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PRJNA207719: Tissue specific transcriptome profiling
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Results for msx1b+msx3
Z-value: 1.56
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Transcription factors associated with msx1b+msx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| msx3 | dr11_v1_chr13_+_24662238_24662238 | -0.82 | 8.8e-02 | Click! |
| msx1b | dr11_v1_chr1_+_49352900_49352900 | -0.48 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_22648007 Show fit | 1.66 |
ENSDART00000121788
|
grass carp reovirus (GCRV)-induced gene 2l |
|
| chr20_+_46040666 Show fit | 1.34 |
ENSDART00000060744
|
si:dkey-7c18.24 |
|
| chr15_-_5815006 Show fit | 1.33 |
ENSDART00000102459
|
retinol binding protein 2a, cellular |
|
| chr11_-_40457325 Show fit | 1.23 |
ENSDART00000128442
|
tumor necrosis factor receptor superfamily, member 1B |
|
| chr21_-_22647695 Show fit | 1.20 |
ENSDART00000187553
|
grass carp reovirus (GCRV)-induced gene 2l |
|
| chr25_+_29160102 Show fit | 1.12 |
ENSDART00000162854
|
pyruvate kinase M1/2b |
|
| chr22_+_12770877 Show fit | 1.11 |
ENSDART00000044683
|
formimidoyltransferase cyclodeaminase |
|
| chr5_-_29534748 Show fit | 1.09 |
ENSDART00000159587
|
|
|
| chr24_+_20373605 Show fit | 1.01 |
ENSDART00000112349
|
phospholipase C, delta 1a |
|
| chr6_+_50451337 Show fit | 1.00 |
ENSDART00000155051
|
myelocytomatosis oncogene homolog |
Network of associatons between targets according to the STRING database.
First level regulatory network of msx1b+msx3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.0 | 1.3 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 0.1 | 1.2 | GO:1901534 | positive regulation of hematopoietic progenitor cell differentiation(GO:1901534) |
| 0.4 | 1.1 | GO:0019556 | formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.2 | 1.1 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.3 | 1.0 | GO:1901533 | negative regulation of hematopoietic progenitor cell differentiation(GO:1901533) |
| 0.1 | 1.0 | GO:0072498 | embryonic skeletal joint development(GO:0072498) |
| 0.0 | 1.0 | GO:0072676 | lymphocyte migration(GO:0072676) |
| 0.0 | 1.0 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) |
| 0.0 | 0.9 | GO:0006658 | phosphatidylserine metabolic process(GO:0006658) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.7 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.6 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 0.5 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 0.4 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.1 | 0.4 | GO:0030891 | VCB complex(GO:0030891) |
| 0.1 | 0.4 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.2 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.1 | 2.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.3 | 1.1 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.2 | 1.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 1.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.0 | GO:0004629 | phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629) |
| 0.0 | 0.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.0 | 0.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 0.8 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.2 | 0.7 | GO:0048030 | disaccharide binding(GO:0048030) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 1.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 0.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.7 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.2 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 0.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |