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PRJNA207719: Tissue specific transcriptome profiling
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Results for neurod1
Z-value: 1.70
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Transcription factors associated with neurod1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| neurod1 | dr11_v1_chr9_-_44295071_44295071 | 0.90 | 3.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_37130450 Show fit | 2.01 |
ENSDART00000183358
|
si:ch1073-174d20.1 |
|
| chr8_+_7359294 Show fit | 1.52 |
ENSDART00000121708
|
proprotein convertase subtilisin/kexin type 1 inhibitor, like |
|
| chr12_+_31744217 Show fit | 1.42 |
ENSDART00000190361
|
si:dkey-49c17.3 |
|
| chr20_+_405811 Show fit | 1.29 |
ENSDART00000149311
|
G protein-coupled receptor 63 |
|
| chr7_+_30823749 Show fit | 1.26 |
ENSDART00000085661
|
amyloid beta (A4) precursor protein-binding, family A, member 2b |
|
| chr25_-_554142 Show fit | 1.23 |
ENSDART00000028997
|
myosin IXAb |
|
| chr23_+_20563779 Show fit | 1.23 |
ENSDART00000146008
|
CaM kinase-like vesicle-associated, like |
|
| chr10_+_15777258 Show fit | 1.20 |
ENSDART00000140511
|
amyloid beta (A4) precursor protein-binding, family A, member 1b |
|
| chr16_-_29334672 Show fit | 1.18 |
ENSDART00000162835
|
brevican |
|
| chr9_-_44295071 Show fit | 1.14 |
ENSDART00000011837
|
neuronal differentiation 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of neurod1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.0 | 2.1 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 1.7 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.0 | 1.6 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 1.5 | GO:0006208 | pyrimidine nucleobase catabolic process(GO:0006208) |
| 0.3 | 1.3 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.0 | 1.3 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 1.3 | GO:1901214 | regulation of neuron death(GO:1901214) |
| 0.2 | 1.2 | GO:0098529 | neuromuscular junction development, skeletal muscle fiber(GO:0098529) |
| 0.2 | 1.2 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0044309 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.1 | 2.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.2 | 1.6 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 1.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.1 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.1 | 1.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 0.8 | GO:0033010 | paranodal junction(GO:0033010) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 3.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.2 | 1.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 1.6 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 1.5 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.2 | 1.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 1.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.3 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 1.2 | GO:0098882 | structural constituent of presynaptic active zone(GO:0098882) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 1.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 1.0 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 0.7 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |