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PRJNA207719: Tissue specific transcriptome profiling
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Results for mafa+mafbb
Z-value: 1.86
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Transcription factors associated with mafa+mafbb
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000015890 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a) | |
| ENSDARG00000070542 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb | |
| ENSDARG00000099120 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mafa | dr11_v1_chr18_+_29402623_29402623 | -0.37 | 5.4e-01 | Click! |
| mafbb | dr11_v1_chr11_-_25384213_25384213 | -0.02 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_24738188 Show fit | 2.00 |
ENSDART00000050238
|
vitellogenin 1 |
|
| chr3_-_18030938 Show fit | 1.85 |
ENSDART00000013540
|
si:ch73-141c7.1 |
|
| chr22_-_24880824 Show fit | 1.65 |
ENSDART00000061165
|
vitellogenin 2 |
|
| chr10_+_10801564 Show fit | 1.65 |
ENSDART00000027026
|
alpha-1-microglobulin/bikunin precursor |
|
| chr10_+_10801719 Show fit | 1.65 |
ENSDART00000193648
|
alpha-1-microglobulin/bikunin precursor |
|
| chr22_-_24757785 Show fit | 1.56 |
ENSDART00000078225
|
vitellogenin 5 |
|
| chr13_-_20381485 Show fit | 1.56 |
ENSDART00000131351
|
si:ch211-270n8.1 |
|
| chr2_+_25816843 Show fit | 1.53 |
ENSDART00000078639
|
solute carrier family 2 (facilitated glucose transporter), member 2 |
|
| chr10_+_28428222 Show fit | 1.50 |
ENSDART00000135003
|
si:ch211-222e20.4 |
|
| chr20_+_38285671 Show fit | 1.42 |
ENSDART00000061432
|
chemokine (C-C motif) ligand 38, duplicate 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafa+mafbb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.1 | 3.3 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.3 | 1.9 | GO:0050764 | regulation of phagocytosis(GO:0050764) |
| 0.0 | 1.7 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.4 | 1.5 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.1 | 1.5 | GO:1901663 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 1.5 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 1.4 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.3 | 1.3 | GO:0071548 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548) |
| 0.0 | 1.2 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 1.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 1.0 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.9 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
| 0.0 | 0.8 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.8 | GO:0031970 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.0 | 0.7 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 0.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.2 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.0 | 2.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.3 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.2 | 1.9 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.0 | 1.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 1.3 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 1.3 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.2 | 1.2 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 1.1 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.1 | 0.8 | GO:0004017 | adenylate kinase activity(GO:0004017) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.0 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 0.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 1.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.0 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.8 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.6 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 0.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 0.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |