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PRJNA207719: Tissue specific transcriptome profiling

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Results for irf1b+irf2+irf2a

Z-value: 4.82

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol Gene ID Gene Info
ENSDARG00000007387 interferon regulatory factor 2a
ENSDARG00000040465 interferon regulatory factor 2
ENSDARG00000043249 interferon regulatory factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf2dr11_v1_chr14_-_4121052_41210520.932.1e-02Click!
irf1bdr11_v1_chr21_+_45627775_456277750.819.7e-02Click!
irf2adr11_v1_chr1_+_39865748_39865753-0.612.8e-01Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_22648007 7.79 ENSDART00000121788
grass carp reovirus (GCRV)-induced gene 2l
chr19_-_7115229 6.78 ENSDART00000001930
proteasome subunit beta 13a
chr19_+_7115223 4.96 ENSDART00000001359
proteasome subunit beta 12
chr16_+_23487051 4.87 ENSDART00000145496
ictacalcin 2
chr11_-_20096018 4.63 ENSDART00000030420
opioid growth factor receptor-like 2
chr3_-_60316118 4.58 ENSDART00000171458
si:ch211-214b16.2
chr13_+_13681681 4.52 ENSDART00000057825
complement factor D (adipsin)
chr9_-_45601103 4.23 ENSDART00000180465
anterior gradient 1
chr12_-_4388704 4.18 ENSDART00000152168
si:ch211-173d10.1
chr5_+_13373593 4.17 ENSDART00000051668
ENSDART00000183883
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr5_-_38170996 4.05 ENSDART00000145805
si:ch211-284e13.12
chr10_-_22095505 3.90 ENSDART00000140210
plac8 onzin related protein 10
chr24_+_12945803 3.85 ENSDART00000005105
proteasome activator subunit 1
chr1_-_7930679 3.77 ENSDART00000146090
si:dkey-79f11.10
chr9_+_30387930 3.58 ENSDART00000112827
si:dkey-18p12.4
chr23_+_642395 3.49 ENSDART00000186995
interferon regulatory factor 10
chr13_+_22675802 3.43 ENSDART00000145538
ENSDART00000143312
zgc:193505
chr23_+_642001 3.41 ENSDART00000030643
ENSDART00000124850
interferon regulatory factor 10
chr1_-_52431220 3.37 ENSDART00000111256
zgc:194101
chr15_-_47929455 3.34 ENSDART00000064462
proteasome subunit alpha 6, like
chr21_-_22673758 3.22 ENSDART00000164910
grass carp reovirus (GCRV)-induced gene 2i
chr14_+_36889893 3.11 ENSDART00000124159
si:ch211-132p1.3
chr19_+_1414604 3.09 ENSDART00000159024
bloodthirsty-related gene family, member 29
chr13_-_37615029 3.02 ENSDART00000111199
si:dkey-188i13.6
chr10_-_4375190 2.82 ENSDART00000016102

chr1_-_8000428 2.70 ENSDART00000133098
si:dkey-79f11.5
chr3_+_1942219 2.65 ENSDART00000114520
zgc:165583
chr3_+_29941777 2.65 ENSDART00000113889
interferon-induced protein 35
chr22_-_17459587 2.65 ENSDART00000142267
si:ch211-197g15.10
chr16_+_29492937 2.65 ENSDART00000011497
cathepsin K
chr5_+_22406672 2.56 ENSDART00000141385
si:dkey-27p18.3
chr4_-_26108053 2.53 ENSDART00000066951
si:ch211-244b2.4
chr12_+_46512881 2.47 ENSDART00000105454

chr4_+_7822773 2.44 ENSDART00000171391
si:ch1073-67j19.2
chr3_+_34670076 2.43 ENSDART00000133457
distal-less homeobox 4a
chr11_+_1584747 2.42 ENSDART00000154583
si:dkey-40c23.2
chr4_-_26095755 2.41 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
chr7_-_19614916 2.37 ENSDART00000169029
zgc:194655
chr3_+_24603923 2.35 ENSDART00000172589
si:dkey-68o6.6
chr22_-_10580194 2.31 ENSDART00000105848
si:dkey-42i9.7
chr7_-_8981507 2.26 ENSDART00000161422
si:ch211-183d5.2
chr21_-_22681534 2.26 ENSDART00000159233
grass carp reovirus (GCRV)-induced gene 2f
chr4_-_26107841 2.25 ENSDART00000172012
si:ch211-244b2.4
chr13_-_37620091 2.24 ENSDART00000135875
ENSDART00000193270
ENSDART00000018064
zgc:152791
chr11_+_1608348 2.23 ENSDART00000162438
si:dkey-40c23.3
chr6_-_11091449 2.22 ENSDART00000127209
PTTG1 interacting protein a
chr1_-_8020589 2.21 ENSDART00000143881
si:dkeyp-9d4.2
chr7_-_19613388 2.21 ENSDART00000173664
si:ch211-212k18.13
chr5_-_30382925 2.19 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr18_-_38270077 2.17 ENSDART00000185546
cell cycle associated protein 1b
chr18_-_38270430 2.16 ENSDART00000139519
cell cycle associated protein 1b
chr19_+_7575141 2.15 ENSDART00000051528
S100 calcium binding protein U
chr5_-_38063585 2.15 ENSDART00000164947
si:dkey-111e8.5
chr4_-_76383223 2.15 ENSDART00000161866
ENSDART00000168456
ENSDART00000174287
ENSDART00000174048
zgc:123107
chr1_-_25177086 2.13 ENSDART00000144711
ENSDART00000177225
transmembrane protein 154
chr15_-_41756454 2.13 ENSDART00000139498
ENSDART00000099302
finTRIM family, member 72
chr8_-_36469117 2.13 ENSDART00000111240
major histocompatibility complex class II DAB gene
chr23_+_26142807 2.12 ENSDART00000158878
protein tyrosine phosphatase, non-receptor type 22
chr7_+_19615056 2.12 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
chr1_-_47161996 2.12 ENSDART00000053153
major histocompatibility complex class I ZBA
chr23_-_5101847 2.10 ENSDART00000122240
ets variant 7
chr22_+_5687615 2.09 ENSDART00000133241
ENSDART00000019854
ENSDART00000138102
deoxyribonuclease 1 like 4, tandem duplicate 2
chr5_-_38179220 2.09 ENSDART00000147701
si:ch211-284e13.11
chr15_-_29162193 2.09 ENSDART00000138449
ENSDART00000099885
XIAP associated factor 1
chr4_+_5842433 2.07 ENSDART00000124085
ENSDART00000179848
ubiquitin specific peptidase 18
chr25_-_25550938 2.06 ENSDART00000150412
ENSDART00000103622
interferon regulatory factor 7
chr20_-_1439256 2.06 ENSDART00000002928
thymocyte selection associated
chr19_-_47570672 2.05 ENSDART00000112155
ribonucleotide reductase M2 polypeptide
chr5_-_38197080 2.00 ENSDART00000140708
si:ch211-284e13.9
chr5_-_57723929 1.99 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr8_+_47099033 1.99 ENSDART00000142979
Rho guanine nucleotide exchange factor (GEF) 16
chr18_-_38270596 1.98 ENSDART00000098889
cell cycle associated protein 1b
chr22_-_36926342 1.97 ENSDART00000151804
si:dkey-37m8.11
chr8_-_27687095 1.97 ENSDART00000086946
Moloney leukemia virus 10b, tandem duplicate 1
chr5_-_38820046 1.95 ENSDART00000182886
CCR4-NOT transcription complex, subunit 6-like
chr13_-_37608441 1.93 ENSDART00000140230
zgc:123068
chr5_+_38619813 1.93 ENSDART00000133314
si:ch211-271e10.3
chr9_+_18023288 1.93 ENSDART00000098355
TNF superfamily member 11
chr10_+_7585928 1.92 ENSDART00000166686
testis expressed 15
chr2_-_42035250 1.89 ENSDART00000056460
ENSDART00000140788
guanylate binding protein 1
chr16_+_48753664 1.89 ENSDART00000155148
si:ch73-31d8.2
chr4_-_12795030 1.88 ENSDART00000150427
beta-2-microglobulin
chr1_-_7951002 1.88 ENSDART00000138187
si:dkey-79f11.8
chr22_+_29990448 1.87 ENSDART00000165313
si:dkey-286j15.3
chr16_-_51271962 1.87 ENSDART00000164021
ENSDART00000046420
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1
chr13_-_34858500 1.86 ENSDART00000184843
serine palmitoyltransferase, long chain base subunit 3
chr3_-_32958505 1.86 ENSDART00000147374
ENSDART00000136919
caspase 6, apoptosis-related cysteine peptidase, like 1
chr19_+_23296616 1.85 ENSDART00000134567
immunity-related GTPase family, f1
chr7_+_20344486 1.84 ENSDART00000134004
ENSDART00000139685
plac8 onzin related protein 1
chr19_+_7575341 1.84 ENSDART00000134271
S100 calcium binding protein U
chr11_+_1575435 1.80 ENSDART00000155713
ENSDART00000156562
si:dkey-40c23.1
chr23_+_26142613 1.80 ENSDART00000165046
protein tyrosine phosphatase, non-receptor type 22
chr17_-_23631400 1.80 ENSDART00000079563
Fas cell surface death receptor
chr24_-_31904924 1.77 ENSDART00000156060
ENSDART00000129741
ENSDART00000154276
si:ch73-78o10.1
chr7_+_19600262 1.76 ENSDART00000007310
zgc:171731
chr19_+_7124337 1.76 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr13_+_47810211 1.76 ENSDART00000122964
zmp:0000001006
chr12_-_17028255 1.75 ENSDART00000152678
interferon-induced protein with tetratricopeptide repeats 10
chr3_+_24618012 1.74 ENSDART00000111997
zgc:171506
chr5_+_38662125 1.73 ENSDART00000136949
si:dkey-58f10.13
chr6_-_42983843 1.71 ENSDART00000130666
tumor necrosis factor receptor superfamily, member 18
chr13_-_37631092 1.71 ENSDART00000108855
si:dkey-188i13.7
chr5_+_8256574 1.71 ENSDART00000171343

chr13_+_17694845 1.71 ENSDART00000079778
interferon-induced protein with tetratricopeptide repeats 8
chr4_-_77216726 1.70 ENSDART00000099943
proteasome subunit beta 10
chr19_-_7144548 1.68 ENSDART00000147177
ENSDART00000134850
proteasome subunit beta 8A
proteasome subunit beta 13a
chr7_+_19482084 1.68 ENSDART00000173873
si:ch211-212k18.7
chr17_+_35362851 1.67 ENSDART00000137659
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr22_-_6941098 1.66 ENSDART00000105864
zgc:171500
chr3_+_36424055 1.65 ENSDART00000170318
si:ch1073-443f11.2
chr3_-_22366562 1.65 ENSDART00000129447
interferon phi 1
chr21_+_5494561 1.64 ENSDART00000169728
lymphocyte antigen 6 family member M3
chr5_-_37116265 1.60 ENSDART00000057613
interleukin 13 receptor, alpha 2
chr1_-_58115298 1.58 ENSDART00000141787
caspase b, like
chr4_+_38550788 1.57 ENSDART00000157412
si:ch211-209n20.1
chr4_-_17669881 1.57 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr14_-_1543834 1.53 ENSDART00000185876

chr20_+_26916639 1.52 ENSDART00000077787
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 2
chr17_+_25397070 1.52 ENSDART00000164254
zgc:154055
chr3_-_336299 1.52 ENSDART00000105021
major histocompatibility complex class I ZFA
chr5_-_38064065 1.52 ENSDART00000137181
si:dkey-111e8.5
chr23_+_46183410 1.52 ENSDART00000167596
ENSDART00000151149
ENSDART00000150896
bloodthirsty-related gene family, member 31
chr22_-_18164671 1.51 ENSDART00000014057
regulatory factor X-associated ankyrin-containing protein
chr6_+_52947699 1.51 ENSDART00000180913
ubiquitin-like modifier activating enzyme 7
chr9_+_25330905 1.51 ENSDART00000101470
integral membrane protein 2Bb
chr14_+_12169979 1.50 ENSDART00000129953
ras homolog gene family, member Gd
chr16_-_9802449 1.49 ENSDART00000081208
TAP binding protein (tapasin)-like
chr15_-_18209672 1.49 ENSDART00000141508
ENSDART00000136280
bloodthirsty-related gene family, member 16
chr24_+_38216340 1.47 ENSDART00000188561

chr16_-_22192006 1.47 ENSDART00000163338
interleukin 6 receptor
chr5_+_38631119 1.46 ENSDART00000131832
ENSDART00000162215
si:ch211-271e10.6
chr24_-_34680956 1.46 ENSDART00000171009
catenin (cadherin-associated protein), alpha 1
chr6_+_13045885 1.46 ENSDART00000104757
caspase 8, apoptosis-related cysteine peptidase
chr11_+_13630107 1.45 ENSDART00000172220
si:ch211-1a19.3
chr22_-_18164835 1.45 ENSDART00000143189
regulatory factor X-associated ankyrin-containing protein
chr8_+_25629722 1.45 ENSDART00000026807
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr22_-_17474583 1.43 ENSDART00000148027
si:ch211-197g15.8
chr23_+_5524247 1.43 ENSDART00000189679
ENSDART00000083622
TEA domain family member 3 a
chr7_+_20344222 1.43 ENSDART00000141186
ENSDART00000139274
plac8 onzin related protein 1
chr21_+_31253048 1.43 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
argininosuccinate lyase
chr15_-_21702317 1.41 ENSDART00000155824
si:dkey-40g16.6
chr7_+_2259413 1.40 ENSDART00000173420
si:dkey-187j14.7
chr21_-_1644414 1.40 ENSDART00000105736
ENSDART00000124904
zgc:152948
chr14_+_36414856 1.39 ENSDART00000123343
ENSDART00000015761
nei-like DNA glycosylase 3
chr23_-_37575030 1.39 ENSDART00000031875
torsin family 1 like 3
chr18_+_17624295 1.39 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
NLR family, CARD domain containing 5
chr21_-_33478164 1.39 ENSDART00000191542
si:ch73-42p12.2
chr18_+_13248956 1.39 ENSDART00000080709
phospholipase C, gamma 2
chr18_+_26422124 1.38 ENSDART00000060245
cathepsin H
chr20_-_34663209 1.38 ENSDART00000132545
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr16_-_31686602 1.37 ENSDART00000170357
complement component 1, s subcomponent
chr4_-_4431975 1.36 ENSDART00000082046
neurotrophin 3
chr13_-_6252498 1.36 ENSDART00000115157
tubulin, alpha 4 like
chr9_+_890536 1.35 ENSDART00000139132
STEAP family member 3, metalloreductase
chr3_-_48980319 1.35 ENSDART00000165319
finTRIM family, member 42
chr5_+_13359146 1.35 ENSDART00000179839
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr1_-_49558223 1.34 ENSDART00000138510
si:ch211-281g13.4
chr16_+_41570653 1.34 ENSDART00000102665
asteroid homolog 1a
chr7_+_39416336 1.34 ENSDART00000171783

chr11_+_37638873 1.34 ENSDART00000186384
ENSDART00000184291
ENSDART00000131782
ENSDART00000140502
SH2 domain containing 5
chr1_+_40148193 1.33 ENSDART00000138072
zgc:194443
chr1_+_1805294 1.33 ENSDART00000103850
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr3_+_866044 1.33 ENSDART00000126857

chr22_+_19230434 1.33 ENSDART00000132929
si:dkey-21e2.8
chr1_-_43933271 1.33 ENSDART00000121605
secretory calcium-binding phosphoprotein 6
chr1_+_58424507 1.32 ENSDART00000114197
si:ch73-236c18.3
chr13_-_46200240 1.32 ENSDART00000056984
finTRIM family, member 69
chr2_+_42330828 1.31 ENSDART00000134802
ENSDART00000193783
finTRIM family, member 9
chr7_+_22675475 1.30 ENSDART00000134423
plac8 onzin related protein 3
chr20_+_54295213 1.30 ENSDART00000074085
zona pellucida glycoprotein 2, tandem duplicate 3
chr13_-_50200042 1.29 ENSDART00000074230
protein kinase containing Z-DNA binding domains
chr19_+_4066449 1.29 ENSDART00000162461
bloodthirsty-related gene family, member 26
chr13_+_7387822 1.29 ENSDART00000148240
exocyst complex component 3-like 4
chr21_-_22676323 1.29 ENSDART00000167392
grass carp reovirus (GCRV)-induced gene 2h
chr21_-_43428040 1.28 ENSDART00000148325
serine/threonine protein kinase 26
chr22_+_6096303 1.28 ENSDART00000139276
zgc:171887
chr21_+_8533533 1.28 ENSDART00000077924

chr9_+_29616854 1.27 ENSDART00000033902
ENSDART00000143493
PHD finger protein 11
chr3_-_29941357 1.27 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
granulin a
chr23_-_6865946 1.27 ENSDART00000056426
finTRIM family, member 58
chr3_-_26921475 1.26 ENSDART00000130281
class II, major histocompatibility complex, transactivator
chr1_+_1896737 1.26 ENSDART00000152442
si:ch211-132g1.6
chr23_-_44723102 1.25 ENSDART00000129138
monoacylglycerol O-acyltransferase 3a
chr7_+_20505311 1.24 ENSDART00000187335
si:dkey-19b23.12
chr7_+_31891110 1.24 ENSDART00000173883
myosin binding protein C, cardiac
chr12_+_31608905 1.23 ENSDART00000152874
ENSDART00000152996

carboxypeptidase N, polypeptide 1
chr7_+_3483334 1.23 ENSDART00000034268
si:ch211-285c6.3
chr3_-_53508580 1.23 ENSDART00000073978
zgc:171711
chr23_-_4409668 1.22 ENSDART00000081823
si:ch73-142c19.1
chr15_-_18197008 1.21 ENSDART00000147632
si:ch211-247l8.8
chr20_-_49704915 1.20 ENSDART00000189232
cytochrome c oxidase subunit 7A2
chr4_+_68776476 1.19 ENSDART00000169135
si:dkey-264f17.3
chr13_+_2830574 1.18 ENSDART00000138143
si:ch211-233m11.1
chr6_+_52947186 1.18 ENSDART00000155831
ubiquitin-like modifier activating enzyme 7
chr6_+_36839509 1.17 ENSDART00000190605
ENSDART00000104160
zgc:110788
chr18_-_14860435 1.16 ENSDART00000018502
mitogen-activated protein kinase 12a
chr2_-_37862380 1.16 ENSDART00000186005
si:ch211-284o19.8
chr2_+_42294944 1.15 ENSDART00000140599
ENSDART00000178811
finTRIM family, member 6
chr1_-_57839070 1.15 ENSDART00000152571
si:dkey-1c7.3
chr18_-_26963473 1.14 ENSDART00000086190
proline-serine-threonine phosphatase interacting protein 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.9 8.7 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.7 2.1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.7 2.1 GO:0043383 negative T cell selection(GO:0043383)
0.6 18.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.6 1.7 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.5 1.5 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.5 1.5 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.4 1.8 GO:0070227 lymphocyte apoptotic process(GO:0070227)
0.4 2.0 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.4 1.5 GO:0042985 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019)
0.4 2.1 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.4 1.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 1.4 GO:0015677 copper ion import(GO:0015677)
0.3 1.0 GO:0071514 genetic imprinting(GO:0071514)
0.3 1.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.3 3.3 GO:0072078 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.3 0.9 GO:0090131 mesenchyme migration(GO:0090131)
0.3 2.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.3 1.1 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.3 1.4 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 1.3 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.3 3.3 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.2 1.0 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.2 1.2 GO:0003210 cardiac atrium formation(GO:0003210)
0.2 2.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.8 GO:0031179 peptide modification(GO:0031179)
0.2 1.1 GO:0010693 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.2 2.1 GO:0051601 exocyst localization(GO:0051601)
0.2 0.8 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.2 1.0 GO:0043420 anthranilate metabolic process(GO:0043420)
0.2 1.4 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 1.0 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 1.1 GO:0032648 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.2 1.9 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.2 9.9 GO:0051607 defense response to virus(GO:0051607)
0.2 6.2 GO:0071346 response to interferon-gamma(GO:0034341) cellular response to interferon-gamma(GO:0071346)
0.2 0.5 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.2 1.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 4.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 1.9 GO:0007140 male meiosis(GO:0007140)
0.1 1.0 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 2.1 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.1 1.2 GO:0014028 notochord formation(GO:0014028)
0.1 2.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.5 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.1 0.6 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 1.5 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.3 GO:0005997 xylulose metabolic process(GO:0005997)
0.1 6.0 GO:0010950 positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.1 1.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 1.4 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.1 1.4 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.7 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 1.5 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.8 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.1 0.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 1.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.3 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 1.3 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 1.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 6.7 GO:0017148 negative regulation of translation(GO:0017148)
0.1 0.7 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.4 GO:0031638 zymogen activation(GO:0031638)
0.1 1.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.2 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.4 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 2.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 2.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.4 GO:0035329 hippo signaling(GO:0035329)
0.1 4.6 GO:0009612 response to mechanical stimulus(GO:0009612)
0.1 1.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.2 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.3 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.6 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 2.1 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 3.4 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 4.4 GO:0031101 fin regeneration(GO:0031101)
0.0 0.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.6 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 4.3 GO:0021782 glial cell development(GO:0021782)
0.0 0.2 GO:0046600 negative regulation of centriole replication(GO:0046600) negative regulation of organelle assembly(GO:1902116)
0.0 1.4 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 1.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 3.4 GO:0017038 protein import(GO:0017038)
0.0 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.7 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 1.5 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.7 GO:0008272 sulfate transport(GO:0008272)
0.0 0.8 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.8 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 1.2 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.9 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.0 0.1 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.4 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.2 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.0 2.8 GO:0016579 protein deubiquitination(GO:0016579)
0.0 2.9 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.5 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.1 GO:0019563 glycerol catabolic process(GO:0019563)
0.0 0.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 1.1 GO:0007254 JNK cascade(GO:0007254)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.4 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 1.6 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.0 1.7 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.4 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0051793 medium-chain fatty acid metabolic process(GO:0051791) medium-chain fatty acid catabolic process(GO:0051793)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 8.1 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0009615 response to virus(GO:0009615)
0.0 0.2 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.8 GO:0016485 protein processing(GO:0016485)
0.0 2.8 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0008537 proteasome activator complex(GO:0008537)
0.7 18.8 GO:0005839 proteasome core complex(GO:0005839)
0.5 4.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 2.8 GO:0042611 MHC protein complex(GO:0042611) MHC class I protein complex(GO:0042612)
0.3 1.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 1.1 GO:0032433 filopodium tip(GO:0032433)
0.2 1.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.9 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 0.5 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.1 1.0 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 0.6 GO:0097433 dense body(GO:0097433)
0.1 0.4 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.1 0.6 GO:0097224 sperm connecting piece(GO:0097224)
0.1 2.9 GO:0000145 exocyst(GO:0000145)
0.1 2.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.5 GO:0030057 desmosome(GO:0030057)
0.1 0.7 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 2.0 GO:0043186 P granule(GO:0043186)
0.1 2.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.9 GO:0005869 dynactin complex(GO:0005869)
0.0 12.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.9 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 9.0 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.5 GO:0030496 midbody(GO:0030496)
0.0 1.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.4 GO:0030426 growth cone(GO:0030426)
0.0 6.5 GO:0000785 chromatin(GO:0000785)
0.0 0.4 GO:0030130 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 1.0 GO:0008305 integrin complex(GO:0008305)
0.0 0.4 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.0 19.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.6 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 17.9 GO:0005829 cytosol(GO:0005829)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.0 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.7 2.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.7 14.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7 3.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.7 2.0 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.6 3.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.6 1.7 GO:0009041 uridylate kinase activity(GO:0009041)
0.5 2.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.5 1.5 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
0.4 20.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 2.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.4 1.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.3 1.4 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 4.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 2.0 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.9 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.3 7.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 1.9 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.3 10.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 1.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 1.0 GO:0031005 filamin binding(GO:0031005)
0.2 0.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 0.9 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.2 0.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2 2.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.2 1.8 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.2 0.6 GO:0032027 myosin light chain binding(GO:0032027)
0.2 0.5 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.2 2.6 GO:0031386 protein tag(GO:0031386)
0.1 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 6.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 1.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 2.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.6 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.8 GO:0019808 polyamine binding(GO:0019808) spermidine binding(GO:0019809)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.4 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 1.0 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.1 0.7 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 1.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.4 GO:0019894 kinesin binding(GO:0019894)
0.1 2.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.6 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 1.5 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 1.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 8.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 1.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 4.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.8 GO:0042805 actinin binding(GO:0042805)
0.0 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 3.1 GO:0019955 cytokine binding(GO:0019955)
0.0 1.4 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 26.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 2.3 GO:0004175 endopeptidase activity(GO:0004175)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 12.0 GO:0005525 GTP binding(GO:0005525)
0.0 1.6 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.1 GO:0031826 G-protein coupled serotonin receptor binding(GO:0031821) type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.1 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.4 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.1 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 1.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.4 GO:0045182 translation regulator activity(GO:0045182)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 1.6 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 1.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 1.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 0.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 1.4 PID SHP2 PATHWAY SHP2 signaling
0.0 1.6 PID AURORA B PATHWAY Aurora B signaling
0.0 1.2 PID BARD1 PATHWAY BARD1 signaling events
0.0 3.6 PID E2F PATHWAY E2F transcription factor network
0.0 2.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 2.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.4 3.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.4 1.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.4 10.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 2.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 2.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 1.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 6.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 1.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 5.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.4 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 1.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives