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PRJNA207719: Tissue specific transcriptome profiling

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Results for mtf1

Z-value: 1.00

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Transcription factors associated with mtf1

Gene Symbol Gene ID Gene Info
ENSDARG00000102898 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mtf1dr11_v1_chr16_+_4133519_41335190.652.3e-01Click!

Activity profile of mtf1 motif

Sorted Z-values of mtf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_59251874 0.94 ENSDART00000168919
olfactomedin 2b
chr3_-_50124413 0.94 ENSDART00000189920
claudin k
chr24_-_38384432 0.81 ENSDART00000140739
leucine rich repeat containing 4Bb
chr16_-_29452039 0.75 ENSDART00000148960
si:ch211-113g11.6
chr22_+_5574952 0.69 ENSDART00000171774
zgc:171566
chr10_+_21789954 0.68 ENSDART00000157769
ENSDART00000171703
protocadherin 1 gamma c 5
chr1_-_53750522 0.67 ENSDART00000190755
v-akt murine thymoma viral oncogene homolog 3b
chr1_+_50085440 0.64 ENSDART00000018469
ENSDART00000134988
nephronectin
chr1_-_12278522 0.62 ENSDART00000142122
ENSDART00000003825
complexin 2, like
chr21_+_3093419 0.60 ENSDART00000162520
SHC adaptor protein 3
chr1_-_12278056 0.60 ENSDART00000139336
ENSDART00000137463
complexin 2, like
chr1_+_50085640 0.60 ENSDART00000158988
ENSDART00000165973
nephronectin
chr23_-_3681026 0.59 ENSDART00000192128
ENSDART00000040086
protein kinase C and casein kinase substrate in neurons 1a
chr4_+_23223881 0.58 ENSDART00000133056
ENSDART00000089126
thyrotropin releasing hormone degrading enzyme, tandem duplicate 1
chr22_-_38607504 0.58 ENSDART00000164609
si:ch211-126j24.1
chr12_+_22745618 0.56 ENSDART00000181024
ENSDART00000183993
ENSDART00000077548
actin binding LIM protein family, member 2
chr3_-_56933578 0.55 ENSDART00000192185
HID1 domain containing a
chr17_-_12385308 0.53 ENSDART00000080927
synaptosomal-associated protein, 25b
chr5_+_36614196 0.50 ENSDART00000150574
neuro-oncological ventral antigen 1
chr4_-_23643272 0.50 ENSDART00000112301
ENSDART00000133184
thyrotropin releasing hormone degrading enzyme, tandem duplicate 2
chr8_-_39977026 0.49 ENSDART00000141707
aspartate beta-hydroxylase domain containing 2
chr14_+_44588353 0.49 ENSDART00000173421
leucine rich repeat and Ig domain containing 2a
chr12_+_41510492 0.48 ENSDART00000170976
ENSDART00000176164
kinesin family member 5B, b
chr20_+_27298783 0.47 ENSDART00000013861
protein phosphatase 4, regulatory subunit 4
chr19_+_37701450 0.47 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr7_+_25323742 0.47 ENSDART00000110347
cytochrome P450, family 26, subfamily b, polypeptide 1
chr6_-_20875111 0.46 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr13_-_23756700 0.44 ENSDART00000057612
regulator of G protein signaling 17
chr6_+_10450000 0.44 ENSDART00000151288
ENSDART00000187431
ENSDART00000192474
ENSDART00000188214
ENSDART00000184766
ENSDART00000190082
potassium channel, voltage gated eag related subfamily H, member 7
chr12_+_41991635 0.43 ENSDART00000186161
ENSDART00000192510
transcription elongation regulator 1 like
chr14_+_597532 0.42 ENSDART00000159805

chr23_-_28239750 0.42 ENSDART00000003548
zinc finger protein 385A
chr24_-_28333029 0.41 ENSDART00000149015
ENSDART00000129174
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr17_+_51499789 0.41 ENSDART00000187701

chr17_-_36988455 0.40 ENSDART00000187180
ENSDART00000126823
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr19_-_19556778 0.39 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr23_+_45611649 0.38 ENSDART00000169521
doublecortin-like kinase 2b
chr22_-_37349967 0.38 ENSDART00000104493
SRY (sex determining region Y)-box 2
chr2_+_33796207 0.38 ENSDART00000124647
KISS1 receptor a
chr15_-_18429550 0.37 ENSDART00000136208
neural cell adhesion molecule 1b
chr1_+_9004719 0.35 ENSDART00000006211
ENSDART00000137211
protein kinase C, beta a
chr14_-_33177935 0.33 ENSDART00000180583
ENSDART00000078856
discs, large homolog 3 (Drosophila)
chr6_+_54498220 0.32 ENSDART00000103282
si:ch211-233f11.5
chr24_-_19718077 0.32 ENSDART00000109107
ENSDART00000056082
cysteine-serine-rich nuclear protein 1b
chr24_-_37877743 0.31 ENSDART00000105658
transmembrane protein 204
chr23_+_23485858 0.29 ENSDART00000114067
agrin
chr20_-_46362606 0.28 ENSDART00000153087
BCL2 modifying factor 2
chr3_+_53052769 0.28 ENSDART00000156935
pre-B-cell leukemia transcription factor 4
chr2_+_54641644 0.28 ENSDART00000027313
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr17_-_125091 0.28 ENSDART00000158825
actin, alpha, cardiac muscle 1b
chr17_+_48831579 0.28 ENSDART00000154824
ENSDART00000178697
ENSDART00000192703
ENSDART00000180378
dishevelled associated activator of morphogenesis 2
chr5_-_45651548 0.27 ENSDART00000097645
neuropeptide FF receptor 2a
chr2_+_33457310 0.27 ENSDART00000056657
zgc:113531
chr6_+_7553085 0.27 ENSDART00000150939
ENSDART00000151114
myosin, heavy chain 10, non-muscle
chr13_+_52006253 0.26 ENSDART00000181259

chr23_+_20931030 0.26 ENSDART00000167014
paired box 7b
chr13_-_36184476 0.26 ENSDART00000057185
mitogen-activated protein kinase kinase kinase 9
chr2_+_49246099 0.26 ENSDART00000179089
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr14_-_45394704 0.26 ENSDART00000173078
ENSDART00000125970
si:ch211-168f7.5
chr7_-_38861741 0.25 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
PHD finger protein 21Aa
chr19_+_43017931 0.25 ENSDART00000132213
sodium/potassium transporting ATPase interacting 1
chr8_-_51524446 0.24 ENSDART00000167394
ENSDART00000147742
fibroblast growth factor receptor 1a
chr14_+_5117072 0.24 ENSDART00000189628
nanos homolog 1
chr15_-_44275069 0.23 ENSDART00000124980

chr13_-_27621246 0.23 ENSDART00000102232
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr1_+_44906517 0.22 ENSDART00000142820
wu:fc21g02
chr8_+_31435452 0.22 ENSDART00000145282
selenoprotein P
chr18_+_8231138 0.22 ENSDART00000140193
arylsulfatase A
chr20_+_700616 0.22 ENSDART00000168166
SUMO1/sentrin specific peptidase 6a
chr20_-_3403033 0.21 ENSDART00000092264
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr22_+_26703026 0.21 ENSDART00000158756
CREB binding protein a
chr13_-_27620815 0.21 ENSDART00000139904
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr15_+_2559875 0.20 ENSDART00000178505
SH2B adaptor protein 2
chr25_-_36020344 0.19 ENSDART00000181448
retinoblastoma-like 2 (p130)
chr2_+_327081 0.18 ENSDART00000155595
zgc:174263
chr2_-_51095743 0.17 ENSDART00000184646
si:ch73-52e5.2
chr8_-_53926228 0.17 ENSDART00000015554
UbiA prenyltransferase domain containing 1
chr23_+_39413163 0.17 ENSDART00000184254
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr23_-_18057553 0.16 ENSDART00000173102
ENSDART00000058742
zgc:92287
chr2_-_16216568 0.16 ENSDART00000173758
Rho guanine nucleotide exchange factor (GEF) 4
chr16_-_42152145 0.16 ENSDART00000038748
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr22_-_20950448 0.16 ENSDART00000002029
FK506 binding protein 8
chr11_-_3334248 0.16 ENSDART00000154314
ENSDART00000121861
peripherin
chr24_-_37877554 0.16 ENSDART00000132219
transmembrane protein 204
chr10_+_5954787 0.15 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr24_+_28525507 0.15 ENSDART00000191121
Rho GTPase activating protein 29a
chr1_-_35928942 0.14 ENSDART00000033566
SMAD family member 1
chr4_+_8376362 0.14 ENSDART00000138653
ENSDART00000132647
ELKS/RAB6-interacting/CAST family member 1b
chr9_-_48397702 0.14 ENSDART00000147169
zgc:172182
chr12_+_20149707 0.13 ENSDART00000181942
forkhead box J1b
chr12_+_48851381 0.13 ENSDART00000187241
ENSDART00000187796
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr23_-_45682136 0.13 ENSDART00000164646
family with sequence similarity 160, member A1b
chr8_+_26329482 0.13 ENSDART00000048676
protein kinase, cAMP-dependent, regulatory, type II, alpha A
chr15_+_3219134 0.13 ENSDART00000113532

chr18_-_7454422 0.12 ENSDART00000124709
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr24_+_10397865 0.12 ENSDART00000155557
si:ch211-69l10.4
chr19_-_35400819 0.12 ENSDART00000148080
ring finger protein 19B
chr23_+_45611980 0.12 ENSDART00000181582
doublecortin-like kinase 2b
chr25_+_3008263 0.11 ENSDART00000160484
neogenin 1b
chr6_+_31684 0.11 ENSDART00000188853
ENSDART00000184553

chr9_-_128036 0.10 ENSDART00000165960

chr18_+_18000887 0.10 ENSDART00000147797
si:ch211-212o1.2
chr5_-_14211487 0.09 ENSDART00000135731
neuropeptide FF receptor 1 like 2
chr24_-_3477103 0.09 ENSDART00000143723
isopentenyl-diphosphate delta isomerase 1
chr6_+_11397269 0.09 ENSDART00000114260
SUMO1/sentrin/SMT3 specific peptidase 2
chr11_-_575786 0.09 ENSDART00000019997
makorin, ring finger protein, 2
chr7_-_74090168 0.09 ENSDART00000050528
tyrosinase-related protein 1a
chr19_-_11336782 0.08 ENSDART00000131014
septin 7a
chr8_+_8973425 0.08 ENSDART00000066107
B cell receptor associated protein 31
chr7_-_50604626 0.07 ENSDART00000073903
ENSDART00000174031
CREB regulated transcription coactivator 3
chr20_-_48470599 0.07 ENSDART00000166857

chr20_-_1314537 0.07 ENSDART00000144288
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr14_-_3070613 0.07 ENSDART00000193729
ENSDART00000090196
solute carrier family 35, member A4
chr3_+_23221047 0.07 ENSDART00000009393
collagen, type I, alpha 1a
chr10_-_26997344 0.06 ENSDART00000146595
zgc:193742
chr4_+_53268458 0.06 ENSDART00000165335
si:dkey-250k10.1
chr7_+_59169081 0.06 ENSDART00000167980
oligosaccharyltransferase complex subunit
chr3_+_18756231 0.05 ENSDART00000089679
nuclear prelamin A recognition factor-like
chr20_+_560805 0.05 ENSDART00000152149
si:dkey-121j17.6
chr2_+_29257942 0.04 ENSDART00000184362
ENSDART00000025562
cadherin 18, type 2a
chr1_-_44000940 0.04 ENSDART00000134932
ENSDART00000138447
zgc:66472
chr2_-_43739740 0.04 ENSDART00000113849
kinesin family member 5B, a
chr17_+_37215820 0.03 ENSDART00000104009
solute carrier family 30 (zinc transporter), member 1b
chr16_+_11029762 0.03 ENSDART00000091183
Ets2 repressor factor like 3
chr2_+_314249 0.03 ENSDART00000082086
zgc:113452
chr20_+_39250673 0.03 ENSDART00000153003
RALBP1 associated Eps domain containing 1
chr15_-_43284021 0.02 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr25_+_17313568 0.02 ENSDART00000125459
CCR4-NOT transcription complex, subunit 1
chr11_-_18017287 0.01 ENSDART00000155443
glutamine-rich 1
chr14_-_41075262 0.01 ENSDART00000180518
dystrophin related protein 2
chr20_-_36408836 0.01 ENSDART00000076419
lamin B receptor
chr6_-_7686594 0.01 ENSDART00000091836
ENSDART00000151697
ubinuclein 2a
chr6_-_37513133 0.01 ENSDART00000147826
jade family PHD finger 3
chr1_-_35929143 0.00 ENSDART00000185002
SMAD family member 1
chr19_+_1005933 0.00 ENSDART00000191953
zinc finger, DHHC-type containing 3b

Network of associatons between targets according to the STRING database.

First level regulatory network of mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2 0.5 GO:0035992 tendon formation(GO:0035992)
0.1 0.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 0.7 GO:0021553 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.1 0.3 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.1 0.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.2 GO:0042373 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.1 0.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 0.2 GO:0090234 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.1 0.4 GO:0021982 pineal gland development(GO:0021982)
0.1 0.3 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.0 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.1 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.0 0.6 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.2 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.1 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.1 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.0 1.0 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.5 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.5 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.4 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.2 GO:0008354 germ cell migration(GO:0008354)
0.0 0.3 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 1.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.0 GO:0097361 CIA complex(GO:0097361)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 1.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0016208 AMP binding(GO:0016208)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.3 GO:0043236 laminin binding(GO:0043236)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex