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PRJNA207719: Tissue specific transcriptome profiling
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Results for irf1a
Z-value: 2.11
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Transcription factors associated with irf1a
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_7115229 Show fit | 3.84 |
ENSDART00000001930
|
proteasome subunit beta 13a |
|
| chr5_+_13373593 Show fit | 3.75 |
ENSDART00000051668
ENSDART00000183883 |
chemokine (C-C motif) ligand 19a, tandem duplicate 2 |
|
| chr13_+_13681681 Show fit | 2.88 |
ENSDART00000057825
|
complement factor D (adipsin) |
|
| chr19_+_7115223 Show fit | 2.83 |
ENSDART00000001359
|
proteasome subunit beta 12 |
|
| chr11_-_20096018 Show fit | 2.50 |
ENSDART00000030420
|
opioid growth factor receptor-like 2 |
|
| chr1_-_52431220 Show fit | 2.03 |
ENSDART00000111256
|
zgc:194101 |
|
| chr15_-_29162193 Show fit | 1.97 |
ENSDART00000138449
ENSDART00000099885 |
XIAP associated factor 1 |
|
| chr1_-_52447364 Show fit | 1.95 |
ENSDART00000140740
|
si:ch211-217k17.10 |
|
| chr23_+_642395 Show fit | 1.78 |
ENSDART00000186995
|
interferon regulatory factor 10 |
|
| chr23_+_642001 Show fit | 1.73 |
ENSDART00000030643
ENSDART00000124850 |
interferon regulatory factor 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of irf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 3.7 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 3.0 | GO:0051607 | defense response to virus(GO:0051607) |
| 1.0 | 2.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 2.7 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 1.8 | GO:0010950 | positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952) |
| 0.0 | 1.7 | GO:0017148 | negative regulation of translation(GO:0017148) |
| 0.1 | 1.4 | GO:0019882 | antigen processing and presentation(GO:0019882) |
| 0.3 | 1.3 | GO:1903019 | negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019) |
| 0.3 | 1.3 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.4 | 1.6 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 1.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.2 | 1.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.0 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 0.9 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 0.6 | GO:0032156 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.0 | 0.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.2 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 3.7 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 3.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 3.0 | GO:0032182 | ubiquitin-like protein binding(GO:0032182) |
| 0.3 | 2.2 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.3 | 1.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 1.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.3 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.3 | 1.0 | GO:0009041 | uridylate kinase activity(GO:0009041) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 0.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.5 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 2.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 2.5 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 2.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 1.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 1.0 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 0.7 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 0.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 0.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 0.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |