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PRJNA207719: Tissue specific transcriptome profiling
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Results for msx1a
Z-value: 1.35
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Transcription factors associated with msx1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| msx1a | dr11_v1_chr14_-_12822_12847 | 0.64 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_6751405 Show fit | 0.99 |
ENSDART00000037265
ENSDART00000146371 |
olfactomedin 1b |
|
| chr17_-_12389259 Show fit | 0.96 |
ENSDART00000185724
|
synaptosomal-associated protein, 25b |
|
| chr15_-_21877726 Show fit | 0.83 |
ENSDART00000127819
ENSDART00000145646 ENSDART00000100897 ENSDART00000144739 |
zgc:162608 |
|
| chr10_+_21867307 Show fit | 0.82 |
ENSDART00000126629
|
cerebellin 17 |
|
| chr13_-_20381485 Show fit | 0.81 |
ENSDART00000131351
|
si:ch211-270n8.1 |
|
| chr21_+_6751760 Show fit | 0.75 |
ENSDART00000135914
|
olfactomedin 1b |
|
| chr16_-_29437373 Show fit | 0.67 |
ENSDART00000148405
|
si:ch211-113g11.6 |
|
| chr23_+_40460333 Show fit | 0.67 |
ENSDART00000184658
|
SOGA family member 3b |
|
| chr5_-_23280098 Show fit | 0.66 |
ENSDART00000126540
ENSDART00000051533 |
proteolipid protein 1b |
|
| chr20_-_23426339 Show fit | 0.64 |
ENSDART00000004625
|
zygote arrest 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of msx1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.2 | 0.8 | GO:0010872 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.0 | 0.7 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.1 | 0.6 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.0 | 0.6 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.6 | GO:2000344 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 0.6 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.0 | 0.6 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.6 | GO:0007586 | digestion(GO:0007586) |
| 0.0 | 0.6 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.9 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 0.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 0.6 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.0 | 0.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 0.5 | GO:0097189 | apoptotic body(GO:0097189) |
| 0.0 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.5 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.1 | 0.4 | GO:0043083 | synaptic cleft(GO:0043083) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 0.9 | GO:0009374 | biotin binding(GO:0009374) |
| 0.2 | 0.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 0.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.6 | GO:0099530 | G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.1 | 0.6 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 0.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 0.5 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.5 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.5 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.3 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |