ISMARA results: lef1

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PRJNA207719: Tissue specific transcriptome profiling

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Results for lef1

Z-value: 1.74

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Transcription factors associated with lef1

Gene Symbol	Gene ID	Gene Info
lef1 NCBI UniProt	ENSDARG00000031894	lymphoid enhancer-binding factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
lef1	dr11_v1_chr1_+_49814942_49814942	0.93	2.4e-02	Click!

Activity profile of lef1 motif

Sorted Z-values of lef1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_35487413 Show fit	1.94	ENSDART00000102461	rgs8 NCBI UniProt Show fit	regulator of G protein signaling 8
chr23_+_23182037 Show fit	1.48	ENSDART00000137353	klhl17 NCBI UniProt Show fit	kelch-like family member 17
chr20_+_30445971 Show fit	1.40	ENSDART00000153150	myt1la NCBI UniProt Show fit	myelin transcription factor 1-like, a
chr17_-_17130942 Show fit	1.28	ENSDART00000064241	nrxn3a NCBI UniProt Show fit	neurexin 3a
chr14_-_32403554 Show fit	1.26	ENSDART00000172873 ENSDART00000173408 ENSDART00000173114 ENSDART00000185594 ENSDART00000186762 ENSDART00000010982	fgf13a NCBI UniProt Show fit	fibroblast growth factor 13a
chr18_-_23875370 Show fit	1.17	ENSDART00000130163	nr2f2 NCBI UniProt Show fit	nuclear receptor subfamily 2, group F, member 2
chr9_-_3671911 Show fit	1.14	ENSDART00000102900	sp5a NCBI UniProt Show fit	Sp5 transcription factor a
chr15_+_7992906 Show fit	1.04	ENSDART00000090790	cadm2b NCBI UniProt Show fit	cell adhesion molecule 2b
chr13_-_31441042 Show fit	1.04	ENSDART00000076571	rtn1a NCBI UniProt Show fit	reticulon 1a
chr22_-_13851297 Show fit	0.99	ENSDART00000080306	s100b NCBI UniProt Show fit	S100 calcium binding protein, beta (neural)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of lef1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6	2.6	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	2.5	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.8	2.3	GO:0060843	lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.2	2.2	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.1	2.2	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1	1.9	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	1.7	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1	1.6	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1	1.6	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)

Showing 1 to 10 of 216 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	GO:0030425	dendrite(GO:0030425)
0.2	3.4	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	3.4	GO:0099503	secretory vesicle(GO:0099503)
0.1	3.1	GO:0030426	growth cone(GO:0030426)
0.0	2.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.9	GO:0043025	neuronal cell body(GO:0043025)
0.0	1.8	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	1.7	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.0	1.5	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1	1.4	GO:0031594	neuromuscular junction(GO:0031594)

Showing 1 to 10 of 69 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	GO:0001972	retinoic acid binding(GO:0001972)
0.0	2.3	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	2.0	GO:0005516	calmodulin binding(GO:0005516)
0.0	1.8	GO:0030276	clathrin binding(GO:0030276)
0.1	1.5	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	1.5	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	1.5	GO:0003714	transcription corepressor activity(GO:0003714)
0.3	1.4	GO:0016521	pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.1	1.4	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	1.3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Showing 1 to 10 of 153 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	1.4	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	1.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.9	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.9	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.9	PID BMP PATHWAY	BMP receptor signaling
0.0	0.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.8	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.8	PID NOTCH PATHWAY	Notch signaling pathway
0.0	0.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	3.2	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	1.1	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.1	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	1.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	1.0	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.0	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	0.9	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	0.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	0.9	REACTOME CGMP EFFECTS	Genes involved in cGMP effects

Showing 1 to 10 of 42 entries

Results for lef1

Z-value: 1.74

Motif logo

Transcription factors associated with lef1

Activity-expression correlation:

Activity profile of lef1 motif

Sorted Z-values of lef1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of lef1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: