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PRJNA207719: Tissue specific transcriptome profiling
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Results for klf12b
Z-value: 2.97
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Transcription factors associated with klf12b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| klf12b | dr11_v1_chr9_+_30720048_30720048 | 0.70 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_13742899 Show fit | 6.50 |
ENSDART00000104722
|
cyclin-dependent kinase 5, regulatory subunit 2a (p39) |
|
| chr19_-_26863626 Show fit | 3.62 |
ENSDART00000145568
|
proline-rich transmembrane protein 1 |
|
| chr21_-_43949208 Show fit | 2.69 |
ENSDART00000150983
|
calcium/calmodulin-dependent protein kinase II alpha |
|
| chr2_+_47582681 Show fit | 2.45 |
ENSDART00000187579
|
secretogranin II (chromogranin C), b |
|
| chr11_-_37509001 Show fit | 2.36 |
ENSDART00000109753
|
bassoon (presynaptic cytomatrix protein) b |
|
| chr9_-_35155089 Show fit | 2.33 |
ENSDART00000077901
|
amyloid beta (A4) precursor protein b |
|
| chr5_-_25174420 Show fit | 2.30 |
ENSDART00000141554
|
ATP-binding cassette, sub-family A (ABC1), member 2 |
|
| chr9_-_31278048 Show fit | 2.20 |
ENSDART00000022204
|
zic family member 5 (odd-paired homolog, Drosophila) |
|
| chr7_-_18601206 Show fit | 2.18 |
ENSDART00000111636
|
si:ch211-119e14.2 |
|
| chr5_-_22501663 Show fit | 2.05 |
ENSDART00000133174
|
si:dkey-27p18.5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of klf12b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.0 | 5.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 4.0 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.2 | 3.9 | GO:0060079 | excitatory postsynaptic potential(GO:0060079) |
| 0.3 | 3.7 | GO:0097090 | presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105) |
| 0.6 | 3.6 | GO:0010801 | regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.1 | 3.6 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.3 | 3.3 | GO:0006798 | polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798) |
| 1.0 | 3.1 | GO:0048677 | axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682) |
| 0.6 | 2.9 | GO:0051659 | maintenance of mitochondrion location(GO:0051659) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0099572 | postsynaptic specialization(GO:0099572) |
| 1.3 | 6.5 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 5.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 3.6 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 3.4 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 3.4 | GO:0043005 | neuron projection(GO:0043005) |
| 0.2 | 2.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 2.9 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 2.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 2.7 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 5.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 3.9 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.1 | 3.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 3.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 3.6 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.1 | 3.5 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.3 | 3.3 | GO:0004309 | exopolyphosphatase activity(GO:0004309) |
| 0.2 | 3.2 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.1 | 2.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 2.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 2.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 2.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 1.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 1.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 1.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 0.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 2.7 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 2.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 2.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 1.9 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 1.9 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 1.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 1.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |