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PRJNA207719: Tissue specific transcriptome profiling

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Results for mef2aa+mef2ab

Z-value: 3.67

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Transcription factors associated with mef2aa+mef2ab

Gene Symbol Gene ID Gene Info
ENSDARG00000031756 myocyte enhancer factor 2aa
ENSDARG00000057527 myocyte enhancer factor 2ab
ENSDARG00000110771 myocyte enhancer factor 2ab

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mef2aadr11_v1_chr18_+_23218980_232189800.847.7e-02Click!
mef2abdr11_v1_chr7_+_15659280_156592800.217.3e-01Click!

Activity profile of mef2aa+mef2ab motif

Sorted Z-values of mef2aa+mef2ab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_61205711 3.91 ENSDART00000055062
parvalbumin 1
chr19_-_7450796 3.69 ENSDART00000104750
MLLT11, transcription factor 7 cofactor
chr3_+_32526263 3.55 ENSDART00000150897
si:ch73-367p23.2
chr16_+_25245857 3.50 ENSDART00000155220
kelch-like family member 38b
chr25_+_31264155 3.43 ENSDART00000012256
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr8_-_11112058 3.21 ENSDART00000042755
adenosine monophosphate deaminase 1 (isoform M)
chr5_-_72125551 3.03 ENSDART00000149412
SET and MYND domain containing 1a
chr7_+_7048245 3.00 ENSDART00000001649
actinin alpha 3b
chr23_+_24926407 2.57 ENSDART00000137486
kelch-like family member 21
chr12_-_26064105 2.46 ENSDART00000168825
LIM domain binding 3b
chr7_+_6969909 2.29 ENSDART00000189886
actinin alpha 3b
chr12_-_17712393 2.23 ENSDART00000143534
ENSDART00000010144
parvalbumin 2
chr14_+_49296052 2.13 ENSDART00000006073
ENSDART00000105346
annexin A6
chr1_+_7546259 2.05 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr12_-_26064480 2.02 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
LIM domain binding 3b
chr6_-_18199062 2.01 ENSDART00000167513
protein phosphatase 1, regulatory subunit 27b
chr5_+_64368770 2.01 ENSDART00000162246
phospholipid phosphatase 7 (inactive)
chr5_+_51597677 1.99 ENSDART00000048210
ENSDART00000184797
creatine kinase, mitochondrial 2b (sarcomeric)
chr24_+_34089977 1.98 ENSDART00000157466
ankyrin repeat and SOCS box containing 10
chr16_+_29663809 1.92 ENSDART00000191336
tropomodulin 4 (muscle)
chr17_-_5583345 1.69 ENSDART00000035944
chloride intracellular channel 5a
chr9_-_42873700 1.69 ENSDART00000125953
titin, tandem duplicate 1
chr21_+_20383837 1.67 ENSDART00000026430
heat shock protein, alpha-crystallin-related, b11
chr1_-_13271085 1.60 ENSDART00000193663
protocadherin 18a
chr6_-_20875111 1.59 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr20_-_26001288 1.57 ENSDART00000136518
ENSDART00000063177
calpain 3b
chr2_-_15324837 1.54 ENSDART00000015655
trans-2,3-enoyl-CoA reductase-like 2b
chr23_+_6077503 1.53 ENSDART00000081714
ENSDART00000139834
myosin binding protein Ha
chr11_+_11200550 1.53 ENSDART00000181339
ENSDART00000187116
myomesin 2a
chr5_+_64732270 1.51 ENSDART00000134241
olfactomedin 1a
chr21_-_131236 1.50 ENSDART00000160005
si:ch1073-398f15.1
chr16_+_34046733 1.49 ENSDART00000058424
family with sequence similarity 46, member Ba
chr8_+_22930627 1.46 ENSDART00000187860
synaptophysin a
chr24_+_9298198 1.46 ENSDART00000165780
OTU deubiquitinase 1
chr25_+_20077225 1.46 ENSDART00000136543
troponin I4b, tandem duplicate 1
chr17_-_14671098 1.40 ENSDART00000037371
protein phosphatase 1, regulatory subunit 13Ba
chr19_-_33087246 1.37 ENSDART00000052078
kelch-like family member 38a
chrM_+_4993 1.33 ENSDART00000093600
NADH dehydrogenase 2, mitochondrial
chr16_-_43356018 1.32 ENSDART00000181683

chr15_+_5923851 1.30 ENSDART00000152520
ENSDART00000145827
ENSDART00000121529
SH3 domain binding glutamate-rich protein
chr12_-_4781801 1.30 ENSDART00000167490
ENSDART00000121718
microtubule-associated protein tau a
chr8_-_26388090 1.29 ENSDART00000147912
si:dkey-20d21.12
chr13_-_2215213 1.29 ENSDART00000129773
muscular LMNA-interacting protein
chr16_-_17200120 1.23 ENSDART00000147739
glyceraldehyde-3-phosphate dehydrogenase
chr6_+_14301214 1.22 ENSDART00000129491
transmembrane protein 182b
chr13_+_22480857 1.20 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
LIM domain binding 3a
chr5_-_57635664 1.16 ENSDART00000074306
heat shock protein, alpha-crystallin-related, b2
chr19_-_31035155 1.16 ENSDART00000161882
basic leucine zipper and W2 domains 2
chr21_-_27507786 1.15 ENSDART00000077657
ENSDART00000191284
ENSDART00000178229
ENSDART00000186153
si:dkeyp-50d11.2
chr9_-_23891102 1.14 ENSDART00000186799
ankyrin repeat and SOCS box containing 18
chr5_-_48260145 1.14 ENSDART00000044083
ENSDART00000163250
ENSDART00000135911
myocyte enhancer factor 2cb
chr12_+_6002715 1.13 ENSDART00000114961
si:ch211-131k2.3
chr22_-_7006974 1.13 ENSDART00000133143
glycerol-3-phosphate dehydrogenase 1b
chr23_-_19953089 1.09 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chrM_-_15232 1.08 ENSDART00000093623
NADH dehydrogenase 6, mitochondrial
chr7_+_69841017 1.08 ENSDART00000169107

chr18_+_23193820 1.06 ENSDART00000148106
myocyte enhancer factor 2aa
chr1_-_13271569 1.04 ENSDART00000127838
protocadherin 18a
chr18_+_23193567 1.04 ENSDART00000190072
ENSDART00000171594
ENSDART00000181762
myocyte enhancer factor 2aa
chr16_-_29164379 1.04 ENSDART00000132589
myocyte enhancer factor 2d
chr21_-_32487061 1.03 ENSDART00000114359
ENSDART00000131591
ENSDART00000131477
si:dkeyp-72g9.4
chr6_+_12462079 1.03 ENSDART00000192029
ENSDART00000065385
nuclear receptor subfamily 4, group A, member 2b
chr13_-_30149973 1.01 ENSDART00000041515
secretion associated, Ras related GTPase 1Ab
chr18_+_26719787 1.01 ENSDART00000141672
alpha-kinase 3a
chr23_+_36601984 1.01 ENSDART00000128598
insulin-like growth factor binding protein 6b
chr19_-_31035325 1.00 ENSDART00000147504
basic leucine zipper and W2 domains 2
chr1_-_11075403 1.00 ENSDART00000102903
ENSDART00000170290
dystrophin
chr3_+_40170216 0.98 ENSDART00000011568
synaptogyrin 3a
chr20_-_36575475 0.95 ENSDART00000062893
enabled homolog (Drosophila)
chr7_-_23745984 0.95 ENSDART00000048050
zgc:92429
chr1_+_6171585 0.94 ENSDART00000024358
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr10_-_22845485 0.93 ENSDART00000079454
vesicle-associated membrane protein 2
chr25_-_23745765 0.92 ENSDART00000089278
si:ch211-236l14.4
chr1_-_42778510 0.90 ENSDART00000190172
leucine rich repeat transmembrane neuronal 1
chr3_-_32170850 0.88 ENSDART00000055307
ENSDART00000157366
troponin T type 1 (skeletal, slow)
chr1_+_8601935 0.87 ENSDART00000152367
si:ch211-160d14.6
chr1_+_33969015 0.87 ENSDART00000042984
ENSDART00000146530
eph receptor A6
chr25_+_14087045 0.86 ENSDART00000155770
actin, alpha, cardiac muscle 1c
chr14_-_24332786 0.86 ENSDART00000173164
family with sequence similarity 13, member B
chr15_-_22139566 0.86 ENSDART00000149017
sodium channel, voltage-gated, type III, beta
chr3_-_52614747 0.85 ENSDART00000154365
tripartite motif containing 35-13
chr13_+_28821841 0.84 ENSDART00000179900

chr7_-_66864756 0.83 ENSDART00000184462
ENSDART00000189424
adenosine monophosphate deaminase 3a
chr17_-_12336987 0.83 ENSDART00000172001
synaptosomal-associated protein, 25b
chr6_+_57541776 0.83 ENSDART00000157330
N-terminal EF-hand calcium binding protein 3
chr3_-_18189283 0.82 ENSDART00000049240
transducer of ERBB2, 1a
chr3_+_59051503 0.82 ENSDART00000160767
rasd family member 4
chr16_+_26777473 0.81 ENSDART00000188870
cadherin 17, LI cadherin (liver-intestine)
chr7_-_26270014 0.80 ENSDART00000079347
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr23_+_20110086 0.80 ENSDART00000054664
troponin C type 1b (slow)
chr14_-_32405387 0.76 ENSDART00000184647
fibroblast growth factor 13a
chr6_-_18698456 0.74 ENSDART00000166587
rhomboid, veinlet-like 3 (Drosophila)
chr23_+_33907899 0.71 ENSDART00000159445
citrate synthase
chr14_+_22113331 0.71 ENSDART00000109759
thioredoxin-related transmembrane protein 2a
chr20_-_40717900 0.70 ENSDART00000181663
connexin 43
chr25_+_3677650 0.69 ENSDART00000154348
prion protein, related sequence 3
chr2_-_28102264 0.68 ENSDART00000013638
cadherin 6
chr7_+_40093662 0.68 ENSDART00000053011
si:ch73-174h16.4
chr18_+_10820430 0.67 ENSDART00000161990
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr8_+_26432677 0.65 ENSDART00000078369
ENSDART00000131925
zgc:136971
chr20_+_34455645 0.65 ENSDART00000135789
methyltransferase like 11B
chr17_-_16069905 0.64 ENSDART00000110383
microtubule-associated protein 7a
chr2_+_2957515 0.64 ENSDART00000160715
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr21_+_40589770 0.63 ENSDART00000164650
ENSDART00000161584
ENSDART00000161108
pyruvate dehydrogenase kinase, isozyme 3b
chr13_+_38817871 0.63 ENSDART00000187708
collagen, type XIX, alpha 1
chr17_+_8184649 0.62 ENSDART00000091818
tubby like protein 4b
chr17_-_5769196 0.62 ENSDART00000113885
si:dkey-100n19.2
chr5_+_69808763 0.61 ENSDART00000143482
fibronectin type III and SPRY domain containing 1-like
chr9_+_54644626 0.60 ENSDART00000190609
EGF-like-domain, multiple 6
chr24_+_38155830 0.60 ENSDART00000152019
si:ch211-234p6.5
chr20_-_26066020 0.59 ENSDART00000078559
myc target 1a
chr5_-_8711157 0.59 ENSDART00000062957
poly(A) binding protein interacting protein 1
chr21_+_11685009 0.58 ENSDART00000014668
proprotein convertase subtilisin/kexin type 1
chr16_+_5774977 0.57 ENSDART00000134202
cholecystokinin a
chr3_+_31953145 0.57 ENSDART00000148861
potassium voltage-gated channel, Shaw-related subfamily, member 3a
chr14_+_23520986 0.55 ENSDART00000170473
ENSDART00000175970
si:ch211-221f10.2
chr23_-_7797207 0.55 ENSDART00000181611
myelin transcription factor 1b
chr4_-_2719128 0.54 ENSDART00000184693
solute carrier organic anion transporter family, member 1C1
chr12_+_26632448 0.54 ENSDART00000185762
Rho GTPase activating protein 12b
chr14_+_23518110 0.54 ENSDART00000112930
si:ch211-221f10.2
chr8_-_18010735 0.53 ENSDART00000125014
acyl-CoA thioesterase 11b
chr12_-_19119176 0.53 ENSDART00000149180
aconitase 2, mitochondrial
chr25_+_11389220 0.52 ENSDART00000187787
si:ch73-141f14.1
chr11_-_33960318 0.52 ENSDART00000087597
collagen, type VI, alpha 2
chr23_-_27633730 0.51 ENSDART00000103639
ADP-ribosylation factor 3a
chr19_-_10394931 0.51 ENSDART00000191549
zgc:194578
chr23_+_14097508 0.51 ENSDART00000087280
calcium channel, voltage-dependent, beta 3a
chr10_+_36458563 0.50 ENSDART00000077008
arachidonate 5-lipoxygenase-activating protein
chr19_-_11315224 0.50 ENSDART00000104933
endonuclease/exonuclease/phosphatase family domain containing 1
chr7_+_72882446 0.50 ENSDART00000131113
ENSDART00000174223
adhesion G protein-coupled receptor L3
chr10_-_24371312 0.50 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr8_-_11229523 0.49 ENSDART00000002164
unc-45 myosin chaperone B
chr21_+_11684830 0.49 ENSDART00000147473
proprotein convertase subtilisin/kexin type 1
chr15_+_15856178 0.48 ENSDART00000080338
dual specificity phosphatase 14
chr1_+_20084389 0.47 ENSDART00000140263
protease, serine, 12 (neurotrypsin, motopsin)
chr16_-_31475904 0.47 ENSDART00000145691
si:ch211-251p5.5
chr18_-_38087875 0.47 ENSDART00000111301
leucine zipper protein 2
chr8_-_17516448 0.46 ENSDART00000100667
v-ski avian sarcoma viral oncogene homolog a
chr2_-_3678029 0.46 ENSDART00000146861
matrix metallopeptidase 16b (membrane-inserted)
chr5_-_65153731 0.45 ENSDART00000171024
SH2 domain containing 3Cb
chr10_-_8033468 0.44 ENSDART00000140476
ATPase H+ transporting V0 subunit a2a
chr16_-_16590489 0.43 ENSDART00000190021
si:ch211-257p13.3
chr8_-_12264486 0.42 ENSDART00000091612
ENSDART00000135812
DAB2 interacting protein a
chr18_-_16791331 0.42 ENSDART00000148222
adenosine monophosphate deaminase 3b
chr4_+_5848229 0.42 ENSDART00000161101
ENSDART00000067357
LYR motif containing 5a
chr16_-_36798783 0.41 ENSDART00000145697
calbindin 1
chr10_+_21776911 0.38 ENSDART00000163077
ENSDART00000186093
protocadherin 1 gamma 22
chr6_-_894006 0.37 ENSDART00000171091
zinc finger E-box binding homeobox 2b
chr1_+_10378706 0.36 ENSDART00000046283
ENSDART00000103535
ENSDART00000132076
dachshund b
chr18_+_34601023 0.35 ENSDART00000149647
TCDD-inducible poly(ADP-ribose) polymerase
chr20_-_47732703 0.35 ENSDART00000193975
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr14_+_30328567 0.35 ENSDART00000105889
microtubule associated tumor suppressor 1a
chr6_-_10863582 0.35 ENSDART00000135454
ENSDART00000133893
ENSDART00000014521
ENSDART00000164342
lunapark, ER junction formation factor
chr4_+_9279515 0.34 ENSDART00000048707
SLIT-ROBO Rho GTPase activating protein 1b
chr9_+_29643036 0.33 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr4_+_9279784 0.33 ENSDART00000014897
SLIT-ROBO Rho GTPase activating protein 1b
chr22_+_25841786 0.33 ENSDART00000180863
vasorin a
chr19_+_30990815 0.32 ENSDART00000134645
syncoilin, intermediate filament protein
chr2_+_35880600 0.31 ENSDART00000004277
laminin, gamma 1
chr14_-_46451249 0.31 ENSDART00000058466
fibroblast growth factor binding protein 2a
chr4_-_25908871 0.31 ENSDART00000066949
FYVE, RhoGEF and PH domain containing 6
chr7_+_39006837 0.30 ENSDART00000173735
diacylglycerol kinase, zeta a
chr10_+_41765616 0.30 ENSDART00000170682
ring finger protein 34b
chr10_+_32561317 0.30 ENSDART00000109029
microtubule-associated protein 6a
chr10_-_26512742 0.30 ENSDART00000135951
si:dkey-5g14.1
chr9_+_29040425 0.30 ENSDART00000150201
si:ch73-116o1.2
chr1_-_35653560 0.29 ENSDART00000142154
Fras1 related extracellular matrix 3
chr24_+_25471196 0.29 ENSDART00000066625
small muscle protein, X-linked
chr8_-_42238543 0.27 ENSDART00000062697
GDNF family receptor alpha 2a
chr16_-_19890303 0.27 ENSDART00000147161
ENSDART00000079159
histone deacetylase 9b
chr16_-_32837806 0.26 ENSDART00000003997
si:dkey-165n16.5
chr7_+_26716321 0.25 ENSDART00000189750
CD82 molecule a
chr12_-_4028079 0.25 ENSDART00000128676
si:ch211-180a12.2
chr1_+_35495368 0.25 ENSDART00000053806
GRB2-associated binding protein 1
chr12_-_20340543 0.25 ENSDART00000055623
hemoglobin beta embryonic-3
chr7_+_33424044 0.24 ENSDART00000180260
glucuronic acid epimerase b
chr1_-_45662774 0.24 ENSDART00000042158
serine hydrolase-like
chr7_+_40094081 0.24 ENSDART00000186054
si:ch73-174h16.4
chr17_+_33495194 0.23 ENSDART00000033691
parathyroid hormone 2
chr3_-_42981739 0.23 ENSDART00000167844
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
chr3_+_32403758 0.23 ENSDART00000156982
si:ch211-195b15.8
chr8_-_32497815 0.23 ENSDART00000122359
si:dkey-164f24.2
chr15_+_28940352 0.22 ENSDART00000154085
gastric inhibitory polypeptide receptor
chr5_-_20678300 0.21 ENSDART00000088639
WSC domain containing 2
chr9_-_28990649 0.21 ENSDART00000078823
protein tyrosine phosphatase, non-receptor type 4a
chr5_-_31926906 0.21 ENSDART00000187340
slingshot protein phosphatase 1b
chr11_-_18253111 0.20 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr17_+_28340138 0.20 ENSDART00000033943
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr7_-_22956889 0.20 ENSDART00000101447
TNF superfamily member 10, like
chr1_-_40102836 0.20 ENSDART00000147317
ciliary neurotrophic factor
chr12_+_6041575 0.20 ENSDART00000091868
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 2
chr8_+_21159122 0.19 ENSDART00000033491
SPRY domain containing 4
chr9_+_27876146 0.19 ENSDART00000133997
armadillo repeat containing 8
chr20_+_2134816 0.19 ENSDART00000039249
l(3)mbt-like 3 (Drosophila)
chr22_+_10678141 0.19 ENSDART00000193341
hyaluronoglucosaminidase 2b
chr24_-_6647275 0.19 ENSDART00000161494
Rho GTPase activating protein 21a
chr18_+_45792035 0.18 ENSDART00000135045
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr11_+_41560792 0.18 ENSDART00000127292
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr7_+_7511914 0.18 ENSDART00000172848
chloride channel 3
chr7_+_42206847 0.18 ENSDART00000149250
phosphorylase kinase, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2aa+mef2ab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.5 2.1 GO:0003418 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.5 1.6 GO:0097264 self proteolysis(GO:0097264)
0.3 7.5 GO:0031033 myosin filament organization(GO:0031033)
0.3 4.5 GO:0032264 IMP salvage(GO:0032264)
0.3 0.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.3 1.1 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 1.0 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 1.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 0.9 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
0.2 0.8 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.2 0.9 GO:0021731 trigeminal motor nucleus development(GO:0021731)
0.2 0.9 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 1.5 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 2.0 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 2.6 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.5 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 5.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.8 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.3 GO:1903373 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.1 1.0 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.1 0.5 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 3.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 2.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.0 GO:0007525 somatic muscle development(GO:0007525)
0.1 1.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 1.1 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.9 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.9 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 0.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.4 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.1 1.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.6 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.5 GO:0061337 cardiac conduction(GO:0061337)
0.0 0.3 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.7 GO:0014823 response to activity(GO:0014823)
0.0 1.2 GO:0050821 protein stabilization(GO:0050821)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.8 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 3.7 GO:0001756 somitogenesis(GO:0001756)
0.0 1.1 GO:0060914 heart formation(GO:0060914)
0.0 0.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.2 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.2 GO:0098900 regulation of action potential(GO:0098900)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 2.0 GO:0006821 chloride transport(GO:0006821)
0.0 0.6 GO:0007586 digestion(GO:0007586)
0.0 0.6 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 1.1 GO:0006936 muscle contraction(GO:0006936)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0046865 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.7 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 5.1 GO:0061061 muscle structure development(GO:0061061)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 GO:0031430 M band(GO:0031430)
0.2 1.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 6.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.9 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 5.7 GO:0031941 filamentous actin(GO:0031941)
0.1 0.3 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.1 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.5 GO:0031672 A band(GO:0031672)
0.1 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.4 GO:0070469 respiratory chain(GO:0070469)
0.0 1.5 GO:0016342 catenin complex(GO:0016342)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 1.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.8 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.5 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 1.3 GO:0005521 lamin binding(GO:0005521)
0.3 1.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.3 5.7 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.3 1.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 0.5 GO:0003994 aconitate hydratase activity(GO:0003994)
0.2 2.0 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 2.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.5 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.9 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.1 1.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.9 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 3.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.2 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.1 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.4 GO:0002039 p53 binding(GO:0002039)
0.1 0.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.2 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.1 2.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 0.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 0.1 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.0 2.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 3.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.9 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0030882 lipid antigen binding(GO:0030882)
0.0 0.5 GO:0051117 ATPase binding(GO:0051117)
0.0 0.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 1.9 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.1 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
0.0 0.2 GO:0031720 haptoglobin binding(GO:0031720)
0.0 1.4 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 2.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 18.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.5 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 0.9 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.1 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.1 0.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.8 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR