chr9_+_19304697 0.05 ENSDART00000040449
5-hydroxytryptamine (serotonin) receptor 1Fa
chr1_+_35473219 0.05 ENSDART00000109678
ubiquitin specific peptidase 38
chr20_-_32981053 0.05 ENSDART00000138708
neuroblastoma amplified sequence
chr24_-_27409599 0.05 ENSDART00000041770
chemokine (C-C motif) ligand 34b, duplicate 3
chr4_+_33012407 0.05 ENSDART00000151873
chr2_-_37134169 0.04 ENSDART00000146123
ELAV like RNA binding protein 1a
chr13_-_23007813 0.04 ENSDART00000057638
hexokinase 1
chr22_-_10354381 0.04 ENSDART00000092050
stabilin 1
chr17_+_51744450 0.04 ENSDART00000190955
ornithine decarboxylase 1
chr7_+_13491452 0.04 ENSDART00000053535
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 like
chr1_+_19943803 0.04 ENSDART00000164661
amyloid beta (A4) precursor protein-binding, family B, member 2b
chr21_+_34686764 0.04 ENSDART00000005479
choroideremia (Rab escort protein 1)
chr3_+_26064091 0.04 ENSDART00000143697
chr8_-_39884359 0.04 ENSDART00000131372
chr23_-_12906228 0.04 ENSDART00000138807
necdin-like 2
chr9_+_23224761 0.04 ENSDART00000142008
mitogen-activated protein kinase kinase kinase 19
chr7_+_50464500 0.03 ENSDART00000191356
serine incorporator 4
chr3_+_32832042 0.03 ENSDART00000132679
CD2 (cytoplasmic tail) binding protein 2
chr2_-_26642831 0.03 ENSDART00000132854
U2 snRNP-associated SURP domain containing
chr7_+_62004048 0.03 ENSDART00000181818
small integral membrane protein 20
chr17_+_15674052 0.03 ENSDART00000156726
BTB and CNC homology 1, basic leucine zipper transcription factor 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of nfe2l2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 0.7 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.2 0.9 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 0.7 GO:0015824 proline transport(GO:0015824)
0.1 0.4 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.1 0.5 GO:0060220 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 0.2 GO:0021611 facial nerve formation(GO:0021611)
0.1 0.7 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.2 GO:1901017 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.5 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 0.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.4 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.5 GO:1904861 excitatory synapse assembly(GO:1904861)
0.1 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.2 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.9 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.4 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.2 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.0 0.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.7 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.3 GO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation(GO:0003262)
0.0 0.5 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 0.4 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.2 GO:0019079 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.0 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.3 GO:0000272 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.5 GO:0010962 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.2 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.4 GO:0014823 response to activity(GO:0014823)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0098838 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.0 0.2 GO:0021684 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) cerebellar granule cell differentiation(GO:0021707)
0.0 0.2 GO:0061709 reticulophagy(GO:0061709)
0.0 0.5 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.9 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.1 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.8 GO:0006414 translational elongation(GO:0006414)
0.0 0.6 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.0 GO:2000622 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.0 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.7 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.6 GO:0043186 P granule(GO:0043186)
0.0 0.3 GO:0043195 terminal bouton(GO:0043195)
0.0 0.5 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.5 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.3 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.1 0.4 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 1.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.5 GO:2001069 glycogen binding(GO:2001069)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.4 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 1.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 1.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex