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PRJNA207719: Tissue specific transcriptome profiling
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Results for irf4a+irf4b
Z-value: 1.57
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Transcription factors associated with irf4a+irf4b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irf4b | dr11_v1_chr20_+_26556174_26556174 | 0.90 | 3.8e-02 | Click! |
| irf4a | dr11_v1_chr2_-_879800_879800 | 0.82 | 9.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_7110617 Show fit | 2.22 |
ENSDART00000104838
|
proteasome subunit beta 8A |
|
| chr1_-_7582859 Show fit | 1.68 |
ENSDART00000110696
|
myxovirus (influenza) resistance B |
|
| chr21_+_45626136 Show fit | 1.44 |
ENSDART00000158742
|
interferon regulatory factor 1b |
|
| chr17_-_22552678 Show fit | 1.21 |
ENSDART00000079401
|
si:ch211-125o16.4 |
|
| chr7_-_19614916 Show fit | 1.14 |
ENSDART00000169029
|
zgc:194655 |
|
| chr1_-_7570181 Show fit | 1.12 |
ENSDART00000103588
|
myxovirus (influenza) resistance A |
|
| chr14_-_33585809 Show fit | 1.09 |
ENSDART00000023540
|
SAM and SH3 domain containing 3 |
|
| chr7_+_19615056 Show fit | 1.07 |
ENSDART00000124752
ENSDART00000190297 |
si:ch211-212k18.15 |
|
| chr4_-_26107841 Show fit | 1.00 |
ENSDART00000172012
|
si:ch211-244b2.4 |
|
| chr16_+_48753664 Show fit | 0.98 |
ENSDART00000155148
|
si:ch73-31d8.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of irf4a+irf4b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0098884 | postsynaptic neurotransmitter receptor internalization(GO:0098884) |
| 0.1 | 3.2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 2.0 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.1 | 1.7 | GO:0050688 | regulation of defense response to virus(GO:0050688) |
| 0.0 | 1.7 | GO:0016485 | protein processing(GO:0016485) |
| 0.0 | 1.4 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 1.1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.2 | 0.9 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.3 | 0.8 | GO:0009211 | pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) |
| 0.0 | 0.8 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
| 0.1 | 3.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.3 | 1.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 1.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.2 | 1.2 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.9 | GO:0043186 | P granule(GO:0043186) |
| 0.3 | 0.8 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.1 | 0.4 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 1.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.3 | 0.9 | GO:0032574 | 5'-3' RNA helicase activity(GO:0032574) |
| 0.3 | 0.8 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.2 | 0.8 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 0.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 0.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 0.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 0.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.7 | 0.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.4 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 1.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.0 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 0.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 0.8 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.8 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.7 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |