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PRJNA207719: Tissue specific transcriptome profiling
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Results for lhx5
Z-value: 1.38
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Transcription factors associated with lhx5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| lhx5 | dr11_v1_chr21_-_15929041_15929041 | 0.85 | 6.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_9669717 Show fit | 2.17 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr15_-_44601331 Show fit | 1.91 |
ENSDART00000161514
|
zgc:165508 |
|
| chr9_+_7998794 Show fit | 1.44 |
ENSDART00000138167
|
myosin XVI |
|
| chr4_-_5019113 Show fit | 1.44 |
ENSDART00000189321
ENSDART00000081990 |
striatin interacting protein 2 |
|
| chr11_-_1509773 Show fit | 1.44 |
ENSDART00000050762
|
phosphatase and actin regulator 3b |
|
| chr3_-_49566364 Show fit | 1.43 |
ENSDART00000161507
|
zgc:153426 |
|
| chr21_-_20939488 Show fit | 1.43 |
ENSDART00000039043
|
regulator of G protein signaling 7 binding protein b |
|
| chr6_-_11768198 Show fit | 1.43 |
ENSDART00000183463
|
membrane-associated ring finger (C3HC4) 7 |
|
| chr6_+_7444899 Show fit | 1.36 |
ENSDART00000053775
|
ADP-ribosylation factor 3b |
|
| chr16_-_28856112 Show fit | 1.35 |
ENSDART00000078543
|
synaptotagmin XIb |
Network of associatons between targets according to the STRING database.
First level regulatory network of lhx5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.1 | 2.4 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.1 | 1.9 | GO:0055117 | regulation of cardiac muscle contraction(GO:0055117) |
| 0.2 | 1.7 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 1.4 | GO:0030050 | vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515) |
| 0.0 | 1.2 | GO:0035138 | pectoral fin morphogenesis(GO:0035138) |
| 0.4 | 1.1 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.0 | 1.0 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 1.0 | GO:0009142 | nucleoside triphosphate biosynthetic process(GO:0009142) |
| 0.0 | 0.9 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 1.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.6 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.4 | GO:0098858 | actin-based cell projection(GO:0098858) |
| 0.0 | 1.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 0.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.8 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.1 | 0.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.6 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.4 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 2.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 1.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.4 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 1.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.0 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 1.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 0.8 | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118) |
| 0.1 | 0.8 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.1 | 0.8 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.1 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 0.8 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.4 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.3 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |