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PRJNA207719: Tissue specific transcriptome profiling

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Results for hnf1a

Z-value: 4.92

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Transcription factors associated with hnf1a

Gene Symbol Gene ID Gene Info
ENSDARG00000009470 HNF1 homeobox a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1adr11_v1_chr8_+_39802506_398025060.856.9e-02Click!

Activity profile of hnf1a motif

Sorted Z-values of hnf1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_24757785 7.09 ENSDART00000078225
vitellogenin 5
chr22_-_24791505 7.06 ENSDART00000136837
vitellogenin 4
chr22_-_23625351 6.87 ENSDART00000192588
ENSDART00000163423
complement factor H like 4
chr22_-_24858042 6.74 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vitellogenin 7
chr1_+_10051763 6.69 ENSDART00000011701
fibrinogen beta chain
chr22_-_24738188 6.04 ENSDART00000050238
vitellogenin 1
chr13_+_23988442 6.03 ENSDART00000010918
angiotensinogen
chr5_+_32345187 5.52 ENSDART00000147132
complement component 9
chr5_+_45677781 5.42 ENSDART00000163120
ENSDART00000126537
group-specific component (vitamin D binding protein)
chr23_+_25856541 5.34 ENSDART00000145426
ENSDART00000028236
hepatocyte nuclear factor 4, alpha
chr9_-_9982696 5.26 ENSDART00000192548
ENSDART00000125852
UDP glucuronosyltransferase 1 family a, b
chr21_+_40092301 5.20 ENSDART00000145150
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr22_-_24818066 5.00 ENSDART00000143443
vitellogenin 6
chr22_-_23668356 4.95 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
complement factor H
chr21_-_45920 4.90 ENSDART00000040422
betaine-homocysteine methyltransferase
chr20_-_40750953 4.77 ENSDART00000061256
connexin 28.9
chr2_-_5475910 4.70 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr11_-_37997419 4.56 ENSDART00000102870
solute carrier family 41 (magnesium transporter), member 1
chr5_+_28830643 4.50 ENSDART00000051448
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_-_6172154 4.43 ENSDART00000185434
apobec1 complementation factor
chr12_-_6177894 4.36 ENSDART00000152292
apobec1 complementation factor
chr1_-_12126535 4.32 ENSDART00000164817
ENSDART00000015251
microsomal triglyceride transfer protein
chr5_+_28830388 4.18 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr22_+_12770877 4.14 ENSDART00000044683
formimidoyltransferase cyclodeaminase
chr15_-_33965440 4.13 ENSDART00000163841
lipolysis stimulated lipoprotein receptor
chr7_-_4296771 4.09 ENSDART00000128855
cerebellin 11
chr5_+_28849155 4.07 ENSDART00000079090
zgc:174259
chr5_+_28848870 4.06 ENSDART00000149563
zgc:174259
chr13_-_40726865 4.03 ENSDART00000099847
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr24_-_17039638 3.97 ENSDART00000048823
complement component 8, gamma polypeptide
chr1_-_59348118 3.84 ENSDART00000170901
cytochrome P450, family 3, subfamily A, polypeptide 65
chr15_-_33964897 3.80 ENSDART00000172075
ENSDART00000158126
ENSDART00000160456
lipolysis stimulated lipoprotein receptor
chr20_+_10544100 3.80 ENSDART00000113927
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_-_41942666 3.77 ENSDART00000075673
Epstein-Barr virus induced 3
chr22_-_23706771 3.76 ENSDART00000159771
complement factor H like 1
chr9_-_35633827 3.75 ENSDART00000077745
zona pellucida glycoprotein 2, like 1
chr10_+_21867307 3.68 ENSDART00000126629
cerebellin 17
chr17_+_4030493 3.62 ENSDART00000151849
hydroxyacid oxidase (glycolate oxidase) 1
chr22_-_23748284 3.43 ENSDART00000162005
complement factor H like 2
chr4_+_18804317 3.39 ENSDART00000101043
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr2_-_5466708 3.35 ENSDART00000136682
protein C (inactivator of coagulation factors Va and VIIIa), a
chr9_-_34269066 3.35 ENSDART00000059955
immunoglobulin-like domain containing receptor 1b
chr5_+_28858345 3.20 ENSDART00000111180
si:ch211-186e20.2
chr18_+_15644559 3.14 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr2_-_127945 3.14 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr3_+_49521106 3.13 ENSDART00000162799
crumbs homolog 3a
chr2_+_26647472 3.06 ENSDART00000145415
ENSDART00000157409
tocopherol (alpha) transfer protein
chr8_-_2616326 3.01 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr5_+_26795773 2.93 ENSDART00000145631
transcobalamin II
chr3_+_15505275 2.79 ENSDART00000141714
nuclear protein 1
chr6_-_59563597 2.78 ENSDART00000166311
inhibin beta E subunit
chr22_-_23781083 2.69 ENSDART00000166563
ENSDART00000170458
ENSDART00000166158
ENSDART00000171246
complement factor H like 3
chr15_+_9297340 2.60 ENSDART00000055554
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr25_+_31323978 2.52 ENSDART00000067030
lymphocyte-specific protein 1
chr16_-_17200120 2.38 ENSDART00000147739
glyceraldehyde-3-phosphate dehydrogenase
chr13_+_2394264 2.29 ENSDART00000168595
ELOVL fatty acid elongase 5
chr5_-_30620625 2.17 ENSDART00000098273
transcobalamin like
chr11_-_23332592 2.16 ENSDART00000125024
golgi transport 1A
chr6_+_8622228 2.16 ENSDART00000110470
thrombospondin-type laminin G domain and EAR repeats a
chr8_-_13013123 2.15 ENSDART00000147802
DENN/MADD domain containing 2Da
chr12_-_20373058 2.14 ENSDART00000066382
aquaporin 8a, tandem duplicate 1
chr22_-_17611742 2.11 ENSDART00000144031
glutathione peroxidase 4a
chr2_+_27855102 2.10 ENSDART00000150330
bucky ball
chr5_+_9405283 2.08 ENSDART00000127306
UDP glucuronosyltransferase 2 family, polypeptide A7
chr3_+_26734162 2.06 ENSDART00000114552
si:dkey-202l16.5
chr22_-_17595310 2.05 ENSDART00000099056
glutathione peroxidase 4a
chr12_+_2648043 2.04 ENSDART00000082220
growth differentiation factor 2
chr7_-_10560964 2.03 ENSDART00000172761
ENSDART00000170476
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr5_+_9382301 2.03 ENSDART00000124017
UDP glucuronosyltransferase 2 family, polypeptide A7
chr23_+_26491931 2.00 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
chr1_-_9134045 1.97 ENSDART00000142132
partner and localizer of BRCA2
chr21_+_38002879 1.96 ENSDART00000065183
claudin 2
chr8_+_999421 1.94 ENSDART00000149528
fatty acid binding protein 1b, tandem duplicate 1
chr9_+_21151138 1.90 ENSDART00000133903
hydroxyacid oxidase 2 (long chain)
chr8_-_40555340 1.88 ENSDART00000163348
NPC1 like intracellular cholesterol transporter 1
chr2_-_24402341 1.85 ENSDART00000155442
ENSDART00000088572
zgc:154006
chr7_-_35066457 1.82 ENSDART00000058067
zgc:112160
chr25_-_27541621 1.80 ENSDART00000130678
sperm adhesion molecule 1
chr13_-_42579437 1.73 ENSDART00000135172
family with sequence similarity 83, member Ha
chr5_+_57480014 1.73 ENSDART00000135520
si:ch211-202f5.3
chr14_-_17622080 1.69 ENSDART00000112149
si:ch211-159i8.4
chr6_+_7977611 1.67 ENSDART00000112290
paralemmin 3
chr5_-_37886063 1.66 ENSDART00000131378
ENSDART00000132152
si:ch211-139a5.9
chr7_-_61901695 1.64 ENSDART00000110328
SH3 domain and tetratricopeptide repeats 1
chr5_+_9417409 1.63 ENSDART00000125421
ENSDART00000130265
UDP glucuronosyltransferase 2 family, polypeptide B5
chr5_+_9377005 1.57 ENSDART00000124924
UDP glucuronosyltransferase 2 family, polypeptide A7
chr24_-_4765740 1.57 ENSDART00000121576
carboxypeptidase B1 (tissue)
chr25_-_27541288 1.53 ENSDART00000187245
sperm adhesion molecule 1
chr12_+_13091842 1.52 ENSDART00000185477
ENSDART00000181435
ENSDART00000124799
si:ch211-103b1.2
chr7_+_40205394 1.51 ENSDART00000173742
ENSDART00000148390
non-SMC condensin II complex, subunit G2
chr10_-_34915886 1.51 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr11_-_27962757 1.44 ENSDART00000147386
endothelin converting enzyme 1
chr2_-_43635777 1.42 ENSDART00000148633
integrin, beta 1b.1
chr25_+_29474583 1.37 ENSDART00000191189
interleukin 17 receptor E-like
chr6_+_41039166 1.34 ENSDART00000125659
ectonucleoside triphosphate diphosphohydrolase 8
chr23_-_31060350 1.33 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
chr3_+_12718100 1.33 ENSDART00000162343
ENSDART00000192425
cytochrome P450, family 2, subfamily k, polypeptide 20
chr7_+_2849020 1.30 ENSDART00000168695

chr21_+_25236297 1.29 ENSDART00000112783
transmembrane protein 45B
chr13_-_23666579 1.28 ENSDART00000192457
ENSDART00000179777
mitogen-activated protein kinase kinase kinase 21
chr6_-_39344259 1.27 ENSDART00000104074
zgc:158846
chr11_+_43419809 1.25 ENSDART00000172982
solute carrier family 29 (equilibrative nucleoside transporter), member 1b
chr14_-_32884138 1.23 ENSDART00000105726
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr7_-_29534001 1.22 ENSDART00000124028
annexin A2b
chr10_-_34916208 1.21 ENSDART00000187371
cyclin A1
chr17_+_30591287 1.21 ENSDART00000154243
si:dkey-190l8.2
chr16_-_42894628 1.21 ENSDART00000045600
hemochromatosis type 2
chr2_-_58183499 1.20 ENSDART00000172281
ENSDART00000186262
si:ch1073-185p12.2
chr20_+_6543674 1.20 ENSDART00000134204
tensin 3, tandem duplicate 1
chr21_-_31286428 1.18 ENSDART00000185334
carbonic anhydrase IV c
chr14_-_11507211 1.16 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
chr25_+_29474982 1.15 ENSDART00000130410
interleukin 17 receptor E-like
chr20_+_35473288 1.14 ENSDART00000047195
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1
chr17_-_34952562 1.08 ENSDART00000021128
kinase D-interacting substrate 220a
chr24_-_23675446 1.08 ENSDART00000066644
hepatocyte nuclear factor 4, gamma
chr25_+_34915762 1.05 ENSDART00000191776
syntrophin, beta 2
chr3_+_25191467 1.05 ENSDART00000156956
ENSDART00000154799
interleukin 2 receptor, beta
chr12_+_5209822 1.04 ENSDART00000152610
si:ch211-197g18.2
chr20_+_48754045 1.03 ENSDART00000062578
zgc:110348
chr24_-_20016817 1.03 ENSDART00000082201
ENSDART00000189448
solute carrier family 22 member 13b
chr2_+_17055069 1.02 ENSDART00000115078
thrombopoietin
chr14_-_41556720 1.02 ENSDART00000149244
integrin, alpha 6, like
chr25_+_23280220 1.02 ENSDART00000153940
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr24_-_34680956 1.02 ENSDART00000171009
catenin (cadherin-associated protein), alpha 1
chr2_-_36500347 0.99 ENSDART00000110528

chr15_-_23467750 0.99 ENSDART00000148804
PDZ domain containing 3a
chr9_+_29994439 0.97 ENSDART00000012447
transmembrane protein 30C
chr21_-_22647695 0.97 ENSDART00000187553
grass carp reovirus (GCRV)-induced gene 2l
chr3_+_31039923 0.96 ENSDART00000147706
cytochrome c oxidase subunit VIa polypeptide 2
chr3_-_6191950 0.95 ENSDART00000161931
si:ch73-144l3.1
chr4_+_57881965 0.93 ENSDART00000162234
si:dkeyp-44b5.4
chr18_+_15683157 0.91 ENSDART00000140933
si:ch211-264e16.2
chr3_+_49097775 0.91 ENSDART00000169185
zgc:123284
chr24_+_5811808 0.91 ENSDART00000132428
si:ch211-157j23.3
chr20_+_18740518 0.91 ENSDART00000142196
family with sequence similarity 167, member Ab
chr6_-_43498996 0.87 ENSDART00000154742
si:dkey-58f6.2
chr22_+_15960514 0.87 ENSDART00000181617
scl/tal1 interrupting locus
chr3_+_13559199 0.86 ENSDART00000166547
si:ch73-106n3.1
chr6_-_43283122 0.84 ENSDART00000186022
FERM domain containing 4Ba
chr6_+_34028532 0.83 ENSDART00000155827
si:ch73-185c24.2
chr25_-_7670616 0.80 ENSDART00000131583
ENSDART00000142794
Bet1 golgi vesicular membrane trafficking protein-like
chr5_+_1877464 0.80 ENSDART00000050658
zgc:101699
chr22_+_15960005 0.80 ENSDART00000033617
scl/tal1 interrupting locus
chr19_+_28256076 0.79 ENSDART00000133354
iroquois homeobox 4b
chr6_-_37744430 0.77 ENSDART00000150177
ENSDART00000149722
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr5_-_67783593 0.75 ENSDART00000010934
calcium-sensing receptor
chr17_+_15388479 0.73 ENSDART00000052439
si:ch211-266g18.6
chr18_+_13182528 0.71 ENSDART00000166298
zgc:56622
chr9_+_30720048 0.71 ENSDART00000146115
Kruppel-like factor 12b
chr16_+_55059026 0.71 ENSDART00000109391
Danio rerio nuclear receptor coactivator 7-like (LOC792958), mRNA.
chr16_+_11623956 0.71 ENSDART00000137788
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr15_+_14109652 0.70 ENSDART00000156370
chloride channel accessory 1
chr3_-_53092509 0.70 ENSDART00000062081
lysophosphatidic acid receptor 2a
chr8_+_1187928 0.70 ENSDART00000127252
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr5_-_63302944 0.69 ENSDART00000047110
gelsolin b
chr16_+_11603096 0.69 ENSDART00000146286
si:dkey-11o1.3
chr20_+_18740799 0.67 ENSDART00000174532
family with sequence similarity 167, member Ab
chr25_+_34915576 0.66 ENSDART00000073441
syntrophin, beta 2
chr12_+_15666949 0.66 ENSDART00000079803
N-myristoyltransferase 1b
chr3_-_53091946 0.66 ENSDART00000187297
lysophosphatidic acid receptor 2a
chr11_-_12800945 0.64 ENSDART00000191178
taxilin gamma
chr17_+_1496107 0.63 ENSDART00000187804

chr3_-_18047150 0.63 ENSDART00000020376
hydroxysteroid (17-beta) dehydrogenase 1
chr4_-_56954002 0.61 ENSDART00000160934
si:dkey-269o24.1
chr11_-_19501439 0.61 ENSDART00000158328
ENSDART00000103983
solute carrier family 2 (facilitated glucose transporter), member 9-like 1
chr6_+_40723554 0.61 ENSDART00000103833
solute carrier family 26, member 6, like
chr14_+_46118834 0.61 ENSDART00000124417
ENSDART00000017785
N(alpha)-acetyltransferase 15, NatA auxiliary subunit a
chr13_+_18523661 0.61 ENSDART00000034852
toll-like receptor 4b, duplicate b
chr11_-_12801157 0.60 ENSDART00000103449
taxilin gamma
chr21_+_11535304 0.59 ENSDART00000158901
ENSDART00000081600
cd8 beta
chr13_+_24853578 0.58 ENSDART00000145865
si:dkey-24f15.2
chr20_-_25481306 0.58 ENSDART00000182495
si:dkey-183n20.15
chr7_-_25126212 0.54 ENSDART00000173588
si:dkey-23i12.11
chr2_-_10821053 0.54 ENSDART00000056034
RNA polymerase II associated protein 2
chr14_+_31721171 0.53 ENSDART00000173034
adhesion G protein-coupled receptor G4a
chr23_-_20345473 0.51 ENSDART00000140935
si:rp71-17i16.6
chr2_+_36121373 0.51 ENSDART00000187002

chr3_-_16250527 0.51 ENSDART00000146699
ENSDART00000141181
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr16_-_31980948 0.50 ENSDART00000182427

chr20_-_43723860 0.49 ENSDART00000122051
Mix paired-like homeobox
chr22_+_15959844 0.48 ENSDART00000182201
scl/tal1 interrupting locus
chr6_+_30456788 0.47 ENSDART00000121492

chr25_+_16194979 0.47 ENSDART00000185592
ENSDART00000158582
ENSDART00000161109
ENSDART00000139013
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr19_-_15229421 0.46 ENSDART00000055619
phosphatase and actin regulator 4a
chr2_-_23778180 0.46 ENSDART00000136782
si:dkey-24c2.7
chr11_-_40647190 0.45 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
family with sequence similarity 213, member B
chr25_-_37191929 0.44 ENSDART00000128108
urate (5-hydroxyiso-) hydrolase b
chr12_+_6117682 0.43 ENSDART00000146650
N-acylsphingosine amidohydrolase 2
chr7_+_67429185 0.43 ENSDART00000162553
ENSDART00000178646
lysyl-tRNA synthetase
chr6_-_32087108 0.42 ENSDART00000150934
ENSDART00000130627
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
chr19_+_31043002 0.42 ENSDART00000171591
ankyrin repeat and MYND domain containing 2b
chr16_+_11724230 0.41 ENSDART00000060266
carcinoembryonic antigen-related cell adhesion molecule 1
chr8_+_17869225 0.40 ENSDART00000080079
solute carrier family 44, member 5b
chr14_-_41556533 0.40 ENSDART00000074401
integrin, alpha 6, like
chr16_-_29403711 0.38 ENSDART00000175571
toll-like receptor 18
chr4_-_14470071 0.37 ENSDART00000143773
plexin b2a
chr5_+_45322734 0.37 ENSDART00000084411
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr23_+_33752275 0.37 ENSDART00000007260
si:ch211-210c8.6
chr15_+_27364394 0.34 ENSDART00000122101
T-box 2b
chr4_-_12766418 0.34 ENSDART00000024312
deoxyribose-phosphate aldolase (putative)

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.4 4.1 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
1.3 3.8 GO:0033210 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
1.0 2.9 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.8 32.2 GO:0032355 response to estradiol(GO:0032355)
0.6 8.8 GO:0016556 mRNA modification(GO:0016556)
0.5 4.3 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.5 5.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.4 6.7 GO:0070527 platelet aggregation(GO:0070527) blood coagulation, fibrin clot formation(GO:0072378)
0.4 4.6 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.4 35.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.4 2.7 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.4 2.1 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.3 8.5 GO:0051180 vitamin transport(GO:0051180)
0.3 4.9 GO:0009086 methionine biosynthetic process(GO:0009086)
0.3 1.2 GO:0015868 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.3 2.0 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.3 3.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 1.4 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 1.2 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.2 2.1 GO:0071539 protein localization to centrosome(GO:0071539)
0.2 2.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 0.7 GO:0018377 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.2 1.3 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.2 3.1 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.2 3.3 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.2 0.5 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 3.4 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.5 GO:0072025 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.2 8.0 GO:0007596 blood coagulation(GO:0007596)
0.1 3.1 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 0.7 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.7 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 2.7 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.6 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.6 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 0.3 GO:0046125 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 1.4 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 8.4 GO:0007492 endoderm development(GO:0007492)
0.1 1.3 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 0.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 3.8 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 1.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 2.4 GO:0050821 protein stabilization(GO:0050821)
0.1 0.2 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.1 1.3 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 2.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.1 5.5 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 1.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 2.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.0 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.2 GO:0045056 transcytosis(GO:0045056)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.5 GO:0030261 chromosome condensation(GO:0030261)
0.0 1.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.6 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.3 GO:0046386 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
0.0 0.8 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.8 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 3.4 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 1.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.7 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.2 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 1.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 2.0 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 1.1 GO:0001894 tissue homeostasis(GO:0001894)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0005577 fibrinogen complex(GO:0005577)
1.8 5.5 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.9 2.7 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.3 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 2.1 GO:0032019 mitochondrial cloud(GO:0032019)
0.2 2.7 GO:0045095 keratin filament(GO:0045095)
0.2 1.5 GO:0000796 condensin complex(GO:0000796)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 0.8 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.9 GO:0030428 cell septum(GO:0030428)
0.1 1.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.1 GO:0030057 desmosome(GO:0030057)
0.0 2.2 GO:0008305 integrin complex(GO:0008305)
0.0 4.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 52.8 GO:0005615 extracellular space(GO:0005615)
0.0 4.7 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 3.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.8 GO:0005770 late endosome(GO:0005770)
0.0 1.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 31.9 GO:0045735 nutrient reservoir activity(GO:0045735)
1.8 5.4 GO:0005499 vitamin D binding(GO:0005499)
1.3 4.0 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
1.1 4.3 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
1.0 4.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.8 4.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.6 3.1 GO:0032052 bile acid binding(GO:0032052)
0.6 2.4 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5 4.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 2.9 GO:0031419 cobalamin binding(GO:0031419)
0.3 1.0 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.3 1.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.3 35.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 3.1 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.3 1.4 GO:0098639 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.3 5.5 GO:0010181 FMN binding(GO:0010181)
0.2 2.1 GO:0015250 water channel activity(GO:0015250)
0.2 1.4 GO:0019215 intermediate filament binding(GO:0019215)
0.2 2.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 4.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 0.7 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.2 12.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 2.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 0.7 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 0.7 GO:0005461 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.2 0.6 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2 0.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 1.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.9 GO:0005504 fatty acid binding(GO:0005504)
0.1 8.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.9 GO:0004100 chitin synthase activity(GO:0004100)
0.1 2.3 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 3.8 GO:0017046 peptide hormone binding(GO:0017046)
0.1 1.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 1.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 0.5 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 0.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.4 GO:0017040 ceramidase activity(GO:0017040)
0.1 4.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 5.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 1.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 3.7 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 9.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 2.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 5.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.0 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 0.4 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.5 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.2 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0043621 protein self-association(GO:0043621)
0.0 1.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.0 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 2.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 6.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 3.8 PID IL27 PATHWAY IL27-mediated signaling events
0.2 2.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.0 PID ALK1 PATHWAY ALK1 signaling events
0.1 11.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.6 6.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 4.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 9.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.4 2.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 6.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 2.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 1.2 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 6.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 2.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 4.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 4.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.0 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 6.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.0 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 7.3 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 1.0 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 2.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein