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PRJNA207719: Tissue specific transcriptome profiling
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Results for irx5a+irx5b_irx3a+irx3b
Z-value: 1.55
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Transcription factors associated with irx5a+irx5b_irx3a+irx3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irx3b | dr11_v1_chr25_-_36492779_36492779 | -0.94 | 1.7e-02 | Click! |
| irx5b | dr11_v1_chr25_+_36152215_36152215 | -0.73 | 1.6e-01 | Click! |
| irx3a | dr11_v1_chr7_+_36041509_36041509 | -0.28 | 6.5e-01 | Click! |
| irx5a | dr11_v1_chr7_-_35710263_35710263 | -0.22 | 7.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_50147948 Show fit | 1.12 |
ENSDART00000149010
|
haptoglobin |
|
| chr11_-_45185792 Show fit | 0.86 |
ENSDART00000171328
|
si:dkey-93h22.7 |
|
| chr3_-_32956808 Show fit | 0.71 |
ENSDART00000183902
|
caspase 6, apoptosis-related cysteine peptidase, like 1 |
|
| chr1_-_7951002 Show fit | 0.70 |
ENSDART00000138187
|
si:dkey-79f11.8 |
|
| chr7_+_56577522 Show fit | 0.62 |
ENSDART00000149130
ENSDART00000149624 |
haptoglobin |
|
| chr7_+_56577906 Show fit | 0.59 |
ENSDART00000184023
|
haptoglobin |
|
| chr17_-_5352924 Show fit | 0.56 |
ENSDART00000167275
|
SPT3 homolog, SAGA and STAGA complex component |
|
| chr20_+_34029820 Show fit | 0.55 |
ENSDART00000143901
ENSDART00000134305 |
proteoglycan 4b |
|
| chr2_-_13333932 Show fit | 0.53 |
ENSDART00000150238
ENSDART00000168258 |
si:dkey-185p13.1 vacuolar protein sorting 4b homolog B (S. cerevisiae) |
|
| chr16_-_42186093 Show fit | 0.53 |
ENSDART00000076030
|
fibrillarin |
Network of associatons between targets according to the STRING database.
First level regulatory network of irx5a+irx5b_irx3a+irx3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.8 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 0.1 | 0.7 | GO:0031126 | snoRNA 3'-end processing(GO:0031126) |
| 0.2 | 0.6 | GO:0032782 | canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782) |
| 0.0 | 0.6 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.0 | 0.6 | GO:1901888 | regulation of cell junction assembly(GO:1901888) |
| 0.0 | 0.6 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.0 | 0.6 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 0.5 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.1 | 0.5 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.6 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.6 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.5 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 0.5 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.5 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.4 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 1.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.7 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 0.6 | GO:0015432 | canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432) |
| 0.1 | 0.6 | GO:0072518 | Rho-dependent protein serine/threonine kinase activity(GO:0072518) |
| 0.0 | 0.6 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 0.5 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.2 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.1 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 1.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 0.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 0.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 0.4 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |