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PRJNA207719: Tissue specific transcriptome profiling

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Results for hoxa9a+hoxa9b

Z-value: 1.12

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Transcription factors associated with hoxa9a+hoxa9b

Gene Symbol Gene ID Gene Info
ENSDARG00000056819 homeobox A9b
ENSDARG00000105013 homeobox A9a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa9bdr11_v1_chr16_+_20915319_209153190.543.5e-01Click!
hoxa9adr11_v1_chr19_+_19750101_197502230.513.8e-01Click!

Activity profile of hoxa9a+hoxa9b motif

Sorted Z-values of hoxa9a+hoxa9b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_6576940 1.27 ENSDART00000138135
V-set and immunoglobulin domain containing 8b
chr24_+_38301080 0.94 ENSDART00000105672
myosin binding protein C, fast type b
chr3_+_32526263 0.82 ENSDART00000150897
si:ch73-367p23.2
chr6_-_46875310 0.75 ENSDART00000154442
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr22_-_5323482 0.70 ENSDART00000145785
sphingosine-1-phosphate receptor 4
chr16_+_34111919 0.67 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr3_+_33300522 0.67 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr1_-_33647138 0.67 ENSDART00000142111
ENSDART00000015547
claudin g
chr5_+_2815021 0.66 ENSDART00000020472
4-hydroxyphenylpyruvate dioxygenase a
chr9_+_48007081 0.65 ENSDART00000060593
ENSDART00000099835
zgc:92380
chr6_+_55032439 0.64 ENSDART00000164232
ENSDART00000158845
ENSDART00000157584
ENSDART00000026359
ENSDART00000122794
ENSDART00000183742
myosin binding protein Hb
chr19_-_10425140 0.63 ENSDART00000145319
si:ch211-171h4.3
chr20_-_33959815 0.62 ENSDART00000133081
selectin P
chr11_-_6048490 0.59 ENSDART00000066164
plasmalemma vesicle associated protein b
chr7_+_39386982 0.58 ENSDART00000146702
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr7_+_35268880 0.56 ENSDART00000182231
dipeptidase 2
chr13_+_13681681 0.56 ENSDART00000057825
complement factor D (adipsin)
chr7_-_8417315 0.54 ENSDART00000173046
jacalin 1
chr1_-_7603734 0.54 ENSDART00000009315
myxovirus (influenza) resistance B
chr7_+_69841017 0.54 ENSDART00000169107

chr21_-_27338639 0.53 ENSDART00000130632
hypoxia-inducible factor 1, alpha subunit, like 2
chr23_+_5631381 0.52 ENSDART00000149143
plakophilin 1a
chr9_-_23807032 0.52 ENSDART00000027443
extended synaptotagmin-like protein 3
chr2_-_10338759 0.50 ENSDART00000150166
ENSDART00000149584
guanine nucleotide binding protein (G protein), gamma 12a
chr6_+_50451337 0.50 ENSDART00000155051
myelocytomatosis oncogene homolog
chr7_+_31879986 0.49 ENSDART00000138491
myosin binding protein C, cardiac
chr16_-_45152169 0.48 ENSDART00000171452
si:ch73-343g19.4
chr5_-_8682590 0.47 ENSDART00000142762
zgc:153352
chr3_+_40809011 0.46 ENSDART00000033713
actin related protein 2/3 complex, subunit 1B
chr16_-_22192006 0.46 ENSDART00000163338
interleukin 6 receptor
chr7_+_31879649 0.46 ENSDART00000099789
myosin binding protein C, cardiac
chr16_-_16761164 0.46 ENSDART00000135872
si:dkey-27n14.1
chr15_+_32711172 0.45 ENSDART00000163936
ENSDART00000168135
periostin, osteoblast specific factor b
chr21_+_11969603 0.45 ENSDART00000142247
ENSDART00000140652
motilin-like
chr6_+_27338512 0.45 ENSDART00000155004
kelch-like family member 30
chr5_-_22590124 0.44 ENSDART00000172353
si:dkey-103e21.5
chr1_-_11642432 0.43 ENSDART00000139755
ENSDART00000115316
si:dkey-26i13.4
chr17_+_1323699 0.43 ENSDART00000172540
adenylosuccinate synthase like 1
chr5_-_32274383 0.43 ENSDART00000122889
myosin, heavy polypeptide 1.3, skeletal muscle
chr1_+_45056371 0.43 ENSDART00000073689
ENSDART00000167309
bloodthirsty-related gene family, member 1
chr7_-_60096318 0.42 ENSDART00000189125

chr4_-_16354292 0.42 ENSDART00000139919
lumican
chr12_-_4346085 0.42 ENSDART00000112433
carbonic anhydrase XV c
chr24_-_4765740 0.41 ENSDART00000121576
carboxypeptidase B1 (tissue)
chr9_-_9415000 0.41 ENSDART00000146210
si:ch211-214p13.9
chr1_-_58900851 0.41 ENSDART00000183085
ENSDART00000188855
ENSDART00000182567
Danio rerio microfibril-associated glycoprotein 4-like (LOC100334800), transcript variant 2, mRNA.
chr1_+_7546259 0.41 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr3_+_5087787 0.41 ENSDART00000162787
si:ch73-338o16.4
chr21_-_20840714 0.40 ENSDART00000144861
ENSDART00000139430
complement component 6
chr13_-_37619159 0.40 ENSDART00000186348
zgc:152791
chr7_+_26545911 0.40 ENSDART00000135313
tyrosine kinase, non-receptor, 1
chr7_-_16598212 0.40 ENSDART00000128488
E2F transcription factor 8
chr3_+_46425262 0.40 ENSDART00000153690
sc:d0202
chr22_+_7480465 0.40 ENSDART00000034545
zgc:92745
chr8_+_32402441 0.40 ENSDART00000191451
epithelial mitogen homolog (mouse)
chr16_+_29509133 0.40 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr11_-_40457325 0.40 ENSDART00000128442
tumor necrosis factor receptor superfamily, member 1B
chr8_-_2616326 0.39 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr3_+_57820913 0.39 ENSDART00000168101

chr2_-_3437862 0.39 ENSDART00000053012
cytochrome P450, family 8, subfamily B, polypeptide 1
chr25_-_3830272 0.39 ENSDART00000055843
CD151 molecule
chr1_+_1805294 0.39 ENSDART00000103850
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr24_-_27419198 0.38 ENSDART00000141124
chemokine (C-C motif) ligand 34b, duplicate 4
chr11_+_36243774 0.38 ENSDART00000023323
zgc:172270
chr17_-_114121 0.38 ENSDART00000172408
ENSDART00000157784
Rho GTPase activating protein 11A
chr12_-_26406323 0.38 ENSDART00000131896
myozenin 1b
chr20_+_6142433 0.38 ENSDART00000054084
ENSDART00000136986
transthyretin (prealbumin, amyloidosis type I)
chr13_-_37620091 0.38 ENSDART00000135875
ENSDART00000193270
ENSDART00000018064
zgc:152791
chr22_+_22437561 0.37 ENSDART00000089622
kinesin family member 14
chr23_-_3758637 0.37 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
high mobility group AT-hook 1a
chr16_-_26855936 0.37 ENSDART00000167320
ENSDART00000078119
INO80 complex subunit C
chr1_-_52431220 0.37 ENSDART00000111256
zgc:194101
chr1_-_681116 0.37 ENSDART00000165894
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_+_11107688 0.37 ENSDART00000109858
kinetochore-localized astrin/SPAG5 binding protein
chr13_+_30228077 0.37 ENSDART00000100813
ENSDART00000147729
ENSDART00000133404
ribosomal protein S24
chr3_-_3209432 0.36 ENSDART00000140635
si:ch211-229i14.2
chr16_+_52966812 0.36 ENSDART00000148435
ENSDART00000049099
ENSDART00000150117
thyroid hormone receptor interactor 13
chr8_+_3405612 0.36 ENSDART00000163437
zgc:112433
chr24_-_12938922 0.36 ENSDART00000024084
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr7_-_4461104 0.36 ENSDART00000023090
ENSDART00000140770
solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 1
chr10_-_8053753 0.36 ENSDART00000162289
si:ch211-251f6.7
chr22_-_10541372 0.36 ENSDART00000179708
si:dkey-42i9.4
chr20_+_29634653 0.35 ENSDART00000101556
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2b
chr7_-_69853453 0.35 ENSDART00000049928
myozenin 2a
chr14_+_22022441 0.35 ENSDART00000149121
cardiotrophin-like cytokine factor 1
chr7_-_41851605 0.35 ENSDART00000142981
myosin light chain kinase 3
chr3_+_21200763 0.35 ENSDART00000067841
zgc:112038
chr7_+_30626378 0.34 ENSDART00000173533
ENSDART00000052541
cyclin B2
chr3_+_23743139 0.34 ENSDART00000187409
homeobox B3a
chr25_-_35497055 0.34 ENSDART00000009271
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr11_+_36675599 0.34 ENSDART00000170464
si:ch211-11c3.11
chr1_+_57145072 0.34 ENSDART00000152776
si:ch73-94k4.4
chr19_-_15229421 0.33 ENSDART00000055619
phosphatase and actin regulator 4a
chr14_+_41345175 0.33 ENSDART00000086104
NADPH oxidase 1
chr4_-_16353733 0.33 ENSDART00000186785
lumican
chr20_-_26491567 0.33 ENSDART00000147154
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr23_+_19790962 0.33 ENSDART00000142228
filamin A, alpha (actin binding protein 280)
chr5_+_32206378 0.33 ENSDART00000126873
ENSDART00000051361
myosin, heavy polypeptide 2, fast muscle specific
chr7_+_13988075 0.33 ENSDART00000186812
furin (paired basic amino acid cleaving enzyme) a
chr3_+_21189766 0.33 ENSDART00000078807
zgc:123295
chr19_+_17385561 0.33 ENSDART00000141397
ENSDART00000143913
ENSDART00000133626
ribosomal protein L15
chr7_-_38659477 0.32 ENSDART00000138071
nephrosin
chr1_+_57187794 0.32 ENSDART00000152485
si:dkey-27j5.9
chr9_-_9992697 0.32 ENSDART00000123415
UDP glucuronosyltransferase 1 family a, b
chr23_-_3759345 0.32 ENSDART00000132205
ENSDART00000137707
ENSDART00000189382
high mobility group AT-hook 1a
chr22_+_28446365 0.32 ENSDART00000189359
ABI family, member 3 (NESH) binding protein b
chr17_-_2595736 0.32 ENSDART00000128797
zona pellucida glycoprotein 3, tandem duplicate 2
chr16_-_13516745 0.31 ENSDART00000145410
si:dkeyp-69b9.3
chr8_-_23599096 0.31 ENSDART00000183096
solute carrier family 38, member 5b
chr23_+_18722715 0.31 ENSDART00000137438
myosin, heavy chain 7B, cardiac muscle, beta b
chr3_-_32957702 0.31 ENSDART00000146586
caspase 6, apoptosis-related cysteine peptidase, like 1
chr7_-_35393900 0.31 ENSDART00000173769
lysophosphatidylcholine acyltransferase 2
chr8_-_32803227 0.31 ENSDART00000110079
zgc:194839
chr17_+_25833947 0.31 ENSDART00000044328
ENSDART00000154604
acyl-CoA synthetase short chain family member 1
chr4_-_1147655 0.31 ENSDART00000171561
si:ch211-117i20.2
chr7_+_48761875 0.30 ENSDART00000003690
aggrecan a
chr5_+_36932718 0.30 ENSDART00000037879
cone-rod homeobox
chr19_+_19775757 0.30 ENSDART00000164677
homeobox A3a
chr13_-_33134611 0.30 ENSDART00000026280
pleckstrin 2
chr3_-_32958505 0.30 ENSDART00000147374
ENSDART00000136919
caspase 6, apoptosis-related cysteine peptidase, like 1
chr7_-_8374950 0.30 ENSDART00000057101
aerolysin-like protein
chr12_-_6172154 0.30 ENSDART00000185434
apobec1 complementation factor
chr25_+_3549584 0.30 ENSDART00000165913
coiled-coil domain containing 77
chr23_-_45897900 0.29 ENSDART00000149263
finTRIM family, member 92
chr4_+_72797711 0.29 ENSDART00000190934
ENSDART00000163236
myelin regulatory factor-like
chr11_-_45216211 0.29 ENSDART00000173211
transmembrane channel-like 8
chr10_-_8046764 0.29 ENSDART00000099031
zgc:136254
chr9_-_30258957 0.29 ENSDART00000144259
si:dkey-100n23.5
chr4_+_15944245 0.29 ENSDART00000134594
si:dkey-117n7.3
chr1_+_38142354 0.29 ENSDART00000179352
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr23_-_31506854 0.28 ENSDART00000131352
ENSDART00000138625
ENSDART00000133002
EYA transcriptional coactivator and phosphatase 4
chr22_+_28446557 0.28 ENSDART00000089546
ABI family, member 3 (NESH) binding protein b
chr23_-_21215311 0.28 ENSDART00000112424
multiple EGF-like-domains 6a
chr11_-_25213651 0.28 ENSDART00000097316
ENSDART00000152186
myosin, heavy chain 7B, cardiac muscle, beta a
chr23_-_24263474 0.28 ENSDART00000160312
heat shock protein family, member 7 (cardiovascular)
chr21_-_13690712 0.28 ENSDART00000065817
POU domain, class 5, transcription factor 3
chr18_+_16426266 0.28 ENSDART00000136626
si:dkey-287h13.1
chr14_+_23520986 0.28 ENSDART00000170473
ENSDART00000175970
si:ch211-221f10.2
chr20_+_2281933 0.28 ENSDART00000137579
si:ch73-18b11.2
chr4_+_37936839 0.27 ENSDART00000164505
si:dkeyp-82b4.2
chr19_-_3777217 0.27 ENSDART00000160510
si:dkey-206d17.15
chr24_-_6078222 0.27 ENSDART00000146830
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_+_52927651 0.27 ENSDART00000141094
si:dkeyp-3f10.11
chr21_+_11749097 0.27 ENSDART00000102408
ENSDART00000102404
elongation factor, RNA polymerase II, 2
chr17_-_30652738 0.27 ENSDART00000154960
SH3 and SYLF domain containing 1
chr2_+_36112273 0.27 ENSDART00000191315
T-cell receptor alpha joining 35
chr2_+_42715995 0.27 ENSDART00000143419
ENSDART00000183914
ENSDART00000184371
ENSDART00000185485
ENSDART00000037332
finTRIM family, member 12
chr24_-_23998897 0.27 ENSDART00000130053
zmp:0000000991
chr25_+_16214854 0.27 ENSDART00000109672
ENSDART00000190093
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr7_-_24046999 0.26 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dehydrogenase/reductase (SDR family) member 4
chr19_-_27550768 0.26 ENSDART00000142313
si:dkeyp-46h3.8
chr7_-_20453661 0.26 ENSDART00000174001
netrin 5
chr10_-_35410518 0.26 ENSDART00000048430
gamma-aminobutyric acid (GABA) A receptor, rho 3a
chr25_-_36362958 0.26 ENSDART00000189965
zgc:165555
chr23_-_21215520 0.26 ENSDART00000143206
multiple EGF-like-domains 6a
chr11_+_141504 0.26 ENSDART00000086166
zgc:172352
chr1_+_58375871 0.26 ENSDART00000166736

chr16_-_17175731 0.26 ENSDART00000183057
opsin 9
chr23_+_43718115 0.25 ENSDART00000149266
ENSDART00000149503
anaphase promoting complex subunit 10
chr10_-_8053385 0.25 ENSDART00000142714
si:ch211-251f6.7
chr8_-_7093507 0.25 ENSDART00000045669
si:dkey-222n6.2
chr15_+_21202820 0.25 ENSDART00000154036
si:dkey-52d15.2
chr19_+_19762183 0.25 ENSDART00000163611
ENSDART00000187604
homeobox A3a
chr21_-_21828261 0.25 ENSDART00000151181
defensin, beta-like 2
chr9_-_51563575 0.25 ENSDART00000167034
ENSDART00000148918
TRAF family member-associated NFKB activator
chr19_+_28256076 0.25 ENSDART00000133354
iroquois homeobox 4b
chr6_-_43047774 0.25 ENSDART00000161722
glycerate kinase
chr12_-_32421046 0.25 ENSDART00000075567
ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1
chr3_+_50602866 0.25 ENSDART00000190069
ENSDART00000153921
gsg1-like 2a
chr7_+_26545502 0.25 ENSDART00000140528
tyrosine kinase, non-receptor, 1
chr12_-_36268723 0.25 ENSDART00000113740
potassium inwardly-rectifying channel, subfamily J, member 16
chr8_-_38159805 0.25 ENSDART00000112331
ENSDART00000180006
adhesion G protein-coupled receptor A2
chr4_+_16715267 0.25 ENSDART00000143849
plakophilin 2
chr13_+_40501455 0.24 ENSDART00000114985
heparanase 2
chr21_+_18997511 0.24 ENSDART00000145591
ribosomal protein L17
chr5_-_38197080 0.24 ENSDART00000140708
si:ch211-284e13.9
chr8_-_36399884 0.24 ENSDART00000108538
si:zfos-2070c2.3
chr12_-_11258404 0.24 ENSDART00000149229
si:ch73-30l9.1
chr16_+_3982590 0.24 ENSDART00000149295
zinc finger CCCH-type containing 12A
chr12_-_29305533 0.24 ENSDART00000189410
SH2 domain containing 4Bb
chr22_-_20695237 0.24 ENSDART00000112722
oogenesis-related gene
chr6_-_43283122 0.24 ENSDART00000186022
FERM domain containing 4Ba
chr22_+_15624371 0.24 ENSDART00000124868
lipoprotein lipase
chr18_+_33725576 0.24 ENSDART00000146816
si:dkey-145c18.5
chr6_-_25165693 0.24 ENSDART00000167259
zinc finger protein 326
chr21_+_11401247 0.24 ENSDART00000143952
carboxyl ester lipase, tandem duplicate 1
chr12_-_30558694 0.24 ENSDART00000153417
si:ch211-28p3.3
chr25_+_36349574 0.24 ENSDART00000184101
zgc:173552
chr19_-_30447611 0.24 ENSDART00000073705
ENSDART00000048977
ENSDART00000191237
ATP-binding cassette, sub-family F (GCN20), member 1
chr24_+_18286427 0.24 ENSDART00000055443
thiamin pyrophosphokinase 1
chr7_+_48761646 0.23 ENSDART00000017467
aggrecan a
chr3_+_23742868 0.23 ENSDART00000153512
homeobox B3a
chr20_-_38758797 0.23 ENSDART00000061394
tripartite motif containing 54
chr9_+_50175366 0.23 ENSDART00000170352
cordon-bleu WH2 repeat protein-like 1b
chr4_+_12340655 0.23 ENSDART00000168487
Pim proto-oncogene, serine/threonine kinase, related 214
chr15_-_452347 0.23 ENSDART00000115233
V-set and transmembrane domain containing 5
chr15_+_37986069 0.23 ENSDART00000156984
si:dkey-238d18.8
chr1_-_58664854 0.23 ENSDART00000109528
adhesion G protein-coupled receptor E5b, duplicate 3
chr16_-_43041324 0.23 ENSDART00000155445
ENSDART00000156836
ENSDART00000154945
si:dkey-7j14.6
chr23_+_11374168 0.23 ENSDART00000163083
cell adhesion molecule L1-like a

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa9a+hoxa9b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0003210 cardiac atrium formation(GO:0003210)
0.2 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.0 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 0.6 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.1 0.4 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.1 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.4 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.1 0.4 GO:0071548 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.1 0.5 GO:0003151 outflow tract morphogenesis(GO:0003151)
0.1 0.3 GO:0090008 convergent extension involved in nephron morphogenesis(GO:0072045) hypoblast development(GO:0090008)
0.1 0.2 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.1 0.2 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229)
0.1 0.3 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 0.3 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.1 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.2 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.2 GO:0015677 copper ion import(GO:0015677)
0.1 0.3 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 0.4 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.3 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.0 0.3 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.4 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.0 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.3 GO:0042554 superoxide anion generation(GO:0042554)
0.0 0.4 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.4 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.4 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.6 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 0.2 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.0 0.1 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.3 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.2 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 0.3 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.3 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.0 0.1 GO:0051876 pigment granule dispersal(GO:0051876)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.5 GO:0016203 muscle attachment(GO:0016203)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.4 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.3 GO:0016556 mRNA modification(GO:0016556)
0.0 0.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.1 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.5 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.5 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:1901655 cellular response to ketone(GO:1901655)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0071939 vitamin transmembrane transport(GO:0035461) vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.3 GO:0060046 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0036076 ligamentous ossification(GO:0036076)
0.0 0.1 GO:2000562 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.1 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.1 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.0 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.0 0.1 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.7 GO:0006354 DNA-templated transcription, elongation(GO:0006354)
0.0 0.6 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.0 GO:0097623 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.0 0.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0044609 DBIRD complex(GO:0044609)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.3 GO:0014704 intercalated disc(GO:0014704)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0030428 cell septum(GO:0030428)
0.0 0.2 GO:0042627 chylomicron(GO:0042627)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.1 0.4 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
0.1 0.6 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 0.3 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.3 GO:0005549 odorant binding(GO:0005549)
0.1 0.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 1.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.3 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1 0.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.2 GO:0004788 thiamine diphosphokinase activity(GO:0004788) thiamine binding(GO:0030975)
0.1 0.7 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 0.2 GO:0008887 glycerate kinase activity(GO:0008887)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.3 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.4 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.2 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.0 0.3 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.1 GO:0051380 norepinephrine binding(GO:0051380)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.3 GO:0070697 activin receptor binding(GO:0070697)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048) cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0043531 ADP binding(GO:0043531)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.1 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+