ISMARA results: hoxa1a+hoxb1b-1+hoxc1a

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PRJNA207719: Tissue specific transcriptome profiling

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Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 1.88

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Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Gene Symbol	Gene ID	Gene Info
hoxb1b-1 NCBI UniProt	ENSDARG00000054033	homeobox B1b
hoxc1a NCBI UniProt	ENSDARG00000070337	homeobox C1a
hoxa1a NCBI UniProt	ENSDARG00000104307	homeobox A1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxc1a	dr11_v1_chr23_+_36178104_36178104	0.77	1.3e-01	Click!
hoxa1a	dr11_v1_chr19_+_19786117_19786213	0.72	1.7e-01	Click!
hoxb1b	dr11_v1_chr12_+_27141140_27141140	0.33	5.9e-01	Click!

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_51370293 Show fit	2.41	ENSDART00000084806	slc4a10b NCBI UniProt Show fit	solute carrier family 4, sodium bicarbonate transporter, member 10b
chr25_+_7461624 Show fit	1.92	ENSDART00000170569	syt12 NCBI UniProt Show fit	synaptotagmin XII
chr12_-_25916530 Show fit	1.89	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr10_+_466926 Show fit	1.74	ENSDART00000145220	arvcfa NCBI UniProt Show fit	ARVCF, delta catenin family member a
chr22_-_600016 Show fit	1.51	ENSDART00000086434	tmcc2 NCBI UniProt Show fit	transmembrane and coiled-coil domain family 2
chr11_-_1131569 Show fit	1.51	ENSDART00000173228	slc6a11b NCBI UniProt Show fit	solute carrier family 6 (neurotransmitter transporter), member 11b
chr20_-_9462433 Show fit	1.46	ENSDART00000152674 ENSDART00000040557	zgc:101840 NCBI UniProt Show fit	zgc:101840
chr7_-_72067475 Show fit	1.44	ENSDART00000017763	LO018380.1 NCBI UniProt Show fit
chr14_-_7888748 Show fit	1.41	ENSDART00000166293	ppp3cb NCBI UniProt Show fit	protein phosphatase 3, catalytic subunit, beta isozyme
chr23_-_12015139 Show fit	1.21	ENSDART00000110627 ENSDART00000193988 ENSDART00000184528	si:dkey-178k16.1 NCBI UniProt Show fit	si:dkey-178k16.1

Showing 1 to 10 of 174 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	3.5	GO:0006814	sodium ion transport(GO:0006814)
0.1	2.4	GO:0015701	bicarbonate transport(GO:0015701)
0.8	2.3	GO:0060838	lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.1	1.9	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.1	1.9	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.1	1.7	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	1.7	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1	1.6	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.3	1.5	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0070382	exocytic vesicle(GO:0070382)
0.0	2.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	2.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	2.2	GO:0099634	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1	1.9	GO:0043679	axon terminus(GO:0043679)
0.2	1.4	GO:0005955	calcineurin complex(GO:0005955)
0.2	1.2	GO:0042584	chromaffin granule membrane(GO:0042584)
0.0	1.2	GO:0005871	kinesin complex(GO:0005871)
0.0	1.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	1.0	GO:0005790	smooth endoplasmic reticulum(GO:0005790)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.2	2.4	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.3	2.3	GO:0001972	retinoic acid binding(GO:0001972)
0.0	2.3	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	2.2	GO:0015026	coreceptor activity(GO:0015026)
0.6	1.9	GO:1903136	cuprous ion binding(GO:1903136)
0.0	1.7	GO:0045296	cadherin binding(GO:0045296)
0.1	1.5	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.2	1.4	GO:0033192	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	1.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	2.2	PID BMP PATHWAY	BMP receptor signaling
0.1	1.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.2	1.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.7	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.6	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.4	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	2.2	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	1.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	1.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	0.6	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.6	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.1	0.5	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.5	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.5	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway

Showing 1 to 10 of 13 entries

Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 1.88

Motif logo

Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Activity-expression correlation:

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: