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PRJNA207719: Tissue specific transcriptome profiling

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Results for mef2ca+mef2cb

Z-value: 3.14

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Transcription factors associated with mef2ca+mef2cb

Gene Symbol Gene ID Gene Info
ENSDARG00000009418 myocyte enhancer factor 2cb
ENSDARG00000029764 myocyte enhancer factor 2ca

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mef2cadr11_v1_chr10_-_43568239_435682410.838.1e-02Click!
mef2cbdr11_v1_chr5_-_48307804_483078040.513.8e-01Click!

Activity profile of mef2ca+mef2cb motif

Sorted Z-values of mef2ca+mef2cb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_11201096 4.69 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myomesin 2a
chr5_+_51597677 3.28 ENSDART00000048210
ENSDART00000184797
creatine kinase, mitochondrial 2b (sarcomeric)
chr11_+_11200550 3.22 ENSDART00000181339
ENSDART00000187116
myomesin 2a
chr8_-_26388090 3.01 ENSDART00000147912
si:dkey-20d21.12
chr25_+_29160102 2.78 ENSDART00000162854
pyruvate kinase M1/2b
chr9_-_42873700 2.73 ENSDART00000125953
titin, tandem duplicate 1
chr12_-_26064480 2.68 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
LIM domain binding 3b
chr12_-_26064105 2.66 ENSDART00000168825
LIM domain binding 3b
chr16_+_25245857 2.62 ENSDART00000155220
kelch-like family member 38b
chr11_-_18253111 2.53 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr6_+_29410986 2.46 ENSDART00000065293
ubiquitin specific peptidase 13
chr9_-_33107237 2.41 ENSDART00000013918
calsequestrin 2
chr8_-_18535822 2.41 ENSDART00000100558
nexilin (F actin binding protein)
chr12_+_18524953 2.37 ENSDART00000090332
neuralized E3 ubiquitin protein ligase 2
chr8_-_17980317 2.31 ENSDART00000129148
TNNI3 interacting kinase
chr12_-_26430507 2.30 ENSDART00000153214
synaptopodin 2-like b
chr6_-_18199062 2.27 ENSDART00000167513
protein phosphatase 1, regulatory subunit 27b
chr12_+_6002715 2.23 ENSDART00000114961
si:ch211-131k2.3
chr23_-_5685023 2.14 ENSDART00000148680
ENSDART00000149365
troponin T type 2a (cardiac)
chr16_-_17200120 2.13 ENSDART00000147739
glyceraldehyde-3-phosphate dehydrogenase
chr12_+_17106117 2.13 ENSDART00000149990
actin, alpha 2, smooth muscle, aorta
chr9_-_23894392 2.08 ENSDART00000133417
ankyrin repeat and SOCS box containing 18
chr7_-_71758613 2.08 ENSDART00000166724
myomesin 1b
chr13_+_22249636 2.07 ENSDART00000108472
ENSDART00000173123
synaptopodin 2-like a
chr24_+_34089977 2.05 ENSDART00000157466
ankyrin repeat and SOCS box containing 10
chr9_-_14108896 2.05 ENSDART00000135209
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr13_-_2189761 2.02 ENSDART00000166255
muscular LMNA-interacting protein
chr24_+_34085940 1.97 ENSDART00000171189
ankyrin repeat and SOCS box containing 10
chr25_-_31396479 1.97 ENSDART00000156828
proline rich 33
chr23_+_24931999 1.94 ENSDART00000136162
ENSDART00000140335
kelch-like family member 21
chr17_-_5583345 1.93 ENSDART00000035944
chloride intracellular channel 5a
chr7_-_48263516 1.92 ENSDART00000006619
ENSDART00000142370
ENSDART00000148273
ENSDART00000147968
RNA binding protein with multiple splicing 2b
chr9_-_23891102 1.91 ENSDART00000186799
ankyrin repeat and SOCS box containing 18
chr23_+_18722715 1.91 ENSDART00000137438
myosin, heavy chain 7B, cardiac muscle, beta b
chr13_+_22480857 1.90 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
LIM domain binding 3a
chr9_-_34191627 1.85 ENSDART00000142664
ddb1 and cul4 associated factor 6
chr1_-_38813679 1.85 ENSDART00000148917
ankyrin repeat and SOCS box containing 5b
chr9_-_43142636 1.85 ENSDART00000134349
ENSDART00000181835
coiled-coil domain containing 141
chr4_-_4119396 1.85 ENSDART00000067409
ENSDART00000138221
leiomodin 2 (cardiac) b
chr21_-_22730832 1.82 ENSDART00000101797
F-box protein 40, tandem duplicate 1
chr5_+_64368770 1.77 ENSDART00000162246
phospholipid phosphatase 7 (inactive)
chr2_+_30916188 1.73 ENSDART00000137012
myomesin 1a (skelemin)
chr4_-_9592402 1.73 ENSDART00000114060
cerebral dopamine neurotrophic factor
chr11_-_43104475 1.72 ENSDART00000125368
acylphosphatase 2, muscle type
chr9_-_6927587 1.63 ENSDART00000059092
transmembrane protein 182a
chr23_+_18722915 1.61 ENSDART00000025057
myosin, heavy chain 7B, cardiac muscle, beta b
chr23_-_21515182 1.60 ENSDART00000142000
ring finger protein 207b
chr7_-_71758307 1.57 ENSDART00000161067
ENSDART00000165253
myomesin 1b
chr20_-_36575475 1.52 ENSDART00000062893
enabled homolog (Drosophila)
chr14_-_12307522 1.52 ENSDART00000163900
myotilin
chr3_+_28953274 1.45 ENSDART00000133528
ENSDART00000103602
lectin, galactoside-binding, soluble, 2a
chr24_-_40700596 1.40 ENSDART00000162635
slow myosin heavy chain 2
chr8_-_32497815 1.39 ENSDART00000122359
si:dkey-164f24.2
chr17_-_20118145 1.34 ENSDART00000149737
ENSDART00000165606
ryanodine receptor 2b (cardiac)
chr25_-_26736088 1.31 ENSDART00000067114
F-box and leucine-rich repeat protein 22
chr2_-_6182098 1.30 ENSDART00000156167
si:ch73-182a11.2
chr25_+_5039050 1.26 ENSDART00000154700
parvin, beta
chr8_-_32497581 1.26 ENSDART00000176298
ENSDART00000183340
si:dkey-164f24.2
chr22_+_16308450 1.23 ENSDART00000105678
leucine rich repeat containing 39
chr24_+_25471196 1.22 ENSDART00000066625
small muscle protein, X-linked
chr2_-_23768818 1.19 ENSDART00000148685
ENSDART00000191167
xin actin binding repeat containing 1
chr11_-_25213651 1.18 ENSDART00000097316
ENSDART00000152186
myosin, heavy chain 7B, cardiac muscle, beta a
chr2_-_31791633 1.17 ENSDART00000180662
reticulophagy regulator 1
chr22_+_16308806 1.15 ENSDART00000162685
leucine rich repeat containing 39
chr7_-_23745984 1.13 ENSDART00000048050
zgc:92429
chr21_-_25685739 1.13 ENSDART00000129619
ENSDART00000101205
phosphorylase kinase, gamma 1b (muscle)
chr20_-_9980318 1.13 ENSDART00000080664
zgc:86709
chr14_-_29906209 1.12 ENSDART00000192952
sorbin and SH3 domain containing 2b
chr3_-_61205711 1.12 ENSDART00000055062
parvalbumin 1
chr7_+_22543963 1.12 ENSDART00000101528
cholinergic receptor, nicotinic, beta 1 (muscle)
chr16_-_43356018 1.12 ENSDART00000181683

chr23_+_17417539 1.11 ENSDART00000182605

chr4_-_2350371 1.11 ENSDART00000166274
pleckstrin homology-like domain, family A, member 1
chr16_+_29663809 1.09 ENSDART00000191336
tropomodulin 4 (muscle)
chr4_+_6572364 1.08 ENSDART00000122574
protein phosphatase 1, regulatory subunit 3Aa
chr23_-_9925568 1.07 ENSDART00000081268
si:ch211-220i18.4
chr24_+_9298198 1.07 ENSDART00000165780
OTU deubiquitinase 1
chr2_+_6181383 1.06 ENSDART00000153307
si:ch73-344o19.1
chr9_+_6578580 1.06 ENSDART00000061577
four and a half LIM domains 2a
chr3_+_59851537 1.06 ENSDART00000180997

chr6_-_20875111 1.03 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr3_+_59784632 1.03 ENSDART00000084729
platelet/endothelial cell adhesion molecule 1
chr15_-_23645810 0.99 ENSDART00000168845
creatine kinase, muscle b
chr21_-_22951604 0.98 ENSDART00000083449
ENSDART00000180129
duboraya
chr12_-_19119176 0.97 ENSDART00000149180
aconitase 2, mitochondrial
chr20_-_26066020 0.95 ENSDART00000078559
myc target 1a
chr14_-_15699528 0.92 ENSDART00000161123
neuralized E3 ubiquitin protein ligase 1B
chr20_+_23173710 0.92 ENSDART00000074172
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr19_-_9662958 0.89 ENSDART00000041094
chloride channel, voltage-sensitive 1a
chr8_-_11229523 0.88 ENSDART00000002164
unc-45 myosin chaperone B
chr9_-_48281941 0.88 ENSDART00000099787
kelch-like family member 41a
chr5_-_72125551 0.87 ENSDART00000149412
SET and MYND domain containing 1a
chr19_-_41069573 0.86 ENSDART00000111982
ENSDART00000193142
sarcoglycan, epsilon
chr25_+_31222069 0.84 ENSDART00000159373
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr14_-_30366196 0.82 ENSDART00000007022
platelet-derived growth factor receptor-like
chr23_+_24926407 0.82 ENSDART00000137486
kelch-like family member 21
chr16_+_31542645 0.81 ENSDART00000163724
Src like adaptor
chr1_+_7546259 0.79 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr13_-_28674422 0.79 ENSDART00000122754
ENSDART00000057574
5'-nucleotidase, cytosolic IIa
chr14_-_24332786 0.78 ENSDART00000173164
family with sequence similarity 13, member B
chr10_-_22803740 0.78 ENSDART00000079469
ENSDART00000187968
ENSDART00000122543
procollagen C-endopeptidase enhancer a
chr1_+_6171585 0.78 ENSDART00000024358
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr9_-_7673856 0.77 ENSDART00000102715
tubulin, alpha 8 like 3
chr6_+_14301214 0.77 ENSDART00000129491
transmembrane protein 182b
chr25_+_16945348 0.76 ENSDART00000016591
fibroblast growth factor 6a
chr13_+_31757331 0.75 ENSDART00000044282
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a
chr19_-_38611814 0.75 ENSDART00000151958
collagen, type XVI, alpha 1
chr16_-_31475904 0.74 ENSDART00000145691
si:ch211-251p5.5
chr6_+_3680651 0.74 ENSDART00000013588
kelch-like family member 41b
chr6_+_43450221 0.74 ENSDART00000075521
zgc:113054
chr2_+_20472150 0.73 ENSDART00000168537
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a
chr12_-_17707449 0.73 ENSDART00000142427
ENSDART00000034914
parvalbumin 3
chr5_-_48268049 0.73 ENSDART00000187454
myocyte enhancer factor 2cb
chr8_+_30456161 0.71 ENSDART00000085894
phosphoglucomutase 5
chr18_+_20494413 0.71 ENSDART00000060295
receptor-associated protein of the synapse, 43kD
chr5_+_22264051 0.69 ENSDART00000143314
Rho GTPase activating protein 20b
chr14_+_30285613 0.69 ENSDART00000173090
microtubule associated tumor suppressor 1a
chr20_+_34455645 0.69 ENSDART00000135789
methyltransferase like 11B
chr7_+_19495905 0.68 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
chr24_+_21540842 0.68 ENSDART00000091529
WAS protein family, member 3b
chr24_+_26276805 0.67 ENSDART00000089749
adiponectin, C1Q and collagen domain containing, a
chr20_+_13175379 0.67 ENSDART00000025644
protein phosphatase 2, regulatory subunit B', alpha isoform
chr15_-_9031996 0.66 ENSDART00000124998
reticulon 2a
chr4_+_5848229 0.65 ENSDART00000161101
ENSDART00000067357
LYR motif containing 5a
chr22_-_7006974 0.64 ENSDART00000133143
glycerol-3-phosphate dehydrogenase 1b
chr9_+_24065855 0.63 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
leucine rich repeat (in FLII) interacting protein 1a
chr7_+_22718251 0.63 ENSDART00000027718
ENSDART00000143341
fragile X mental retardation, autosomal homolog 2
chr4_-_1720648 0.63 ENSDART00000103484
growth arrest-specific 2 like 3
chr16_+_36748538 0.62 ENSDART00000139069
2,4-dienoyl CoA reductase 1, mitochondrial
chr21_-_22737228 0.62 ENSDART00000151366
F-box protein 40, tandem duplicate 2
chr19_+_44039849 0.62 ENSDART00000086040
leucine rich repeat containing 14B
chr23_+_6077503 0.60 ENSDART00000081714
ENSDART00000139834
myosin binding protein Ha
chr16_-_19890303 0.60 ENSDART00000147161
ENSDART00000079159
histone deacetylase 9b
chr13_-_11536951 0.60 ENSDART00000018155
adenylosuccinate synthase
chr4_+_14717502 0.59 ENSDART00000067031
potassium inwardly-rectifying channel, subfamily J, member 8
chr11_+_6819050 0.58 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr20_-_39271844 0.57 ENSDART00000192708
clusterin
chr10_+_32104305 0.57 ENSDART00000099880
wingless-type MMTV integration site family, member 11, related
chr7_-_28658143 0.57 ENSDART00000173556
adhesion G protein-coupled receptor G1
chr22_+_396840 0.57 ENSDART00000163198
capping protein (actin filament) muscle Z-line, beta
chr16_+_5259886 0.56 ENSDART00000186668
plectin b
chr5_-_26330313 0.54 ENSDART00000148656
ARVCF, delta catenin family member b
chr16_-_7228276 0.54 ENSDART00000149030
5'-nucleotidase, cytosolic IIIA
chr12_+_23866368 0.53 ENSDART00000188652
ENSDART00000192478
supervillin a
chr21_+_19368720 0.53 ENSDART00000187759
ENSDART00000185829
ENSDART00000158471
ENSDART00000168728
betacellulin, epidermal growth factor family member
chr14_+_29780113 0.53 ENSDART00000173195
zgc:153146
chr11_-_18468570 0.53 ENSDART00000155474
ENSDART00000193869
FYVE, RhoGEF and PH domain containing 5a
chr20_+_19066858 0.52 ENSDART00000192086
SRY (sex determining region Y)-box 7
chr4_+_21717793 0.49 ENSDART00000040266
myogenic factor 6
chr6_-_25201810 0.49 ENSDART00000168683
leucine rich repeat containing 8 VRAC subunit C
chr17_+_24111392 0.48 ENSDART00000180123
ENSDART00000182787
ENSDART00000189752
ENSDART00000184940
ENSDART00000185363
ENSDART00000064067
EH domain binding protein 1
chr23_-_35347714 0.48 ENSDART00000161770
ENSDART00000165615
copine family member IX
chr7_-_30143092 0.47 ENSDART00000173636
FERM domain containing 5
chr18_+_23193820 0.47 ENSDART00000148106
myocyte enhancer factor 2aa
chr1_-_44638058 0.46 ENSDART00000081835
solute carrier family 43 (amino acid system L transporter), member 1b
chr9_+_29040425 0.46 ENSDART00000150201
si:ch73-116o1.2
chr12_+_34119439 0.45 ENSDART00000032821
cytohesin 1b
chr2_+_35880600 0.45 ENSDART00000004277
laminin, gamma 1
chr18_-_25177230 0.45 ENSDART00000013363
solute carrier organic anion transporter family, member 3A1
chr8_+_45294767 0.44 ENSDART00000191527
ubiquitin associated protein 2b
chr11_-_3860534 0.44 ENSDART00000082425
GATA binding protein 2a
chr22_+_16497670 0.44 ENSDART00000014330
immediate early response 5
chr18_+_23193567 0.42 ENSDART00000190072
ENSDART00000171594
ENSDART00000181762
myocyte enhancer factor 2aa
chr17_-_20236228 0.42 ENSDART00000136490
ENSDART00000029380
BCL2 interacting protein 4
chr6_+_11250033 0.41 ENSDART00000065411
ENSDART00000132677
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr2_-_4496358 0.40 ENSDART00000158216
adiponectin, C1Q and collagen domain containing, b
chr18_+_23218980 0.40 ENSDART00000185014
myocyte enhancer factor 2aa
chr1_+_13930625 0.40 ENSDART00000111026
nocturnin b
chr9_-_12424791 0.40 ENSDART00000135447
ENSDART00000088199
zgc:162707
chr2_-_43545342 0.40 ENSDART00000179796

chr8_-_13362757 0.39 ENSDART00000188608
coiled-coil domain containing 124
chr25_+_35212919 0.39 ENSDART00000180127
anoctamin 5a
chr12_+_3078221 0.38 ENSDART00000148835
ENSDART00000149427
sarcoglycan, alpha
chr10_-_32890617 0.38 ENSDART00000134922
potassium channel tetramerization domain containing 7
chr5_-_35456269 0.37 ENSDART00000051312
tetratricopeptide repeat domain 33
chr7_-_25697285 0.37 ENSDART00000082620
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
chr3_-_53114299 0.36 ENSDART00000109390

chr15_-_506010 0.36 ENSDART00000155472
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr13_-_11035420 0.36 ENSDART00000108709
centrosomal protein 170Aa
chr14_-_34513103 0.36 ENSDART00000136306
zgc:194246
chr8_+_10304981 0.35 ENSDART00000160766
Pim-1 proto-oncogene, serine/threonine kinase
chr13_-_24379271 0.34 ENSDART00000046360
ras homolog family member Ua
chr16_-_36748374 0.34 ENSDART00000133310
phosphoinositide-3-kinase, regulatory subunit 4
chr6_-_6248893 0.34 ENSDART00000124662
reticulon 4a
chr6_+_27896657 0.34 ENSDART00000079419
centrosomal protein 63
chr1_-_49250490 0.33 ENSDART00000150386
si:ch73-6k14.2
chr9_+_31795343 0.33 ENSDART00000139584
integrin, beta-like 1
chr6_+_3373665 0.33 ENSDART00000134133
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr14_+_22129096 0.33 ENSDART00000132514
cyclin G1
chr6_+_27897313 0.32 ENSDART00000128935
centrosomal protein 63
chr11_+_25157374 0.32 ENSDART00000019450
transient receptor potential cation channel, subfamily C, member 4 associated protein a
chr7_+_32695954 0.31 ENSDART00000184425
solute carrier family 39 (zinc transporter), member 13
chr16_+_21330634 0.31 ENSDART00000191285
ENSDART00000183267
oxysterol binding protein-like 3b
chr8_-_4972916 0.31 ENSDART00000101576
transmembrane protein 230b
chr6_+_12462079 0.31 ENSDART00000192029
ENSDART00000065385
nuclear receptor subfamily 4, group A, member 2b
chr1_-_45662774 0.30 ENSDART00000042158
serine hydrolase-like
chr23_-_1557195 0.30 ENSDART00000136436
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr20_-_32332736 0.29 ENSDART00000062982
forkhead box O3b
chr16_+_34111919 0.29 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr9_-_48184823 0.29 ENSDART00000180264
kelch-like family member 23

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2ca+mef2cb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0090131 mesenchyme migration(GO:0090131)
0.6 2.4 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.5 2.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.5 1.6 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.5 1.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.5 2.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.4 1.9 GO:0051148 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.3 2.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.3 4.3 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3 1.0 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.3 2.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 0.9 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.2 2.9 GO:0048769 sarcomerogenesis(GO:0048769)
0.2 1.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 0.6 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 0.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 2.8 GO:0034629 cellular protein complex localization(GO:0034629)
0.2 0.6 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.2 4.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 2.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.4 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1 1.3 GO:0086003 cardiac muscle cell contraction(GO:0086003)
0.1 4.6 GO:0050821 protein stabilization(GO:0050821)
0.1 0.7 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 2.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 1.2 GO:0061709 reticulophagy(GO:0061709)
0.1 0.6 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 1.4 GO:0090303 positive regulation of wound healing(GO:0090303)
0.1 0.5 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 0.6 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 0.4 GO:0001778 plasma membrane repair(GO:0001778) monocyte activation(GO:0042117)
0.1 0.6 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.1 0.3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.1 2.4 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 12.8 GO:0006936 muscle contraction(GO:0006936)
0.1 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.6 GO:0044805 late nucleophagy(GO:0044805)
0.1 0.3 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.1 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.5 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 0.5 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 1.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 2.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 1.3 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 1.3 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.4 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.7 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0071715 icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571)
0.0 2.8 GO:0006096 glycolytic process(GO:0006096)
0.0 0.2 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.8 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.3 GO:0003404 optic vesicle morphogenesis(GO:0003404)
0.0 3.4 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.7 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.2 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 1.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0061337 cardiac conduction(GO:0061337)
0.0 0.7 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.2 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.3 GO:0002698 negative regulation of immune effector process(GO:0002698)
0.0 0.8 GO:0071456 cellular response to decreased oxygen levels(GO:0036294) cellular response to hypoxia(GO:0071456)
0.0 0.4 GO:0070193 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.2 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.3 GO:0045824 negative regulation of innate immune response(GO:0045824) negative regulation of immune response(GO:0050777)
0.0 0.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.4 GO:0048512 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 6.2 GO:0061061 muscle structure development(GO:0061061)
0.0 0.1 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 1.1 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 2.3 GO:0006821 chloride transport(GO:0006821)
0.0 0.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.0 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 2.0 GO:0021782 glial cell development(GO:0021782)
0.0 0.3 GO:0007634 optokinetic behavior(GO:0007634)
0.0 10.1 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.6 GO:1901214 regulation of neuron death(GO:1901214)
0.0 0.0 GO:0045730 respiratory burst(GO:0045730)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 0.5 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 17.8 GO:0031430 M band(GO:0031430)
0.3 2.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 2.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 17.2 GO:0030018 Z disc(GO:0030018)
0.2 1.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 0.6 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.1 2.1 GO:0005869 dynactin complex(GO:0005869)
0.1 1.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 6.1 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 3.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 4.6 GO:0042383 sarcolemma(GO:0042383)
0.1 0.6 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 6.2 GO:0016459 myosin complex(GO:0016459)
0.0 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.3 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.5 2.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5 2.0 GO:0005521 lamin binding(GO:0005521)
0.5 2.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 7.2 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.3 4.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3 1.0 GO:0003994 aconitate hydratase activity(GO:0003994)
0.3 1.3 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 0.7 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 5.1 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 3.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 0.7 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.2 0.6 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 1.5 GO:0005522 profilin binding(GO:0005522)
0.1 1.4 GO:0016936 galactoside binding(GO:0016936)
0.1 1.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 3.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 2.8 GO:0016208 AMP binding(GO:0016208)
0.1 0.3 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.3 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
0.1 0.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.7 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.3 GO:2001070 starch binding(GO:2001070)
0.1 0.8 GO:2001069 glycogen binding(GO:2001069)
0.1 21.4 GO:0051015 actin filament binding(GO:0051015)
0.1 0.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 1.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 2.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.7 GO:0048038 quinone binding(GO:0048038)
0.0 0.7 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 1.9 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 3.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 2.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 3.7 GO:0003779 actin binding(GO:0003779)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) phosphofructokinase activity(GO:0008443)
0.0 1.1 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.9 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 6.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 2.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes