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PRJNA207719: Tissue specific transcriptome profiling

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Results for irf10+irf8+irf9

Z-value: 3.93

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Transcription factors associated with irf10+irf8+irf9

Gene Symbol Gene ID Gene Info
ENSDARG00000016457 interferon regulatory factor 9
ENSDARG00000027658 interferon regulatory factor 10
ENSDARG00000056407 interferon regulatory factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf10dr11_v1_chr23_+_642395_6423950.866.1e-02Click!
irf8dr11_v1_chr18_+_30567945_305679450.583.0e-01Click!
irf9dr11_v1_chr12_+_13282797_132828070.503.9e-01Click!

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_13373593 4.83 ENSDART00000051668
ENSDART00000183883
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr11_-_20096018 4.71 ENSDART00000030420
opioid growth factor receptor-like 2
chr21_-_22648007 4.65 ENSDART00000121788
grass carp reovirus (GCRV)-induced gene 2l
chr19_-_7115229 4.65 ENSDART00000001930
proteasome subunit beta 13a
chr1_-_52443379 3.56 ENSDART00000144676
si:ch211-217k17.11
chr13_-_37608441 3.36 ENSDART00000140230
zgc:123068
chr19_+_7115223 3.34 ENSDART00000001359
proteasome subunit beta 12
chr21_-_22673758 3.25 ENSDART00000164910
grass carp reovirus (GCRV)-induced gene 2i
chr21_-_22647695 3.22 ENSDART00000187553
grass carp reovirus (GCRV)-induced gene 2l
chr22_-_10580194 3.21 ENSDART00000105848
si:dkey-42i9.7
chr23_+_642395 3.19 ENSDART00000186995
interferon regulatory factor 10
chr1_-_7951002 3.15 ENSDART00000138187
si:dkey-79f11.8
chr23_+_642001 3.13 ENSDART00000030643
ENSDART00000124850
interferon regulatory factor 10
chr4_-_76383223 3.08 ENSDART00000161866
ENSDART00000168456
ENSDART00000174287
ENSDART00000174048
zgc:123107
chr22_+_25274712 3.08 ENSDART00000137341

chr22_+_25289360 3.07 ENSDART00000143782
si:ch211-154a22.8
chr15_-_17071328 3.07 ENSDART00000122617
si:ch211-24o10.6
chr3_+_29941777 2.96 ENSDART00000113889
interferon-induced protein 35
chr19_-_325584 2.94 ENSDART00000134266
glycerol-3-phosphate dehydrogenase 1c
chr3_+_24603923 2.91 ENSDART00000172589
si:dkey-68o6.6
chr1_-_8000428 2.85 ENSDART00000133098
si:dkey-79f11.5
chr4_+_7822773 2.84 ENSDART00000171391
si:ch1073-67j19.2
chr25_-_25550938 2.76 ENSDART00000150412
ENSDART00000103622
interferon regulatory factor 7
chr3_+_1942219 2.75 ENSDART00000114520
zgc:165583
chr22_-_17459587 2.74 ENSDART00000142267
si:ch211-197g15.10
chr10_-_4375190 2.70 ENSDART00000016102

chr19_-_7110617 2.68 ENSDART00000104838
proteasome subunit beta 8A
chr6_+_52947699 2.56 ENSDART00000180913
ubiquitin-like modifier activating enzyme 7
chr22_+_34616151 2.53 ENSDART00000155399
ENSDART00000104705
si:ch1073-214b20.2
chr16_+_29514473 2.50 ENSDART00000034102
cathepsin S, ortholog 2, tandem duplicate 2
chr13_+_22675802 2.50 ENSDART00000145538
ENSDART00000143312
zgc:193505
chr4_-_26108053 2.49 ENSDART00000066951
si:ch211-244b2.4
chr15_-_29162193 2.48 ENSDART00000138449
ENSDART00000099885
XIAP associated factor 1
chr15_-_21702317 2.44 ENSDART00000155824
si:dkey-40g16.6
chr13_-_45155792 2.39 ENSDART00000163556
runt-related transcription factor 3
chr13_-_37642890 2.34 ENSDART00000146483
ENSDART00000136071
ENSDART00000111786
si:dkey-188i13.9
chr4_-_26095755 2.33 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
chr21_-_22676323 2.31 ENSDART00000167392
grass carp reovirus (GCRV)-induced gene 2h
chr4_+_5842433 2.23 ENSDART00000124085
ENSDART00000179848
ubiquitin specific peptidase 18
chr8_-_27656765 2.23 ENSDART00000078491
Moloney leukemia virus 10b, tandem duplicate 2
chr1_-_25177086 2.22 ENSDART00000144711
ENSDART00000177225
transmembrane protein 154
chr5_-_30382925 2.21 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr12_-_17028255 2.13 ENSDART00000152678
interferon-induced protein with tetratricopeptide repeats 10
chr4_-_26107841 2.12 ENSDART00000172012
si:ch211-244b2.4
chr17_+_35362851 2.11 ENSDART00000137659
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr16_-_31686602 2.09 ENSDART00000170357
complement component 1, s subcomponent
chr15_+_24588963 2.09 ENSDART00000155075
zgc:198241
chr15_-_47929455 2.05 ENSDART00000064462
proteasome subunit alpha 6, like
chr6_+_52947186 2.03 ENSDART00000155831
ubiquitin-like modifier activating enzyme 7
chr16_+_29509133 2.03 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr20_-_16223245 2.01 ENSDART00000014721
enoyl CoA hydratase domain containing 2
chr7_-_19614916 2.01 ENSDART00000169029
zgc:194655
chr5_+_38662125 1.96 ENSDART00000136949
si:dkey-58f10.13
chr11_-_19775182 1.92 ENSDART00000037894
nicotinamide phosphoribosyltransferase b
chr16_-_9802449 1.90 ENSDART00000081208
TAP binding protein (tapasin)-like
chr13_-_37631092 1.88 ENSDART00000108855
si:dkey-188i13.7
chr9_+_23765587 1.88 ENSDART00000145120
si:ch211-219a4.3
chr2_-_43135700 1.87 ENSDART00000098284
finTRIM family, member 14
chr7_-_52417060 1.87 ENSDART00000148579
myocardial zonula adherens protein
chr9_-_23765480 1.82 ENSDART00000027212
si:ch211-219a4.6
chr16_+_29492937 1.82 ENSDART00000011497
cathepsin K
chr7_+_19615056 1.80 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
chr1_-_21563040 1.79 ENSDART00000049572
non-SMC condensin II complex, subunit D3
chr1_-_7930679 1.72 ENSDART00000146090
si:dkey-79f11.10
chr1_-_47161996 1.72 ENSDART00000053153
major histocompatibility complex class I ZBA
chr19_+_23296616 1.72 ENSDART00000134567
immunity-related GTPase family, f1
chr12_-_23658888 1.65 ENSDART00000088319
mitogen-activated protein kinase kinase kinase 8
chr15_-_43625549 1.63 ENSDART00000168589
cathepsin C
chr16_+_25285998 1.63 ENSDART00000154112
si:dkey-29h14.10
chr17_+_45395846 1.61 ENSDART00000058793
neudesin neurotrophic factor
chr25_-_6223567 1.60 ENSDART00000067512
proteasome subunit alpha 4
chr24_+_12945803 1.58 ENSDART00000005105
proteasome activator subunit 1
chr7_+_3483334 1.57 ENSDART00000034268
si:ch211-285c6.3
chr7_+_29509255 1.55 ENSDART00000076172
si:dkey-182o15.5
chr1_-_8966046 1.54 ENSDART00000136198
suppressor of cytokine signaling 1b
chr22_-_17474583 1.54 ENSDART00000148027
si:ch211-197g15.8
chr11_+_1584747 1.52 ENSDART00000154583
si:dkey-40c23.2
chr12_-_30583668 1.48 ENSDART00000153406
caspase 7, apoptosis-related cysteine peptidase
chr4_-_12795030 1.45 ENSDART00000150427
beta-2-microglobulin
chr2_+_42708674 1.45 ENSDART00000141989
ENSDART00000005767
finTRIM family, member 11
chr18_-_38270430 1.44 ENSDART00000139519
cell cycle associated protein 1b
chr4_-_17669881 1.44 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr10_+_31809226 1.42 ENSDART00000087898
forkhead box O1 b
chr18_+_26422124 1.41 ENSDART00000060245
cathepsin H
chr3_+_938438 1.38 ENSDART00000165671
immunity-related GTPase family, f4
chr13_+_27232848 1.36 ENSDART00000138043
Ras and Rab interactor 2
chr22_-_17499513 1.34 ENSDART00000105460
si:ch211-197g15.6
chr15_+_13984879 1.33 ENSDART00000159438
zgc:162730
chr6_-_49983329 1.32 ENSDART00000113083
agouti signaling protein 1
chr23_-_37536127 1.31 ENSDART00000078253
torsin family 1 like 1
chr23_-_4409668 1.31 ENSDART00000081823
si:ch73-142c19.1
chr25_+_32390794 1.31 ENSDART00000012600
galactokinase 2
chr13_-_50200042 1.31 ENSDART00000074230
protein kinase containing Z-DNA binding domains
chr18_+_13248956 1.30 ENSDART00000080709
phospholipase C, gamma 2
chr5_+_38619813 1.28 ENSDART00000133314
si:ch211-271e10.3
chr18_-_38270077 1.28 ENSDART00000185546
cell cycle associated protein 1b
chr8_+_47188154 1.27 ENSDART00000137319
si:dkeyp-100a1.6
chr3_-_29941357 1.27 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
granulin a
chr18_-_38270596 1.26 ENSDART00000098889
cell cycle associated protein 1b
chr22_+_19405517 1.26 ENSDART00000138245
ENSDART00000155144
si:dkey-78l4.2
chr5_-_38179220 1.25 ENSDART00000147701
si:ch211-284e13.11
chr3_-_1906976 1.25 ENSDART00000180953
zgc:101806
chr22_+_8979955 1.25 ENSDART00000144005
si:ch211-213a13.1
chr7_+_25053331 1.21 ENSDART00000173998
si:dkey-23i12.7
chr22_-_6941098 1.20 ENSDART00000105864
zgc:171500
chr5_+_8919698 1.18 ENSDART00000046440
1-acylglycerol-3-phosphate O-acyltransferase 9, like
chr19_+_7124337 1.17 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr19_+_4066449 1.17 ENSDART00000162461
bloodthirsty-related gene family, member 26
chr9_-_18215644 1.17 ENSDART00000145876
epithelial stromal interaction 1
chr9_+_11293830 1.17 ENSDART00000144440
wingless-type MMTV integration site family, member 6b
chr3_-_45361573 1.17 ENSDART00000154796
interleukin 21 receptor, tandem duplicate 1
chr6_+_59029485 1.15 ENSDART00000050140

chr2_-_37744951 1.14 ENSDART00000144807
myosin IXb
chr17_-_23631400 1.11 ENSDART00000079563
Fas cell surface death receptor
chr5_-_57723929 1.11 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr3_-_32079916 1.10 ENSDART00000040900
BCL2 associated X, apoptosis regulator b
chr10_+_17776981 1.10 ENSDART00000141693
chemokine (C-C motif) ligand 19b
chr5_+_38631119 1.06 ENSDART00000131832
ENSDART00000162215
si:ch211-271e10.6
chr13_+_27232694 1.06 ENSDART00000131128
Ras and Rab interactor 2
chr12_+_38556462 1.03 ENSDART00000021069
ENSDART00000145377
ribosomal protein L38
chr3_+_6291635 1.02 ENSDART00000185055
ENSDART00000157707
si:ch211-12p12.2
chr15_-_5624361 1.01 ENSDART00000176446
ENSDART00000114410
WD repeat domain 62
chr2_-_42035250 0.99 ENSDART00000056460
ENSDART00000140788
guanylate binding protein 1
chr19_+_43878049 0.99 ENSDART00000165261
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr22_-_8692305 0.98 ENSDART00000181602

chr1_-_44928987 0.98 ENSDART00000134635
si:dkey-9i23.15
chr3_+_8826905 0.95 ENSDART00000167474
ENSDART00000168088
si:dkeyp-30d6.2
chr15_+_24572926 0.93 ENSDART00000155636
ENSDART00000187800
dehydrogenase/reductase (SDR family) member 13b
chr6_+_58569808 0.93 ENSDART00000154393
helicase with zinc finger 2, transcriptional coactivator
chr16_-_5115993 0.92 ENSDART00000138654
ttk protein kinase
chr7_+_17908235 0.91 ENSDART00000077113
metastasis associated 1 family, member 2
chr3_-_7997887 0.91 ENSDART00000172256
si:ch211-175l6.2
chr23_-_37575030 0.90 ENSDART00000031875
torsin family 1 like 3
chr20_+_37393134 0.90 ENSDART00000128321
adhesion G protein-coupled receptor G6
chr13_-_50200348 0.89 ENSDART00000038391
protein kinase containing Z-DNA binding domains
chr22_+_36902352 0.88 ENSDART00000036273
tripartite motif containing 35-20
chr9_+_18023288 0.87 ENSDART00000098355
TNF superfamily member 11
chr7_+_3442834 0.87 ENSDART00000138247
si:ch211-285c6.2
chr12_-_35936329 0.86 ENSDART00000166634
ring finger protein 213b
chr1_+_58424507 0.86 ENSDART00000114197
si:ch73-236c18.3
chr1_-_10669436 0.86 ENSDART00000152421
si:dkey-31e10.5
chr23_-_29357764 0.85 ENSDART00000156512
si:ch211-129o18.4
chr22_-_17474781 0.84 ENSDART00000186817
si:ch211-197g15.8
chr1_-_30510839 0.84 ENSDART00000168189
ENSDART00000174868
insulin-like growth factor 2 mRNA binding protein 2b
chr23_-_31266586 0.83 ENSDART00000139746
si:dkey-261l7.2
chr2_+_41926707 0.83 ENSDART00000023208
zgc:110183
chr8_+_22277198 0.81 ENSDART00000005989
DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
chr12_-_17035339 0.80 ENSDART00000152814
interferon-induced protein with tetratricopeptide repeats 9
chr16_-_24703603 0.80 ENSDART00000131167
neuromast-expressed gpi-anchored lymphocyte antigen 6
chr13_-_2112450 0.80 ENSDART00000189343
family with sequence similarity 83, member B
chr11_+_25481046 0.79 ENSDART00000065940
opsin 1 (cone pigments), long-wave-sensitive, 2
chr5_+_27421639 0.78 ENSDART00000146285
cytochrome b561 family, member A3a
chr3_-_22366562 0.78 ENSDART00000129447
interferon phi 1
chr20_-_20402500 0.77 ENSDART00000190747
ENSDART00000185065
protein kinase C, eta, b
chr10_+_26646104 0.77 ENSDART00000187685
adhesion G protein-coupled receptor G4b
chr12_-_4598237 0.75 ENSDART00000152489
interferon regulatory factor 3
chr23_-_31974060 0.74 ENSDART00000168087

chr6_+_32834760 0.74 ENSDART00000121562
cylindromatosis (turban tumor syndrome), like
chr6_+_32834007 0.73 ENSDART00000157353
cylindromatosis (turban tumor syndrome), like
chr15_+_28355023 0.71 ENSDART00000122159
si:dkey-118k5.3
chr9_-_35633827 0.71 ENSDART00000077745
zona pellucida glycoprotein 2, like 1
chr23_+_2666944 0.70 ENSDART00000192861

chr9_+_51147764 0.70 ENSDART00000188480
interferon induced with helicase C domain 1
chr4_+_68776476 0.69 ENSDART00000169135
si:dkey-264f17.3
chr12_-_18578432 0.69 ENSDART00000122858
zinc finger, DHHC-type containing 4
chr19_+_4059200 0.69 ENSDART00000161676
ENSDART00000172424
ENSDART00000161804
bloodthirsty-related gene family, member 25
chr2_+_42005475 0.69 ENSDART00000056461
guanylate binding protein 2
chr2_-_47904043 0.69 ENSDART00000185328
ENSDART00000126740
finTRIM family, member 22
chr15_-_28785512 0.68 ENSDART00000152147
bleomycin hydrolase
chr25_+_14092871 0.68 ENSDART00000067239
guanylate cyclase activator 1g
chr4_-_56673431 0.68 ENSDART00000161464
ENSDART00000191926
si:ch211-227p7.5
chr6_-_19271210 0.67 ENSDART00000163628
ENSDART00000159124
zgc:174863
chr5_-_67661102 0.67 ENSDART00000013605
zinc finger and BTB domain containing 20
chr10_+_26645953 0.65 ENSDART00000131482
adhesion G protein-coupled receptor G4b
chr3_+_36127287 0.65 ENSDART00000058605
ENSDART00000182500
serine carboxypeptidase 1
chr14_+_6159356 0.65 ENSDART00000157730
Bernardinelli-Seip congenital lipodystrophy 2, like
chr12_-_290413 0.65 ENSDART00000152496
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr1_+_58332000 0.64 ENSDART00000145234
gamma-glutamyltransferase 1 like 2.1
chr2_+_16585549 0.64 ENSDART00000134135
si:dkeyp-13a3.10
chr5_+_28497956 0.63 ENSDART00000191935
notochord formation related
chr24_-_28419444 0.63 ENSDART00000105749
negative regulator of reactive oxygen species
chr16_-_43344859 0.62 ENSDART00000058680
proteasome subunit alpha 2
chr15_-_1484795 0.61 ENSDART00000129356
si:dkeyp-97b10.3
chr22_-_30678518 0.61 ENSDART00000138282
si:dkey-42l16.1
chr22_+_19262161 0.61 ENSDART00000163654
si:dkey-21e2.12
chr3_-_4455951 0.60 ENSDART00000193908
ENSDART00000074077
tripartite motif containing 35-3
chr3_-_7961226 0.60 ENSDART00000159801
tripartite motif containing 35-23
chr13_-_2112008 0.59 ENSDART00000110814
family with sequence similarity 83, member B
chr16_-_24703855 0.59 ENSDART00000182422
neuromast-expressed gpi-anchored lymphocyte antigen 6
chr3_+_1724941 0.59 ENSDART00000193402

chr2_+_45479841 0.57 ENSDART00000151856
si:ch211-66k16.28
chr1_+_58360935 0.57 ENSDART00000140754
si:dkey-222h21.1
chr4_-_13567387 0.56 ENSDART00000132971
ENSDART00000102010
Mdm1 nuclear protein homolog (mouse)
chr5_-_45958838 0.56 ENSDART00000135072
POC5 centriolar protein homolog (Chlamydomonas)
chr19_-_24745317 0.55 ENSDART00000142774
si:dkeyp-92c9.3
chr7_-_37563883 0.55 ENSDART00000148805
nucleotide-binding oligomerization domain containing 2
chr4_+_35198656 0.54 ENSDART00000187990
si:dkey-269p2.1
chr2_-_47870649 0.53 ENSDART00000142854
finTRIM family, member 5
chr5_-_37820878 0.53 ENSDART00000165513
Danio rerio uncharacterized LOC567472 (LOC567472), mRNA.
chr4_+_68939595 0.52 ENSDART00000168331
ENSDART00000193212
si:dkey-264f17.2

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.7 2.9 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.7 2.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.5 3.1 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.4 1.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 2.2 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.4 2.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.4 1.3 GO:0043455 regulation of secondary metabolic process(GO:0043455)
0.4 13.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 0.9 GO:1901993 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.3 0.9 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.3 2.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.3 1.1 GO:0070227 lymphocyte apoptotic process(GO:0070227)
0.2 0.7 GO:0005997 xylulose metabolic process(GO:0005997)
0.2 0.6 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.2 1.0 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.2 1.0 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.2 1.1 GO:0032608 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.2 1.5 GO:0031179 peptide modification(GO:0031179)
0.2 1.3 GO:0006012 galactose metabolic process(GO:0006012)
0.2 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 0.8 GO:0030262 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.2 3.4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) antigen processing and presentation of peptide antigen(GO:0048002)
0.2 1.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 5.9 GO:0071346 cellular response to interferon-gamma(GO:0071346)
0.1 1.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 1.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 8.0 GO:0051607 defense response to virus(GO:0051607)
0.1 1.3 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.1 0.5 GO:0034969 histone arginine methylation(GO:0034969)
0.1 1.1 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.1 0.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.7 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 1.2 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.4 GO:0098773 skin epidermis development(GO:0098773)
0.1 1.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 2.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.2 GO:2000561 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 3.4 GO:0061136 regulation of proteasomal protein catabolic process(GO:0061136)
0.0 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.3 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.0 4.2 GO:0017148 negative regulation of translation(GO:0017148)
0.0 2.1 GO:0031638 zymogen activation(GO:0031638)
0.0 16.9 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0 0.1 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 1.1 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 1.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.6 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.4 GO:0036065 fucosylation(GO:0036065)
0.0 0.4 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.3 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 2.4 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.6 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.6 GO:0007632 visual behavior(GO:0007632)
0.0 0.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.1 GO:0030048 actin filament-based movement(GO:0030048)
0.0 1.4 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.9 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 0.7 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.9 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 0.8 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.4 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 13.2 GO:0005839 proteasome core complex(GO:0005839)
0.4 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.4 3.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 2.2 GO:0043186 P granule(GO:0043186)
0.1 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.2 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.1 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.2 GO:0030426 growth cone(GO:0030426)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 9.9 GO:0005764 lysosome(GO:0005764)
0.0 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.9 GO:0000776 kinetochore(GO:0000776)
0.0 1.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.8 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 15.1 GO:0005829 cytosol(GO:0005829)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.7 2.9 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.7 2.1 GO:0009041 uridylate kinase activity(GO:0009041)
0.7 4.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.5 2.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.5 10.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 1.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.3 17.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 2.0 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.2 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.2 1.3 GO:0031779 melanocortin receptor binding(GO:0031779)
0.2 1.5 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.2 0.5 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 1.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 5.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 2.0 GO:0031386 protein tag(GO:0031386)
0.1 0.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.4 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.1 2.2 GO:0019894 kinesin binding(GO:0019894)
0.1 0.4 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 1.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 12.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.7 GO:0030250 calcium sensitive guanylate cyclase activator activity(GO:0008048) cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1 3.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.6 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.5 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.9 GO:0043236 laminin binding(GO:0043236)
0.0 1.3 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 1.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.8 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 1.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0051117 ATPase binding(GO:0051117)
0.0 1.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.1 GO:0004175 endopeptidase activity(GO:0004175)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 2.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 7.7 GO:0005525 GTP binding(GO:0005525)
0.0 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.8 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 1.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 3.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 5.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 4.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 1.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 6.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 2.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 1.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 1.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 0.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 1.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.6 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 1.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 3.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA