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PRJNA207719: Tissue specific transcriptome profiling
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Results for lhx3+lhx4
Z-value: 1.36
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Transcription factors associated with lhx3+lhx4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| lhx4 | dr11_v1_chr8_-_14484599_14484599 | 0.95 | 1.3e-02 | Click! |
| LHX3 | dr11_v1_chr5_+_71802014_71802014 | 0.84 | 7.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_9669717 Show fit | 2.51 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr21_-_20939488 Show fit | 2.00 |
ENSDART00000039043
|
regulator of G protein signaling 7 binding protein b |
|
| chr9_+_34641237 Show fit | 1.75 |
ENSDART00000133996
|
short stature homeobox |
|
| chr20_+_34933183 Show fit | 1.51 |
ENSDART00000062738
|
synaptosomal-associated protein, 25a |
|
| chr15_-_44601331 Show fit | 1.34 |
ENSDART00000161514
|
zgc:165508 |
|
| chr9_-_42418470 Show fit | 1.30 |
ENSDART00000144353
|
calcitonin receptor-like a |
|
| chr10_-_27049170 Show fit | 1.27 |
ENSDART00000143451
|
cornichon family AMPA receptor auxiliary protein 2 |
|
| chr9_+_54039006 Show fit | 1.19 |
ENSDART00000112441
|
toll-like receptor 7 |
|
| chr21_+_3093419 Show fit | 1.18 |
ENSDART00000162520
|
SHC adaptor protein 3 |
|
| chr4_-_5019113 Show fit | 1.13 |
ENSDART00000189321
ENSDART00000081990 |
striatin interacting protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of lhx3+lhx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0033339 | pectoral fin development(GO:0033339) |
| 0.1 | 2.4 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 2.0 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 1.9 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.2 | 1.6 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 1.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 1.5 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.5 | 1.4 | GO:1900620 | acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620) |
| 0.1 | 1.3 | GO:0048844 | artery morphogenesis(GO:0048844) |
| 0.0 | 1.3 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.3 | 1.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.3 | 1.0 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.8 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 0.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 0.7 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 1.9 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 1.9 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 1.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 1.4 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.4 | 1.3 | GO:0001635 | adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635) |
| 0.1 | 1.0 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 1.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 1.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 0.6 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.4 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |