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PRJNA207719: Tissue specific transcriptome profiling
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Results for ikzf1
Z-value: 1.43
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Transcription factors associated with ikzf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ikzf1 | dr11_v1_chr13_-_15994419_15994472 | 0.27 | 6.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_29161609 Show fit | 1.03 |
ENSDART00000180752
|
pyruvate kinase M1/2b |
|
| chr5_-_71722257 Show fit | 0.97 |
ENSDART00000013404
|
adenylate kinase 1 |
|
| chr5_+_32222303 Show fit | 0.77 |
ENSDART00000051362
|
myosin heavy chain 4 |
|
| chr3_-_32817274 Show fit | 0.76 |
ENSDART00000142582
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr23_-_23256726 Show fit | 0.72 |
ENSDART00000131353
|
si:dkey-98j1.5 |
|
| chr8_-_18535822 Show fit | 0.68 |
ENSDART00000100558
|
nexilin (F actin binding protein) |
|
| chr6_-_39764995 Show fit | 0.65 |
ENSDART00000085277
|
phosphofructokinase, muscle b |
|
| chr13_-_2189761 Show fit | 0.63 |
ENSDART00000166255
|
muscular LMNA-interacting protein |
|
| chr6_-_29195642 Show fit | 0.62 |
ENSDART00000078625
|
dermatopontin |
|
| chr7_+_39386982 Show fit | 0.61 |
ENSDART00000146702
|
troponin I type 2b (skeletal, fast), tandem duplicate 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ikzf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0006172 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) |
| 0.3 | 0.9 | GO:0003223 | ventricular compact myocardium morphogenesis(GO:0003223) |
| 0.1 | 0.7 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.1 | 0.7 | GO:0006007 | glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.7 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.0 | 0.6 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 0.5 | GO:1904825 | protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825) |
| 0.0 | 0.5 | GO:0042761 | very long-chain fatty acid biosynthetic process(GO:0042761) |
| 0.1 | 0.4 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.4 | GO:0043649 | dicarboxylic acid catabolic process(GO:0043649) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 1.3 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 0.9 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.1 | 0.7 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.4 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.4 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.2 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.7 | GO:0070095 | 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095) |
| 0.2 | 0.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.6 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.6 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.0 | 0.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.5 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.3 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 0.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.2 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |