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PRJNA207719: Tissue specific transcriptome profiling

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Results for hnf1ba+hnf1bb

Z-value: 4.85

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Transcription factors associated with hnf1ba+hnf1bb

Gene Symbol Gene ID Gene Info
hnf1ba
ENSDARG00000006615 HNF1 homeobox Ba
hnf1bb
ENSDARG00000022295 HNF1 homeobox Bb
hnf1ba
ENSDARG00000115522 HNF1 homeobox Ba

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1badr11_v1_chr15_-_16012963_160129630.922.8e-02Click!
hnf1bbdr11_v1_chr21_+_38817785_388178430.875.6e-02Click!

Activity profile of hnf1ba+hnf1bb motif

Sorted Z-values of hnf1ba+hnf1bb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_23440632 7.11 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr20_-_40750953 7.03 ENSDART00000061256
cx28.9
connexin 28.9
chr22_-_24791505 7.01 ENSDART00000136837
vtg4
vitellogenin 4
chr1_+_10051763 6.51 ENSDART00000011701
fgb
fibrinogen beta chain
chr22_-_24880824 6.11 ENSDART00000061165
vtg2
vitellogenin 2
chr5_+_32345187 6.10 ENSDART00000147132
c9
complement component 9
chr22_-_24738188 6.03 ENSDART00000050238
vtg1
vitellogenin 1
chr6_+_60055168 5.81 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_+_1486822 5.72 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr2_+_1487118 5.64 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr20_-_40754794 5.56 ENSDART00000187251
cx32.3
connexin 32.3
chr11_-_37997419 5.56 ENSDART00000102870
slc41a1
solute carrier family 41 (magnesium transporter), member 1
chr22_-_24818066 5.53 ENSDART00000143443
vtg6
vitellogenin 6
chr23_+_25856541 5.39 ENSDART00000145426
ENSDART00000028236
hnf4a
hepatocyte nuclear factor 4, alpha
chr22_-_23668356 5.24 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
cfh
complement factor H
chr2_-_41942666 5.11 ENSDART00000075673
ebi3
Epstein-Barr virus induced 3
chr13_+_23988442 5.04 ENSDART00000010918
agt
angiotensinogen
chr15_+_28202170 4.86 ENSDART00000077736
vtna
vitronectin a
chr1_-_12126535 4.63 ENSDART00000164817
ENSDART00000015251
mttp
microsomal triglyceride transfer protein
chr20_+_10538025 4.42 ENSDART00000129762
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr5_+_45677781 4.36 ENSDART00000163120
ENSDART00000126537
gc
group-specific component (vitamin D binding protein)
chr22_-_24757785 4.20 ENSDART00000078225
vtg5
vitellogenin 5
chr2_-_5466708 4.07 ENSDART00000136682
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
chr5_+_28830388 4.05 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_-_22294265 3.99 ENSDART00000124718
aqp10a
aquaporin 10a
chr2_-_5475910 3.91 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
proca
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr10_+_21867307 3.81 ENSDART00000126629
cbln17
cerebellin 17
chr22_-_23706771 3.80 ENSDART00000159771
cfhl1
complement factor H like 1
chr23_+_28770225 3.78 ENSDART00000132179
ENSDART00000142273
masp2
mannan-binding lectin serine peptidase 2
chr14_+_38654300 3.76 ENSDART00000148938
ENSDART00000150107
rnasel3
ribonuclease like 3
chr6_-_59563597 3.72 ENSDART00000166311
INHBE
inhibin beta E subunit
chr22_-_23748284 3.67 ENSDART00000162005
cfhl2
complement factor H like 2
chr5_+_28830643 3.65 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr22_-_23781083 3.54 ENSDART00000166563
ENSDART00000170458
ENSDART00000166158
ENSDART00000171246
cfhl3
complement factor H like 3
chr20_+_10544100 3.48 ENSDART00000113927
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr24_-_17039638 3.47 ENSDART00000048823
c8g
complement component 8, gamma polypeptide
chr12_-_6177894 3.45 ENSDART00000152292
a1cf
apobec1 complementation factor
chr5_+_28848870 3.41 ENSDART00000149563
zgc:174259
zgc:174259
chr5_+_28849155 3.38 ENSDART00000079090
zgc:174259
zgc:174259
chr2_-_127945 3.30 ENSDART00000056453
igfbp1b
insulin-like growth factor binding protein 1b
chr22_+_21317597 3.21 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr3_-_16760923 3.14 ENSDART00000055855
aspdh
aspartate dehydrogenase domain containing
chr14_+_32430982 3.13 ENSDART00000017179
ENSDART00000123382
ENSDART00000075593
f9a
coagulation factor IXa
chr23_+_26491931 3.09 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
si:ch73-206d17.1
chr21_+_38002879 3.08 ENSDART00000065183
cldn2
claudin 2
chr2_+_26647472 3.05 ENSDART00000145415
ENSDART00000157409
ttpa
tocopherol (alpha) transfer protein
chr3_+_26734162 2.91 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr20_-_40755614 2.90 ENSDART00000061247
cx32.3
connexin 32.3
chr6_+_10094061 2.87 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr5_+_28858345 2.81 ENSDART00000111180
si:ch211-186e20.2
si:ch211-186e20.2
chr16_+_26777473 2.73 ENSDART00000188870
cdh17
cadherin 17, LI cadherin (liver-intestine)
chr13_-_40726865 2.72 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr20_-_23440955 2.66 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr7_-_4296771 2.56 ENSDART00000128855
cbln11
cerebellin 11
chr10_-_17159761 2.25 ENSDART00000080449
slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr22_+_16555939 2.19 ENSDART00000012604
pdzk1ip1
PDZK1 interacting protein 1
chr8_+_30699429 2.05 ENSDART00000005345
upb1
ureidopropionase, beta
chr10_+_25369859 2.00 ENSDART00000047541
bach1b
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr5_-_12063381 1.98 ENSDART00000026749
nipsnap1
nipsnap homolog 1 (C. elegans)
chr8_+_15254564 1.95 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr9_+_21151138 1.93 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr10_+_25369254 1.89 ENSDART00000164375
bach1b
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr10_+_25726694 1.87 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr16_-_42894628 1.86 ENSDART00000045600
hfe2
hemochromatosis type 2
chr7_-_27696958 1.84 ENSDART00000173470
calca
calcitonin/calcitonin-related polypeptide, alpha
chr18_-_48550426 1.72 ENSDART00000145189
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr25_-_35497055 1.70 ENSDART00000009271
slc5a12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr9_-_8314028 1.67 ENSDART00000102739
si:ch211-145c1.1
si:ch211-145c1.1
chr5_-_30620625 1.64 ENSDART00000098273
tcnl
transcobalamin like
chr1_+_12178215 1.57 ENSDART00000090380
stra6l
STRA6-like
chr4_+_18804317 1.51 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr8_-_53490376 1.46 ENSDART00000158789
chdh
choline dehydrogenase
chr13_-_23666579 1.46 ENSDART00000192457
ENSDART00000179777
map3k21
mitogen-activated protein kinase kinase kinase 21
chr9_+_30720048 1.44 ENSDART00000146115
klf12b
Kruppel-like factor 12b
chr7_+_27317174 1.44 ENSDART00000193058
sox6
SRY (sex determining region Y)-box 6
chr5_-_37886063 1.38 ENSDART00000131378
ENSDART00000132152
si:ch211-139a5.9
si:ch211-139a5.9
chr6_+_7977611 1.36 ENSDART00000112290
palm3
paralemmin 3
chr9_+_29994439 1.34 ENSDART00000012447
tmem30c
transmembrane protein 30C
chr18_-_48492951 1.30 ENSDART00000146346
kcnj1a.6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr12_+_5209822 1.29 ENSDART00000152610
SLC35G1
si:ch211-197g18.2
chr2_-_7845110 1.25 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr24_-_21913426 1.22 ENSDART00000081178
c1qtnf9
C1q and TNF related 9
chr25_+_23280220 1.21 ENSDART00000153940
ptprjb.1
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr5_+_57480014 1.18 ENSDART00000135520
si:ch211-202f5.3
si:ch211-202f5.3
chr12_-_3940768 1.15 ENSDART00000134292
zgc:92040
zgc:92040
chr19_+_19772765 1.15 ENSDART00000182028
ENSDART00000161019
hoxa3a
homeobox A3a
chr5_-_42904329 1.14 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr15_+_25156121 1.04 ENSDART00000189709
slc35f2l
info solute carrier family 35, member F2, like
chr23_+_27740592 1.01 ENSDART00000137875
dhh
desert hedgehog
chr5_-_67661102 0.99 ENSDART00000013605
zbtb20
zinc finger and BTB domain containing 20
chr11_-_19501439 0.99 ENSDART00000158328
ENSDART00000103983
slc2a9l1
solute carrier family 2 (facilitated glucose transporter), member 9-like 1
chr18_-_48500545 0.97 ENSDART00000058989
ENSDART00000098450
kcnj1a.6
kcnj1a.5
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 5
chr23_-_20345473 0.95 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr23_+_27740788 0.94 ENSDART00000053871
dhh
desert hedgehog
chr25_-_27541621 0.92 ENSDART00000130678
spam1
sperm adhesion molecule 1
chr6_+_41039166 0.92 ENSDART00000125659
entpd8
ectonucleoside triphosphate diphosphohydrolase 8
chr4_-_77624155 0.89 ENSDART00000099761
si:ch211-250m6.7
si:ch211-250m6.7
chr20_-_25481306 0.89 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr15_+_25156382 0.87 ENSDART00000171092
slc35f2l
info solute carrier family 35, member F2, like
chr8_+_23391263 0.87 ENSDART00000149687
si:dkey-16n15.6
si:dkey-16n15.6
chr7_+_19817306 0.85 ENSDART00000044425
BX957278.1

chr18_-_48530221 0.84 ENSDART00000188134
ENSDART00000142107
kcnj1a.2
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 2
chr19_+_28256076 0.83 ENSDART00000133354
irx4b
iroquois homeobox 4b
chr22_+_17261801 0.82 ENSDART00000192978
ENSDART00000193187
ENSDART00000179953
ENSDART00000134798
tdrd5
tudor domain containing 5
chr16_+_11623956 0.82 ENSDART00000137788
cxcr3.1
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr5_+_45921234 0.81 ENSDART00000134355
ankdd1b
ankyrin repeat and death domain containing 1B
chr3_-_16250527 0.81 ENSDART00000146699
ENSDART00000141181
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr8_+_23390844 0.76 ENSDART00000184556
si:dkey-16n15.6
si:dkey-16n15.6
chr18_+_2554666 0.75 ENSDART00000167218
p2ry2.1
purinergic receptor P2Y2, tandem duplicate 1
chr7_-_29534001 0.75 ENSDART00000124028
anxa2b
annexin A2b
chr13_+_43050562 0.68 ENSDART00000016602
cdh23
cadherin-related 23
chr2_-_43635777 0.68 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr18_-_48517040 0.68 ENSDART00000143645
kcnj1a.3
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr13_+_24853578 0.67 ENSDART00000145865
si:dkey-24f15.2
si:dkey-24f15.2
chr16_+_11603096 0.62 ENSDART00000146286
si:dkey-11o1.3
si:dkey-11o1.3
chr6_+_54221654 0.62 ENSDART00000128456
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr5_+_45322734 0.57 ENSDART00000084411
adamts3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr4_-_32179699 0.56 ENSDART00000124106
ENSDART00000158835
si:dkey-72l17.6
si:dkey-72l17.6
chr6_+_30456788 0.56 ENSDART00000121492
FP236735.1

chr21_-_20328375 0.51 ENSDART00000079593
slc26a1
solute carrier family 26 (anion exchanger), member 1
chr25_-_37191929 0.50 ENSDART00000128108
urahb
urate (5-hydroxyiso-) hydrolase b
chr22_+_15960005 0.50 ENSDART00000033617
stil
scl/tal1 interrupting locus
chr22_+_15960514 0.47 ENSDART00000181617
stil
scl/tal1 interrupting locus
chr4_+_58016732 0.47 ENSDART00000165777
CT027609.1

chr24_+_35787629 0.46 ENSDART00000136721
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr25_+_16194979 0.46 ENSDART00000185592
ENSDART00000158582
ENSDART00000161109
ENSDART00000139013
mical2b
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr18_+_13182528 0.44 ENSDART00000166298
zgc:56622
zgc:56622
chr5_+_44846434 0.44 ENSDART00000145299
ENSDART00000136521
kank1a
KN motif and ankyrin repeat domains 1a
chr4_-_56954002 0.43 ENSDART00000160934
si:dkey-269o24.1
si:dkey-269o24.1
chr14_+_31721171 0.40 ENSDART00000173034
adgrg4a
adhesion G protein-coupled receptor G4a
chr16_-_9675982 0.40 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)
chr18_-_48508585 0.39 ENSDART00000133364
kcnj1a.4
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 4
chr4_+_54798291 0.37 ENSDART00000165113
ENSDART00000109624
si:dkeyp-82b4.6
si:dkeyp-82b4.6
chr5_+_1877464 0.37 ENSDART00000050658
zgc:101699
zgc:101699
chr20_-_43723860 0.37 ENSDART00000122051
mixl1
Mix paired-like homeobox
chr2_-_17828279 0.35 ENSDART00000083314
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr11_-_45152912 0.35 ENSDART00000167540
ENSDART00000173050
ENSDART00000170795
afmid
arylformamidase
chr8_+_17869225 0.33 ENSDART00000080079
slc44a5b
solute carrier family 44, member 5b
chr11_-_45152702 0.31 ENSDART00000168066
afmid
arylformamidase
chr2_+_17055069 0.31 ENSDART00000115078
thpo
thrombopoietin
chr18_+_14342326 0.29 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
si:dkey-246g23.2
chr3_+_19446997 0.28 ENSDART00000079352
zgc:123297
zgc:123297
chr9_-_14108896 0.25 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr21_+_39941559 0.25 ENSDART00000189718
ENSDART00000160875
ENSDART00000135235
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr4_-_12766418 0.25 ENSDART00000024312
dera
deoxyribose-phosphate aldolase (putative)
chr22_+_15959844 0.24 ENSDART00000182201
stil
scl/tal1 interrupting locus
chr5_+_37854685 0.23 ENSDART00000051222
ENSDART00000185283
ins
preproinsulin
chr2_-_58183499 0.22 ENSDART00000172281
ENSDART00000186262
si:ch1073-185p12.2
si:ch1073-185p12.2
chr6_-_43283122 0.20 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr19_-_15229421 0.19 ENSDART00000055619
phactr4a
phosphatase and actin regulator 4a
chr10_-_41664427 0.17 ENSDART00000150213
ggt1b
gamma-glutamyltransferase 1b
chr18_+_3530769 0.17 ENSDART00000163469
si:ch73-338a16.3
si:ch73-338a16.3
chr11_+_575665 0.16 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr11_-_40647190 0.16 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
fam213b
family with sequence similarity 213, member B
chr6_-_49078702 0.15 ENSDART00000135185
slc5a8l
solute carrier family 5 (iodide transporter), member 8-like
chr25_+_3759553 0.15 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
thoc5
THO complex 5
chr6_-_25180438 0.14 ENSDART00000159696
lrrc8db
leucine rich repeat containing 8 VRAC subunit Db
chr15_+_29283981 0.13 ENSDART00000099895
rap1gap2a
RAP1 GTPase activating protein 2a
chr6_-_56103718 0.12 ENSDART00000191002
gcnt7
glucosaminyl (N-acetyl) transferase family member 7
chr21_-_38853737 0.11 ENSDART00000184100
tlr22
toll-like receptor 22
chr9_+_28232522 0.10 ENSDART00000031761
fzd5
frizzled class receptor 5
chr23_+_33752275 0.10 ENSDART00000007260
si:ch211-210c8.6
si:ch211-210c8.6
chr3_+_13559199 0.10 ENSDART00000166547
si:ch73-106n3.1
si:ch73-106n3.1
chr6_-_29515709 0.09 ENSDART00000180205
pex5la
peroxisomal biogenesis factor 5-like a
chr15_+_35139457 0.08 ENSDART00000059204
slc19a3a
solute carrier family 19 (thiamine transporter), member 3a
chr4_-_73136420 0.08 ENSDART00000160907
si:ch73-170d6.3
si:ch73-170d6.3
chr11_+_45153104 0.07 ENSDART00000159204
ENSDART00000177585
tk1
thymidine kinase 1, soluble
chr17_-_17948587 0.06 ENSDART00000090447
hhipl1
HHIP-like 1
chr5_-_19394440 0.05 ENSDART00000163771
foxn4
forkhead box N4
chr3_-_34084387 0.05 ENSDART00000155365
ighv4-3
immunoglobulin heavy variable 4-3
chr6_-_43028270 0.05 ENSDART00000149092
ENSDART00000149559
glyctk
glycerate kinase
chr2_+_36121373 0.04 ENSDART00000187002
CT867973.2

chr5_+_21225017 0.03 ENSDART00000141573
si:dkey-13n15.11
si:dkey-13n15.11
chr12_+_27061720 0.03 ENSDART00000153426
srcap
Snf2-related CREBBP activator protein
chr17_-_50233493 0.03 ENSDART00000172266
fosaa
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr23_+_32335871 0.02 ENSDART00000149698
slc39a5
solute carrier family 39 (zinc transporter), member 5
chr2_+_35880600 0.02 ENSDART00000004277
lamc1
laminin, gamma 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1ba+hnf1bb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.7 5.1 GO:0044321 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
1.5 5.8 GO:0071548 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
1.0 6.1 GO:0050764 regulation of phagocytosis(GO:0050764)
0.6 22.9 GO:0032355 response to estradiol(GO:0032355)
0.6 5.4 GO:0070365 hepatocyte differentiation(GO:0070365)
0.6 4.6 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.6 2.9 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.5 5.6 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.5 1.5 GO:0019695 choline metabolic process(GO:0019695)
0.4 6.5 GO:0072378 platelet aggregation(GO:0070527) blood coagulation, fibrin clot formation(GO:0072378)
0.4 2.0 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.4 11.4 GO:0019835 cytolysis(GO:0019835)
0.4 30.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.3 1.6 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.3 7.5 GO:0051180 vitamin transport(GO:0051180)
0.3 1.8 GO:0055064 chloride ion homeostasis(GO:0055064)
0.3 3.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 1.9 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.3 3.8 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 3.4 GO:0016556 mRNA modification(GO:0016556)
0.2 3.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 1.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 11.1 GO:0007596 blood coagulation(GO:0007596)
0.2 1.3 GO:0005513 detection of calcium ion(GO:0005513)
0.2 2.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 0.8 GO:0070257 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.2 3.8 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 1.1 GO:0060017 parathyroid gland development(GO:0060017)
0.2 1.4 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.7 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.7 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.1 1.2 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.1 0.8 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.1 1.1 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 0.4 GO:0045056 transcytosis(GO:0045056)
0.1 0.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.9 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.1 GO:0046104 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 5.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 1.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.4 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 3.1 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.2 GO:0048521 positive regulation of epithelial cell differentiation(GO:0030858) negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
0.1 0.9 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 1.2 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.7 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.2 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
0.0 4.6 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.5 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.3 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 2.7 GO:0048793 pronephros development(GO:0048793)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0005577 fibrinogen complex(GO:0005577)
2.0 6.1 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.8 11.4 GO:0005579 membrane attack complex(GO:0005579)
0.3 0.8 GO:0033391 chromatoid body(GO:0033391)
0.1 0.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 3.4 GO:0016342 catenin complex(GO:0016342)
0.0 49.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 5.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.1 GO:0005770 late endosome(GO:0005770)
0.0 14.4 GO:0005576 extracellular region(GO:0005576)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.3 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 1.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 28.9 GO:0045735 nutrient reservoir activity(GO:0045735)
1.5 4.4 GO:0005499 vitamin D binding(GO:0005499)
1.2 4.6 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
1.0 4.0 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
0.9 2.7 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.7 4.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.6 1.8 GO:0031716 calcitonin receptor binding(GO:0031716)
0.6 2.9 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.5 1.9 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.4 2.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 5.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 3.3 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.3 1.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.3 1.1 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.3 30.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 0.7 GO:0004061 arylformamidase activity(GO:0004061)
0.2 1.9 GO:0005113 patched binding(GO:0005113)
0.2 0.8 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 4.9 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 5.8 GO:0030145 manganese ion binding(GO:0030145)
0.1 5.1 GO:0017046 peptide hormone binding(GO:0017046)
0.1 0.7 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 2.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 3.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 3.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.9 GO:0010181 FMN binding(GO:0010181)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.5 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 0.9 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 1.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 14.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.7 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 0.9 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 3.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.0 5.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 3.8 GO:0004540 ribonuclease activity(GO:0004540)
0.0 3.1 GO:0019842 vitamin binding(GO:0019842)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 1.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 2.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 2.0 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.2 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 11.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 5.1 PID IL27 PATHWAY IL27-mediated signaling events
0.2 3.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 3.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 21.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID BMP PATHWAY BMP receptor signaling
0.0 4.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.3 5.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.1 24.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.6 6.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.5 3.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.5 4.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 3.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.3 5.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 2.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 5.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 3.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 4.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 5.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 2.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.5 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 3.4 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation