ISMARA results: mecp2

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PRJNA207719: Tissue specific transcriptome profiling

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Results for mecp2

Z-value: 2.42

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Transcription factors associated with mecp2

Gene Symbol	Gene ID	Gene Info
mecp2 NCBI UniProt	ENSDARG00000014218	methyl CpG binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mecp2	dr11_v1_chr8_-_7637626_7637640	0.66	2.2e-01	Click!

Activity profile of mecp2 motif

Sorted Z-values of mecp2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_13685047 Show fit	2.28	ENSDART00000018351	zgc:65851 NCBI UniProt Show fit	zgc:65851
chr8_+_16004154 Show fit	2.18	ENSDART00000134787 ENSDART00000172510 ENSDART00000141173	elavl4 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr22_+_11535131 Show fit	2.14	ENSDART00000113930	npb NCBI UniProt Show fit	neuropeptide B
chr9_-_31278048 Show fit	2.05	ENSDART00000022204	zic5 NCBI UniProt Show fit	zic family member 5 (odd-paired homolog, Drosophila)
chr8_-_25422186 Show fit	2.01	ENSDART00000113492 ENSDART00000131736	kcnq2a NCBI UniProt Show fit	potassium voltage-gated channel, KQT-like subfamily, member 2a
chr12_-_29624638 Show fit	1.85	ENSDART00000126744	nrg3b NCBI UniProt Show fit	neuregulin 3b
chr16_+_32559821 Show fit	1.79	ENSDART00000093250	pou3f2b NCBI UniProt Show fit	POU class 3 homeobox 2b
chr3_+_31396149 Show fit	1.78	ENSDART00000151423 ENSDART00000193580	c1ql3b NCBI UniProt Show fit	complement component 1, q subcomponent-like 3b
chr5_+_64739762 Show fit	1.76	ENSDART00000161112 ENSDART00000135610 ENSDART00000002908	olfm1a NCBI UniProt Show fit	olfactomedin 1a
chr19_+_232536 Show fit	1.66	ENSDART00000137880	syngap1a NCBI UniProt Show fit	synaptic Ras GTPase activating protein 1a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	GO:0048812	neuron projection morphogenesis(GO:0048812)
0.0	3.9	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	3.5	GO:0034765	regulation of ion transmembrane transport(GO:0034765)
0.0	3.4	GO:0051260	protein homooligomerization(GO:0051260)
0.0	2.5	GO:0099643	neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1	2.1	GO:0007631	feeding behavior(GO:0007631)
0.3	2.0	GO:0033278	cell proliferation in midbrain(GO:0033278)
0.3	1.9	GO:0089700	protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
0.2	1.8	GO:1902868	positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.0	1.6	GO:0000187	activation of MAPK activity(GO:0000187)

Showing 1 to 10 of 134 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	GO:0005882	intermediate filament(GO:0005882)
0.1	3.7	GO:0043204	perikaryon(GO:0043204)
0.0	2.9	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4	2.7	GO:0043194	axon initial segment(GO:0043194)
0.3	1.6	GO:0005883	neurofilament(GO:0005883)
0.0	1.6	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	1.5	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	1.5	GO:0014069	postsynaptic density(GO:0014069)
0.4	1.4	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1	1.4	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.1	3.2	GO:0004698	protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0	1.9	GO:0045499	chemorepellent activity(GO:0045499)
0.1	1.7	GO:0030552	cAMP binding(GO:0030552)
0.0	1.7	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	1.6	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	1.6	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	1.5	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	1.5	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.2	1.4	GO:0005483	soluble NSF attachment protein activity(GO:0005483)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	PID IGF1 PATHWAY	IGF1 pathway
0.1	1.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.4	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	1.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	0.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.9	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.8	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.8	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	0.6	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.6	PID INSULIN PATHWAY	Insulin Pathway

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.5	2.7	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	1.9	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	1.5	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	1.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.3	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.1	1.1	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	1.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	0.9	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors

Showing 1 to 10 of 34 entries

Results for mecp2

Z-value: 2.42

Motif logo

Transcription factors associated with mecp2

Activity-expression correlation:

Activity profile of mecp2 motif

Sorted Z-values of mecp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: