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PRJNA207719: Tissue specific transcriptome profiling
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Results for nfe2l2a
Z-value: 1.35
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Transcription factors associated with nfe2l2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfe2l2a | dr11_v1_chr9_+_1654284_1654284 | -0.19 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_7450796 Show fit | 1.86 |
ENSDART00000104750
|
MLLT11, transcription factor 7 cofactor |
|
| chr10_-_7974155 Show fit | 1.25 |
ENSDART00000147368
ENSDART00000075524 |
oxysterol binding protein 2 |
|
| chr23_-_15878879 Show fit | 1.16 |
ENSDART00000010119
|
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr13_+_35746440 Show fit | 1.11 |
ENSDART00000187859
|
G protein-coupled receptor 75 |
|
| chr22_-_13857729 Show fit | 0.91 |
ENSDART00000177971
|
S100 calcium binding protein, beta (neural) |
|
| chr19_-_6385594 Show fit | 0.90 |
ENSDART00000104950
|
ATPase Na+/K+ transporting subunit alpha 3a |
|
| chr18_+_1703984 Show fit | 0.88 |
ENSDART00000114010
|
SLIT and NTRK-like family, member 3a |
|
| chr15_+_37559570 Show fit | 0.80 |
ENSDART00000085522
|
heat shock protein, alpha-crystallin-related, b6 |
|
| chr2_+_9822319 Show fit | 0.78 |
ENSDART00000144078
ENSDART00000144371 |
annexin A13, like |
|
| chr1_-_40227166 Show fit | 0.78 |
ENSDART00000146680
|
si:ch211-113e8.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfe2l2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.9 | GO:0051881 | regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.2 | 0.9 | GO:0021557 | oculomotor nerve development(GO:0021557) |
| 0.0 | 0.9 | GO:0036376 | cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436) |
| 0.0 | 0.9 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 0.8 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.0 | 0.8 | GO:0006414 | translational elongation(GO:0006414) |
| 0.2 | 0.7 | GO:0014014 | negative regulation of gliogenesis(GO:0014014) |
| 0.2 | 0.7 | GO:0015824 | proline transport(GO:0015824) |
| 0.1 | 0.7 | GO:0097105 | presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105) |
| 0.0 | 0.7 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 0.8 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 0.7 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.0 | 0.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.6 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 0.5 | GO:0033181 | plasma membrane proton-transporting V-type ATPase complex(GO:0033181) |
| 0.0 | 0.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 0.4 | GO:0042583 | chromaffin granule(GO:0042583) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.1 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.0 | 1.1 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 1.0 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.2 | 0.9 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.9 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 0.8 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.7 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.6 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.7 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 0.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |