ISMARA results: mef2aa+mef2ab

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PRJNA207719: Tissue specific transcriptome profiling

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Results for mef2aa+mef2ab

Z-value: 3.67

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Transcription factors associated with mef2aa+mef2ab

Gene Symbol	Gene ID	Gene Info
mef2aa NCBI UniProt	ENSDARG00000031756	myocyte enhancer factor 2aa
mef2ab NCBI UniProt	ENSDARG00000057527	myocyte enhancer factor 2ab
mef2ab NCBI UniProt	ENSDARG00000110771	myocyte enhancer factor 2ab

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mef2aa	dr11_v1_chr18_+_23218980_23218980	0.84	7.7e-02	Click!
mef2ab	dr11_v1_chr7_+_15659280_15659280	0.21	7.3e-01	Click!

Activity profile of mef2aa+mef2ab motif

Sorted Z-values of mef2aa+mef2ab motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_61205711 Show fit	3.91	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr19_-_7450796 Show fit	3.69	ENSDART00000104750	mllt11 NCBI UniProt Show fit	MLLT11, transcription factor 7 cofactor
chr3_+_32526263 Show fit	3.55	ENSDART00000150897	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2
chr16_+_25245857 Show fit	3.50	ENSDART00000155220	klhl38b NCBI UniProt Show fit	kelch-like family member 38b
chr25_+_31264155 Show fit	3.43	ENSDART00000012256	tnni2a.3 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 3
chr8_-_11112058 Show fit	3.21	ENSDART00000042755	ampd1 NCBI UniProt Show fit	adenosine monophosphate deaminase 1 (isoform M)
chr5_-_72125551 Show fit	3.03	ENSDART00000149412	smyd1a NCBI UniProt Show fit	SET and MYND domain containing 1a
chr7_+_7048245 Show fit	3.00	ENSDART00000001649	actn3b NCBI UniProt Show fit	actinin alpha 3b
chr23_+_24926407 Show fit	2.57	ENSDART00000137486	klhl21 NCBI UniProt Show fit	kelch-like family member 21
chr12_-_26064105 Show fit	2.46	ENSDART00000168825	ldb3b NCBI UniProt Show fit	LIM domain binding 3b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2aa+mef2ab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.5	GO:0031033	myosin filament organization(GO:0031033)
0.1	5.7	GO:0003009	skeletal muscle contraction(GO:0003009)
0.0	5.1	GO:0061061	muscle structure development(GO:0061061)
0.3	4.5	GO:0032264	IMP salvage(GO:0032264)
0.7	3.7	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	3.7	GO:0001756	somitogenesis(GO:0001756)
0.1	3.3	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2	2.6	GO:0034629	cellular protein complex localization(GO:0034629)
0.5	2.1	GO:0003418	plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.2	2.0	GO:0006603	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)

Showing 1 to 10 of 71 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.6	GO:0005861	troponin complex(GO:0005861)
0.1	5.7	GO:0031941	filamentous actin(GO:0031941)
0.2	4.8	GO:0031430	M band(GO:0031430)
0.1	2.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	2.4	GO:0070469	respiratory chain(GO:0070469)
0.1	2.1	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	1.9	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0	1.7	GO:0034707	chloride channel complex(GO:0034707)
0.0	1.5	GO:0016342	catenin complex(GO:0016342)
0.0	1.5	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	18.5	GO:0005509	calcium ion binding(GO:0005509)
0.3	5.7	GO:0051371	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.4	4.5	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	3.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	3.0	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.1	2.9	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	2.8	GO:0005523	tropomyosin binding(GO:0005523)
0.1	2.4	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	2.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	2.1	GO:0001786	phosphatidylserine binding(GO:0001786)

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.3	NABA COLLAGENS	Genes encoding collagen proteins
1.2	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
1.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
1.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.9	PID EPHA FWDPATHWAY	EPHA forward signaling
0.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	1.8	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.1	1.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	1.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	1.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.1	1.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	1.1	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.3	0.9	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	0.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 16 entries

Results for mef2aa+mef2ab

Z-value: 3.67

Motif logo

Transcription factors associated with mef2aa+mef2ab

Activity-expression correlation:

Activity profile of mef2aa+mef2ab motif

Sorted Z-values of mef2aa+mef2ab motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2aa+mef2ab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: