ISMARA results: maff+mafga+mafgb

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PRJNA207719: Tissue specific transcriptome profiling

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Results for maff+mafga+mafgb

Z-value: 1.38

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Transcription factors associated with maff+mafga+mafgb

Gene Symbol	Gene ID	Gene Info
mafga NCBI UniProt	ENSDARG00000018109	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ga
maff NCBI UniProt	ENSDARG00000028957	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
mafgb NCBI UniProt	ENSDARG00000100097	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
maff NCBI UniProt	ENSDARG00000111050	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mafgb	dr11_v1_chr11_+_45299447_45299447	0.68	2.1e-01	Click!
mafga	dr11_v1_chr3_-_55404985_55404985	0.58	3.0e-01	Click!
maff	dr11_v1_chr12_-_19346678_19346678	0.42	4.8e-01	Click!

Activity profile of maff+mafga+mafgb motif

Sorted Z-values of maff+mafga+mafgb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_36040820 Show fit	1.05	ENSDART00000003550	nmnat2 NCBI UniProt Show fit	nicotinamide nucleotide adenylyltransferase 2
chr3_+_32526799 Show fit	1.02	ENSDART00000185755	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2
chr3_+_15907458 Show fit	0.91	ENSDART00000163525	mapk8ip3 NCBI UniProt Show fit	mitogen-activated protein kinase 8 interacting protein 3
chr3_+_15907297 Show fit	0.88	ENSDART00000139206	mapk8ip3 NCBI UniProt Show fit	mitogen-activated protein kinase 8 interacting protein 3
chr7_+_25059845 Show fit	0.88	ENSDART00000077215	ppp2r5b NCBI UniProt Show fit	protein phosphatase 2, regulatory subunit B', beta
chr19_-_19339285 Show fit	0.88	ENSDART00000158413 ENSDART00000170479	cspg5b NCBI UniProt Show fit	chondroitin sulfate proteoglycan 5b
chr21_+_9666347 Show fit	0.83	ENSDART00000163853	mapk10 NCBI UniProt Show fit	mitogen-activated protein kinase 10
chr13_+_36146415 Show fit	0.82	ENSDART00000140301	TTC9 NCBI UniProt Show fit	si:ch211-259k16.3
chr6_+_27667359 Show fit	0.81	ENSDART00000159624 ENSDART00000049177	rab6ba NCBI UniProt Show fit	RAB6B, member RAS oncogene family a
chr21_-_45613564 Show fit	0.77	ENSDART00000160324	LO018363.1 NCBI UniProt Show fit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of maff+mafga+mafgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.4	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	2.0	GO:0070509	calcium ion import(GO:0070509)
0.0	1.3	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	1.3	GO:0010921	regulation of phosphatase activity(GO:0010921)
0.1	1.2	GO:2000601	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0	1.1	GO:0048484	enteric nervous system development(GO:0048484)
0.1	1.0	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	1.0	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.1	0.9	GO:0099550	trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.0	0.9	GO:0031952	regulation of protein autophosphorylation(GO:0031952)

Showing 1 to 10 of 85 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.3	GO:0014069	postsynaptic density(GO:0014069)
0.1	1.2	GO:0031209	SCAR complex(GO:0031209)
0.0	1.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.7	GO:0001518	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1	0.6	GO:0033181	plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1	0.6	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.6	GO:1990246	uniplex complex(GO:1990246)
0.0	0.6	GO:0005579	membrane attack complex(GO:0005579)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.8	GO:0008432	JUN kinase binding(GO:0008432)
0.0	1.4	GO:0030276	clathrin binding(GO:0030276)
0.1	1.2	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	1.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	1.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	1.1	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	1.0	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	1.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.9	GO:0072542	phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0	0.9	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993)

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.7	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.4	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.2	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	1.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	1.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	0.7	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	0.6	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.3	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression

Showing 1 to 8 of 8 entries

Results for maff+mafga+mafgb

Z-value: 1.38

Motif logo

Transcription factors associated with maff+mafga+mafgb

Activity-expression correlation:

Activity profile of maff+mafga+mafgb motif

Sorted Z-values of maff+mafga+mafgb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of maff+mafga+mafgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: